Peter R Kowey

Summary

Affiliation: Main Line Health Heart Center
Country: USA

Publications

  1. ncbi request reprint Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?
    Victor A Medina-Ravell
    Centro Medico Guerra Mendez, Valencia, Venezuela
    Circulation 107:740-6. 2003
  2. ncbi request reprint Effectiveness of oral propafenone for the prevention of atrial fibrillation after coronary artery bypass grafting
    Peter R Kowey
    Main Line Health Heart Center and the Lankenau Hospital and Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Am J Cardiol 94:663-5. 2004
  3. ncbi request reprint Losartan and end-organ protection--lessons from the RENAAL study
    Peter R Kowey
    Main Line Health Heart Center, Wynnewood, Philadelphia, USA
    Clin Cardiol 28:136-42. 2005
  4. doi request reprint Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: a randomized, double-blind, placebo-controlled trial
    Peter R Kowey
    Division of Cardiovascular Disease, Lankenau Hospital and Institute of Medical Research, Wynnewood, PA 19096, USA
    Circ Arrhythm Electrophysiol 2:652-9. 2009
  5. ncbi request reprint A review of carvedilol arrhythmia data in clinical trials
    Peter R Kowey
    Division of Cardiovascular Diseases, Main Line Health Heart Center, Wynnewood, PA, Philadelphia, PA 19096, USA
    J Cardiovasc Pharmacol Ther 10:S59-68. 2005
  6. ncbi request reprint Selection of drugs in pursuit of a rhythm control strategy
    Peter R Kowey
    Department of Cardiology, Lankenau Hospital, MOBE Suite 558, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Prog Cardiovasc Dis 48:139-45. 2005
  7. doi request reprint Celivarone for maintenance of sinus rhythm and conversion of atrial fibrillation/flutter
    Avinash R Khitri
    Lankenau Medical Center and Institute of Medical Research, Wynnewood, PA, USA
    J Cardiovasc Electrophysiol 23:462-72. 2012
  8. ncbi request reprint L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:196-203. 2007
  9. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
  10. doi request reprint Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit
    Donglin Guo
    Main Line Health Heart Ctr, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 295:H97-H104. 2008

Detail Information

Publications61

  1. ncbi request reprint Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?
    Victor A Medina-Ravell
    Centro Medico Guerra Mendez, Valencia, Venezuela
    Circulation 107:740-6. 2003
    ..The present study examined pacing site-dependent changes in QT interval and transmural dispersion of repolarization (TDR) and their potential role in the development of torsade de pointes (TdP)...
  2. ncbi request reprint Effectiveness of oral propafenone for the prevention of atrial fibrillation after coronary artery bypass grafting
    Peter R Kowey
    Main Line Health Heart Center and the Lankenau Hospital and Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Am J Cardiol 94:663-5. 2004
    ..Adverse events and discontinuations for untoward events were equal among the 3 groups...
  3. ncbi request reprint Losartan and end-organ protection--lessons from the RENAAL study
    Peter R Kowey
    Main Line Health Heart Center, Wynnewood, Philadelphia, USA
    Clin Cardiol 28:136-42. 2005
    ..Diabetic or renally impaired patients are at high cardiovascular risk, a risk potentially increased in patients with both conditions...
  4. doi request reprint Vernakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery: a randomized, double-blind, placebo-controlled trial
    Peter R Kowey
    Division of Cardiovascular Disease, Lankenau Hospital and Institute of Medical Research, Wynnewood, PA 19096, USA
    Circ Arrhythm Electrophysiol 2:652-9. 2009
    ..This study was designed to evaluate the efficacy and safety of vernakalant for the conversion of atrial fibrillation (AF) or atrial flutter (AFL) after cardiac surgery...
  5. ncbi request reprint A review of carvedilol arrhythmia data in clinical trials
    Peter R Kowey
    Division of Cardiovascular Diseases, Main Line Health Heart Center, Wynnewood, PA, Philadelphia, PA 19096, USA
    J Cardiovasc Pharmacol Ther 10:S59-68. 2005
    ....
  6. ncbi request reprint Selection of drugs in pursuit of a rhythm control strategy
    Peter R Kowey
    Department of Cardiology, Lankenau Hospital, MOBE Suite 558, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Prog Cardiovasc Dis 48:139-45. 2005
    ..Some newer drugs are currently under investigation and hold promise for improved efficacy and/or more favorable side effect profile and will be mentioned in this article...
