David Clark

Summary

Affiliation: Maine Medical Center
Country: USA

Publications

  1. pmc Inverse propensity weighting to adjust for bias in fatal crash samples
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress Street, Portland, ME 04102, USA
    Accid Anal Prev 50:1244-51. 2013
  2. pmc Hazard regression models of early mortality in trauma centers
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress St, Portland, ME 04102, USA
    J Am Coll Surg 215:841-9. 2012
  3. pmc The distribution of survival times after injury
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress Street, Suite 210, Portland, ME 04102, USA
    World J Surg 36:1562-70. 2012
  4. ncbi request reprint Epidemiology and short-term outcomes of injured medicare patients
    David E Clark
    Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, Maine 04102, USA
    J Am Geriatr Soc 52:2023-30. 2004
  5. pmc Injuries among older Americans with and without Medicare
    David E Clark
    MMC Surgical Associates, Maine Medical Center, 887 Congress St, Suite 210, Portland, ME 04102, USA
    Am J Public Health 95:273-8. 2005
  6. ncbi request reprint Increasing importance of the elderly in a trauma system
    David E Clark
    Harvard Injury Control Research Center, Boston, MA, USA
    Am J Emerg Med 20:108-11. 2002
  7. ncbi request reprint Is the number of traffic fatalities in American hospitals decreasing?
    David E Clark
    Department of Surgery, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Accid Anal Prev 37:755-60. 2005
  8. pmc Estimating injury severity using the Barell matrix
    D E Clark
    Department of Surgery, Maine Medical Center, Portland, ME, USA
    Inj Prev 12:111-6. 2006
  9. ncbi request reprint Predicting hospital mortality, length of stay, and transfer to long-term care for injured patients
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, ME, USA
    J Trauma 62:592-600. 2007
  10. ncbi request reprint Initial presentation of older injured patients to high-volume hospitals is not associated with lower 30-day mortality in Medicare data
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, ME, USA
    Crit Care Med 35:1829-36. 2007

