Robert H Fitts

Summary

Affiliation: Marquette University
Country: USA

Publications

  1. ncbi request reprint The cross-bridge cycle and skeletal muscle fatigue
    Robert H Fitts
    Dept of Biological Sciences, Wehr Life Sciences Bldg, Marquette Univ, P O Box 1881, Milwaukee, WI 53201 1881, USA
    J Appl Physiol 104:551-8. 2008
  2. ncbi request reprint The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation
    R H Fitts
    Dept of Biology, Marquette University, Wehr Life Sciences Bldg, PO Box 1881, Milwaukee, WI 53201 1881, USA
    Am J Physiol Cell Physiol 293:C313-20. 2007
  3. ncbi request reprint Functional and structural adaptations of skeletal muscle to microgravity
    R H Fitts
    Department of Biology, Marquette University, Milwaukee, WI 53201, USA
    J Exp Biol 204:3201-8. 2001
  4. ncbi request reprint Spaceflight effects on single skeletal muscle fiber function in the rhesus monkey
    R H Fitts
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53201, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1546-57. 2000
  5. ncbi request reprint Functional properties of slow and fast gastrocnemius muscle fibers after a 17-day spaceflight
    J J Widrick
    Department of Biology, Marquette University, Milwaukee 53201, Wisconsin, USA
    J Appl Physiol 90:2203-11. 2001
  6. pmc Low cell pH depresses peak power in rat skeletal muscle fibres at both 30 degrees C and 15 degrees C: implications for muscle fatigue
    S T Knuth
    Marquette University, Department of Biological Sciences, PO Box 1881, Milwaukee, WI 53201 1881, USA
    J Physiol 575:887-99. 2006
  7. ncbi request reprint Unilateral lower limb suspension does not mimic bed rest or spaceflight effects on human muscle fiber function
    J J Widrick
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53201, USA
    J Appl Physiol 93:354-60. 2002
  8. ncbi request reprint The depressive effect of Pi on the force-pCa relationship in skinned single muscle fibers is temperature dependent
    E P Debold
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Am J Physiol Cell Physiol 290:C1041-50. 2006
  9. ncbi request reprint Contractile responses of the rat gastrocnemius and soleus muscles to isotonic resistance exercise
    K M Norenberg
    Dept of Biological Sciences, Marquette University, P O Box 1881, Milwaukee, WI 53201 1881, USA
    J Appl Physiol 97:2322-32. 2004
  10. ncbi request reprint Fiber type and temperature dependence of inorganic phosphate: implications for fatigue
    E P Debold
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA
    Am J Physiol Cell Physiol 287:C673-81. 2004

