Patrick Kupelian

Summary

Affiliation: M. D. Anderson Cancer Center Orlando
Country: USA

Publications

  1. ncbi request reprint Year of treatment as independent predictor of relapse-free survival in patients with localized prostate cancer treated with definitive radiotherapy in the PSA era
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 63:795-9. 2005
  2. ncbi request reprint Serial megavoltage CT imaging during external beam radiotherapy for non-small-cell lung cancer: observations on tumor regression during treatment
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 63:1024-8. 2005
  3. ncbi request reprint Improved biochemical relapse-free survival with increased external radiation doses in patients with localized prostate cancer: the combined experience of nine institutions in patients treated in 1994 and 1995
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 61:415-9. 2005
  4. ncbi request reprint Intraprostatic fiducials for localization of the prostate gland: monitoring intermarker distances during radiation therapy to test for marker stability
    Patrick A Kupelian
    Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 62:1291-6. 2005
  5. ncbi request reprint Radical prostatectomy, external beam radiotherapy <72 Gy, external beam radiotherapy > or =72 Gy, permanent seed implantation, or combined seeds/external beam radiotherapy for stage T1-T2 prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 58:25-33. 2004
  6. ncbi request reprint Improvement in relapse-free survival throughout the PSA era in patients with localized prostate cancer treated with definitive radiotherapy: year of treatment an independent predictor of outcome
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 57:629-34. 2003
  7. ncbi request reprint External beam radiation therapy: role of androgen deprivation
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400 South Orange Avenue, FL 32806, Orlando, USA
    World J Urol 21:190-9. 2003
  8. ncbi request reprint Factors affecting recurrence rates after prostatectomy or radiotherapy in localized prostate carcinoma patients with biopsy Gleason score 8 or above
    Patrick A Kupelian
    Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer 95:2302-7. 2002
  9. ncbi request reprint Failure definition-dependent differences in outcome following radiation for localized prostate cancer: can one size fit all?
    Deborah Kuban
    Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 61:409-14. 2005
  10. doi request reprint 4π noncoplanar stereotactic body radiation therapy for centrally located or larger lung tumors
    Peng Dong
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 86:407-13. 2013

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Year of treatment as independent predictor of relapse-free survival in patients with localized prostate cancer treated with definitive radiotherapy in the PSA era
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 63:795-9. 2005
    ..Accounting for these changes would facilitate the retrospective comparison of outcomes for patients treated in different periods...
  2. ncbi request reprint Serial megavoltage CT imaging during external beam radiotherapy for non-small-cell lung cancer: observations on tumor regression during treatment
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 63:1024-8. 2005
    ....
  3. ncbi request reprint Improved biochemical relapse-free survival with increased external radiation doses in patients with localized prostate cancer: the combined experience of nine institutions in patients treated in 1994 and 1995
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 61:415-9. 2005
    ..To study the radiation dose-response as determined by Kaplan-Meier prostate-specific antigen (PSA) disease-free survival (PSA-DFS) estimates in patients with stage T1-T2 prostate cancer treated within a 2-year period (1994-1995)...
  4. ncbi request reprint Intraprostatic fiducials for localization of the prostate gland: monitoring intermarker distances during radiation therapy to test for marker stability
    Patrick A Kupelian
    Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 62:1291-6. 2005
    ..To test this assumption, the intermarker distances (IMD) of implanted markers was monitored during the full course of radiation therapy to determine marker stability within the prostate gland...
  5. ncbi request reprint Radical prostatectomy, external beam radiotherapy <72 Gy, external beam radiotherapy > or =72 Gy, permanent seed implantation, or combined seeds/external beam radiotherapy for stage T1-T2 prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 58:25-33. 2004
    ....
  6. ncbi request reprint Improvement in relapse-free survival throughout the PSA era in patients with localized prostate cancer treated with definitive radiotherapy: year of treatment an independent predictor of outcome
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 57:629-34. 2003
    ..The purpose of the present study was to study a similar phenomenon with definitive radiotherapy (RT)...
