J Himmelfarb

Summary

Affiliation: Maine Medical Center
Country: USA

Publications

  1. pmc Primary mouse renal tubular epithelial cells have variable injury tolerance to ischemic and chemical mediators of oxidative stress
    Anne C Breggia
    Maine Medical Center Research Institute, Clinical and Translational Research, Portland, Maine 04102, USA
    Oxid Med Cell Longev 1:33-8. 2008
  2. ncbi The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 62:1524-38. 2002
  3. ncbi Hemodialysis complications
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, ME 04102, USA
    Am J Kidney Dis 45:1122-31. 2005
  4. pmc Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD
    Luis F Ramos
    Division of Nephrology and Renal Transplantation and Clinical and Translational Research, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102
    J Am Soc Nephrol 19:593-9. 2008
  5. ncbi Relevance of oxidative pathways in the pathophysiology of chronic kidney disease
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Cardiol Clin 23:319-30. 2005
  6. ncbi Oxidative stress is increased in critically ill patients with acute renal failure
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Am Soc Nephrol 15:2449-56. 2004
  7. ncbi Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients
    Jonathan Himmelfarb
    Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA
    J Ren Nutr 17:296-304. 2007
  8. ncbi Continuous renal replacement therapy in the treatment of acute renal failure: critical assessment is required
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 2:385-9. 2007
  9. ncbi Impaired monocyte cytokine production in critically ill patients with acute renal failure
    Jonathan Himmelfarb
    Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 66:2354-60. 2004
  10. ncbi Payment for quality in end-stage renal disease
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Am Soc Nephrol 15:3263-9. 2004