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc Inverse propensity weighting to adjust for bias in fatal crash samples
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress Street, Portland, ME 04102, USA
    Accid Anal Prev 50:1244-51. 2013
    ..Combining the strengths of these two samples might offset their limitations...
  2. pmc Hazard regression models of early mortality in trauma centers
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress St, Portland, ME 04102, USA
    J Am Coll Surg 215:841-9. 2012
    ..Hazard regression (HR) models might therefore be more useful than logistic regression (LR) models for analysis of trauma mortality, especially when treatment effects at different time points are of interest...
  3. pmc The distribution of survival times after injury
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress Street, Suite 210, Portland, ME 04102, USA
    World J Surg 36:1562-70. 2012
    ..The distribution of survival times after injury has been described as "trimodal," but several studies have not confirmed this. The purpose of this study was to clarify the distribution of survival times after injury...
  4. ncbi request reprint Epidemiology and short-term outcomes of injured medicare patients
    David E Clark
    Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, Maine 04102, USA
    J Am Geriatr Soc 52:2023-30. 2004
    ..To describe characteristics and short-term outcomes of Medicare patients hospitalized after injuries in 1999...
  5. pmc Injuries among older Americans with and without Medicare
    David E Clark
    MMC Surgical Associates, Maine Medical Center, 887 Congress St, Suite 210, Portland, ME 04102, USA
    Am J Public Health 95:273-8. 2005
    ..We evaluated the generalizability of Medicare fee-for-service data for patients hospitalized with injuries...
  6. ncbi request reprint Increasing importance of the elderly in a trauma system
    David E Clark
    Harvard Injury Control Research Center, Boston, MA, USA
    Am J Emerg Med 20:108-11. 2002
    ..Major changes have occurred in populations served by trauma systems. Preventing injuries in the elderly is increasingly important. Accurate evaluation of cost-effectiveness in the elderly must include outcomes from SNF...
  7. ncbi request reprint Is the number of traffic fatalities in American hospitals decreasing?
    David E Clark
    Department of Surgery, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Accid Anal Prev 37:755-60. 2005
    ..Along with occasional misclassification in some states, the decrease in cases transported only to be pronounced DOA could explain why FARS data show a decrease in deaths after hospital transport...
  8. pmc Estimating injury severity using the Barell matrix
    D E Clark
    Department of Surgery, Maine Medical Center, Portland, ME, USA
    Inj Prev 12:111-6. 2006
    ..To determine whether the Barell matrix (Inj Prev 2002;8:91-6) could effectively categorize injuries by severity...
  9. ncbi request reprint Predicting hospital mortality, length of stay, and transfer to long-term care for injured patients
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, ME, USA
    J Trauma 62:592-600. 2007
    ..Using hospital length of stay (LOS) to measure trauma care efficiency is complicated by short LOS resulting from early mortality or transfer to long-term care (LTC)...
  10. ncbi request reprint Initial presentation of older injured patients to high-volume hospitals is not associated with lower 30-day mortality in Medicare data
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, ME, USA
    Crit Care Med 35:1829-36. 2007
    ..To evaluate whether survival of older patients with severe injuries is positively associated with initial presentation to high-volume trauma hospitals...
  11. doi request reprint Systeme International in the ICU in the United States
    David E Clark
    Division of Trauma and Surgical Critical Care, Maine Medical Center, 887 Congress St, Portland, ME 04102, USA
    Chest 137:932-7. 2010
    ..Because it would thus improve critical care practice, SI should be increasingly accepted in the United States and especially promoted in the ICU...
  12. pmc Predicting risk-adjusted mortality for trauma patients: logistic versus multilevel logistic models
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, ME, USA
    J Am Coll Surg 211:224-31. 2010
    ....
  13. ncbi request reprint Rural and urban traffic fatalities, vehicle miles, and population density
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress Street, Suite 210, Portland, ME 04102, USA
    Accid Anal Prev 36:967-72. 2004
    ..The presence of a state trauma system did not measurably affect mortality. After controlling for VMT and southern location, state population density was a moderately strong predictor of rural but not urban traffic mortality rates...
  14. ncbi request reprint Risk adjustment for injured patients using administrative data
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, Maine, USA
    J Trauma 57:130-40; discussion 140. 2004
    ..Risk adjustment methods are needed for population-based studies of injured patients...
  15. ncbi request reprint Effect of population density on mortality after motor vehicle collisions
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress Street, Suite 210, Portland, ME 04102, USA
    Accid Anal Prev 35:965-71. 2003
    ..R. 2.10, 95% C.I. 1.62-2.73). The excess risk for residents of rural areas to die in traffic crashes can be attributed in part to post-crash factors...
  16. pmc Practical introduction to record linkage for injury research
    D E Clark
    Center for Outcomes Research and Evaluation, Maine Medical Center and the Harvard Injury Control Research Center, Harvard School of Public Health, USA
    Inj Prev 10:186-91. 2004
    ..Whatever techniques are used, researchers must realize that the combination of data sources entails additional ethical obligations beyond the use of each source alone...
  17. ncbi request reprint Operative technique, paraplegia, and mortality after blunt traumatic aortic injury
    Gary M Hochheiser
    Department of Surgery, Maine Medical Center, Portland, USA
    Arch Surg 137:434-8. 2002
    ..The use of mechanical circulatory support (MCS) during repair of traumatic aortic injuries is associated with a decreased incidence of postoperative paraplegia and mortality...
  18. ncbi request reprint Trauma system evaluation using the fatality analysis reporting system
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, USA
    J Trauma 54:1199-204; discussion 1204. 2003
    ..At least three prior studies have used declining mortality rates derived from FARS as evidence of regional trauma system effectiveness...
