Research Topics
Genomes and GenesSpecies | Catherine A McCartySummaryAffiliation: Marshfield Clinic Country: USA Publications
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Publications
Intraocular pressure response to medication in a clinical setting: the Marshfield Clinic Personalized Medicine Research ProjectCatherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
J Glaucoma 17:372-7. 2008..To estimate glaucoma and ocular hypertension prevalence and to describe temporal trends in prescribing patterns and intraocular pressure (IOP) response to topical medications used in glaucoma and ocular hypertension...- Intraocular pressure response to topical beta-blockers associated with an ADRB2 single-nucleotide polymorphismCatherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 N Oak Ave, Marshfield, WI 54449, USA
Arch Ophthalmol 126:959-63. 2008..To determine whether candidate pharmacodynamic (beta-adrenergic receptor) and pharmacokinetic (cytochrome P450 2D6) gene polymorphisms are associated with the intraocular pressure (IOP) response to topical beta-blockers... 
Calories from newspaper dessert recipes are associated with community obesity ratesCatherine A McCarty
Marshfield Clinic Research Foundation, Center for Human Genetics, 1000 N Oak Ave ML1, Marshfield, WI 54449, USA
WMJ 106:68-70. 2007..The purpose of this study was to determine if the nutrient content of recipes available in newspapers is related to community obesity rates...- Differences in preventive screening rates in Wisconsin farm and non-farm resident womenCatherine A McCarty
Marshfield Clinic Research Foundation, 1000 North Oak Avenue ML1 Marshfield, WI 54449, USA
WMJ 102:22-6. 2003..To determine the proportion of rural women who met screening recommendations for Pap smears, mammograms, blood cholesterol, and blood pressure measurements... 
Community consultation and communication for a population-based DNA biobank: the Marshfield clinic personalized medicine research projectCatherine A McCarty
Marshfield Clinic Research Foundation, Center for Human Genetics, Marshfield, Wisconsin 54449, USA
Am J Med Genet A 146:3026-33. 2008..Researchers need to balance the provision of information for potential subjects to make informed decisions about study participation, with respect for individuals' time to read and interpret study materials...- Novel measures of cardiovascular health and its association with prevalence and progression of age-related macular degeneration: the CHARM StudyCatherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, MA, USA
BMC Ophthalmol 8:25. 2008..To determine if novel measures of cardiovascular health are associated with prevalence or progression of age-related macular degeneration (AMD)... - Informed consent and subject motivation to participate in a large, population-based genomics study: the Marshfield Clinic Personalized Medicine Research ProjectCatherine A McCarty
Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Community Genet 10:2-9. 2007..The objective of this study was to measure subject perspective and reaction to participation in the Personalized Medicine Research Project (PMRP) and to identify factors predicting understanding of the study elements... - Biobanking and pharmacogenomicsCatherine A McCarty
Marshfield Clinic Research Foundation, Center for Human Genetics, Marshfield, WI 54449, USA
Pharmacogenomics 11:637-41. 2010..Longitudinal data available in practice-based datasets will position investigators to characterize genetic factors with small but reproducible effects on drug outcome in the context of gene-environment interactions... - Lessons learned from employee fitness programs at the Marshfield ClinicCatherine A McCarty
Marshfield Clinic Research Foundation, 1000 N Oak Ave, Marshfield, WI 54449, USA
WMJ 104:61-5. 2005..To describe and evaluate employee fitness programs at the Marshfield Clinic... - Food offerings in Marshfield area businesses: a survey conducted in collaboration with the healthy lifestyles--Marshfield Area CoalitionCatherine A McCarty
Marshfield Clinic Research Foundation, 1000 N Oak Ave, Marshfield, WI 54449, USA
WMJ 104:66-9. 2005..To survey Marshfield area businesses to determine the types of foods currently available to employees at the workplace and the potential need for nutrition information to facilitate the ordering of healthy food options at workplaces... - Study newsletters, community and ethics advisory boards, and focus group discussions provide ongoing feedback for a large biobankCatherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
Am J Med Genet A 155:737-41. 2011..The multi-faceted approach to communication including newsletters, external advisory boards, and focus group discussions has been successful for the PMRP biobank and may be a model for others to consider... - Sunlight exposure assessment: can we accurately assess vitamin D exposure from sunlight questionnaires?Catherine A McCarty