Research Grants

Collaborators

Detail Information

Publications84

  1. pmc Primary mouse renal tubular epithelial cells have variable injury tolerance to ischemic and chemical mediators of oxidative stress
    Anne C Breggia
    Maine Medical Center Research Institute, Clinical and Translational Research, Portland, Maine 04102, USA
    Oxid Med Cell Longev 1:33-8. 2008
    ..A simple method for the culture and injury of primary mouse renal tubular epithelial cells has thereby been established and provides a useful tool for future investigations of ischemic kidney injury...
  2. ncbi The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 62:1524-38. 2002
    ..Anti-oxidative therapeutic strategies for patients with uremia are in their very early stages; nonetheless, early studies demonstrate the potential for significant efficacy in reducing cardiovascular complications...
  3. ncbi Hemodialysis complications
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, ME 04102, USA
    Am J Kidney Dis 45:1122-31. 2005
  4. pmc Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD
    Luis F Ramos
    Division of Nephrology and Renal Transplantation and Clinical and Translational Research, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102
    J Am Soc Nephrol 19:593-9. 2008
    ..Interventions focused on weight loss may decrease the inflammatory and oxidative burden in CKD, which may ultimately attenuate cardiovascular risk in this population...
  5. ncbi Relevance of oxidative pathways in the pathophysiology of chronic kidney disease
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Cardiol Clin 23:319-30. 2005
    ..Two recently published studies have suggested that antioxidative therapy may be particularly promising in reducing cardiovascular events in this patient population.Further definitive studies of antioxidant use are greatly needed...
  6. ncbi Oxidative stress is increased in critically ill patients with acute renal failure
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Am Soc Nephrol 15:2449-56. 2004
    ..Increased oxidative stress may be an important target for nutritional and pharmacologic therapy in ARF patients...
  7. ncbi Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients
    Jonathan Himmelfarb
    Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA
    J Ren Nutr 17:296-304. 2007
    ..Increased cardiovascular risk in hemodialysis patients may be related to augmented oxidative stress and inflammation, for which no proven beneficial therapies are available...
  8. ncbi Continuous renal replacement therapy in the treatment of acute renal failure: critical assessment is required
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 2:385-9. 2007
    ..When examining the totality of evidence from recent observational studies and clinical trials, there is no convincing evidence to support superiority of CRRT over IHD in the treatment of critically ill patients with ARF...
  9. ncbi Impaired monocyte cytokine production in critically ill patients with acute renal failure
    Jonathan Himmelfarb
    Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 66:2354-60. 2004
    ..Anti-inflammatory strategies are postulated to be beneficial in treatment. However, there are few studies simultaneously examining monocyte cytokine production and plasma cytokine levels in patients with ARF...
  10. ncbi Payment for quality in end-stage renal disease
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Am Soc Nephrol 15:3263-9. 2004
  11. ncbi Linking oxidative stress and inflammation in kidney disease: which is the chicken and which is the egg?
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Semin Dial 17:449-54. 2004
    ..Theoretical constructs evaluating the linkage of oxidative stress and inflammation in uremia and their contribution to the pathogenesis of atherosclerosis are suggested...
  12. ncbi Dialysis at a crossroads: reverse engineering renal replacement therapy
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 1:896-902. 2006
  13. ncbi Chronic kidney disease and the public health: gaps in evidence from interventional trials
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    JAMA 297:2630-3. 2007
  14. ncbi Cost, quality, and value: the changing political economy of dialysis care
    Jonathan Himmelfarb
    Maine Medical Center, Division of Nephrology, Portland, ME 04102, USA
    J Am Soc Nephrol 18:2021-7. 2007
  15. ncbi Acute kidney injury: changing lexicography, definitions, and epidemiology
    J Himmelfarb
    Maine Medical Center, Portland, ME and Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Kidney Int 71:971-6. 2007
    ..Promising strategies are now being developed which may ultimately lead to improved outcomes for patients at risk for or who have developed AKI, which should be readily testable in the coming decade...
  16. ncbi Continuous dialysis is not superior to intermittent dialysis in acute kidney injury of the critically ill patient
    Jonathan Himmelfarb
    Division of Nephrology and Transplantation at Maine Medical Center, Portland, ME 04102, USA
    Nat Clin Pract Nephrol 3:120-1. 2007
  17. pmc Evaluation and initial management of acute kidney injury
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 3:962-7. 2008
    ....
  18. ncbi Oxidative stress in uremia