  7. doi request reprint Celivarone for maintenance of sinus rhythm and conversion of atrial fibrillation/flutter
    Avinash R Khitri
    Lankenau Medical Center and Institute of Medical Research, Wynnewood, PA, USA
    J Cardiovasc Electrophysiol 23:462-72. 2012
    ..The purpose of the 2 trials presented here (MAIA and CORYFEE) was to assess celivarone efficacy in the maintenance of sinus rhythm postcardioversion and for the conversion of atrial fibrillation (AF)/atrial flutter (AFL)...
  8. ncbi request reprint L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:196-203. 2007
    ..AP triangulation has been shown to be an important predictor of drug-induced TdP...
  9. doi request reprint L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species
    Donglin Guo
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 5:271-9. 2008
    ..Long QT syndrome is associated with early after-depolarization (EAD) that may result in torsade de pointes (TdP). Interestingly, the corrected QT interval seems to be proportional to body mass across species under physiologic conditions...
  10. doi request reprint Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit
    Donglin Guo
    Main Line Health Heart Ctr, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 295:H97-H104. 2008
    ..Our data indicate that abnormal intracellular Ca(2+) fluctuation may exert a strong feedback on the membrane I(Cl,Ca), leading to a beat-to-beat change in the net repolarizing current that manifests as T-wave alternans on the ECG...
  11. ncbi request reprint Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia
    Gan Xin Yan
    Main Line Health Heart Center and Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA, 19096, USA
    Circulation 110:1036-41. 2004
    ..The present study examined the role of phase 2 reentry in the initiation of VF during early myocardial ischemia...
  12. ncbi request reprint Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes
    Ying Wu
    Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    J Cardiovasc Electrophysiol 16:898-904. 2005
    ..This study examined the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide...
  13. doi request reprint Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias
    Donglin Guo
    Main Line Health Heart Center and Lankenau Inst, Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 298:H1375-81. 2010
    ..The I(Na-L) may serve as a potentially useful ionic target for antiarrhythmic drugs for the treatment of atrial arrhythmias in the setting of LVH...
  14. doi request reprint New horizons in antiarrhythmic therapy: will novel agents overcome current deficits?
    Emily Conway
    Division of Cardiovascular Diseases, Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Am J Cardiol 102:12H-19H. 2008
    ....
  15. pmc Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias
    Tengxian Liu
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Heart Rhythm 3:948-56. 2006
    ..The present study provides a blinded appraisal of drugs, in an isolated arterially-perfused rabbit ventricular wedge preparation, with and without the potential to produce TdP...
  16. doi request reprint Celivarone in patients with an implantable cardioverter-defibrillator: adjunctive therapy for the reduction of ventricular arrhythmia-triggered implantable cardioverter-defibrillator interventions
    Olivera Gojkovic
    Lankenau Hospital and Institute of Medical Research, Wynnewood, Philadelphia, Pennsylvania, USA
    Heart Rhythm 9:217-224.e2. 2012
    ..However, many patients with ICDs require additional antiarrhythmic therapy to reduce the morbidity associated with recurrent arrhythmia-triggered ICD interventions...
  17. doi request reprint Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Cardiovasc Pharmacol 57:79-85. 2011
    ..HBI-3000 may be a promising antiarrhythmic agent with low proarrhythmic risk...
  18. doi request reprint Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents
    Donglin Guo
    Lankenau Institute for Medical Research and Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    Heart Rhythm 8:762-9. 2011
    ..Abnormal rate adaptation of ventricular repolarization is arrhythmogenic. There is controversy on the underlying ionic mechanisms for rate-dependent change in repolarization...
  19. doi request reprint Physician stated atrial fibrillation management in light of treatment guidelines: data from an international, observational prospective survey
    Peter R Kowey
    Lankenau Hospital, 100 Lancaster Avenue, Wynnewood, PA, USA
    Clin Cardiol 33:172-8. 2010
    ....
  20. ncbi request reprint ECG repolarization waves: their genesis and clinical implications
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    Ann Noninvasive Electrocardiol 10:211-23. 2005
    ..A physiological U wave is thought to be due to delayed repolarization of the Purkinje system...
  21. doi request reprint Adjuvant therapy for atrial fibrillation
    Khaja S Mohammed
    Lankenau Hospital, MOB East Suite 558, Wynnewood, PA 19096, USA
    Future Cardiol 6:67-81. 2010
    ..This article reviews the data on the role of these agents in the prevention and management of AF as an adjunct to standard therapy...
  22. doi request reprint Risks and benefits of anticoagulation in atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry
    Michael W Cullen
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Circ Cardiovasc Qual Outcomes 6:461-9. 2013
    ..Those with the highest stroke risk have been paradoxically less likely to receive OAC. This study assessed the association between stroke and bleeding risk on rates of OAC...
