C Antzelevitch

Summary

Affiliation: Masonic Medical Research Laboratory
Country: USA

Publications

  1. ncbi request reprint Brugada syndrome: a decade of progress
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Circ Res 91:1114-8. 2002
  2. ncbi request reprint Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure
    Alexander Burashnikov
    From the Masonic Medical Research Laboratory, Utica, NY A B, J M D D, H B M, D H, A C Z, J M C, C A Department of Clinical and Biological Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY N S M, B G K and Gilead Sciences, Foster City, CA L B
    Circ Heart Fail 7:627-33. 2014
  3. pmc The role of late I Na in development of cardiac arrhythmias
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY, 13501, USA
    Handb Exp Pharmacol 221:137-68. 2014
  4. pmc J wave syndromes: molecular and cellular mechanisms
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY, USA Electronic address
    J Electrocardiol 46:510-8. 2013
  5. pmc Genetic, molecular and cellular mechanisms underlying the J wave syndromes
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    Circ J 76:1054-65. 2012
  6. pmc Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 3501 1787, USA
    J Intern Med 259:48-58. 2006
  7. ncbi request reprint Molecular genetics of arrhythmias and cardiovascular conditions associated with arrhythmias
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Pacing Clin Electrophysiol 26:2194-208. 2003
  8. pmc The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York, NY 13501, USA
    J Cardiovasc Electrophysiol 17:S79-S85. 2006
  9. ncbi request reprint Cellular mechanisms underlying the long QT syndrome
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York, USA National Cardiovascular Center, Osaka, Japan
    Curr Opin Cardiol 17:43-51. 2002
  10. ncbi request reprint Brugada syndrome: 1992-2002: a historical perspective
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    J Am Coll Cardiol 41:1665-71. 2003

Research Grants

  1. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2007
  2. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2006
  3. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2005
  4. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2004
  5. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2003
  6. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2002
  7. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2001
  8. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2000
  9. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 1999
  10. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 1993

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Brugada syndrome: a decade of progress
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Circ Res 91:1114-8. 2002
    ..This minireview briefly summarizes the progress made over the past decade in our understanding of the clinical, genetic, cellular, ionic, and molecular aspects of this disease...
  2. ncbi request reprint Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure
    Alexander Burashnikov
    From the Masonic Medical Research Laboratory, Utica, NY A B, J M D D, H B M, D H, A C Z, J M C, C A Department of Clinical and Biological Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY N S M, B G K and Gilead Sciences, Foster City, CA L B
    Circ Heart Fail 7:627-33. 2014
    ..There is a critical need for safer and more effective pharmacological management of atrial fibrillation (AF) in the setting of heart failure (HF)...
  3. pmc The role of late I Na in development of cardiac arrhythmias
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY, 13501, USA
    Handb Exp Pharmacol 221:137-68. 2014
    ..Selective inhibition of late I Na is expected to be an effective strategy for correcting these acquired and congenital channelopathies...
  4. pmc J wave syndromes: molecular and cellular mechanisms
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY, USA Electronic address
    J Electrocardiol 46:510-8. 2013
    ..Identifying subjects truly at risk is the challenge ahead. Our goal here is to review the clinical and genetic aspects as well as the cellular and molecular mechanisms underlying the J wave syndromes. ..
  5. pmc Genetic, molecular and cellular mechanisms underlying the J wave syndromes
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    Circ J 76:1054-65. 2012
    ..The challenge ahead is to be able to identify those at risk for sudden cardiac death. Here I review the clinical and genetic aspects as well as the cellular and molecular mechanisms underlying the J wave syndromes...
  6. pmc Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 3501 1787, USA
    J Intern Med 259:48-58. 2006
    ..In conclusion, the long QT, short QT, Brugada and catecholaminergic VT syndromes are pathologies with very different phenotypes and aetiologies, but which share a common final pathway in causing sudden death...