  7. ncbi request reprint External beam radiation therapy: role of androgen deprivation
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400 South Orange Avenue, FL 32806, Orlando, USA
    World J Urol 21:190-9. 2003
  8. ncbi request reprint Factors affecting recurrence rates after prostatectomy or radiotherapy in localized prostate carcinoma patients with biopsy Gleason score 8 or above
    Patrick A Kupelian
    Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer 95:2302-7. 2002
    ..To review the biochemical recurrence-free survival (bRFS) rates of treatment with either external beam radiotherapy or radical prostatectomy in patients with biopsy Gleason score 8 or above in the prostate specific antigen (PSA) era...
  9. ncbi request reprint Failure definition-dependent differences in outcome following radiation for localized prostate cancer: can one size fit all?
    Deborah Kuban
    Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 61:409-14. 2005
    ..To compare long-term outcome using alternative failure definitions after external beam radiation for localized prostate cancer...
  10. doi request reprint 4π noncoplanar stereotactic body radiation therapy for centrally located or larger lung tumors
    Peng Dong
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 86:407-13. 2013
    ..To investigate the dosimetric improvements in stereotactic body radiation therapy for patients with larger or central lung tumors using a highly noncoplanar 4π planning system...
  11. doi request reprint Assessment of interfraction patient setup for head-and-neck cancer intensity modulated radiation therapy using multiple computed tomography-based image guidance
    X Sharon Qi
    Department of Radiation Oncology, David of Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Int J Radiat Oncol Biol Phys 86:432-9. 2013
    ..The purpose of this study was to assess interfraction patient setup variations for 3 computed tomography (CT)-based on-board image guided radiation therapy (IGRT) modalities...
  12. ncbi request reprint Age and PSA predict likelihood of organ-confined disease in men presenting with PSA less than 10 ng/mL: implications for screening
    Michael Aleman
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 62:70-4. 2003
    ..5 and 4.0 ng/mL are associated with a 20% detection rate. Furthermore, age has been shown to represent an independent predictor of outcome after radical prostatectomy...
  13. ncbi request reprint Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA era
    Deborah A Kuban
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Int J Radiat Oncol Biol Phys 57:915-28. 2003
    ..To report the long-term outcome for patients with Stage T1-T2 adenocarcinoma of the prostate definitively irradiated in the prostate-specific antigen (PSA) era...
  14. ncbi request reprint Impact of biochemical failure on overall survival after radiation therapy for localized prostate cancer in the PSA era
    Patrick A Kupelian
    Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Radiat Oncol Biol Phys 52:704-11. 2002
    ..To study the impact of biochemical failure on overall survival rates during the first 10 years after definitive radiotherapy for localized prostate cancer...
  15. ncbi request reprint Dose/volume relationship of late rectal bleeding after external beam radiotherapy for localized prostate cancer: absolute or relative rectal volume?
    Patrick A Kupelian
    Department of Radiation Oncology, Cleveland Clinic Foundation, Ohio 44195, USA
    Cancer J 8:62-6. 2002
    ..The purpose of this study was to analyze predictors of late rectal bleeding after external-beam radiotherapy for localized prostate cancer, with a focus on the volume of rectum irradiated...
  16. doi request reprint Modeling simulation and visualization of conformal 3D lung tumor dosimetry
    Anand Santhanam
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400S Orange Ave, Orlando, FL 32806, USA
    Phys Med Biol 54:6165-80. 2009
    ..The real-time capability enables the framework to be coupled with real-time tumor monitoring systems such as implanted fiducials for computing the dose delivered in real time during the treatment...
  17. doi request reprint Validation of a computational method for assessing the impact of intra-fraction motion on helical tomotherapy plans
    Wilfred Ngwa
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400 South Orange Avenue, Orlando, FL 32806, USA
    Phys Med Biol 54:6611-21. 2009
    ..The profile and gamma analysis results validate the accuracy of this method for incorporating intra-fraction motion into the dose calculation engine for assessment of dosimetric effects on helical tomotherapy dose deliveries...
  18. ncbi request reprint Preoperative combined nested reverse transcriptase polymerase chain reaction for prostate-specific antigen and prostate-specific membrane antigen does not correlate with pathologic stage or biochemical failure in patients with localized prostate cancer un
    John Thomas
    Urological Institute, Taussig Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Clin Oncol 20:3213-8. 2002
    ....
