DOUGLAS LOBNER

Summary

Affiliation: Marquette University
Country: USA

Publications

  1. doi request reprint beta-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc(-)
    Xiaoqian Liu
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 446 Milwaukee, WI 53233, USA
    Exp Neurol 217:429-33. 2009
  2. ncbi request reprint Mechanisms of bFGF and NT-4 potentiation of necrotic neuronal death
    Doug Lobner
    Department of Biomedical Sciences and Integrative Neuroscience Research Center, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Brain Res 954:42-50. 2002
  3. doi request reprint Mechanisms of beta-N-methylamino-L-alanine induced neurotoxicity
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Milwaukee, Wisconsin 53233, USA
    Amyotroph Lateral Scler 10:56-60. 2009
  4. ncbi request reprint Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Neurobiol Dis 25:360-6. 2007
  5. ncbi request reprint Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53233, USA
    Neurochem Res 29:2303-9. 2004
  6. ncbi request reprint Saturation of neuroprotective effects of adenosine in cortical culture
    Doug Lobner
    Department of Biomedical Sciences and Integrative Neuroscience Research Center, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Neuroreport 13:2075-8. 2002
  7. ncbi request reprint Neurotrophic factor effects on oxidative stress-induced neuronal death
    Doug Lobner
    Department of Biomedical Sciences and Integrative Neuroscience Research Center, Marquette University, Milwaukee, Wisconsin 53233, USA
    Neurochem Res 28:749-56. 2003
  8. ncbi request reprint Neurotoxicity of dental amalgam is mediated by zinc
    D Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53201, USA
    J Dent Res 82:243-6. 2003
  9. pmc Toxicity of Flow Line, Durafill VS, and Dycal to dental pulp cells: effects of growth factors
    Alyssa Furey
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Endod 36:1149-53. 2010
  10. ncbi request reprint In vitro neurotoxic evaluation of root-end-filling materials
    Mahshid Asrari
    Department of Endodontics, Marquette University School of Dentistry, Milwaukee, WI 53233, USA
    J Endod 29:743-6. 2003

Research Grants

Collaborators

  • Robert W Peoples
  • Mahshid Asrari
  • Travis Rush
  • Alyssa Furey
  • Xiao qian Liu
  • Julie Hjelmhaug
  • Xiaoqian Liu
  • Smita Cabrera
  • Mark Hanson
  • Alexis David
  • Jennifer Ciske
  • Jasmine Zapata
  • Megan Wolf
  • Doug Barden