  7. ncbi request reprint Molecular genetics of arrhythmias and cardiovascular conditions associated with arrhythmias
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Pacing Clin Electrophysiol 26:2194-208. 2003
  8. pmc The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York, NY 13501, USA
    J Cardiovasc Electrophysiol 17:S79-S85. 2006
    ....
  9. ncbi request reprint Cellular mechanisms underlying the long QT syndrome
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York, USA National Cardiovascular Center, Osaka, Japan
    Curr Opin Cardiol 17:43-51. 2002
    ..The available data suggest that that the principal problem with the long QT syndrome is not long QT intervals but rather the dispersion of repolarization that often accompanies prolongation of the QT interval...
  10. ncbi request reprint Brugada syndrome: 1992-2002: a historical perspective
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    J Am Coll Cardiol 41:1665-71. 2003
    ..The purpose of this brief review is to chronicle the historical highlights that have brought us to our present understanding of Brugada syndrome...
  11. pmc Cellular basis for the repolarization waves of the ECG
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Ann N Y Acad Sci 1080:268-81. 2006
    ..Although direct evidence in support of any of these three hypotheses is lacking, recent studies involving the short QT syndrome have generated renewed interest in the mechanoelectrical hypothesis...
  12. pmc Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 115:442-9. 2007
    ..We describe a new clinical entity that consists of an ST-segment elevation in the right precordial ECG leads, a shorter-than-normal QT interval, and a history of sudden cardiac death...
  13. pmc Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleeker Street, Utica, NY 13501, USA
    Heart Rhythm 2:S9-15. 2005
    ....
  14. ncbi request reprint Molecular genetics of arrhythmias and cardiovascular conditions associated with arrhythmias
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    J Cardiovasc Electrophysiol 14:1259-72. 2003
  15. pmc Modulation of transmural repolarization
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501 1787, USA
    Ann N Y Acad Sci 1047:314-23. 2005
    ..These actions also lead to a TDR that manifests as the Brugada syndrome in RV and the short QT syndrome in LV...
  16. ncbi request reprint Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Cardiovasc Pharmacol Ther 9:S65-83. 2004
    ..Ranolazine's actions to reduce TDR and suppress early after depolarization suggest that in addition to its anti-anginal actions, the drug possesses antiarrhythmic activity...
  17. pmc Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 110:904-10. 2004
    ..The present study examines its electrophysiological effects in isolated canine ventricular myocytes, tissues, and arterially perfused left ventricular wedge preparations...
  18. ncbi request reprint Cellular basis and mechanism underlying normal and abnormal myocardial repolarization and arrhythmogenesis
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, New York 13501, USA
    Ann Med 36:5-14. 2004
    ....
  19. ncbi request reprint Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem?
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Electrocardiol 37:15-24. 2004
    ..Moreover, drugs such as sodium pentobarbital, which reduce transmural dispersion of repolarization, can diminish the likelihood of TdP, despite their ability to prolong the QT interval...
  20. pmc Brugada syndrome: from cell to bedside
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Curr Probl Cardiol 30:9-54. 2005
    ....
  21. pmc Brugada syndrome
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Pacing Clin Electrophysiol 29:1130-59. 2006
    ..Controversies with regard to risk stratification and newly proposed pharmacologic strategies are discussed...
  22. ncbi request reprint Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 111:659-70. 2005
    ....
  23. ncbi request reprint Brugada syndrome: clinical, genetic, molecular, cellular and ionic aspects
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Expert Rev Cardiovasc Ther 1:177-85. 2003
    ..This brief review summarizes the key clinical and experimental milestones that have brought us to our current understanding and approach to therapy of the Brugada syndrome...
  24. ncbi request reprint Brugada syndrome: report of the second consensus conference
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Heart Rhythm 2:429-40. 2005
    ....