  19. ncbi request reprint Comparison of the efficacy of local therapies for localized prostate cancer in the prostate-specific antigen era: a large single-institution experience with radical prostatectomy and external-beam radiotherapy
    Patrick A Kupelian
    Department of Radiation Oncology, Desk 728, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Clin Oncol 20:3376-85. 2002
    ..To review biochemical relapse-free survival (bRFS) rates after either external-beam radiotherapy (RT) or radical prostatectomy (RP) for localized prostate cancer...
  20. ncbi request reprint A model for predicting lung cancer response to therapy
    Rebecca M Seibert
    Department of Radiation Oncology, Thompson Cancer Survival Center, Knoxville, TN 37916, USA
    Int J Radiat Oncol Biol Phys 67:601-9. 2007
    ..The goal of this study was to develop and test a model for predicting lung tumor response during IGRT treatment using serial megavoltage CT (MVCT)...
  21. doi request reprint Comparison of biochemical relapse-free survival between primary Gleason score 3 and primary Gleason score 4 for biopsy Gleason score 7 prostate cancer
    Michael J Burdick
    Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44113, USA
    Int J Radiat Oncol Biol Phys 73:1439-45. 2009
    ..Most of the present data regarding the PG of GS7 CaP refer to surgical specimens. Our goal was to determine whether the biopsy GS used at the time of medical decision making predicted for the biochemical outcome...
  22. ncbi request reprint Nadir prostate-specific antigen within 12 months after radiotherapy predicts biochemical and distant failure
    Michael E Ray
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
    Urology 68:1257-62. 2006
    ..To determine whether nadir prostate-specific antigen (PSA) levels within 12 months (nadir PSA12) after completion of radiotherapy (RT) can be used as an early marker of recurrence risk...
  23. ncbi request reprint Influence of intrafraction motion on margins for prostate radiotherapy
    Dale W Litzenberg
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 65:548-53. 2006
    ..To assess the impact of intrafraction intervention on margins for prostate radiotherapy...
  24. doi request reprint A comparison of soft-tissue implanted markers and bony anatomy alignments for image-guided treatments of head-and-neck cancers
    Omar A Zeidan
    Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 76:767-74. 2010
    ..Dosimetric impact of the two alignment techniques on target coverage is presented...
  25. ncbi request reprint Dosimetric effects of rotational output variation and x-ray target degradation on helical tomotherapy plans
    Robert J Staton
    Department of Radiation Physics, M D Anderson Cancer Center Orlando, Orlando, Florida 32806, USA
    Med Phys 36:2881-8. 2009
    ....
  26. ncbi request reprint Rates of biochemical remission remain higher in black men compared to white men after radical prostatectomy despite similar trends in prostate specific antigen induced stage migration
    Hadley M Wood
    Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 178:1271-6. 2007
    ..Our hypothesis was that the gap in biochemical relapse-free survival between these groups would lessen in the later prostate specific antigen era due to catch-up awareness/availability of screening and treatment in the black population...
  27. doi request reprint Evaluation of high ipsilateral subventricular zone radiation therapy dose in glioblastoma: a pooled analysis
    Percy Lee
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Int J Radiat Oncol Biol Phys 86:609-15. 2013
    ..Because of their radioresistance, we hypothesized that high doses of radiation (>59.4 Gy) to the SVZ are necessary to control CSCs and improve progression-free survival (PFS) or overall survival (OS) in glioblastoma...
  28. doi request reprint 4π non-coplanar liver SBRT: a novel delivery technique
    Peng Dong
    Department of Radiation Oncology, University of California, Los Angeles, California, USA
    Int J Radiat Oncol Biol Phys 85:1360-6. 2013
    ..The dose optimization is performed on a patient-specific deliverable beam geometry solution space, parameterized with patient and linear accelerator gantry orientations...
  29. ncbi request reprint Multi-institutional clinical experience with the Calypso System in localization and continuous, real-time monitoring of the prostate gland during external radiotherapy
    Patrick Kupelian
    M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 67:1088-98. 2007
    ..To report the clinical experience with an electromagnetic treatment target positioning and continuous monitoring system in patients with localized prostate cancer receiving external beam radiotherapy...
  30. ncbi request reprint Recurrence-free survival rates after external-beam radiotherapy for patients with clinical T1-T3 prostate carcinoma in the prostate-specific antigen era: what should we expect?
    Deepak Khuntia
    Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer 100:1283-92. 2004
    ....