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Am J Clin Nutr 87:1097S-101S. 2008..Research should be directed to develop more objective, nonintrusive, and economical measures of sunlight exposure to quantify personal vitamin D status... - Importance of multi-modal approaches to effectively identify cataract cases from electronic health recordsPeggy L Peissig
Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
J Am Med Inform Assoc 19:225-34. 2012..We describe the construction and validation of an EHR-based algorithm to identify subjects with age-related cataracts... - Lack of association between polymorphisms in the prostaglandin F2α receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogsCatherine A McCarty
Marshfield Clinic Research Foundation, Marshfield, USA
Ophthalmic Genet 33:74-6. 2012..To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs... - Use of an electronic medical record for the identification of research subjects with diabetes mellitusRussell A Wilke
Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449, USA
Clin Med Res 5:1-7. 2007..This algorithm yielded an estimated prevalence of 24.2% for diabetes mellitus in adult subjects aged > or =50 years... - Cataract research using electronic health recordsCarol J Waudby
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
BMC Ophthalmol 11:32. 2011.... - Prevalence and associations of epiretinal membranes in the visual impairment projectDaniel J McCarty
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
Am J Ophthalmol 140:288-94. 2005..To determine the prevalence and factors associated with epiretinal membranes in a random sample of the population aged 40 years and older in Victoria, Australia... - Wisconsin rural women's health study psychological factors and blood cholesterol level: difference between normal and overweight rural womenVatsal Chikani
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
Clin Med Res 2:47-53. 2004..Similar studies are needed to determine the efficacy of intervention for the primary prevention of CHD risk factors... - Apolipoprotein e4 genotype increases the risk of being diagnosed with posttraumatic fibromyalgiaJonathan C Reeser
Office of Research Integrity and Protections, Marshfield Clinic Research Foundation, 1000 North Oak Ave, Marshfield, WI 54449, USA
PM R 3:193-7. 2011..To determine whether the apolipoprotein E4 (Apo E4) allele may be a genetic risk factor for fibromyalgia syndrome (FMS)... - Development of cataract and associated risk factors: the Visual Impairment ProjectBickol N Mukesh
Marshfield Clinic Research Foundation ML2, 1000 N Oak Avenue, Marshfield, WI 54449, USA
Arch Ophthalmol 124:79-85. 2006..To evaluate risk factors for the development of cataract in Australian residents... - Construction of atorvastatin dose-response relationships using data from a large population-based DNA biobankPeggy Peissig
Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Basic Clin Pharmacol Toxicol 100:286-8. 2007 - Dietary intake in the Personalized Medicine Research Project: a resource for studies of gene-diet interactionLacie Strobush
Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 N, Oak Ave MLR, Marshfield, WI 54449, USA
Nutr J 10:13. 2011.... - Use of an electronic medical record to characterize cases of intermediate statin-induced muscle toxicityRavi K Mareedu
Department of Internal Medicine, Marshfield Clinic, Marshfield, WI, USA
Prev Cardiol 12:88-94. 2009..The lines reflecting these relationships cross at a CK level of approximately 1175 U/L, approximately half the threshold level needed to make a clinical diagnosis of "myopathy" (ie, CK >10-fold the upper limit of normal)... - A pilot study of gene/gene and gene/environment interactions in Alzheimer diseaseNader Ghebranious
Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Clin Med Res 9:17-25. 2011..The purpose of this pilot study was to explore gene/gene and gene/environment associations in AD and to obtain data for sample size estimates for larger, more definitive studies of AD... - Five-year incidence of age-related maculopathy: the Visual Impairment ProjectBickol N Mukesh
Centre for Eye Research Australia, The University of Melbourne, Melbourne, Australia
Ophthalmology 111:1176-82. 2004..To describe the 5-year incidence of age-related maculopathy (ARM) and the progression of the early stages of ARM lesions in Melbourne, Australia... - Five-year incidence of diabetic retinopathy in the Melbourne Visual Impairment ProjectDaniel J McCarty
Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 31:397-402. 2003..The purpose of the present paper was to describe the 5-year incidence and progression of diabetic retinopathy in the Melbourne Visual Impairment Project (VIP) cohort... - Development of a fingerprinting panel using medically relevant polymorphismsDeanna S Cross
Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 N, Oak Avenue, Marshfield, WI, USA
BMC Med Genomics 2:17. 2009..In addition, this panel can serve as a resource for investigators who are interested in the effects of disease in a population, particularly for common diseases... - Predictors of falls in the Melbourne visual impairment projectCatherine A McCarty