  25. pmc Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501 1787, USA
    Am J Physiol Heart Circ Physiol 293:H2024-38. 2007
    ..In conclusion, long QT, short QT, Brugada, and catecholaminergic polymorphic VT syndromes are pathologies with very different phenotypes and etiologies, but they share a common final pathway in causing sudden cardiac death...
  26. pmc J-wave syndromes. from cell to bedside
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Electrocardiol 44:656-61. 2011
    ....
  27. pmc Electrophysiologic basis for the antiarrhythmic actions of ranolazine
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York, USA
    Heart Rhythm 8:1281-90. 2011
    ..This review summarizes the available data regarding the electrophysiologic actions and antiarrhythmic properties of ranolazine in preclinical and clinical studies...
  28. pmc Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac voltage-dependent L-type calcium channel
    Carlo Napolitano
    Executive Director and Director of Research, Gordon K Moe Scholar, Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circ Res 108:607-18. 2011
    ....
  29. ncbi request reprint Cellular and ionic mechanisms responsible for the Brugada syndrome
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Electrocardiol 33:33-9. 2000
    ..Therapy is directed at restoring the balance of current via inhibition of the transient outward current, Ito, and/or stimulation of inward calcium using beta adrenergic agonists, among several strategies...
  30. pmc Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Ann N Y Acad Sci 1188:78-86. 2010
    ..These findings suggest that atrial-selective sodium channel block may be a fruitful new strategy for the management of AF...
  31. pmc Molecular basis for the transmural distribution of the transient outward current
    C Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    J Physiol 533:1. 2001
    ..1999; Antzelevitch & Dumaine, 2000)...
  32. ncbi request reprint The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Electrophysiol 10:1124-52. 1999
    ..These observations may explain the inability of earlier studies to detect the M cell...
  33. pmc J wave syndromes
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Heart Rhythm 7:549-58. 2010
    ....
  34. ncbi request reprint Electrical heterogeneity within the ventricular wall
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Basic Res Cardiol 96:517-27. 2001
    ....
  35. pmc Cardiac repolarization. The long and short of it
    Charles Antzelevitch
    Gordon K Moe Scholar, Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    Europace 7:3-9. 2005
    ....
  36. pmc Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY, USA
    J Electrocardiol 42:543-8. 2009
    ..Our observations suggest that atrial-selective sodium channel block may be a fruitful strategy for the management of AF...
  37. ncbi request reprint Ion channels and ventricular arrhythmias: cellular and ionic mechanisms underlying the Brugada syndrome
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Curr Opin Cardiol 14:274-9. 1999
    ....
  38. pmc Brugada syndrome: recent advances and controversies
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    Curr Cardiol Rep 10:376-83. 2008
    ..This article provides a brief overview of recent advances in our understanding of the clinical presentation and molecular and cellular mechanisms and an update of existing controversies...
  39. pmc Drug-induced spatial dispersion of repolarization
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501 1787, USA
    Cardiol J 15:100-21. 2008
    ..This review also discusses the value of the interval between the peak and end of the T wave (T(peak)-T(end), T(p)-T(e)) as an index of SDR and transmural dispersion of repolarization, in particular...
  40. pmc Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    Europace 9:iv4-15. 2007
    ..This article reviews recent advances in our understanding of these mechanisms, particularly the role of TDR in the genesis of drug-induced TdP, and examines how these may guide us towards development of safer drugs...
  41. pmc Heterogeneity and cardiac arrhythmias: an overview
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    Heart Rhythm 4:964-72. 2007
    ..However, these syndromes share a common final pathway in their predisposition to sudden cardiac death...
  42. ncbi request reprint Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes
    C Antzelevitch
    Masonic Medical Research Laboratory Utica, New York 13501, USA
    J Am Coll Cardiol 28:1836-48. 1996
    ..This study sought to elucidate the cellular and ionic basts for erythromycin-induced long QT syndrome...