  31. ncbi request reprint PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: a multi-institutional analysis
    Michael E Ray
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 64:1140-50. 2006
    ....
  32. ncbi request reprint Real-time simulation of 4D lung tumor radiotherapy using a breathing model
    Anand P Santhanam
    College of Optics and Photonics, University of Central Florida, USA
    Med Image Comput Comput Assist Interv 11:710-7. 2008
    ..A radiation treatment plan for the lung tumor is developed using one of the 4D CT phases. During the simulation of radiation delivery, the dose on the lung tumor is computed for each beam independently...
  33. ncbi request reprint Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 68:1424-30. 2007
    ..To study the outcomes in patients treated for localized prostate cancer with 70 Gy delivered at 2.5-Gy/fraction within 5 weeks...
  34. ncbi request reprint Positional stability of electromagnetic transponders used for prostate localization and continuous, real-time tracking
    Dale W Litzenberg
    Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 68:1199-206. 2007
    ..Ideally, the distances between transponders remains constant over the course of treatment. In this work, we evaluate the accuracy of these conditions...
  35. ncbi request reprint Implantation and stability of metallic fiducials within pulmonary lesions
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 69:777-85. 2007
    ..To report and describe implantation techniques and stability of metallic fiducials in lung lesions to be treated with external beam radiotherapy...
  36. ncbi request reprint Optical tracking technology in stereotactic radiation therapy
    Thomas H Wagner
    Department of Radiation Physics, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Med Dosim 32:111-20. 2007
    ..Applications of radiotherapy optical tracking technology to respiratory gating and the monitoring of implanted fiducial markers are also discussed...
  37. ncbi request reprint Impact of image guidance on outcomes after external beam radiotherapy for localized prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 70:1146-50. 2008
    ..To verify whether rectal distention at the time of planning impacts outcomes in patients with localized prostate cancer treated with daily image guidance...
  38. ncbi request reprint Effect of increasing radiation doses on local and distant failures in patients with localized prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 71:16-22. 2008
    ..To study the effect of radiation dose on local failure (LF) and distant metastasis (DM) in prostate cancer patients treated with external beam radiotherapy...
  39. ncbi request reprint Image-guided radiotherapy for localized prostate cancer: treating a moving target
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400 South Orange Avenue, Orlando, FL 32806, USA
    Semin Radiat Oncol 18:58-66. 2008
    ..Understanding and managing the consequences of anatomic variations within the lower pelvis should be a priority in designing and implementing future clinical trials...
  40. doi request reprint Investigation of accelerated partial breast patient alignment and treatment with helical tomotherapy unit
    Katja M Langen
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 70:1272-80. 2008
    ....
  41. doi request reprint Patient dose from megavoltage computed tomography imaging
    Amish P Shah
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 70:1579-87. 2008
    ..The purpose of this investigation was to show that the MVCT dose can be computed in phantoms, and further, that the dose can be reported for actual patients from MVCT on a helical tomotherapy unit...
  42. ncbi request reprint Characterization and use of EBT radiochromic film for IMRT dose verification
    Omar A Zeidan
    Department of Radiation Physics, M D Anderson Cancer Center Orlando, 1400 South Orange Avenue, MP 730, Orlando, Florida 32806, USA
    Med Phys 33:4064-72. 2006
    ..Based on this study, we show that EBT film has several favorable features that allow for its use in routine IMRT patient-specific QA...
  43. ncbi request reprint Megavoltage computed tomography image-based low-dose rate intracavitary brachytherapy planning for cervical carcinoma
    Thomas H Wagner
    Department of Radiation Physics, M D Anderson Cancer Center Orlando, 1400 S Orange Avenue, MP 730, Orlando, FL 32828, USA
    Technol Cancer Res Treat 8:123-30. 2009
    ..1 cm(3) and 2.0 cm(3), respectively. Our initial experience in using MVCT imaging for clinical LDR gynecological brachytherapy indicates that the MVCT images are of sufficient quality for use in 3D, MVCT-based dose planning...
  44. doi request reprint Dosimetric effect of prostate motion during helical tomotherapy
    Katja M Langen
    Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 74:1134-42. 2009
    ..To assess the dosimetric consequence of intrafraction prostate motion on helical tomotherapy plans...
