Research Topics
| Hilary G MorrisonSummaryAffiliation: Marine Biological Laboratory Country: USA Publications
| Collaborators
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Detail Information
Publications
Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transpositionAndrew Adey
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Genome Biol 11:R119. 2010..We also extend its capabilities by developing protocols for sub-nanogram library construction, exome capture from 50 ng of input DNA, PCR-free and colony PCR library construction, and 96-plex sample indexing...- The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolutionRodney D Adam
Departments of Medicine and Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA
BMC Genomics 11:424. 2010..The variable expression of the variant-specific surface protein (VSP) genes may contribute to this prolonged infection. Only one is expressed at a time, and switching expression from one gene to another occurs by an epigenetic mechanism... 
Genomic minimalism in the early diverging intestinal parasite Giardia lambliaHilary G Morrison
Marine Biological Laboratory, Woods Hole, MA 02543 1015, USA
Science 317:1921-6. 2007..This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite...- Inferring protein function from genomic sequence: Giardia lamblia expresses a phosphatidylinositol kinase-related kinase similar to yeast and mammalian TORHilary G Morrison
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543 1015, USA
Comp Biochem Physiol B Biochem Mol Biol 133:477-91. 2002..Our investigation of the Giardia genome suggests that PIK-related kinases are of ancient origin and are highly conserved... - Effect of PCR amplicon size on assessments of clone library microbial diversity and community structureJulie A Huber
Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA 02543, USA
Environ Microbiol 11:1292-302. 2009.... - Ironing out the wrinkles in the rare biosphere through improved OTU clusteringSusan M Huse
Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, 7 MBL Street, Woods Hole, MA 02543, USA
Environ Microbiol 12:1889-98. 2010..This new clustering method can reduce the OTU richness in environmental samples by as much as 30-60% but does not reduce the fraction of OTUs in long-tailed rank abundance curves that defines the rare biosphere... - Microbial population structures in the deep marine biosphereJulie A Huber
Josephine Bay Paul Center, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
Science 318:97-100. 2007.... - Accuracy and quality of massively parallel DNA pyrosequencingSusan M Huse
Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, MBL Street, Woods Hole, MA 02543, USA
Genome Biol 8:R143. 2007.... - Microbial community composition in sediments resists perturbation by nutrient enrichmentJennifer L Bowen
The Ecosystems Center, Marine Biological Laboratory, Woods Hole, MA, USA
ISME J 5:1540-8. 2011.... - Salt marsh sediment diversity: a test of the variability of the rare biosphere among environmental replicatesJennifer L Bowen
The Ecosystems Center, Marine Biological Laboratory, Woods Hole, MA, USA
ISME J 6:2014-23. 2012..These results demonstrate that deep sequencing of 16s tags is well suited to distinguish site-specific similarities and differences among rare taxa and is a valuable tool for hypothesis testing in microbial ecology... - Microbial diversity in the deep sea and the underexplored "rare biosphere"Mitchell L Sogin
Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, 7 MBL Street, Woods Hole, MA 02543, USA
Proc Natl Acad Sci U S A 103:12115-20. 2006..Members of the rare biosphere are highly divergent from each other and, at different times in earth's history, may have had a profound impact on shaping planetary processes... - Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus)Wade H Powell
Marine Biological Laboratory, Woods Hole, MA, USA
Mar Environ Res 58:119-24. 2004..These studies may ultimately shed light on the importance of P4501A activity in xenobiotic toxicity... - Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6Anjali Prabhu
Department of Immunobiology, University of Arizona College of Medicine, 1501 N Campbell, Tucson, AZ 85724 5049, USA
Int J Parasitol 37:503-13. 2007..These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure... - Exploring the relationship between sequence similarity and accurate phylogenetic treesBrandi L Cantarel
Department of Biochemistry and Molecular Genetics, University of Virginia, VA, USA
Mol Biol Evol 23:2090-100. 2006..Accuracy can be improved by combining genes from the same organism when creating species trees or by selecting protein families with the best bootstrap values in comprehensive studies... - Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia lambliaMalin E-L Weiland
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Int J Parasitol 35:617-26. 2005..These localisation experiments suggest alpha-giardins play a role in cell motility, attachment and membrane stability... - Evolution of eukaryotic transcription: insights from the genome of Giardia lambliaAaron A Best
Department of Microbiology, University of Illinois at Urbana-Champaign, B103 Chemical and Life Sciences Laboratory, Urbana, Illinois 61801, USA
Genome Res 14:1537-47. 2004..Consequently, Giardia is predicted to be unique in many aspects of transcription initiation with respect to paradigms derived from studies in crown eukaryotes... - Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolyticaJulie E J Nixon
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Eukaryot Cell 1:181-90. 2002..In further support of lateral transfer, the G. lamblia NADH oxidase and adh3 genes appeared to have an evolutionary history distinct from those of E. histolytica... - A spliceosomal intron in Giardia lambliaJulie E J Nixon
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115-6018, USA
Proc Natl Acad Sci U S A 99:3701-5. 2002..If introns were added during eukaryotic evolution (the introns-late hypothesis), then these results push back the date of this event before the branching of G. lamblia... 
Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusiNicolas Corradi
Department of Botany, Canadian Institute for Advanced Research, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 2:e1277. 2007..It is therefore difficult to determine how conservation has been maintained through microsporidian evolution, and impossible to identify whether certain regions are more prone to genomic stasis...- Myelin tetraspan family proteins but no non-tetraspan family proteins are present in the ascidian (Ciona intestinalis) genomeRobert M Gould
Department of Anatomy and Cell Biology, University of Illinois, Chicago, Illinois 60612, USA
Biol Bull 209:49-66. 2005..In contrast, no MBP, P0, or CNP homologs were found. These studies provide a framework for understanding how myelin proteins were recruited during evolution and how structural adaptations enabled them to play key roles in myelination... - Calcium signaling in excystation of the early diverging eukaryote, Giardia lambliaDavid S Reiner
Department of Pathology, University of California, San Diego, 92103, USA
J Biol Chem 278:2533-40. 2003..Thus, the basal bodies may be a cellular control center to coordinate the resumption of motility and cytokinesis in excystation...