  23. ncbi request reprint Overview of the management of atrial fibrillation: what is the current state of the art?
    Peter R Kowey
    Cardiovascular Division, Lankenau Hospital and Medical Research Center, and the Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 14:S275-80; discussion S280. 2003
    ..The use of warfarin, however, presents its own complications. We conclude that individualization of therapy is paramount when treating AF...
  24. doi request reprint Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation
    Tengxian Liu
    Lankenau Institute for Medical Research and Main Line Health Heart Center, 100 Lancaster Ave, Wynnewood, PA 19096, USA
    Heart Rhythm 9:1706-15. 2012
    ..However, the correlation of ECG ventricular waveforms with underlying ion actions is not well established and has been extensively debated...
  25. doi request reprint Drug therapy for atrial fibrillation
    Emily L Conway
    Lankenau Hospital, Division of Cardiovascular Diseases, Main Line Heart Center, Suite 556, Medical Office Building East, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Cardiol Clin 27:109-23, ix. 2009
    ..Many new antiarrhythmic drugs are currently being tested in clinical trials. Drugs that target remodeling and inflammation have shown potential in prevention of atrial fibrillation, or as adjunctive therapy...
  26. ncbi request reprint The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension
    Thinn Hlaing
    Main Line Health Heart Center, Wynnewood, PA 19096, USA
    J Electrocardiol 38:154-8. 2005
    ....
  27. doi request reprint Warfarin and aspirin use in atrial fibrillation among practicing cardiologist (from the AFFECTS Registry)
    Peter R Kowey
    Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Am J Cardiol 105:1130-4. 2010
    ..In conclusion, these results suggest that continued physician education of appropriate anticoagulation use in patients with AF is needed...
  28. doi request reprint Unanswered questions in patients with concurrent atrial fibrillation and acute coronary syndrome
    Daniel S Ice
    Division of Cardiovascular Diseases, Lankenau Medical Center and Lankenau Institute of Medical Research, Wynnewood, Jefferson Medical College, Philadelphia, Pennsylvania Electronic address
    Am J Cardiol 113:888-96. 2014
    ..In conclusion, until the results of additional ongoing or planned randomized trials are known, clinicians must continue to rely on expert opinion and their own clinical judgment when treating these patients...
  29. ncbi request reprint Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance
    Gan Xin Yan
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Am Coll Cardiol 42:401-9. 2003
    ....
  30. ncbi request reprint Pharmacologic and nonpharmacologic options to maintain sinus rhythm: guideline-based and new approaches
    Peter R Kowey
    Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19096, USA
    Am J Cardiol 91:33D-38D. 2003
    ..New and evolving therapies and how they might fit into the evolving treatment paradigm are also briefly reviewed...
  31. ncbi request reprint Non-antiarrhythmic drugs in atrial fibrillation: a review of non-antiarrhythmic agents in prevention of atrial fibrillation
    James A Lally
    Lankenau Hospital, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 18:1222-8. 2007
    ..The mechanisms of action and clinical trials regarding the effectiveness of these agents in atrial fibrillation prevention are reviewed...
  32. doi request reprint Dronedarone
    Chinmay Patel
    Main Line Health Heart Center and Lankenau Hospital, Wynnewood, PA 19096, USA
    Circulation 120:636-44. 2009
    ..This article will review evidence of safety and effectiveness of dronedarone in patients with atrial fibrillation...
  33. doi request reprint Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: a randomized controlled trial
    Peter R Kowey
    Division of Cardiovascular Diseases, Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    JAMA 304:2363-72. 2010
    ..Current pharmacological treatments have limited efficacy and significant adverse events. Limited data from small trials suggest omega-3 polyunsaturated fatty acids may provide a safe, effective treatment option for AF patients...
  34. ncbi request reprint Sudden death secondary to cardiac arrhythmias: mechanisms and treatment strategies
    Adnan Siddiqui
    Main Line Health Heart Center and the Lankenau Hospital and Institute for Medical Research, Main Line Health Systems, Wynnewood, Pennsylvania 19096, USA
    Curr Opin Cardiol 21:517-25. 2006
    ..This article reviews mechanisms and available therapeutic options for arrhythmias leading to sudden cardiac death in patients with coronary artery disease...