  45. doi request reprint Outcomes for intermediate risk prostate cancer: are there advantages for surgery, external radiation, or brachytherapy?
    Eric A Klein
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Urol Oncol 27:67-71. 2009
    ..The results suggest similar short-term survival but domain-specific effects on QOL after treatment with radical prostatectomy, brachytherapy, or external beam radiotherapy...
  46. doi request reprint Correlation between dosimetric effect and intrafraction motion during prostate treatments delivered with helical tomotherapy
    Katja M Langen
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400 South Orange Av, Orlando, FL 32806, USA
    Phys Med Biol 53:7073-86. 2008
    ..However, when motion management techniques are evaluated, it should be kept in mind that the dosimetric impact of observed prostate motion is small for the majority of fractions...
  47. doi request reprint Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration
    Choonik Lee
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Radiother Oncol 89:81-8. 2008
    ..To assess and evaluate geometrical changes in parotid glands using deformable image registration and megavoltage CT (MVCT) images...
  48. doi request reprint Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily megavoltage computed tomography and deformable image registration
    Choonik Lee
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, 1400 South Orange Avenue, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 71:1563-71. 2008
    ..To analyze changes in parotid gland dose resulting from anatomic changes throughout a course of radiotherapy in a cohort of head-and-neck cancer patients...
  49. doi request reprint Observations on real-time prostate gland motion using electromagnetic tracking
    Katja M Langen
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 71:1084-90. 2008
    ..To quantify and describe the real-time movement of the prostate gland in a large data set of patients treated with radiotherapy...
  50. ncbi request reprint Predictive factors for late genitourinary and gastrointestinal toxicity in patients with prostate cancer treated with adjuvant or salvage radiotherapy
    Mary Feng
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 68:1417-23. 2007
    ..To determine the rate and magnitude of late genitourinary (GU) and gastrointestinal (GI) toxicities after salvage or adjuvant radiotherapy (RT) for prostate cancer, and to determine predictive factors for these toxicities...
  51. ncbi request reprint Use of different definitions of biochemical failure after external beam radiotherapy changes conclusions about relative treatment efficacy for localized prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, Florida 32806, USA
    Urology 68:593-8. 2006
    ..To report biochemical relapse-free survival (bRFS) after radiotherapy (RT) for localized prostate cancer with two separate failure definitions and compare the results with those after radical prostatectomy (RP)...
  52. ncbi request reprint Performance characterization of megavoltage computed tomography imaging on a helical tomotherapy unit
    Sanford L Meeks
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, Florida 32806, USA
    Med Phys 32:2673-81. 2005
    ..In conjunction with the ability to recalculate radiotherapy doses on these images, this enables dose guidance as well as image guidance of radiotherapy treatments...
  53. ncbi request reprint A technique for adaptive image-guided helical tomotherapy for lung cancer
    Chester R Ramsey
    Department of Radiation Oncology, Thompson Cancer Survival Center, Knoxville, TN 37916, USA
    Int J Radiat Oncol Biol Phys 64:1237-44. 2006
    ....
  54. ncbi request reprint Initial experience with megavoltage (MV) CT guidance for daily prostate alignments
    Katja M Langen
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 62:1517-24. 2005
    ..Three manual techniques of registering the MVCT images with the planning kilovoltage (kV) CT images were evaluated. The techniques are based on visual alignment of (1) fiducial prostate markers, (2) CT anatomy, and (3) kVCT contours...
  55. ncbi request reprint Evaluation of image-guidance strategies in the treatment of localized prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 70:1151-7. 2008
    ..Using data from patients treated using daily image guidance, the remaining setup errors for several different strategies were retrospectively calculated...
  56. ncbi request reprint Biochemical and clinical significance of the posttreatment prostate-specific antigen bounce for prostate cancer patients treated with external beam radiation therapy alone: a multiinstitutional pooled analysis
    Eric M Horwitz
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer 107:1496-502. 2006
    ....
  57. ncbi request reprint Aggressiveness of familial prostate cancer
    Patrick A Kupelian
    Glickman Urological Institute and Radiation Oncology Department, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Clin Oncol 24:3445-50. 2006
    ..To report on the aggressiveness of sporadic versus familial prostate cancer...