Detail Information

Publications15

  1. doi request reprint beta-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc(-)
    Xiaoqian Liu
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 446 Milwaukee, WI 53233, USA
    Exp Neurol 217:429-33. 2009
    ..The multiple mechanisms of BMAA toxicity, particularly the depletion of glutathione and enhanced oxidative stress, may account for its ability to induce complex neurodegenerative diseases...
  2. ncbi request reprint Mechanisms of bFGF and NT-4 potentiation of necrotic neuronal death
    Doug Lobner
    Department of Biomedical Sciences and Integrative Neuroscience Research Center, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Brain Res 954:42-50. 2002
    ..The fact that neurotrophic factors from two distinct families can potentiate neuronal death by two different mechanisms suggests that such injury potentiation may be a common concern regarding the use of neurotrophic factors...
  3. doi request reprint Mechanisms of beta-N-methylamino-L-alanine induced neurotoxicity
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Milwaukee, Wisconsin 53233, USA
    Amyotroph Lateral Scler 10:56-60. 2009
    ..This action of BMAA provides an attractive mechanism for the multiple neurological deficits that BMAA has been implicated in inducing...
  4. ncbi request reprint Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Neurobiol Dis 25:360-6. 2007
    ..The results provide further support for the hypothesis that BMAA plays a role in neurodegenerative diseases...
  5. ncbi request reprint Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death
    Doug Lobner
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53233, USA
    Neurochem Res 29:2303-9. 2004
    ....
  6. ncbi request reprint Saturation of neuroprotective effects of adenosine in cortical culture
    Doug Lobner
    Department of Biomedical Sciences and Integrative Neuroscience Research Center, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53233, USA
    Neuroreport 13:2075-8. 2002
    ..Thus, while activation of A1 receptors can provide neuroprotection, the protective effect appears to become saturated by high levels of endogenous extracellular adenosine during oxygen-glucose deprivation...
  7. ncbi request reprint Neurotrophic factor effects on oxidative stress-induced neuronal death
    Doug Lobner
    Department of Biomedical Sciences and Integrative Neuroscience Research Center, Marquette University, Milwaukee, Wisconsin 53233, USA
    Neurochem Res 28:749-56. 2003
    ..The results indicate that oxidative insults can induce either apoptotic or necrotic death and that the effects of neurotrophic factors are dependent on the type of cell death...
  8. ncbi request reprint Neurotoxicity of dental amalgam is mediated by zinc
    D Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53201, USA
    J Dent Res 82:243-6. 2003
    ..These results indicate that amalgam is toxic to nerve cells in culture by releasing zinc. While zinc is known to be neurotoxic, ingestion of zinc is not a major concern because zinc levels in the body are tightly regulated...
  9. pmc Toxicity of Flow Line, Durafill VS, and Dycal to dental pulp cells: effects of growth factors
    Alyssa Furey
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Endod 36:1149-53. 2010
    ..The objective was to determine the effects of growth factor treatment on dental pulp cell sensitivity to toxicity of 2 composite restoration materials, Flow Line and Durafill VS, and a calcium hydroxide pulp capping material, Dycal...
  10. ncbi request reprint In vitro neurotoxic evaluation of root-end-filling materials
    Mahshid Asrari
    Department of Endodontics, Marquette University School of Dentistry, Milwaukee, WI 53233, USA
    J Endod 29:743-6. 2003
    ..05). Thus, each material, except for mineral trioxide aggregate, can induce neurotoxicity, even when allowed to set thoroughly...
  11. ncbi request reprint In vitro cytotoxicity of orthodontic archwires in cortical cell cultures
    Alexis David
    Department of Biomedical Sciences and School of Dentistry, Marquette University, Milwaukee, WI 53201, USA
    Eur J Orthod 26:421-6. 2004
    ..The specific metal responsible for the toxicity was not determined; the metals common to each of the toxic archwires were nickel, iron, and chromium...
  12. doi request reprint Selective death of cholinergic neurons induced by beta-methylamino-L-alanine
    Xiao qian Liu
    Department of Biomedical Sciences, Marquette University, Milwaukee, Wisconsin 53233, USA
    Neuroreport 21:55-8. 2010
    ..The toxicity of BMAA to total septal neurons involved activation of N-methyl D-aspartate receptors, whereas the death of cholinergic neurons was mediated by AMPA/kainate receptors...
  13. doi request reprint Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture
    Travis Rush
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 464, Milwaukee, WI 53233, USA
    Neurotoxicology 30:47-51. 2009
    ..The potentiation of Fe-citrate toxicity is of concern because of iron's role in oxidative stress in the body. Potentiation of iron toxicity could have serious health consequences when using chelation therapy...
  14. ncbi request reprint In vitro neuronal cytotoxicity of latex and nonlatex orthodontic elastics
    Mark Hanson
    Department of Biomedical Sciences, School of Dentistry, Marquette University, 561 N 15th Street, Room 426, Milwaukee, WI 53201, USA
    Am J Orthod Dentofacial Orthop 126:65-70. 2004
    ..Because ingestion of zinc is not a health risk, the results suggest that, in spite of the finding that latex elastics have higher in vitro cytotoxicity than nonlatex elastics, the use of latex elastics in orthodontics is acceptable...
  15. ncbi request reprint Effects of growth factors on dental pulp cell sensitivity to amalgam toxicity
    Smita Cabrera
    Department of Orthodontics, Marquette University Dental School, 561 N 15th Street, Milwaukee, WI 53233, USA
    Dent Mater 23:1205-10. 2007
    ..The objective was to determine the effects of growth factor treatment on dental pulp cell sensitivity to toxicity...

Research Grants6

  1. MECHANISMS OF INJURY POTENTIATION BY GROWTH FACTORS
    DOUGLAS LOBNER; Fiscal Year: 2004
    ..It is believed that these studies will aid in determining under what conditions growth factor induced potentiation of cell death may be of concern regarding their therapeutic use, and how those concerns may be addressed. ..