Pinfen Yang

Summary

Affiliation: Marquette University
Country: USA

Publications

  1. ncbi Flagellar radial spoke protein 2 is a calmodulin binding protein required for motility in Chlamydomonas reinhardtii
    Pinfen Yang
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53233, USA
    Eukaryot Cell 3:72-81. 2004
  2. ncbi Radial spoke proteins of Chlamydomonas flagella
    Pinfen Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Cell Sci 119:1165-74. 2006
  3. ncbi Novel LC8 mutations have disparate effects on the assembly and stability of flagellar complexes
    Pinfen Yang
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin 53233, USA
    J Biol Chem 284:31412-21. 2009
  4. ncbi Dimeric novel HSP40 is incorporated into the radial spoke complex during the assembly process in flagella
    Chun Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    Mol Biol Cell 16:637-48. 2005
  5. ncbi Dimeric heat shock protein 40 binds radial spokes for generating coupled power strokes and recovery strokes of 9 + 2 flagella
    Chun Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Cell Biol 180:403-15. 2008
  6. ncbi The flagellar motility of Chlamydomonas pf25 mutant lacking an AKAP-binding protein is overtly sensitive to medium conditions
    Chun Yang
    Department of Biological Sciences, Marquette University, Milwaukee WI 53233, USA
    Mol Biol Cell 17:227-38. 2006
  7. ncbi A flagellar A-kinase anchoring protein with two amphipathic helices forms a structural scaffold in the radial spoke complex
    Priyanka Sivadas
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA
    J Cell Biol 199:639-51. 2012
  8. ncbi The versatile molecular complex component LC8 promotes several distinct steps of flagellar assembly
    Anjali Gupta
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA
    J Cell Biol 198:115-26. 2012
  9. ncbi Chlamydomonas mutants display reversible deficiencies in flagellar beating and axonemal assembly
    Mei Wei
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Cytoskeleton (Hoboken) 67:71-80. 2010
  10. ncbi The DPY-30 domain and its flanking sequence mediate the assembly and modulation of flagellar radial spoke complexes
    Radhika Gopal
    Department of Biological Sciences, Marquette University, Milwaukee, WI, USA
    Mol Cell Biol 32:4012-24. 2012

Research Grants

  1. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2007
  2. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2009

Collaborators

  • Anjali Gupta
  • Yi Liu
  • Kenneth W Foster
  • Maureen Wirschell
  • David R Mitchell
  • Ritsu Kamiya
  • Elizabeth F Smith
  • G J Pazour
  • J L Rosenbaum
  • S M King
  • George Witman
  • A Hallmann
  • Martin Lohr
  • CAROL DIECKMANN
  • Wallace Marshall
  • Arthur R Grossman
  • Chun Yang
  • Priyanka Sivadas
  • Mei Wei
  • Xiaoyan Zhu
  • Radhika Gopal
  • Pooja Kelekar
  • Heather A Owen
  • Sabeeha S Merchant
  • Triscia W Hendrickson
  • Jennifer M Dienes
  • Martin St Maurice
  • William D Meek
  • Ming Kalanon
  • Saul Purton
  • Anton A Sanderfoot
  • Hideya Fukuzawa
  • Charles Hauser
  • Marc Hanikenne
  • Richard Kuras
  • Stephen Mayfield
  • Annkatrin Rose
  • Sanja Roje
  • Ian T Paulsen
  • Guillaume Chanfreau
  • Chun Long Chen
  • Valerie Cognat
  • Simon E Prochnik
  • Pamela Green
  • Chun-Long Chen
  • Daniel S Rokhsar
  • Michael Schroda
  • Laurens Mets
  • Wayne Riekhof
  • Susan M Lucas
  • Jean Philippe Ral
  • Laurence Maréchal-Drouard
  • Liang Hu Qu
  • Jun Minagawa
  • Diego Mauricio Riaño-Pachón
  • Alexander Poliakov
  • David Goodstein
  • Richard Jorgensen
  • William Inwood
  • Leila Hornick
  • Jeffrey Moseley
  • Igor V Grigoriev
  • Bernd Mueller-Roeber
  • Eric Stahlberg
  • Alexey V Lobanov
  • Maria Mittag
  • Astrid Terry
  • Lillian K Fritz-Laylin
  • Aaron Porter
  • Sergey V Novoselov
  • Katerina Bisova
  • Harris Shapiro
  • Joanne C Long
  • Junmin Pan
  • Vadim N Gladyshev
  • Susan Dutcher
  • Mary Rose Lamb
  • BOBBY OTILLAR
  • Telsa Mittelmeier
  • Jeremy Schmutz
  • Sara Lana Zimmer
  • Kemin Zhou
  • Yigong Luo
  • Emilio Fernandez
  • Andrea Manuell
  • Peter Brokstein
  • Qinghu Ren
  • Heriberto Cerutti
  • Linda Rymarquis
  • Erika Lindquist

