Gan Xin Yan

Summary

Affiliation: Main Line Health Heart Center
Country: USA

Publications

  1. ncbi request reprint Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia
    Gan Xin Yan
    Main Line Health Heart Center and Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA, 19096, USA
    Circulation 110:1036-41. 2004
  2. ncbi request reprint Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes
    Ying Wu
    Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    J Cardiovasc Electrophysiol 16:898-904. 2005
  3. ncbi request reprint Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action
    Xiaoping Xu
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Pharmacol 41:414-21. 2003
  4. doi request reprint Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias
    Donglin Guo
    Main Line Health Heart Center and Lankenau Inst, Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 298:H1375-81. 2010
  5. ncbi request reprint L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:196-203. 2007
  6. pmc Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias
    Tengxian Liu
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Heart Rhythm 3:948-56. 2006
  7. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
  8. ncbi request reprint ECG repolarization waves: their genesis and clinical implications
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Ann Noninvasive Electrocardiol 10:211-23. 2005
  9. doi request reprint Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Cardiovasc Pharmacol 57:79-85. 2011
  10. doi request reprint Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 8:762-9. 2011

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia
    Gan Xin Yan
    Main Line Health Heart Center and Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA, 19096, USA
    Circulation 110:1036-41. 2004
    ..The present study examined the role of phase 2 reentry in the initiation of VF during early myocardial ischemia...
  2. ncbi request reprint Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes
    Ying Wu
    Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    J Cardiovasc Electrophysiol 16:898-904. 2005
    ..This study examined the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide...
  3. ncbi request reprint Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action
    Xiaoping Xu
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Pharmacol 41:414-21. 2003
    ..These effects are self-limited due to SB-237376-induced I(Ca,L) blockade at high concentrations, which may explain its lower proarrhythmic risk than dl-sotalol...
  4. doi request reprint Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias
    Donglin Guo
    Main Line Health Heart Center and Lankenau Inst, Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 298:H1375-81. 2010
    ..The I(Na-L) may serve as a potentially useful ionic target for antiarrhythmic drugs for the treatment of atrial arrhythmias in the setting of LVH...
  5. ncbi request reprint L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:196-203. 2007
    ..AP triangulation has been shown to be an important predictor of drug-induced TdP...
  6. pmc Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias
    Tengxian Liu
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Heart Rhythm 3:948-56. 2006
    ..The present study provides a blinded appraisal of drugs, in an isolated arterially-perfused rabbit ventricular wedge preparation, with and without the potential to produce TdP...
  7. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
    ..Long QT syndrome is associated with early after-depolarization (EAD) that may result in torsade de pointes (TdP). Interestingly, the corrected QT interval seems to be proportional to body mass across species under physiologic conditions...
  8. ncbi request reprint ECG repolarization waves: their genesis and clinical implications
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Ann Noninvasive Electrocardiol 10:211-23. 2005
    ..A physiological U wave is thought to be due to delayed repolarization of the Purkinje system...
  9. doi request reprint Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Cardiovasc Pharmacol 57:79-85. 2011
    ..HBI-3000 may be a promising antiarrhythmic agent with low proarrhythmic risk...
  10. doi request reprint Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 8:762-9. 2011
    ..Abnormal rate adaptation of ventricular repolarization is arrhythmogenic. There is controversy on the underlying ionic mechanisms for rate-dependent change in repolarization...
  11. ncbi request reprint The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:154-8. 2005
    ....
  12. ncbi request reprint Mechanisms underlying arrhythmogenesis in long QT syndrome
    Ramarao S Lankipalli
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:69-73. 2005
    ..Enhanced TDR is essential not only for the genesis of the first initiating beat of TdP by facilitating the propagation of EAD, but also for the maintenance of TdP by serving as a functional reentrant substrate...
  13. ncbi request reprint Increasing I(Ks) corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy
    Xiaoping Xu
    Main Line Health Heart Center, Suite 558, Medical Office Building East, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 283:H664-70. 2002