  43. ncbi request reprint Molecular biology and cellular mechanisms of Brugada and long QT syndromes in infants and young children
    C Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Electrocardiol 34:177-81. 2001
    ..These issues are discussed in other articles. These concerns notwithstanding, it is important that we continue to question whether the economic inefficiencies of current screening methodologies supersede the value of a young life...
  44. ncbi request reprint Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing
    Jeffrey M Fish
    Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    Circulation 109:2136-42. 2004
    ..The present study examines the cellular basis for QT prolongation and arrhythmogenesis after reversal of the direction of activation of the LV wall...
  45. pmc Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine
    Serge Sicouri
    Masonic Medical Research Laboratory, Utica, New York 13501 1787, USA
    Heart Rhythm 4:638-47. 2007
    ..2 resulting in gain of function of the L-type calcium current (I(Ca,L)). Ranolazine is an antianginal agent shown to exert an antiarrhythmic effect in experimental models of long QT syndrome...
  46. pmc Potent antiarrhythmic effects of chronic amiodarone in canine pulmonary vein sleeve preparations
    Serge Sicouri
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Electrophysiol 20:803-10. 2009
    ..To examine the effects of chronic amiodarone on the electrophysiology of canine pulmonary vein (PV) sleeve preparations and left ventricular wedge preparation...
  47. pmc Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression
    J M Cordeiro
    Masonic Medical Research Laboratory, Utica, NY 13504, USA
    Am J Physiol Heart Circ Physiol 295:H154-62. 2008
    ....
  48. ncbi request reprint I(NaCa) contributes to electrical heterogeneity within the canine ventricle
    A C Zygmunt
    Department of Experimental Cardiology, Masonic Medical Research Laboratory, Utica, New York 13501 1787, USA
    Am J Physiol Heart Circ Physiol 278:H1671-8. 2000
    ..A large midmyocardial I(NaCa) may contribute to the prolonged action potential of these cells as well as to the development of triggered activity under calcium-loading conditions...
  49. pmc AZD1305 exerts atrial predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its reinduction in the dog
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Cardiovasc Pharmacol 56:80-90. 2010
    ..In conclusion, AZD1305 exerts atrial predominant sodium channel-blocking effects in vitro and in vivo and effectively suppresses AF...
  50. ncbi request reprint Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males
    Jose M Di Diego
    Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    Circulation 106:2004-11. 2002
    ..The present study tests the hypothesis that the disparity in expression of the Brugada phenotype is a result of a more prominent I(to)-mediated action potential notch in the right ventricular (RV) epicardium of males versus females...
  51. ncbi request reprint Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes
    Z Q Sun
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Electrophysiol 12:472-8. 2001
    ..CONCLUSION: Our results indicate that chromanol 293B is a relatively selective blocker of I(Ks) in canine left ventricular myocytes...
  52. ncbi request reprint Cellular basis for complex T waves and arrhythmic activity following combined I(Kr) and I(Ks) block
    T Emori
    Masonic Medical Research Laboratory, Utica, New York 13501-1787, USA
    J Cardiovasc Electrophysiol 12:1369-78. 2001
    ..Our results also suggest possible guidelines for the estimation of TDR from complex T waves appearing in the precordial leads of the surface ECG...
  53. ncbi request reprint Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome
    W Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Cardiovasc Electrophysiol 11:1320-9. 2000
    ..The aim of this study was to examine the effects of Na+ channel blockers on ST segment elevation, QRS, corrected QT (QTc) interval, and ventricular arrhythmias in patients with Brugada syndrome...
  54. pmc Novel mutation in the SCN5A gene associated with arrhythmic storm development during acute myocardial infarction
    Dan Hu
    Masonic Medical Research Laboratory, Utica, New York, USA
    Heart Rhythm 4:1072-80. 2007
    ..Ventricular tachycardia (VT) and ventricular fibrillation (VF) complicating Brugada syndrome, a genetic disorder linked to SCN5A mutations, and VF complicating acute myocardial infarction (AMI) both have been linked to phase 2 reentry...