  19. pmc Concurrent prediction of hospital mortality and length of stay from risk factors on admission
    David E Clark
    Department of Surgery, Maine Medical Center, Portland 04102, USA
    Health Serv Res 37:631-45. 2002
    ..To develop a method for predicting concurrently both hospital survival and length of stay (LOS) for seriously ill or injured patients, with particular attention to the competing risks of death or discharge alive as determinants of LOS...
  20. ncbi request reprint Long-term survival of Medicare patients with head injury
    Joseph T Donohue
    Maine Medical Center, Portland ME, USA
    J Trauma 62:419-23. 2007
    ..An increasing number of older patients are being hospitalized with traumatic brain injury (TBI). Knowledge of their expected long-term survival may be useful in making clinical decisions...
  21. ncbi request reprint Predicted effect of automatic crash notification on traffic mortality
    David E Clark
    Department of Surgery, Maine Medical Center, Portland, USA
    Accid Anal Prev 34:507-13. 2002
    ..To estimate the reduction in traffic mortality in the United States that would result from an automatic crash notification (ACN) system...
  22. doi request reprint The Trauma Quality Improvement Program: pilot study and initial demonstration of feasibility
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 5033, USA
    J Trauma 68:253-62. 2010
    ..This study details the feasibility and acceptance of TQIP among the participating centers...
  23. doi request reprint Regional variation in hospital mortality and 30-day mortality for injured Medicare patients
    Adam S Gorra
    Department of Surgery, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    World J Surg 32:954-9. 2008
    ..We sought to evaluate how survival of older patients with injuries differs by geographic region within the United States...
  24. ncbi request reprint Evaluating an inclusive trauma system using linked population-based data
    David E Clark
    Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, Maine, USA
    J Trauma 57:501-9. 2004
    ..Federal and professional programs require "inclusive" trauma systems. We wished to evaluate an inclusive trauma system using administrative data combined from multiple sources...
  25. ncbi request reprint Management of adult splenic injury: a 20-year perspective
    Kimberly L Hartnett
    Department of Surgery, Maine Medical Center, Portland, Maine, USA
    Am Surg 69:608-11. 2003
    ..Rates of operative intervention were lower at the trauma hospitals despite higher injury severity. Frequency of delayed intervention was low and did not increase with lower operative rate...
  26. pmc Using a hierarchical model to estimate risk-adjusted mortality for hospitals not included in the reference sample
    David E Clark
    Department of Surgery, Maine Medical Center, 887 Congress Street, Suite 210, Portland, ME 04102, USA
    Health Serv Res 45:577-87. 2010
    ..To provide a method for any hospital to evaluate patient mortality using a hierarchical risk-adjustment equation derived from a reference sample...
  27. doi request reprint Using hospital outcomes to predict 30-day mortality among injured patients insured by Medicare
    Adam S Gorra
    Department of Surgery, Maine Medical Center, 887 Congress St, Portland, ME 04102, USA
    Arch Surg 146:195-200. 2011
    ..Survival until a fixed time after injury is a more useful outcome variable than survival until hospital discharge...
  28. doi request reprint Asymptomatic isolated celiac artery dissection after a fall
    Adam S Gorra
    Department of Surgery, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    Arch Surg 144:279-81. 2009
    ..The patient was treated with 3 months of oral anticoagulation alone...
  29. doi request reprint Comparison of injury patient information from hospitals with records in both the national trauma data bank and the nationwide inpatient sample
    Bart Phillips
    Division of Research and Optimal Patient Care, American College of Surgeons, Chicago, Illinois, USA
    J Trauma 64:768-79; discussion 779-80. 2008
    ..We compared injury records from a large administrative database and the National Trauma Data Bank (NTDB) with the goal of furthering the understanding of their respective limitations...
  30. ncbi request reprint Guidelines for emergency tracheal intubation immediately after traumatic injury
    C Michael Dunham
    St Elizabeth Health Center, Youngstown, Ohio 44501 1790, USA
    J Trauma 55:162-79. 2003
  31. ncbi request reprint A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor
    David E Clark
    Argenta Discovery Ltd, 8 9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, UK david clark argentadiscovery com
    J Med Chem 47:3962-71. 2004
    ..More potent compounds were identified by follow-up searches around the initial hit. A proposed binding mode for compound 12 in a homology model of the MCH-1R is also presented...
  32. ncbi request reprint Outsourcing lead optimisation--the quiet revolution
    David E Clark
    Argenta Discovery, 8 9 Spire Green Centre, Flex Meadow, Harlow, Essex, UK CM19 5TR
    Drug Discov Today 9:492-500. 2004
    ..Currently, a particularly significant trend is the move towards 'off-shoring', which promises to drive further changes in this rapidly evolving market in the near future...
  33. pmc Avoidable mortality
    David E Clark
    Am J Public Health 93:186; author reply 186-7. 2003
  34. ncbi request reprint In silico predictions of blood-brain barrier penetration: considerations to "keep in mind"
    Jay T Goodwin
    ADMETRx, Inc, Kalamazoo, MI 49008, USA
    J Pharmacol Exp Ther 315:477-83. 2005
    ..This article will address these key considerations for the development and application of in silico methods in drug discovery...

Research Grants4

  1. Evaluating Hospital Outcomes for Injured Patients
    David Clark; Fiscal Year: 2007
    ..This project is designed to produce a credible and verifiable data management structure and analytic methodology that can be used for the continuing evaluation of trauma care by the ACS, AHRQ, and others. ..
  2. Trauma System Evaluation with Survival Time Models
    David Clark; Fiscal Year: 2009
    ..This will enable us to distinguish between the impact of level of trauma system development and other factors affecting the disparity in rural and urban trauma mortality. ..
  3. Trauma System Evaluation with Survival Time Models
    David E Clark; Fiscal Year: 2010
    ..This will enable us to distinguish between the impact of level of trauma system development and other factors affecting the disparity in rural and urban trauma mortality. ..