Detail Information

Publications16

  1. ncbi Flagellar radial spoke protein 2 is a calmodulin binding protein required for motility in Chlamydomonas reinhardtii
    Pinfen Yang
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53233, USA
    Eukaryot Cell 3:72-81. 2004
    ..As predicted from the sequence, recombinant RSP2 binds calmodulin in a calcium-dependent manner. We postulate that RSP2 is a regulatory subunit of the radial spoke involved in localization of calmodulin for control of motility...
  2. ncbi Radial spoke proteins of Chlamydomonas flagella
    Pinfen Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Cell Sci 119:1165-74. 2006
    ..The human genes encoding these proteins are candidates for causing primary ciliary dyskinesia, a severe inherited disease involving missing or defective axonemal structures, including the radial spokes...
  3. ncbi Novel LC8 mutations have disparate effects on the assembly and stability of flagellar complexes
    Pinfen Yang
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin 53233, USA
    J Biol Chem 284:31412-21. 2009
    ....
  4. ncbi Dimeric novel HSP40 is incorporated into the radial spoke complex during the assembly process in flagella
    Chun Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    Mol Biol Cell 16:637-48. 2005
    ....
  5. ncbi Dimeric heat shock protein 40 binds radial spokes for generating coupled power strokes and recovery strokes of 9 + 2 flagella
    Chun Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Cell Biol 180:403-15. 2008
    ..This enables 9 + 2 cilia and flagella to bend and switch to generate alternate power strokes and recovery strokes...
  6. ncbi The flagellar motility of Chlamydomonas pf25 mutant lacking an AKAP-binding protein is overtly sensitive to medium conditions
    Chun Yang
    Department of Biological Sciences, Marquette University, Milwaukee WI 53233, USA
    Mol Biol Cell 17:227-38. 2006
    ..We postulate that radial spokes use the RIIa/AKAP module to regulate ciliary and flagellar beating; absence of the spoke RIIa protein exposes a medium-sensitive regulatory mechanism that is not obvious in wild-type Chlamydomonas...
  7. ncbi A flagellar A-kinase anchoring protein with two amphipathic helices forms a structural scaffold in the radial spoke complex
    Priyanka Sivadas
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA
    J Cell Biol 199:639-51. 2012
    ..Thus, AHs and D/D domains constitute a versatile yet potentially promiscuous system for localizing various effector mechanisms. These results greatly expand the current concept about anchoring mechanisms and AKAPs...
  8. ncbi The versatile molecular complex component LC8 promotes several distinct steps of flagellar assembly
    Anjali Gupta
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA
    J Cell Biol 198:115-26. 2012
    ..These multiple effects shed new light on fundamental questions about LC8-containing complexes and axoneme assembly...
  9. ncbi Chlamydomonas mutants display reversible deficiencies in flagellar beating and axonemal assembly
    Mei Wei
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Cytoskeleton (Hoboken) 67:71-80. 2010
    ..Consistently, several organisms only possess one RSP4/6 gene. Gene duplication in Chlamydomonas enhances RS assembly to maintain optimal motility in various environments...
  10. ncbi The DPY-30 domain and its flanking sequence mediate the assembly and modulation of flagellar radial spoke complexes
    Radhika Gopal
    Department of Biological Sciences, Marquette University, Milwaukee, WI, USA
    Mol Cell Biol 32:4012-24. 2012
    ..Thus, in general, D/D domains may function to localize molecular modules for both the assembly and modulation of macromolecular complexes...
  11. ncbi Isolation and analysis of radial spoke proteins
    Pooja Kelekar
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Methods Cell Biol 92:181-96. 2009
    ..With appropriate modifications, the lessons learned from the radial spoke complex may be applicable to other axonemal complexes...
  12. ncbi Molecular tools for studying the radial spoke
    Xiaoyan Zhu
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Methods Enzymol 524:19-36. 2013
    ..They could be adapted for the study of many other axonemal complexes and for classroom settings as well...
  13. ncbi The radial spokes and central apparatus: mechano-chemical transducers that regulate flagellar motility
    Elizabeth F Smith
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell Motil Cytoskeleton 57:8-17. 2004
  14. ncbi Building a radial spoke: flagellar radial spoke protein 3 (RSP3) is a dimer
    Maureen Wirschell
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cell Motil Cytoskeleton 65:238-48. 2008
    ....
  15. ncbi IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending
    Triscia W Hendrickson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 15:5431-42. 2004
    ....
  16. ncbi The Chlamydomonas genome reveals the evolution of key animal and plant functions
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 318:245-50. 2007
    ....

Research Grants7

  1. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2007
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..
  2. REGULATION OF DYNEIN-DRIVEN FLAGELLAR MOTILITY
    Pinfen Yang; Fiscal Year: 2009
    ..The results will also have broad impact on how dynein-driven motility is controlled and how kinases and calcium sensors are anchored in the microtubule cytoskeleton. ..