  55. pmc Atrial-selective sodium channel block as a strategy for suppression of atrial fibrillation
    Alexander Burashnikov
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    Ann N Y Acad Sci 1123:105-12. 2008
    ..Our findings suggest that atrial-selective sodium channel block may be a valuable strategy to combat AF...
  56. ncbi request reprint Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent
    R Dumaine
    Departments of Molecular Biology and Experimental Cardiology, Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Circ Res 85:803-9. 1999
    ....
  57. ncbi request reprint Prominent I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Electrophysiol 13:172-7. 2002
    ..This study tests the hypothesis that these two characteristics are interrelated...
  58. pmc Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome
    Chinmay Patel
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Heart Rhythm 5:585-90. 2008
    ..Short QT syndrome (SQTS) is a primary electrical disease of the heart associated with a high risk of sudden cardiac death. A gain-of-function in I(Kr), due to a mutation in KCNH2, underlies SQT1...
  59. ncbi request reprint Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle
    A C Zygmunt
    Department of Experimental Cardiology, Masonic Medical Research Laboratory, Utica, New York 13501 1787, USA
    Am J Physiol Heart Circ Physiol 281:H689-97. 2001
    ..More importantly, drugs that slow inactivation of sodium channels will produce a nonuniform response across the ventricular wall that is proarrhythmic...
  60. ncbi request reprint Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis
    S Sicouri
    Masonic Medical Research Laboratory, Utica, New York 13504
    J Cardiovasc Electrophysiol 4:48-58. 1993
    ..Epicardial, M region, and endocardial tissues and cells show distinct, sometimes opposite, responses to a variety of drugs, including those capable of inducing EADs and DADs...
  61. pmc Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria
    Serge Sicouri
    Masonic Medical Research Laboratory, Utica, NY
    Circ Arrhythm Electrophysiol 3:88-95. 2010
    ..This study tests the hypothesis that their combined actions synergistically depress I(Na)-dependent parameters in atria but not ventricles...
  62. pmc Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Heart Rhythm 5:1735-42. 2008
    ..Although amiodarone is one of the most effective pharmacologic agents used in clinical management of atrial fibrillation (AF), little is known about its differential effects in atrial and ventricular myocardium...
  63. pmc Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia
    Gi Byoung Nam
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501 1787, USA
    Circulation 111:2727-33. 2005
    ..We examined the cellular basis for the ECG features and arrhythmia mechanisms using low-dose caffeine to mimic the defective calcium homeostasis encountered under these conditions...
  64. ncbi request reprint Afterdepolarizations and triggered activity develop in a select population of cells (M cells) in canine ventricular myocardium: the effects of acetylstrophanthidin and Bay K 8644
    S Sicouri
    Masonic Medical Research Laboratory, Utica, New York 13504
    Pacing Clin Electrophysiol 14:1714-20. 1991
    ..Afterdepolarization-induced triggered activity was never observed in the epicardial or endocardial layers...
  65. pmc Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome
    Dan Hu
    Masonic Medical Research Laboratory, Utica, New York, NY 13501 1787, USA
    Pacing Clin Electrophysiol 33:274-85. 2010
    ..The mechanisms responsible for the development of one without the other are poorly understood...
  66. pmc Value of electrocardiographic parameters and ajmaline test in the diagnosis of Brugada syndrome caused by SCN5A mutations
    Kui Hong
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 110:3023-7. 2004
    ..Sodium channel blockers are effective in unmasking carriers of the disease. However, the value of the test remains controversial...
  67. ncbi request reprint Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome
    Fabrice Extramiana
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Circulation 110:3661-6. 2004
    ..The present study examined the cellular basis of VT/VF in an experimental model associated with short QT intervals created with a potassium channel activator...
