Kinsley K Kiningham

Summary

Affiliation: Marshall University
Country: USA

Publications

  1. pmc IkappaBalpha (inhibitory kappaBalpha) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression
    Kelley K Kiningham
    Department of Pharmacology, Joan C Edwards School of Medicine, Marshall University, 1542 Spring Valley Road, Huntington, WV 25704, USA
    Biochem J 384:543-9. 2004
  2. pmc All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB
    Kinsley K Kiningham
    Department of Pharmacology, Physiology, and Toxicology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
    Free Radic Biol Med 44:1610-6. 2008
  3. ncbi request reprint Pyruvate reduces 4-aminophenol in vitro toxicity
    R Christopher Harmon
    Department of Pharmacology, Marshall University Joan C Edwards School of Medicine, 1542 Spring Valley Drive, Huntington, WV 25704 9388, USA
    Toxicol Appl Pharmacol 213:179-86. 2006
  4. ncbi request reprint Progestin inhibition of cell death in human breast cancer cell lines
    Michael R Moore
    Department of Biochemistry and Molecular Biology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
    J Steroid Biochem Mol Biol 98:218-27. 2006
  5. pmc Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells
    Aaron K Holley
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755 9320, USA
    J Steroid Biochem Mol Biol 117:23-30. 2009
  6. ncbi request reprint Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)
    Michelle L Humphrey
    Department of Pharmacology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25704 9388, USA
    Neurotoxicology 26:407-16. 2005
  7. ncbi request reprint Time-dependent effect of p-aminophenol (PAP) toxicity in renal slices and development of oxidative stress
    R Christopher Harmon
    Department of Pharmacology, Marshall University, Joan C Edwards School of Medicine, 1542 Spring Valley Drive Huntington, WV 25704 9388, USA
    Toxicol Appl Pharmacol 209:86-94. 2005
  8. ncbi request reprint The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity
    Marsha P Cole
    Graduate Centers for Toxicology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, 464 Health Sciences Research Building, Lexington, KY 40536, USA
    Cardiovasc Res 69:186-97. 2006

Research Grants

  1. Mechanism of Thimerosal Induced Neurotoxicity
    KINSLEY KININGHAM; Fiscal Year: 2003

Collaborators

  • M R Moore
  • T D Oberley
  • D P Edwards
  • R Christopher Harmon
  • Marsha P Cole
  • Aaron K Holley
  • Michelle L Humphrey
  • Jeffrey T Jenkins
  • Douglas R Spitz
  • Michael T Piascik
  • Luksana Chaiswing
  • Stephanie E Edelmann
  • Daret K St Clair
  • Shu Mei Lin
  • Monica A Valentovic
  • Marcus V Terneus
  • James C Pendergrass
  • Monica Valentovic

Detail Information

Publications8

  1. pmc IkappaBalpha (inhibitory kappaBalpha) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression
    Kelley K Kiningham
    Department of Pharmacology, Joan C Edwards School of Medicine, Marshall University, 1542 Spring Valley Road, Huntington, WV 25704, USA
    Biochem J 384:543-9. 2004
    ....
  2. pmc All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB
    Kinsley K Kiningham
    Department of Pharmacology, Physiology, and Toxicology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
    Free Radic Biol Med 44:1610-6. 2008
    ..These results suggest that signaling events involving NF-kappaB and SOD2 may contribute to the effects of retinoids used in cancer therapy...
  3. ncbi request reprint Pyruvate reduces 4-aminophenol in vitro toxicity
    R Christopher Harmon
    Department of Pharmacology, Marshall University Joan C Edwards School of Medicine, 1542 Spring Valley Drive, Huntington, WV 25704 9388, USA
    Toxicol Appl Pharmacol 213:179-86. 2006
    ..These results indicate that pyruvate provided protection for PAP toxicity by providing an energy substrate and reducing oxidative stress...
  4. ncbi request reprint Progestin inhibition of cell death in human breast cancer cell lines
    Michael R Moore
    Department of Biochemistry and Molecular Biology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
    J Steroid Biochem Mol Biol 98:218-27. 2006
    ....
  5. pmc Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells
    Aaron K Holley
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755 9320, USA
    J Steroid Biochem Mol Biol 117:23-30. 2009
    ..To our knowledge, this is the first characterization of progestin stimulation of MnSOD in human breast cancer cells...
  6. ncbi request reprint Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH)
    Michelle L Humphrey
    Department of Pharmacology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25704 9388, USA
    Neurotoxicology 26:407-16. 2005
    ..Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis...
  7. ncbi request reprint Time-dependent effect of p-aminophenol (PAP) toxicity in renal slices and development of oxidative stress
    R Christopher Harmon
    Department of Pharmacology, Marshall University, Joan C Edwards School of Medicine, 1542 Spring Valley Drive Huntington, WV 25704 9388, USA
    Toxicol Appl Pharmacol 209:86-94. 2005
    ..PAP induces oxidative stress as indicated by an increase in GSSG and 4-HNE-adducted proteins. Ascorbic acid pretreatment prevents PAP toxicity by maintaining GSH status...
  8. ncbi request reprint The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity
    Marsha P Cole
    Graduate Centers for Toxicology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, 464 Health Sciences Research Building, Lexington, KY 40536, USA
    Cardiovasc Res 69:186-97. 2006
    ..Because nitric oxide (*NO) reacts with O2*-, generating peroxynitrite, we hypothesized that decreased *NO production would lead to protection in acute cardiac injury...

Research Grants1

  1. Mechanism of Thimerosal Induced Neurotoxicity
    KINSLEY KININGHAM; Fiscal Year: 2003
    ..This project will generate mechanistic data on thimerosal neurotoxicity and potentially identify specific targets for pharmacological intervention. ..