    ..2 Hz. Pharmacological activation of I(Ks) is a promising new strategy to suppress arrhythmias resulting from excessive AP prolongation in patients with certain forms of long QT syndrome or cardiac hypertrophy and failure...
  14. ncbi request reprint Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance
    Gan Xin Yan
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Am Coll Cardiol 42:401-9. 2003
    ....
  15. ncbi request reprint Ischemia versus amiodarone induced polymorphic ventricular tachycardia
    Harinder Sharma
    Department of Internal Medicine, Main Line Health Heart Center, Lankenau Hospital and Institute of Medical Research, Wynnewood, Pennsylvania, USA
    Pacing Clin Electrophysiol 25:1382-4. 2002
  16. doi request reprint Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit
    Donglin Guo
    Main Line Health Heart Ctr, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 295:H97-H104. 2008
    ..Our data indicate that abnormal intracellular Ca(2+) fluctuation may exert a strong feedback on the membrane I(Cl,Ca), leading to a beat-to-beat change in the net repolarizing current that manifests as T-wave alternans on the ECG...
  17. ncbi request reprint Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models
    Ajay Joshi
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 37:7-14. 2004
    ..Signals specifically pertinent to the development of TdP, ie, early afterdepolarization (EAD) and an increase in TDR can be detected as well. The preclinical data obtained from the wedge preparation correlate well with clinical outcomes...
  18. doi request reprint Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation
    Tengxian Liu
    Lankenau Institute for Medical Research and Main Line Health Heart Center, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Heart Rhythm 9:1706-15. 2012
    ..However, the correlation of ECG ventricular waveforms with underlying ion actions is not well established and has been extensively debated...
  19. ncbi request reprint Overview of the management of atrial fibrillation: what is the current state of the art?
    Peter R Kowey
    Cardiovascular Division, Lankenau Hospital and Medical Research Center, and the Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 14:S275-80; discussion S280. 2003
    ..The use of warfarin, however, presents its own complications. We conclude that individualization of therapy is paramount when treating AF...
  20. doi request reprint Role of antiarrhythmic drugs: frequent implantable cardioverter-defibrillator shocks, risk of proarrhythmia, and new drug therapy
    Christopher Droogan
    Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 356, Wynnewood, PA 19096, USA
    Heart Fail Clin 7:195-205, viii. 2011
    ..This article describes data supporting the need for and potential risks and benefits of adjuvant antiarrhythmic drug therapy and examines the benefits and pitfalls of the same in ICD-implanted patients...
  21. doi request reprint T(p-e)/QT ratio as an index of arrhythmogenesis
    Prasad Gupta
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 41:567-74. 2008
    ..Functional reentry is the underlying mechanism for arrhythmogenesis associated with an increased T(p-e)/QT ratio...
  22. pmc Does Tpeak-Tend provide an index of transmural dispersion of repolarization?
    Charles Antzelevitch
    Heart Rhythm 4:1114-6; author reply 1116-9. 2007
  23. ncbi request reprint ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage
    Juan Shu
    Cardiology Department, The First Hospital of Xi An Jiaotong University, Xi an, Shaanxi 710061, China
    J Electrocardiol 38:26-32. 2005
    ..When Ito is relatively small as in the ERS, partial depression of the dome occurs without the development of phase 2 reentry...
  24. ncbi request reprint Electrocardiographic T wave: a symbol of transmural dispersion of repolarization in the ventricles
    Gan Xin Yan
    J Cardiovasc Electrophysiol 14:639-40. 2003
  25. ncbi request reprint Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?
    Victor A Medina-Ravell
    Centro Medico Guerra Mendez, Valencia, Venezuela
    Circulation 107:740-6. 2003
    ..The present study examined pacing site-dependent changes in QT interval and transmural dispersion of repolarization (TDR) and their potential role in the development of torsade de pointes (TdP)...
  26. ncbi request reprint Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome
    Fadi G Akar
    Heart and Vascular Research Center and Departments of Medicine and Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Circulation 105:1247-53. 2002
    ..However, the mechanisms by which dysfunction at the molecular level translates into functional electrical instability leading to torsade de pointes (TdP) in LQTS are poorly understood...
  27. ncbi request reprint Race and gender equality in health care: are we there yet?
    Chinmay Patel
    Heart Rhythm 4:1427-9. 2007
  28. ncbi request reprint "Doctor, why didn't you tell me about this before the ICD?"
    Peter R Kowey
    J Cardiovasc Electrophysiol 17:296-7. 2006
  29. ncbi request reprint Proarrhythmias and antiarrhythmias: two sides of the same coin
    Peter R Kowey
    Heart Rhythm 2:957-9. 2005
  30. ncbi request reprint Making a silk purse out of a sow's ear
    Peter R Kowey
    J Am Coll Cardiol 46:688-9. 2005
  31. ncbi request reprint Accurate interpretation of the QT interval: a vital task that remains unaccomplished
    Rong Bai
    Heart Rhythm 2:575-7. 2005