Jennifer Wernegreen

Summary

Affiliation: Marine Biological Laboratory
Country: USA

Publications

  1. pmc One nutritional symbiosis begat another: phylogenetic evidence that the ant tribe Camponotini acquired Blochmannia by tending sap-feeding insects
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    BMC Evol Biol 9:292. 2009
  2. pmc Endosymbiosis: lessons in conflict resolution
    Jennifer J Wernegreen
    Josephine Bay Paul Center in Comparative Molecular Biology and Evolution at the Marine Biological Laboratory at Woods Hole, Massachusetts, USA
    PLoS Biol 2:E68. 2004
  3. ncbi request reprint Genome evolution in an insect cell: distinct features of an ant-bacterial partnership
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Biol Bull 204:221-31. 2003
  4. ncbi request reprint Genome evolution in bacterial endosymbionts of insects
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Nat Rev Genet 3:850-61. 2002
  5. ncbi request reprint Mutation exposed: a neutral explanation for extreme base composition of an endosymbiont genome
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    J Mol Evol 59:849-58. 2004
  6. pmc Remaining flexible in old alliances: functional plasticity in constrained mutualisms
    Jennifer J Wernegreen
    Josephine Bay Paul Center, Woods Hole, Massachusetts 02543, USA
    DNA Cell Biol 28:371-82. 2009
  7. pmc Slip into something more functional: selection maintains ancient frameshifts in homopolymeric sequences
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA, USA
    Mol Biol Evol 27:833-9. 2010
  8. ncbi request reprint Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition
    J J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Mol Phylogenet Evol 19:479-85. 2001
  9. pmc Vertical transmission of biosynthetic plasmids in aphid endosymbionts (Buchnera)
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 183:785-90. 2001
  10. pmc Decay of mutualistic potential in aphid endosymbionts through silencing of biosynthetic loci: Buchnera of Diuraphis
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, Center for Insect Science, University of Arizona, Tucson 85721, USA
    Proc Biol Sci 267:1423-31. 2000