  68. pmc Role of sodium and calcium channel block in unmasking the Brugada syndrome
    Jeffrey M Fish
    Masonic Medical Research Laboratory, Utica, New York, USA
    Heart Rhythm 1:210-7. 2004
    ..The present study was designed to test this hypothesis in an in vitro model of BS...
  69. pmc Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation
    Alexander Burashnikov
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    J Am Coll Cardiol 56:1216-24. 2010
    ..The aim of this study was to evaluate the effectiveness of a combination of dronedarone and ranolazine in suppression of atrial fibrillation (AF)...
  70. ncbi request reprint Cellular and ionic basis for the sex-related difference in the manifestation of the Brugada syndrome and progressive conduction disease phenotypes
    Jeffrey M Fish
    Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    J Electrocardiol 36:173-9. 2003
    ..Using canine RV wedge preparations, we developed an experimental model of the BS using terfenadine to depress the AP dome in RV Epi...
  71. pmc New developments in atrial antiarrhythmic drug therapy
    Alexander Burashnikov
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    Nat Rev Cardiol 7:139-48. 2010
    ....
  72. ncbi request reprint Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation
    Jose M Di Diego
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501 1787, USA
    Circulation 108:1027-33. 2003
    ..The present study examines the electrophysiological actions of cisapride in the isolated arterially perfused canine left ventricular wedge preparation...
  73. pmc Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations
    Serge Sicouri
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Heart Rhythm 5:1019-26. 2008
    ..Ectopic activity arising from the pulmonary veins (PV) plays a prominent role in the development of atrial fibrillation (AF)...
  74. pmc Cellular basis for electrocardiographic and arrhythmic manifestations of Andersen-Tawil syndrome (LQT7)
    Masato Tsuboi
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501 1787, USA
    Heart Rhythm 3:328-35. 2006
    ..Andersen-Tawil syndrome, a skeletal muscle syndrome associated with periodic paralysis and long QT intervals on the ECG, has been linked to defects in KCNJ2, the gene encoding for the inward rectifier potassium channel (I(K1).)..
  75. pmc Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy
    Eyal Nof
    Masonic Medical Research Laboratory, Utica, NY, USA
    Heart Rhythm 7:251-7. 2010
    ..Short QT (SQT) syndrome (SQT) 1 is an inherited sudden death syndrome often associated with atrial fibrillation (AF). We examined the cellular basis for AF in a newly developed experimental atrial model of SQT1...
  76. ncbi request reprint Transmural heterogeneity of calcium activity and mechanical function in the canine left ventricle
    Jonathan M Cordeiro
    Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA and
    Am J Physiol Heart Circ Physiol 286:H1471-9. 2004
    ..Although these distinctions are conferred in part by differences in electrical characteristics of the three cell types, intrinsic differences in excitation-contraction coupling are evident...
  77. pmc Genetic predisposition and cellular basis for ischemia-induced ST-segment changes and arrhythmias
    Dan Hu
    Masonic Medical Research Laboratory, Utica, NY, USA
    J Electrocardiol 40:S26-9. 2007
    ..These preliminary studies provide support for the hypothesis that there is a genetic predisposition to the type and severity of arrhythmias that develop during and after an AMI, and that additional studies are warranted...
  78. pmc Potential proarrhythmic effects of biventricular pacing
    Jeffrey M Fish
    Masonic Medical Research Laboratory, Utica, New York 13501 1787, USA
    J Am Coll Cardiol 46:2340-7. 2005
    ....
  79. ncbi request reprint Cellular basis for the monophasic action potential. Which electrode is the recording electrode?
    Masahiko Kondo
    Gordon K Moe Scholar, Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501 1787, USA
    Cardiovasc Res 63:635-44. 2004
    ..At the center of the controversy is the issue as to which of the two electrodes is the recording electrode and which is the indifferent electrode. The present study is designed to address this issue...
  80. ncbi request reprint Cellular basis for ST-segment changes observed during ischemia
    Jose M Di Diego
    Masonic Medical Research Laboratory, Utica, NY 13504, USA
    J Electrocardiol 36:1-5. 2003
    ....