Centre for Eye Research Australia, University of Melbourne
Aust N Z J Public Health 26:116-9. 2002..To assess factors associated with falls in the past month, including visual acuity and other vision-related variables... - A review of the epidemiologic evidence linking ultraviolet radiation and cataractsCatherine A McCarty
Centre for Eye Research Australia, University of Melbourne, Australia
Dev Ophthalmol 35:21-31. 2002..Cataract is the most common cause of blindness in the world and there are currently no strategies to prevent it. The aim of this paper is to review the epidemiologic evidence linking ultraviolet (UV) radiation and cataract... - Development of an optical character recognition pipeline for handwritten form fields from an electronic health recordLuke V Rasmussen
Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
J Am Med Inform Assoc 19:e90-5. 2012..The few previous studies on automated extraction of data from these handwritten notes have focused on monolithic, custom-developed recognition systems or third-party systems that require proprietary forms... - Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research ProjectDeanna S Cross
Center for Human Genetics, Marshfield Clinic Research Foundation, WI, USA
BMC Genet 11:51. 2010..We compared these allele frequencies to those in dbSNP and other data sources stratified by race. Differences in allele frequencies between self reported race, region of origin, and sex were determined... - Clinical genetics provider real-time workflow studyElizabeth McPherson
Department of Medical Genetic Services, Marshfield Clinic, Marshfield, Wisconsin 54449, USA
Genet Med 10:699-706. 2008..Our work is the first documentation, in real time, of workflow in a general genetics department including data on patient care, research, and other activities for both clinical geneticists and genetic counselors... - Cataract in the 21st Century: lessons from previous epidemiological researchCatherine A McCarty
Marshfield Medical Research Foundation, Marshfield Clinic, WI 54449, USA
Clin Exp Optom 85:91-6. 2002..Given our current state of knowledge about cataract, it seems most feasible immediately to alter the health service delivery side of the equation to reduce the public health burden of cataract... - Diabetic retinopathy: yet another reason for a comprehensive eye-care programme for Australian Aborigines and Torres Strait IslandersCatherine A McCarty
Clin Experiment Ophthalmol 31:6-7. 2003 - Five-year incidence of open-angle glaucoma: the visual impairment projectBickol N Mukesh
Centre for Eye Research Australia, The University of Melbourne, Melbourne, Victoria, Australia
Ophthalmology 109:1047-51. 2002..To determine the incidence of open-angle glaucoma (OAG) in Melbourne, Victoria, Australia... - Vitamin E supplementation and macular degeneration: randomised controlled trialHugh R Taylor
Centre for Eye Research Australia, University of Melbourne, Locked Bag 8, East Melbourne, Victoria, Australia, 8002
BMJ 325:11. 2002..To determine whether vitamin E supplementation influences the incidence or rate of progression of age related maculopathy (AMD)... - Risk factors associated with the incidence of open-angle glaucoma: the visual impairment projectAnhchuong Le
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 44:3783-9. 2003..To assess the relationship between potential risk factors and the development of open-angle glaucoma (OAG) in Australian residents aged 40 and or more years... - Population-based assessment of refractive error in India: the Andhra Pradesh eye disease studyRakhi Dandona
International Centre forAdvancement of Rural Eye Care, LV Prasad Eye Institute, and Centre for Social Services, Administrative Staff College of India, Hyderabad, India
Clin Experiment Ophthalmol 30:84-93. 2002..To assess the prevalence, distribution, and demographic associations of refractive error in the population of the southern Indian state of Andhra Pradesh... - Five-year incidence of bilateral cause-specific visual impairment in the Melbourne Visual Impairment ProjectPeter N Dimitrov
Center for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
Invest Ophthalmol Vis Sci 44:5075-81. 2003..To describe the age-, gender-, and cause-specific 5-year incidence of bilateral visual impairment in participants in the Melbourne Visual Impairment Project, Victoria, Australia... - Psychosocial work characteristics predict cardiovascular disease risk factors and health functioning in rural women: the Wisconsin Rural Women's Health StudyVatsal Chikani
Arizona Department of Health Services, Phoenix, AZ, USA
J Rural Health 21:295-302. 2005..Job stress predicted more CVD risk factors among farm residents compared to nonfarm residents. Therefore, interventions reducing job strain among rural farm residents are timely and necessary... - Progression of visual field loss in open angle glaucoma in the Melbourne Visual Impairment ProjectMimiwati Zahari