  58. ncbi request reprint Evaluation of an infrared camera and X-ray system using implanted fiducials in patients with lung tumors for gated radiation therapy
    Twyla R Willoughby
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 66:568-75. 2006
    ..To report on the initial clinical use of a commercially available system to deliver gated treatment using implanted fiducials, in-room kV X-rays, and an infrared camera tracking system...
  59. ncbi request reprint Hypofractionated intensity-modulated radiotherapy (70 gy at 2.5 Gy per fraction) for localized prostate cancer: long-term outcomes
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 63:1463-8. 2005
    ..To analyze the long-term relapse-free survival and toxicity rates in patients treated with hypofractionated intensity-modulated radiotherapy...
  60. ncbi request reprint Evaluation of image-guidance protocols in the treatment of head and neck cancers
    Omar A Zeidan
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 67:670-7. 2007
    ..Using data from patients who were treated with daily IG, the residual setup errors for several different protocols are retrospectively calculated...
  61. ncbi request reprint Monotherapy for stage T1-T2 prostate cancer: radical prostatectomy, external beam radiotherapy, or permanent seed implantation
    Louis Potters
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center at Mercy Medical Center, Rockville Centre, NY, USA
    Radiother Oncol 71:29-33. 2004
    ....
  62. ncbi request reprint Optically guided patient positioning techniques
    Sanford L Meeks
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, FL 32806, USA
    Semin Radiat Oncol 15:192-201. 2005
    ..Lastly, optical tracking has been integrated with ultrasound or stereoscopic x-ray imaging to determine the position of internal anatomy targets relative to isocenter...
  63. ncbi request reprint Daily variations in the position of the prostate bed in patients with prostate cancer receiving postoperative external beam radiation therapy
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 66:593-6. 2006
    ..The aim of this study was to evaluate the extent of the variation in the position of the prostate bed with respect to the bony anatomy...
  64. ncbi request reprint Daily variations in delivered doses in patients treated with radiotherapy for localized prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, The M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 66:876-82. 2006
    ..The aim of this work was to study the variations in delivered doses to the prostate, rectum, and bladder during a full course of image-guided external beam radiotherapy...
  65. pmc Long-term (10-year) gastrointestinal and genitourinary toxicity after treatment with external beam radiotherapy, radical prostatectomy, or brachytherapy for prostate cancer
    Grant K Hunter
    Cleveland Clinic Department of Radiation Oncology, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Prostate Cancer 2012:853487. 2012
    ..The presence of DM at the time of treatment was significantly associated with worse late GI and GU toxicity. RT was significantly associated with worse late GI toxicity compared to PI and RP...
  66. doi request reprint Radiotherapy: Effect of treatment interruptions in prostate cancer
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center, 1400 S Orange Avenue, Orlando, FL 32806, USA
    Nat Rev Clin Oncol 6:312-3. 2009
    ..D'Ambrosio et al. demonstrated that prolonging treatment duration has an adverse effect in low-risk patients with prostate cancer. Thus, limiting or modifying the overall elapsed time between treatments is necessary...
  67. ncbi request reprint Prostate cancer: image guidance and adaptive therapy
    Patrick Kupelian
    Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Front Radiat Ther Oncol 40:289-314. 2007
    ..The workflow and capabilities of each imaging system need to be evaluated and investigated individually...
  68. doi request reprint Image-guided, adaptive radiotherapy of prostate cancer: toward new standards of radiotherapy practice
    Patrick Kupelian
    Department of Radiation Oncology, University of California School of Medicine, Los Angeles, Calif, USA
    Front Radiat Ther Oncol 43:344-68. 2011
    ..On-line adaptive radiotherapy requires robust deformable registration and replanning programs. These are beginning to emerge in useful clinic applications...
  69. doi request reprint Modeling real-time 3-d lung deformations for medical visualization
    Anand P Santhanam
    M D Anderson Cancer Center Orlando and the College of Optics and Photonics, University of Central Florida, Orlando, FL 32816, USA
    IEEE Trans Inf Technol Biomed 12:257-70. 2008
    ....
  70. ncbi request reprint Definitions of biochemical failure that best predict clinical failure in patients with prostate cancer treated with external beam radiation alone: a multi-institutional pooled analysis
    Eric M Horwitz
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Urol 173:797-802. 2005
    ..In this report we determined the sensitivity and specificity of several BF definitions using distant failure (DF) alone or clinical failure (CF), defined as local failure (LF) and/or DF...