  81. pmc Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel
    Hector M Barajas-Martínez
    Masonic Medical Research Laboratory, Utica, New York, USA
    Circ Res 103:396-404. 2008
    ..These findings suggest caution when treating patients carrying such genetic variations with Class I antiarrhythmic drugs...
  82. pmc Transseptal dispersion of repolarization and its role in the development of Torsade de Pointes arrhythmias
    Serge Sicouri
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Electrophysiol 21:441-7. 2010
    ....
  83. pmc Accelerated inactivation of the L-type calcium current due to a mutation in CACNB2b underlies Brugada syndrome
    Jonathan M Cordeiro
    Department of Experimental Cardiology, Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Mol Cell Cardiol 46:695-703. 2009
    ..We report the first BrS mutation in CaCNB2b resulting in accelerated inactivation of L-type calcium channel current. Our results suggest that the faster current decay results in a loss-of-function responsible for the Brugada phenotype..
  84. pmc Electrophysiologic and antiarrhythmic effects of AZD1305 in canine pulmonary vein sleeves
    Serge Sicouri
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    J Pharmacol Exp Ther 334:255-9. 2010
    ....
  85. pmc Brugada syndrome and ischemia-induced ST-segment elevation. Similarities and differences
    Jose M Di Diego
    Experimental Cardiology Department, Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    J Electrocardiol 38:14-7. 2005
    ....
  86. ncbi request reprint Sudden death associated with short-QT syndrome linked to mutations in HERG
    Ramon Brugada
    Molecular Genetics Program, Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 109:30-5. 2004
    ..The present study describes the genetic basis for a new clinical entity characterized by sudden death and short-QT intervals in the ECG...
  87. pmc Atrial-selective sodium channel blockers: do they exist?
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Pharmacol 52:121-8. 2008
    ..A major focus will be on the ability of the atrial-selective sodium channel blocking properties of these agents, possibly in conjunction with I Kur and/or I Kr blocking properties, to suppress and prevent the reinduction of AF...
  88. ncbi request reprint Phenotypic characterization of a large European family with Brugada syndrome displaying a sudden unexpected death syndrome mutation in SCN5A:
    Kui Hong
    Molecular Genetics Program, Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Electrophysiol 15:64-9. 2004
    ..This ECG pattern often is concealed but can be unmasked using potent sodium channel blockers. Like congenital long QT syndrome type 3 (LQT3) and sudden unexpected death syndrome, Brugada syndrome has been linked to mutations in SCN5A...
  89. pmc Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome
    Jeffrey M Fish
    Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    Circulation 113:1393-400. 2006
    ..We hypothesized that this action would be antiarrhythmic in the setting of Brugada syndrome...
  90. pmc Role of repolarization restitution in the development of coarse and fine atrial fibrillation in the isolated canine right atria
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    J Cardiovasc Electrophysiol 16:639-45. 2005
    ..The cellular and ionic basis for coarse versus fine AF is not well delineated...
  91. pmc Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT Conditions
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Circ Arrhythm Electrophysiol 1:202-8. 2008
    ..The present study examines the effect of hyperthermia on transmural dispersion of action potential duration (TD-APD), early afterdepolarization (EAD) activity, and torsade de pointes (TdP) under long-QT conditions...
  92. ncbi request reprint Molecular mechanisms underlying the long QT syndrome
    Robert Dumaine
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Curr Opin Cardiol 17:36-42. 2002
    ..In this brief review, our goal is to summarize the molecular mechanisms proposed to underlie the susceptibility to arrhythmias in LQTS and discuss the direction of current and future research...
  93. pmc Can inhibition of IKur promote atrial fibrillation?
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Heart Rhythm 5:1304-9. 2008
    ..However, it has been shown that I(Kur) block may abbreviate atrial repolarization and that loss-of-function mutations in KCNA5, which encodes K(v) 1.5 channels responsible for I(Kur), is associated with familial AF...