    Jonathan Himmelfarb
    Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine, USA
    Curr Opin Nephrol Hypertens 12:593-8. 2003
    ....
  19. ncbi Plasma aminothiol oxidation in chronic hemodialysis patients
    Jonathan Himmelfarb
    Maine Medical Center and Maine Medical Center Research Institute, Portland, Maine 04102, USA
    Kidney Int 61:705-16. 2002
    ..We examined the plasma aminothiol concentration and redox status in ten chronic hemodialysis patients compared to ten age-matched healthy subjects...
  20. ncbi Iron regulation
    Jonathan Himmelfarb
    Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Am Soc Nephrol 18:379-81. 2007
  21. ncbi Oxidative stress in hemodialysis
    Jonathan Himmelfarb
    Department of Medicine, Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA
    Contrib Nephrol 161:132-7. 2008
    ..The pathophysiology of increased oxidative stress in uremia is multifactorial, but the retention of oxidized solute by the loss of kidney function is probably a major contributor...
  22. ncbi Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients
    J Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, ME 04102, USA
    Free Radic Biol Med 31:1163-9. 2001
    ..Our observations suggest that oxidants generated by myeloperoxidase contribute to the increased oxidative stress observed in renal-failure patients but do not damage plasma proteins during the hemodialysis procedure itself...
  23. ncbi Albumin is the major plasma protein target of oxidant stress in uremia
    J Himmelfarb
    Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 60:358-63. 2001
    ....
  24. ncbi Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease
    Jonathan Himmelfarb
    Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 64:978-91. 2003
    ..Alpha and gamma CEHC are water soluble, renally excreted, with known potent anti-inflammatory and antioxidative properties...
  25. ncbi The HEMO study - where do we go from here?
    Jonathan Himmelfarb
    Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland 04102, USA
    Curr Opin Nephrol Hypertens 12:587-91. 2003
    ..This review analyzes the results of the study and discusses how the HEMO study results affect efforts to lower morbidity and mortality in the hemodialysis population...
  26. ncbi End-stage renal disease measures of quality
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, Maine 04102, USA
    Annu Rev Med 58:387-99. 2007
    ..The feasibility, value, pitfalls, and appropriate quality metrics in a "payment-for-quality" program for dialysis care are currently under vigorous discussion...
  27. ncbi Plasma protein thiol oxidation and carbonyl formation in chronic renal failure
    J Himmelfarb
    Maine Medical Center, Portland, and Maine Medical Center Research Institute, South Portland, Maine 04102, USA
    Kidney Int 58:2571-8. 2000
    ..We have also examined the effect of the dialysis procedure on plasma protein oxidation using biocompatible and bioincompatible membranes...
  28. ncbi Plasma cytokine levels predict mortality in patients with acute renal failure
    Edith M Simmons
    Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1357-65. 2004
    ..This process has not been specifically described in critically ill patients with ARF...
  29. doi Uremic toxicity, oxidative stress, and hemodialysis as renal replacement therapy
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Semin Dial 22:636-43. 2009
    ....
  30. ncbi Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:2371-9. 2004
    ..To our knowledge, no prospective studies have examined how initiation of maintenance hemodialysis (MHD) affects biomarkers of inflammation and oxidative stress status...
  31. pmc Use of aspirin associates with longer primary patency of hemodialysis grafts
    Bradley S Dixon
    Division of Nephrology, University of Iowa College of Medicine, E 300D GH, 200 Hawkins Drive, Iowa City, IA 52242 1081, USA
    J Am Soc Nephrol 22:773-81. 2011
    ..In conclusion, use of aspirin associates with a trend toward longer primary unassisted patency of newly placed hemodialysis grafts similar to that observed for ERDP/ASA...
  32. ncbi Recombinant human growth hormone in patients with acute renal failure
    E Saadeh
    Division of Nephrology, Maine Medical Center, Portland, ME 04102, USA
    J Ren Nutr 11:212-9. 2001
    ..These changes corresponded to increases in serum growth hormone, IGF-1, IGF-1 binding protein 3, and leptin levels after growth hormone administration...
  33. ncbi Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy
    Michael Danielski
    Maine Medical Center, Portland, ME 04102, USA
    Am J Kidney Dis 42:286-94. 2003
    ..We hypothesized that a high proportion of hypoalbuminemic hemodialysis patients also would manifest increased levels of biomarkers of inflammation and oxidative stress...
  34. ncbi Mortality after acute renal failure: models for prognostic stratification and risk adjustment
    G M Chertow
    Department of Medicine Research, Division of Nephrology, University of California San Francisco, San Francisco, California, USA
    Kidney Int 70:1120-6. 2006
    ..By incorporating exposures over time, the discriminatory power of predictive models in ARF can be significantly improved...