Centre for Eye Research Australia, The University of Melbourne, Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 34:20-6. 2006..CONCLUSION: Despite use of glaucoma medications the majority of glaucoma patients managed by their regular ophthalmologist experienced progressive visual field loss over a 5-year period... - Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD)Paul N Baird
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia
Hum Mutat 27:337-42. 2006..A gender-related factor is therefore implicated either directly or indirectly in the AMD disease process... - Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment projectHien T V Vu
Centre for Eye Research Australia, University of Melbourne, East Melbourne, Australia
Invest Ophthalmol Vis Sci 47:3783-6. 2006..58 (0.37-0.92; P = 0.023 for trend), and it was 0.64 (0.40-1.03) for energy adjusted LZ intake (P = 0.018 for trend). CONCLUSIONS: This study found an inverse association between high dietary LZ intake and prevalence of nuclear cataract... - Utilization of eye care services by Victorians likely to benefit from eye careGuy W Bylsma
Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 32:573-7. 2004..To assess the utilization of eye care services by Australians most likely to benefit from eye assessment... - The need for routine eye examinationsHugh R Taylor
Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
Invest Ophthalmol Vis Sci 45:2539-42. 2004..To determine the incidence and causes of vision loss to assist in the objective determination of the preferred frequency of routine screening for those with normal vision... - Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern IndiaSatagopan Uthra
SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai, India
Ophthalmic Genet 28:77-81. 2007..We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India... - Diabetic retinopathy and IGF-1 gene polymorphic cytosine-adenine repeats in a Southern Indian cohortSatagopan Uthra
SN ONGC Department of Genetics and Molecular Biology, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India
Ophthalmic Res 39:294-9. 2007..In the present study, a cytosine-adenine (CA)(n) repeat in the promoter of the IGF-1 gene is studied for association with DR... - Gene-environment interaction in progression of AMD: the CFH gene, smoking and exposure to chronic infectionPaul N Baird
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, VIC 3002, Australia
Hum Mol Genet 17:1299-305. 2008..This demonstrates for the first time the existence of a gene environment-interaction between pathogenic load of C. pneumoniae and the CFH gene in the aetiology of AMD... - Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohortSatagopan Uthra
SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
Ophthalmic Genet 29:11-5. 2008..Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3'UTR variation are studied for association with DR... - Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trialD Michal Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 17:889-94. 2008.... - Vitamin E supplementation and cataract: randomized controlled trialJohn J McNeil
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Ophthalmology 111:75-84. 2004..To determine whether treatment with vitamin E (500 IU daily) reduces either the incidence or rate of progression of age-related cataracts... - Eye health in rural AustraliaAnna C Madden
Department of Rural Health, University of Melbourne, Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 30:316-21. 2002..Further epidemiological data and evaluated interventions are urgently required to help identify and address the needs of rural Australian communities... - A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancerDavid J Hunter
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 39:870-4. 2007..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci... - The impact of rubella immunization on the serological status of women of childbearing age: a retrospective longitudinal study in Melbourne, AustraliaBarbara H Francis
Mercy Hospital for Women, Melbourne, Australia
Am J Public Health 93:1274-6. 2003 - Vacations improve mental health among rural women: the Wisconsin Rural Women's Health StudyVatsal Chikani
Arizona Department of Health Services, AZ 85007, USA
WMJ 104:20-3. 2005..To compare psychological stress, quality of marital life, and disruptive homelife due to work among rural women of central Wisconsin who take vacations frequently and those who do not... - Iris colour, ethnic origin and progression of age-related macular degenerationCaroline M Nicolas
Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia
Clin Experiment Ophthalmol 31:465-9. 2003..To investigate the relationship between iris colour, ethnic origin and the progression of age-related macular degeneration (AMD)...
Research Grants
- Genome-Wide Study of Cataract and Low HDL in the Personalized Medicine Research PCatherine McCarty; Fiscal Year: 2007..The strength of the research team and the depth and breadth of the electronic medical record at the Marshfield Clinic make this the ideal setting for this RFA. ..