  94. pmc Functional expression of "cardiac-type" Nav1.5 sodium channel in canine intracardiac ganglia
    Fabiana S Scornik
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Heart Rhythm 3:842-50. 2006
    ..Scarce information on the cellular components of the intrinsic cardiac ganglia from higher mammals has limited our understanding of the role of the autonomic nervous system in such diseases...
  95. pmc Late-phase 3 EAD. A unique mechanism contributing to initiation of atrial fibrillation
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Pacing Clin Electrophysiol 29:290-5. 2006
    ..This review briefly describes the mechanisms and properties of late-phase 3 EADs, how they differ from conventional EADs and DADs, as well as their role in the initiation of cardiac arrhythmias, such as atrial fibrillation...
  96. pmc Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, New York 13501, USA
    Heart Rhythm 7:1273-9. 2010
    ..There are no full-length published reports describing the effectiveness of acute dronedarone use against AF in experimental or clinical studies...
  97. ncbi request reprint Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect of IKr and IKur/Ito block
    Alexander Burashnikov
    Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501, USA
    Am J Physiol Heart Circ Physiol 286:H2393-400. 2004
    ..Our study also points to major differences in the transmembrane activity recorded using superfused vs. arterially perfused atrial preparations...
  98. pmc Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Circulation 116:1449-57. 2007
    ..The development of selective atrial antiarrhythmic agents is a current strategy for suppression of atrial fibrillation (AF)...
  99. pmc Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome
    Jonathan M Cordeiro
    Department of Experimental Cardiology, Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 114:2026-33. 2006
    ..We report the first Brugada syndrome family with compound heterozygous mutations in SCN5A. The proband inherited 1 mutation from each parent and transmitted 1 to each daughter...
  100. pmc Cellular and subcellular alternans in the canine left ventricle
    Jonathan M Cordeiro
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501 1787, USA
    Am J Physiol Heart Circ Physiol 293:H3506-16. 2007
    ....

Research Grants17

  1. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2007
    ..Our long-range goal is to generate information that will contribute meaningfully to our understanding of arrhythmic death in infants and young children. ..
  2. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2006
    ..Our long-range goal is to generate information that will contribute meaningfully to our understanding of arrhythmic death in infants and young children. ..
  3. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2005
    ..Our long-range goal is to generate information that will contribute meaningfully to our understanding of arrhythmic death in infants and young children. ..
  4. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2004
    ..Our long-range goal is to generate information that will contribute to our understanding of the causes for arrhythmic death in infants and young children. ..
  5. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2003
    ..Our long-range goal is to generate information that will contribute to our understanding of the causes for arrhythmic death in infants and young children. ..
  6. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2002
    ..Our long-range goal is to generate information that will contribute to our understanding of the causes for arrhythmic death in infants and young children. ..
  7. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2001
    ..Our long-range goal is to generate information that will contribute to our understanding of the causes for arrhythmic death in infants and young children. ..
  8. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 2000
    ..The long range goal is to generate information that will contribute to a more definitive and less empiric approach in the medical management of cardiac arrhythmias and sudden cardiac death. ..
  9. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 1999
    ..The long range goal is to generate information that will contribute to a more definitive and less empiric approach in the medical management of cardiac arrhythmias and sudden cardiac death. ..
  10. ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIAS
    Charles Antzelevitch; Fiscal Year: 1993
    ..Our long-range goal is to narrow the gap that currently exists in this area and to generate information that will contribute to a more definitive and less empiric approach in the medical management of cardiac arrhythmias...
  11. Development of Novel Approaches for the Pharmacologic Treatment of Atrial Fibrill
    Charles Antzelevitch; Fiscal Year: 2011
    ..Successful completion of the studies proposed in this competing renewal will significantly advance this goal and lead to the development of innovative and effective pharmacologic treatments for AF. ..