  35. ncbi Plasma F2-isoprostane levels are elevated in chronic hemodialysis patients
    T A Ikizler
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Clin Nephrol 58:190-7. 2002
    ..Further, hemodialysis membrane bioincompatibility can contribute to increased oxidative stress and prevalence of inflammation...
  36. ncbi Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease
    B Payson Oberg
    Maine Medical Center, Portland, Maine, USA
    Kidney Int 65:1009-16. 2004
    ..The prevalence of increased oxidative stress and acute-phase inflammation in patients with chronic kidney disease (CKD) has not been thoroughly investigated...
  37. ncbi Elevated plasma glycocalicin levels and decreased ristocetin-induced platelet agglutination in hemodialysis patients
    J Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland 04102, USA
    Am J Kidney Dis 32:132-8. 1998
    ....
  38. ncbi Increased susceptibility to erythrocyte C5b-9 deposition and complement-mediated lysis in chronic renal failure
    J Himmelfarb
    Maine Medical Center Research Institute, South Portland
    Kidney Int 55:659-66. 1999
    ....
  39. doi Determinants of plasma adiponectin levels in nondiabetic subjects with moderate to severe chronic kidney disease
    Luis F Ramos
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    J Ren Nutr 19:197-203. 2009
    ..Our objective was to determine factors associated with adiponectin levels in subjects with stage III to IV chronic kidney disease (CKD)...
  40. pmc Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stress
    Thomas D Nolin
    Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 852:554-61. 2007
    ..This assay is well suited for high-throughput quantitative determination of aminothiols in clinical studies, and is currently being used to support investigations of oxidative stress in patients with chronic kidney disease...
  41. pmc Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients
    J K Inrig
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Kidney Int 71:454-61. 2007
    ..Further research should attempt to elucidate the mechanisms behind these findings...
  42. ncbi Effect of renal transplantation on biomarkers of inflammation and oxidative stress in end-stage renal disease patients
    Edith M Simmons
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA
    Transplantation 79:914-9. 2005
    ..Because maintenance hemodialysis is ineffective in controlling these factors, we hypothesized that restoration of kidney function by transplantation would be required to improve uremic inflammation and oxidative stress...
  43. ncbi Timing of initiation of dialysis in critically ill patients with acute kidney injury
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California San Francisco, USA
    Clin J Am Soc Nephrol 1:915-9. 2006
    ..Although the results could reflect residual confounding by severity of illness, they provide a rationale for prospective testing of alternative dialysis initiation strategies in critically ill patients with severe AKI...
  44. doi Prediction, progression, and outcomes of chronic kidney disease in older adults
    Sharon Anderson
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Am Soc Nephrol 20:1199-209. 2009
    ..Answers to emerging research questions will support the integration of geriatrics and nephrology and thus improve care for older patients at risk for chronic kidney disease...
  45. pmc Comparison of methods for estimating glomerular filtration rate in critically ill patients with acute kidney injury
    Josee Bouchard
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 25:102-7. 2010
    ....
  46. ncbi Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients
    M Luisa Trirogoff
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Clin Nutr 86:1642-8. 2007
    ..Insulin resistance has been noted in patients with chronic kidney disease (CKD). The determinants of insulin resistance have not been well-studied in CKD patients...
  47. ncbi Survival by dialysis modality in critically ill patients with acute kidney injury
    Kerry C Cho
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94118, USA
    J Am Soc Nephrol 17:3132-8. 2006
    ..Larger, prospective, randomized clinical trials to compare CRRT and IHD in severe AKI are needed...
  48. doi Acute kidney injury in the elderly: problems and prospects
    Jonathan Himmelfarb
    Kidney Research Institute, Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98104, USA
    Semin Nephrol 29:658-64. 2009
    ..The increasing prevalence and extended clinical consequences of AKI in the elderly are of great concern from a clinical and public health perspective...
  49. pmc JAK2/Y343/STAT5 signaling axis is required for erythropoietin-mediated protection against ischemic injury in primary renal tubular epithelial cells
    A C Breggia
    Division of Nephrology and Transplantation, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    Am J Physiol Renal Physiol 295:F1689-95. 2008
    ..In addition, we identified Pim-3, a prosurvival STAT5 target gene, as responsive to EPO in the noninjured kidney both in vitro and in vivo...
  50. ncbi Pharmacologic prevention of vascular access stenosis
    J Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland 04102, USA
    Curr Opin Nephrol Hypertens 8:569-72. 1999