  35. ncbi request reprint The diagnosis of cardiac arrhythmias: a prospective multi-center randomized study comparing mobile cardiac outpatient telemetry versus standard loop event monitoring
    Steven A Rothman
    Lankenau Hospital and Institute for Medical Research Main Line Health Heart Center, Wynnewood, PA, USA
    J Cardiovasc Electrophysiol 18:241-7. 2007
    ..The purpose of this study was to compare the relative value of a mobile cardiac outpatient telemetry system (MCOT) with a patient-activated external looping event monitor (LOOP) for symptoms thought to be due to an arrhythmia...
  36. ncbi request reprint First experience with a Mobile Cardiac Outpatient Telemetry (MCOT) system for the diagnosis and management of cardiac arrhythmia
    Ajay K Joshi
    Lankenau Hospital and Institute for Medical Research Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    Am J Cardiol 95:878-81. 2005
    ..MCOT does not require activation by the patient. We report data from the first 100 consecutive patients monitored by this new technology...
  37. ncbi request reprint Pharmacologic therapies for atrial fibrillation
    Heather M Ross
    Main Line Health Heart Center and the Lankenau Hospital and Institute for Medical Research, Wynnewood, PA, USA
    Am J Geriatr Cardiol 14:62-7. 2005
    ..A carefully constructed therapeutic regimen can provide effective symptom control and atrial fibrillation management for elderly patients...
  38. doi request reprint Stroke prevention in atrial fibrillation
    Ilyas Mohammed
    Lankenau Hospital and Institute for Medical Research Center, Wynnewood, Pennsylvania, USA
    J Cardiovasc Med (Hagerstown) 13:73-85. 2012
    ..This article is intended to help clinicians gain a better understanding of available risk stratification tools and therapies available for prevention of stroke in patients with atrial fibrillation...
  39. doi request reprint Efficacy and safety of celivarone, with amiodarone as calibrator, in patients with an implantable cardioverter-defibrillator for prevention of implantable cardioverter-defibrillator interventions or death: the ALPHEE study
    Peter R Kowey
    Lankenau Hospital and Institute of Medical Research, Wynnewood, PA, USA
    Circulation 124:2649-60. 2011
    ..This study investigated the efficacy and safety of celivarone in preventing implantable cardioverter-defibrillator (ICD) interventions or death...
  40. ncbi request reprint Real-world algorithms for the optimal use of drugs and devices in the patient post myocardial infarction and the future of post myocardial infarction management
    Todd J Rudo
    Main Line Health and Jefferson Medical College, Wynnewood, Pennsylvania 19096, USA
    Clin Cardiol 28:I58-63. 2005
    ..Addition of an aldosterone antagonist is also advised in patients with heart failure. In selected patients with reduced ejection fractions, use of surgical/catheter treatment and device therapy offers further benefits...
  41. doi request reprint Dronedarone: a new treatment for atrial fibrillation
    James C Laughlin
    Thomas Jefferson University College of Medicine, Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Electrophysiol 19:1220-6. 2008
    ..Dronedarone has proved efficacious without toxic or proarrhythmic effects and has minimal side effects, but remaining concerns exist regarding its use in patients with advanced heart failure...
  42. ncbi request reprint Drug therapy for atrial fibrillation
    Simone Musco
    Division of Cardiovascular Diseases, Main Line Heart Center, 556 Medical Office, Building East, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Med Clin North Am 92:121-41, xi. 2008
    ..New antiarrhythmic drugs are being tested in clinical trials. Drugs that target remodeling and inflammation are being tested for their use as prevention of AF or as adjunctive therapy...
  43. doi request reprint Role of antiarrhythmic drugs: frequent implantable cardioverter-defibrillator shocks, risk of proarrhythmia, and new drug therapy
    Christopher Droogan
    Department of Cardiology, Main Line Health Heart Center and Lankenau Hospital, 100 Lancaster Avenue, MOBE 356, Wynnewood, PA 19096, USA
    Heart Fail Clin 7:195-205, viii. 2011
    ..This article describes data supporting the need for and potential risks and benefits of adjuvant antiarrhythmic drug therapy and examines the benefits and pitfalls of the same in ICD-implanted patients...
  44. ncbi request reprint Ischemia versus amiodarone induced polymorphic ventricular tachycardia
    Harinder Sharma
    Department of Internal Medicine, Main Line Health Heart Center, Lankenau Hospital and Institute of Medical Research, Wynnewood, Pennsylvania, USA
    Pacing Clin Electrophysiol 25:1382-4. 2002
  45. ncbi request reprint Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action
    Xiaoping Xu
    Main Line Health Heart Center, Wynnewood, Pennsylvania 19096, USA
    J Cardiovasc Pharmacol 41:414-21. 2003
    ..These effects are self-limited due to SB-237376-induced I(Ca,L) blockade at high concentrations, which may explain its lower proarrhythmic risk than dl-sotalol...