Research Grants

Detail Information

Publications30

  1. pmc One nutritional symbiosis begat another: phylogenetic evidence that the ant tribe Camponotini acquired Blochmannia by tending sap-feeding insects
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    BMC Evol Biol 9:292. 2009
    ..In this study, we performed a molecular screen, based on PCR amplification of 16S rDNA, to identify bacterial associates of diverse Camponotini species...
  2. pmc Endosymbiosis: lessons in conflict resolution
    Jennifer J Wernegreen
    Josephine Bay Paul Center in Comparative Molecular Biology and Evolution at the Marine Biological Laboratory at Woods Hole, Massachusetts, USA
    PLoS Biol 2:E68. 2004
  3. ncbi request reprint Genome evolution in an insect cell: distinct features of an ant-bacterial partnership
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Biol Bull 204:221-31. 2003
    ..This review describes some recent insights into the evolutionary genetics of obligate insect-bacteria symbioses, with a particular focus on an intriguing association between the bacterial endosymbiont Blochmannia and its ant hosts...
  4. ncbi request reprint Genome evolution in bacterial endosymbionts of insects
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Nat Rev Genet 3:850-61. 2002
    ..Further genomic comparisons should reveal the generality of these features among bacterial mutualists and the extent to which they are shared with other intracellular bacteria, including obligate pathogens...
  5. ncbi request reprint Mutation exposed: a neutral explanation for extreme base composition of an endosymbiont genome
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    J Mol Evol 59:849-58. 2004
    ..Thus they further corroborate recent evidence for the critical role of reduced N(e) in the molecular evolution of bacterial endosymbionts...
  6. pmc Remaining flexible in old alliances: functional plasticity in constrained mutualisms
    Jennifer J Wernegreen
    Josephine Bay Paul Center, Woods Hole, Massachusetts 02543, USA
    DNA Cell Biol 28:371-82. 2009
    ..This symbiont variation is best understood by considering ant colony as the host superorganism. In this eusocial host, the bacteria meet the needs of the colony and not necessarily the individual ants that house them...
  7. pmc Slip into something more functional: selection maintains ancient frameshifts in homopolymeric sequences
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA, USA
    Mol Biol Evol 27:833-9. 2010
    ..Although the advantage of the frameshift itself is less clear, it may offer a mechanism to lower effective gene expression by reducing but not eliminating transcripts that encode full-length proteins...
  8. ncbi request reprint Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition
    J J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Mol Phylogenet Evol 19:479-85. 2001
    ..In addition, the discovery of trpEG pseudogenes in Buchnera-U. obscurum further supports reduced selection on amino acid biosynthesis...
  9. pmc Vertical transmission of biosynthetic plasmids in aphid endosymbionts (Buchnera)
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 183:785-90. 2001
    ..Synonymous divergences indicate elevated mutation on plasmids relative to chromosomal genes...
  10. pmc Decay of mutualistic potential in aphid endosymbionts through silencing of biosynthetic loci: Buchnera of Diuraphis
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, Center for Insect Science, University of Arizona, Tucson 85721, USA
    Proc Biol Sci 267:1423-31. 2000
    ....
  11. pmc Decoupling of genome size and sequence divergence in a symbiotic bacterium
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 182:3867-9. 2000
    ..This exceptional size conservation may reflect the inability of this obligate mutualist to acquire foreign DNA and reduced selection for genetic novelty within a static intracellular environment...
  12. pmc Intraspecific phylogenetic congruence among multiple symbiont genomes
    D J Funk
    Department of Ecology and Evolutionary Biology, and Center for Insect Science, University of Arizona, Tucson 85721, USA
    Proc Biol Sci 267:2517-21. 2000
    ..These results may reflect the obligate nature of this intimate mutualism and indicate opportunities for adaptive coevolution among linked symbiont genomes...
  13. pmc Intraspecific variation in symbiont genomes: bottlenecks and the aphid-buchnera association
    D J Funk
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Genetics 157:477-89. 2001
    ..However, our study cannot rule out the possibility that mechanisms other than bottlenecks also contribute to reduced N(e) at aphid and endosymbiont loci...
  14. ncbi request reprint Comparison of the evolutionary dynamics of symbiotic and housekeeping loci: a case for the genetic coherence of rhizobial lineages
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, Yale University, USA
    Mol Biol Evol 16:98-113. 1999
    ..Differences across rhizobial genera in the specificity of host associations imply that the evolutionary dynamics of the symbiosis vary considerably across lineages in native settings...
  15. ncbi request reprint Evidence for genetic drift in endosymbionts (Buchnera): analyses of protein-coding genes
    J J Wernegreen
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 16:83-97. 1999
    ..Combined, these results suggest a decreased effectiveness of purifying selection in purging endosymbiont populations of slightly deleterious mutations, particularly those affecting codon usage and amino acid identity...
  16. ncbi request reprint Small genome of Candidatus Blochmannia, the bacterial endosymbiont of Camponotus, implies irreversible specialization to an intracellular lifestyle
    J J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    Microbiology 148:2551-6. 2002
    ..Due to restricted gene exchange in obligate endosymbionts, the substantial gene loss in Blochmannia and other insect mutualists may reflect irreversible specialization to a host cellular environment...
  17. pmc A conservative test of genetic drift in the endosymbiotic bacterium Buchnera: slightly deleterious mutations in the chaperonin groEL
    Joshua T Herbeck
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Genetics 165:1651-60. 2003