Detail Information

Publications16

  1. ncbi request reprint The cross-bridge cycle and skeletal muscle fatigue
    Robert H Fitts
    Dept of Biological Sciences, Wehr Life Sciences Bldg, Marquette Univ, P O Box 1881, Milwaukee, WI 53201 1881, USA
    J Appl Physiol 104:551-8. 2008
    ..In vitro, reactive oxygen species reduce myofibrillar Ca2+ sensitivity; however, the importance of this mechanism during in vivo exercise is unknown...
  2. ncbi request reprint The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation
    R H Fitts
    Dept of Biology, Marquette University, Wehr Life Sciences Bldg, PO Box 1881, Milwaukee, WI 53201 1881, USA
    Am J Physiol Cell Physiol 293:C313-20. 2007
    ..These results provide evidence that an AA/CHO supplement might serve as a successful countermeasure to help preserve muscle function during periods of relative inactivity...
  3. ncbi request reprint Functional and structural adaptations of skeletal muscle to microgravity
    R H Fitts
    Department of Biology, Marquette University, Milwaukee, WI 53201, USA
    J Exp Biol 204:3201-8. 2001
    ..The damage occurs with re-loading and not in-flight, but the etiology has not been established...
  4. ncbi request reprint Spaceflight effects on single skeletal muscle fiber function in the rhesus monkey
    R H Fitts
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53201, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1546-57. 2000
    ..However, only SF elicited atrophy and reduced force (mN) in the MG type I fiber and a decline in relative force (kN/m(2)) in the Sol type I and MG type II fibers...
  5. ncbi request reprint Functional properties of slow and fast gastrocnemius muscle fibers after a 17-day spaceflight
    J J Widrick
    Department of Biology, Marquette University, Milwaukee 53201, Wisconsin, USA
    J Appl Physiol 90:2203-11. 2001
    ..J. Widrick, S. K. Knuth, K. M. Norenberg, J. G. Romatowski, J. L. W. Bain, D. A. Riley, M. Karhanek, S. W. Trappe, T. A. Trappe, D. L. Costill, and R. H. Fitts. J Physiol (Lond) 516: 915-930, 1999]...
  6. pmc Low cell pH depresses peak power in rat skeletal muscle fibres at both 30 degrees C and 15 degrees C: implications for muscle fatigue
    S T Knuth
    Marquette University, Department of Biological Sciences, PO Box 1881, Milwaukee, WI 53201 1881, USA
    J Physiol 575:887-99. 2006
    ....
  7. ncbi request reprint Unilateral lower limb suspension does not mimic bed rest or spaceflight effects on human muscle fiber function
    J J Widrick
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53201, USA
    J Appl Physiol 93:354-60. 2002
    ..However, in contrast to these other models, slow soleus fibers obtained after ULLS showed a decrease in unloaded shortening velocity and a greater reduction in specific force...
  8. ncbi request reprint The depressive effect of Pi on the force-pCa relationship in skinned single muscle fibers is temperature dependent
    E P Debold
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Am J Physiol Cell Physiol 290:C1041-50. 2006
    ..Consequently, the combined changes in these ions likely account for a greater portion of fatigue than previously predicted based on studies at lower temperatures or high temperatures at saturating Ca(2+) levels...
  9. ncbi request reprint Contractile responses of the rat gastrocnemius and soleus muscles to isotonic resistance exercise
    K M Norenberg
    Dept of Biological Sciences, Marquette University, P O Box 1881, Milwaukee, WI 53201 1881, USA
    J Appl Physiol 97:2322-32. 2004
    ..These results indicate that isotonic resistance exercise of the calf targets the Gast (type I and type IIa fibers) and has little effect on the Sol...
  10. ncbi request reprint Fiber type and temperature dependence of inorganic phosphate: implications for fatigue
    E P Debold
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53201, USA
    Am J Physiol Cell Physiol 287:C673-81. 2004
    ..These data suggest that near physiological temperatures and at saturating levels of intracellular Ca(2+), elevated levels of P(i) contribute less to fatigue than might be inferred from data obtained at lower temperatures...
  11. ncbi request reprint Hindlimb unloading-induced muscle atrophy and loss of function: protective effect of isometric exercise
    J E Hurst
    Dept of Biology, Marquette Univ, Wehr Life Sciences Bldg P O Box 1881, Milwaukee, WI 53201 1881, USA
    J Appl Physiol 95:1405-17. 2003
    ..In summary, IE resulted in greater protection from HU-induced atrophy in the slow soleus than in the fast gastrocnemius or plantaris...
  12. ncbi request reprint Physiology of a microgravity environment invited review: microgravity and skeletal muscle
    R H Fitts
    Department of Biology, Marquette University, Milwaukee, WI 53201, USA
    J Appl Physiol 89:823-39. 2000
    ..Future studies will be required to establish the cellular and molecular mechanisms of the SF-induced muscle atrophy and functional loss and to develop effective exercise countermeasures...
  13. ncbi request reprint Skeletal muscle fiber atrophy: altered thin filament density changes slow fiber force and shortening velocity
    D A Riley
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Am J Physiol Cell Physiol 288:C360-5. 2005
    ..Osmotically compacting myofilaments with 5% dextran returned density, spacing, and specific tension and slowed V0 to near-control levels and provided evidence for myofilament spacing modulating tension and V0...
  14. ncbi request reprint Effects of depolarization and low intracellular pH on charge movement currents of frog skeletal muscle fibers
    E M Balog
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53210, USA
    J Appl Physiol 90:228-34. 2001
    ..However, if t-tubular Ca(2+) increases, some of the charge may be stabilized in the active state and remain available to initiate sarcoplasmic reticulum Ca(2+) release...
  15. ncbi request reprint Effects of regular exercise training on skeletal muscle contractile function
    Robert H Fitts
    Department of Biology, Marquette University, Milwaukee, Wisconsin 53201, USA
    Am J Phys Med Rehabil 82:320-31. 2003
    ..Another important goal of this article is to present the current understanding of how the contractile properties of limb skeletal muscle adapt to programs of regular exercise...
  16. ncbi request reprint Thin filament diversity and physiological properties of fast and slow fiber types in astronaut leg muscles
    Danny A Riley
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee 53226, USA
    J Appl Physiol 92:817-25. 2002
    ..Thin filament density is inversely related to shortening velocity in all fibers. Thin filament structural variation contributes to the functional diversity of normal and spaceflight-unloaded muscles...