  46. ncbi request reprint I've fallen and I can't get up
    Peter R Kowey
    Lankenau Hospital and Main Line Health System, Jefferson Medical College, Philadelphia, PA, USA
    Am J Geriatr Cardiol 12:306. 2003
  47. ncbi request reprint Cardiology patient pages. Ambulatory electrocardiographic recording
    Peter R Kowey
    Division of Cardiovascular Disease, Lankenau Hospital, Main Line Health Heart Center, Wynnewood, PA, USA
    Circulation 108:e31-3. 2003
  48. ncbi request reprint Case of polymorphic ventricular tachycardia in diphenhydramine poisoning
    Ajay K Joshi
    Division of Cardiovascular Diseases, Lankenau Hospital and Institute for Medical Research, Main Line Health Heart Center, Wynnewood, Pennsylvania, USA
    J Cardiovasc Electrophysiol 15:591-3. 2004
    ..This case illustrates the variation in repolarization reserve that exists in a free-standing population...
  49. ncbi request reprint Increasing I(Ks) corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy
    Xiaoping Xu
    Main Line Health Heart Center, Suite 558, Medical Office Building East, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Am J Physiol Heart Circ Physiol 283:H664-70. 2002
    ..2 Hz. Pharmacological activation of I(Ks) is a promising new strategy to suppress arrhythmias resulting from excessive AP prolongation in patients with certain forms of long QT syndrome or cardiac hypertrophy and failure...
  50. ncbi request reprint Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter
    Bramah N Singh
    Cardiology Division, Veterans Affairs Greater Los Angeles Healthcare System and the David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    N Engl J Med 357:987-99. 2007
    ..Dronedarone is a new antiarrhythmic agent pharmacologically related to amiodarone but developed to reduce the risk of side effects...
  51. ncbi request reprint You only get so many heartbeats
    Peter R Kowey
    J Am Coll Cardiol 43:1209-10. 2004
  52. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Thromb Thrombolysis 20:147-53. 2005
    ..The rationale, design, and methods of the EVOLVE study, along with two sub-studies, are described in this paper...
  53. ncbi request reprint Proarrhythmias and antiarrhythmias: two sides of the same coin
    Peter R Kowey
    Heart Rhythm 2:957-9. 2005
  54. ncbi request reprint Hospitalizations for new heart failure among subjects with diabetes mellitus in the RENAAL and LIFE studies
    Albert A Carr
    Circulatory Disease Center, Augusta, Georgia, USA
    Am J Cardiol 96:1530-6. 2005
    ..The beneficial effect of losartan on the reduction of risk for hospitalization for new HF was demonstrated in patients who were at high renal and/or high cardiovascular risk...
  55. ncbi request reprint The geriatric paradox
    Peter R Kowey
    Am J Geriatr Cardiol 17:69-70. 2008
  56. ncbi request reprint Predictors of adverse outcome among patients with hypertension and coronary artery disease
    Carl J Pepine
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
    J Am Coll Cardiol 47:547-51. 2006
    ..We sought to determine predictors for adverse outcomes in hypertensive patients with coronary artery disease (CAD)...
  57. ncbi request reprint "Doctor, why didn't you tell me about this before the ICD?"
    Peter R Kowey
    J Cardiovasc Electrophysiol 17:296-7. 2006
  58. ncbi request reprint A pharmacokinetic study of the combined administration of amiodarone and ximelagatran, an oral direct thrombin inhibitor
    Renli Teng
    Experimental Medicine, AstraZeneca LP, FOC SW1 724, 1800 Concord Pike, P O Box 15437, Wilmington, DE 19850 5437, USA
    J Clin Pharmacol 44:1063-71. 2004
    ..Evaluation of the safety of the combination is needed to confirm that the relatively small pharmacokinetic changes in this study are of no clinical significance...
  59. ncbi request reprint The meta-analysis: supportive or illuminating?
    Peter R Kowey
    Eur Heart J 27:2744-5. 2006
  60. ncbi request reprint The clinical use of angiotensin-converting enzyme inhibitors
    Joseph Wong
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Prog Cardiovasc Dis 47:116-30. 2004
    ..It is envisioned that an updated and detailed understanding of ACE inhibitors and ARBs will facilitate their successful use in the treatment of heart failure, myocardial infarction, hypertension, renal failure, and diabetic nephropathy...
  61. ncbi request reprint Making a silk purse out of a sow's ear
    Peter R Kowey
    J Am Coll Cardiol 46:688-9. 2005