    ..Rather, they further support the hypothesis that drift is an important force driving accelerated protein evolution in this obligate mutualist...
  18. ncbi request reprint 50 million years of genomic stasis in endosymbiotic bacteria
    Ivica Tamas
    Department of Molecular Evolution, Evolutionary Biology Center, University of Uppsala, Uppsala, Sweden
    Science 296:2376-9. 2002
    ..The genomic stasis of B. aphidicola, likely attributable to the loss of phages, repeated sequences, and recA, indicates that B. aphidicola is no longer a source of ecological innovation for its hosts...
  19. pmc Endosymbiont gene functions impaired and rescued by polymerase infidelity at poly(A) tracts
    Ivica Tamas
    Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 105:14934-9. 2008
    ..These features of homopolymeric tracts could be exploited to manipulate gene expression in small synthetic genomes...
  20. ncbi request reprint Toward a Wolbachia multilocus sequence typing system: discrimination of Wolbachia strains present in Drosophila species
    Charalampos Paraskevopoulos
    Department of Environmental and Natural Resources Management, University of Ioannina, 2 Seferi St, 30100, Agrinio, Greece
    Curr Microbiol 53:388-95. 2006
    ..The results demonstrate the discriminatory power of MLST for identifying strains and clonal lineages of Wolbachia and provide a robust foundation for studying the ecology and evolution of this widespread endosymbiont...
  21. pmc The tripartite associations between bacteriophage, Wolbachia, and arthropods
    Seth R Bordenstein
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    PLoS Pathog 2:e43. 2006
    ..Clarifying the roles of lytic and lysogenic phage development in Wolbachia biology will effectively structure inquiries into this research topic...
  22. ncbi request reprint Widespread recombination throughout Wolbachia genomes
    Laura Baldo
    Department of Biology, University of California, Riverside, USA
    Mol Biol Evol 23:437-49. 2006
    ....
  23. ncbi request reprint For better or worse: genomic consequences of intracellular mutualism and parasitism
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    Curr Opin Genet Dev 15:572-83. 2005
    ..Surprising discoveries of conjugation machinery in the parasite Rickettsia felis and the amoebae symbiont Parachlamydia sp. suggest that DNA transfer might play key roles in some intracellular taxa...
  24. pmc Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects
    Patrick H Degnan
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Genome Res 15:1023-33. 2005
    ..Furthermore, the increased rates of amino acid substitution and gene loss in Blochmannia have occurred in a lineage-specific fashion, which may reflect life history differences of their ant hosts...
  25. ncbi request reprint The roles of positive and negative selection in the molecular evolution of insect endosymbionts
    Adam J Fry
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Gene 355:1-10. 2005
    ..In the course of this study, we reanalyzed variation at Buchnera groEL and found no evidence of positive selection that was previously reported...
  26. ncbi request reprint A strong effect of AT mutational bias on amino acid usage in Buchnera is mitigated at high-expression genes
    Carmen Palacios
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Mol Biol Evol 19:1575-84. 2002
    ....
  27. ncbi request reprint Nonhomogeneous model of sequence evolution indicates independent origins of primary endosymbionts within the enterobacteriales (gamma-Proteobacteria)
    Joshua T Herbeck
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    Mol Biol Evol 22:520-32. 2005
    ..This application of a nonhomogeneous model offers a computationally feasible way to test specific phylogenetic hypotheses for taxa with heterogeneous and nonstationary base composition...
  28. ncbi request reprint Bacteriophage flux in endosymbionts (Wolbachia): infection frequency, lateral transfer, and recombination rates
    Seth R Bordenstein
    The Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, Massachusetts, USA
    Mol Biol Evol 21:1981-91. 2004
    ..Gene transfer by bacteriophages could drive significant evolutionary change in the genomes of intracellular bacteria that are typically considered highly stable and prone to genomic degradation...
  29. ncbi request reprint Host-symbiont stability and fast evolutionary rates in an ant-bacterium association: cospeciation of camponotus species and their endosymbionts, candidatus blochmannia
    Patrick H Degnan
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Syst Biol 53:95-110. 2004
    ..These rates are several-fold higher than those for related bacteria Buchnera aphidicola and Escherichia coli. Phylogenetic congruence among Blochmannia genes indicates genome stability that typifies primary endosymbionts of insects...
  30. ncbi request reprint Gene expression level influences amino acid usage, but not codon usage, in the tsetse fly endosymbiont Wigglesworthia
    Joshua T Herbeck
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    Microbiology 149:2585-96. 2003
    ..However, these impacts of mutation and drift are apparently attenuated by selection on amino acid composition at high-expression genes...

Research Grants9

  1. MOLECULAR EVOLUTIONARY CONSEQUENCES OF ENDOSYMBIOSIS
    Jennifer Wernegreen; Fiscal Year: 2006
    ..abstract_text> ..
  2. MECHANISMS AND CONSEQUENCES OF DELETERIOUS EVOLUTION IN BACTERIA
    Jennifer Wernegreen; Fiscal Year: 2007
    ..By deciphering fundamental mechanisms that influence bacterial genome evolution, this study will contribute to a predictive framework for understanding how microbes evolve. ..
  3. MECHANISMS AND CONSEQUENCES OF DELETERIOUS EVOLUTION IN BACTERIA
    Jennifer Wernegreen; Fiscal Year: 2009
    ..By deciphering fundamental mechanisms that influence bacterial genome evolution, this study will contribute to a predictive framework for understanding how microbes evolve. ..
  4. MECHANISMS AND CONSEQUENCES OF DELETERIOUS EVOLUTION IN BACTERIA
    Jennifer J Wernegreen; Fiscal Year: 2010
    ..By deciphering fundamental mechanisms that influence bacterial genome evolution, this study will contribute to a predictive framework for understanding how microbes evolve. ..