    ..This review summarizes currently available information and future prospects in pharmacologic and molecular biologic approaches to preventing vascular access stenosis...
  51. doi Creating research infrastructure and functionality to address chronic kidney disease: the Kidney Research Institute
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Semin Nephrol 29:457-66. 2009
    ....
  52. ncbi Are biomarkers useful for assessing cardiovascular risk in patients with chronic kidney disease?
    Clifford Rubin
    Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Curr Opin Nephrol Hypertens 16:506-11. 2007
    ..This review will summarize these studies and critically assess the utility of cardiovascular risk biomarkers for clinical practice...
  53. ncbi Sepsis and the kidney
    Jennifer Klenzak
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Crit Care Clin 21:211-22. 2005
    ..Experimental therapies to improve outcomes in sepsis-associated ARF include the provision of plasmapheresis and adsorption therapies, and the recent development and deployment of a renal tubule assist device...
  54. ncbi Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..Understanding the changing spectrum of ARF will be necessary to facilitate quality improvement efforts and to design successful interventional trials...
  55. ncbi Perioperative topical bovine thrombin exposure is not associated with hemodialysis graft thrombosis
    Mark D Vannorsdall
    Division of Nephrology, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 64:690-6. 2003
    ..We conclude that perioperative topical bovine thrombin exposure is not associated with subsequent graft thrombosis...
  56. ncbi Anemia of kidney disease and clinical practice guidelines: quo vadis?
    Jonathan Himmelfarb
    Maine Nephrology Associates, Portland, Maine, USA
    Clin J Am Soc Nephrol 2:213-4. 2007
  57. pmc Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients
    Jula K Inrig
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 50:108-18, 118.e1-4. 2007
    ..This study seeks to define the relationship between IDWG and BP in prevalent hemodialysis subjects...
  58. ncbi Insulin resistance in critically ill patients with acute renal failure
    Seema Basi
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 289:F259-64. 2005
    ..Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process...
  59. ncbi Technology Insight: biomarker development in acute kidney injury--what can we anticipate?
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine and the Indiana Center for Biologic Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Clin Pract Nephrol 4:154-65. 2008
    ..Great strides forward are being made in breaking down important barriers to the successful prevention and treatment of this devastating disorder...
  60. pmc Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes
    Jula K Inrig
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8523, USA
    Kidney Int 76:1098-107. 2009
    ..Our study found that in prevalent dialysis subjects, a decrease in pulse pressure during dialysis was associated with improved outcomes. Further study is needed to identify how to control pulse pressure to improve outcomes...
  61. ncbi Urea volume of distribution exceeds total body water in patients with acute renal failure
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, Maine, USA
    Kidney Int 61:317-23. 2002
    ..While Vurea has been shown to be substantially the same as total body water (TBW) in other patient populations, this relationship has not been adequately studied in detail in ARF patients...
  62. ncbi Hemodialysis acutely improves hepatic CYP3A4 metabolic activity
    Thomas D Nolin
    Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Am Soc Nephrol 17:2363-7. 2006
    ..50, P = 0.012), but not to several middle molecules. This is the first study in humans characterizing uremia as a state in which hepatic CYP3A4 activity is acutely improved by hemodialysis...
  63. pmc Tubular expression of KIM-1 does not predict delayed function after transplantation
    Bernd Schroppel
    Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Am Soc Nephrol 21:536-42. 2010
    ..Our findings are consistent with a role for KIM-1 as an early indicator of tubular injury but do not support tissue KIM-1 measurement before transplantation to identify kidneys at risk for DGF...
  64. ncbi Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury
    Josee Bouchard
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 76:422-7. 2009
    ..Whether the fluid overload was the result of a more severe renal failure or it contributed to its cause will require clinical trials in which the role of fluid administration to such patients is directly tested...
  65. ncbi Urea space and total body water measurements by stable isotopes in patients with acute renal failure
    T Alp Ikizler
    Vanderbilt University Medical Center, Division of Nephrology, Nashville, Tennessee 37232 2372, USA
    Kidney Int 65:725-32. 2004
    ..However, these estimates of Vurea and TBW have not been validated by isotopic methods, considered as reference measurement standards...
  66. ncbi Success and challenge in dialysis therapy
    Jonathan Himmelfarb
    N Engl J Med 347:2068-70. 2002
  67. ncbi Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 608, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 3:887-94. 2008
    ..An international, consensus-based, prioritized research agenda was sought to guide clinical and translational research in acute kidney injury...
  68. ncbi Muscle wasting in kidney disease: Let's get physical
    T Alp Ikizler
    J Am Soc Nephrol 17:2097-8. 2006
  69. ncbi What is the current and future status of interventional nephrology?
    Gerald A Beathard
    R M S Lifeline, Vernon Hills, Illinois, USA
    Semin Dial 18:370-9. 2005
  70. ncbi Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a randomized trial
    Donal N Reddan
    Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    J Am Soc Nephrol 16:2162-9. 2005
    ..The atypically low hospitalization and mortality rates for the conventional monitoring group suggest that these findings should be generalized to the US hemodialysis population with caution...
  71. ncbi Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort
    Mona Boaz
    Epidemiology Unit, E Wolfson Medical Center, Holon, Israel
    Nephron Clin Pract 100:c111-9. 2005
    ..This study was designed to compare levels of the oxysterols 7-ketocholesterol (7KC) and 7beta-hydroxycholesterol (7betaOH) between a cohort of HD patients and healthy controls...
  72. ncbi Medicare ESRD prospective payment system: weighing the evidence
    Jonathan Himmelfarb
    J Am Soc Nephrol 16:1164-5. 2005
  73. ncbi Antioxidant therapy in uremia: evidence-based medicine?
    Carrie A Gordon
    Semin Dial 17:327-32. 2004
    ..Further investigation in this area should be supported to see if reported benefits can be duplicated in more widespread study populations, and to more accurately define the most appropriate choice of therapy, mode of therapy, and dose...
  74. ncbi Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001
    Jay L Xue
    United States Renal Data System, 914 South 8th Street, Suite D 206, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 17:1135-42. 2006
    ..Those of older age, male gender, and black race are more likely to have ARF. These data show ARF to be a major contributor to morbidity and mortality in hospitalized patients...
  75. ncbi Uremic retention solutes: the free and the bound
    Thomas Depner
    J Am Soc Nephrol 18:675-6. 2007
  76. ncbi The chronic kidney disease initiative
    Thomas F Parker
    Dallas Nephrology Associates, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
    J Am Soc Nephrol 15:708-16. 2004
    ..This article describes the process, the barriers encountered, and the solutions required to fully identify and manage this large and complicated population of patients...
  77. ncbi Design of the Dialysis Access Consortium (DAC) Clopidogrel Prevention of Early AV Fistula Thrombosis Trial
    Laura M Dember
    Renal Section, Boston University School of Medicine, MA 02118 USA
    Clin Trials 2:413-22. 2005
    ..The autogenous arteriovenous fistula created by direct connection of native artery to vein is the recommended vascular access for hemodialysis. However, it fails frequently due to clotting after surgery...
  78. ncbi Online hemodiafiltration: back to the future?
    Jonathan Himmelfarb
    Artif Organs 30:577-8. 2006
  79. ncbi Design of the Dialysis Access Consortium (DAC) Aggrenox Prevention Of Access Stenosis Trial
    Bradley S Dixon
    Nephrology Division, Veterans Affairs Medical Center and University of Iowa School of Medicine, Iowa City 52242 1081, USA
    Clin Trials 2:400-12. 2005
    ..The Dialysis Access Consortium (DAC) Aggrenox Prevention of Access Stenosis Trial tests the hypothesis that Aggrenox (containing dipyridamole and aspirin) can prevent stenosis and prolong survival of arteriovenous grafts...
  80. ncbi Balancing Fistula First with Catheters Last
    Eduardo Lacson
    Fresenius Medical Care, North America, Waltham, MA 02451 1457, USA
    Am J Kidney Dis 50:379-95. 2007
    ..In the same vein as Fistula First, the renal community should once again be galvanized in working together toward controlling the catheter epidemic in our dialysis population...
  81. doi World Kidney Day 2008: think globally, speak locally
    Connie L Davis
    J Am Soc Nephrol 19:413-6. 2008
  82. ncbi Trials and trade-offs in haemodialysis vascular access monitoring
    Talat Alp Ikizler
    Nephrol Dial Transplant 21:3362-3. 2006
  83. ncbi Dose-ranging trial with a recombinant urokinase (urokinase alfa) for occluded central venous catheters in oncology patients
    Steven R Deitcher
    Section of Hematology and Coagulation Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Vasc Interv Radiol 15:575-80. 2004
    ....
  84. doi Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial
    Laura M Dember
    Boston University, School of Medicine, Renal Section, EBRC 504, 650 Albany St, Boston, Massachusetts 02118, USA
    JAMA 299:2164-71. 2008
    ..Small, inconclusive trials have suggested that antiplatelet agents may reduce thrombosis of new fistulas...

Research Grants2

  1. Continuation of Dialysis Access Consortium Clinical Trials
    Jonathan Himmelfarb; Fiscal Year: 2007
    ..The health care cost o maintaining adequate vascular access should also decrease from its current rate of over one billion dollars per year. ..