  71. ncbi request reprint Comparison of transabdominal ultrasound and electromagnetic transponders for prostate localization
    Ryan D Foster
    Department of Radiation Oncology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390 9183, USA
    J Appl Clin Med Phys 11:2924. 2010
    ..Our study finds that there are systematic differences between Calypso and ultrasound for prostate localization...
  72. ncbi request reprint Target localization and real-time tracking using the Calypso 4D localization system in patients with localized prostate cancer
    Twyla R Willoughby
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 65:528-34. 2006
    ..This study involves the first human use of the system, to evaluate the localization accuracy of this technique compared with radiographic localization and to assess its ability to obtain real-time prostate-motion information...
  73. ncbi request reprint Pathologic stage migration has slowed in the late PSA era
    Fei Dong
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Urology 70:839-42. 2007
    ..We examined patients treated by radical prostatectomy between 1987 and 2005 to establish temporal trends in pathologic stage migration as assessed by the proportion of patients with nonorgan-confined disease (NOCD)...
  74. ncbi request reprint Continuing trends in pathological stage migration in radical prostatectomy specimens
    Ithaar H Derweesh
    Section of Urologic Oncology, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Urol Oncol 22:300-6. 2004
    ..1% for 1987 to 1994 and 82.6% for 1995 to 2001 (P-value = 0.0022). PSA screening has resulted in a downward pathological stage migration. These observations demonstrate improved biochemical failure rates in more recently treated patients...
  75. ncbi request reprint Multi-scale, multi-modal image integration for image-guided clinical interventions in the head and neck anatomy
    Anand P Santhanam
    Department of Radiation Oncology, University of California, Los Angeles, CA, USA
    Stud Health Technol Inform 184:380-6. 2013
    ..The results show the accuracy of the two tracking algorithms and the 3D head and neck deformation representing the multiple poses, the subject will take during the OCM imaging...
  76. pmc A client-server framework for 3D remote visualization of radiotherapy treatment space
    Anand P Santhanam
    Department of Radiation Oncology, University of California Los Angeles, CA, USA
    Front Oncol 3:18. 2013
    ..This work demonstrated the feasibility of remote real-time stereoscopic patient setup visualization, enabling expansion of high quality radiation therapy into challenging environments...
  77. doi request reprint Helical tomotherapy: image-guided and adaptive radiotherapy
    Patrick Kupelian
    Department of Radiation Oncology, University of California School of Medicine, Los Angeles, Calif, USA
    Front Radiat Ther Oncol 43:165-80. 2011
    ..At the same time, routine clinical use of MVCT imaging has provided a wealth of clinical experience. Both technical and clinical experiences with the MVCT system will be reviewed in this chapter...
  78. ncbi request reprint Early prostate-specific antigen (PSA) kinetics following prostate carcinoma radiotherapy: prognostic value of a time-and-PSA threshold model
    Sean X Cavanaugh
    Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cancer 101:96-105. 2004
    ....
  79. ncbi request reprint Localized prostate cancer: radiation or surgery?
    Eric A Klein
    Section of Urology Oncology, Urological Institute, Cleveland Clinic Foundation, Desk A100, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Urol Clin North Am 30:315-30, ix. 2003
    ..The available data suggest that these two modalities provide similar rates of cancer control at 10 years, and that except for the youngest patients, choice of therapy should be based on toxicity and QOL issues...
  80. ncbi request reprint Preliminary observations on biochemical relapse-free survival rates after short-course intensity-modulated radiotherapy (70 Gy at 2.5 Gy/fraction) for localized prostate cancer
    Patrick A Kupelian
    Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Radiat Oncol Biol Phys 53:904-12. 2002
    ....
  81. pmc Current concepts in F18 FDG PET/CT-based radiation therapy planning for lung cancer
    Percy Lee
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Front Oncol 2:71. 2012
    ..More research is needed to incorporate other biomarkers such as proliferative and hypoxia biomarkers in PET as well as integrating metabolic information in adaptive, patient-centered, tailored radiation therapy...
  82. doi request reprint Image guidance during head-and-neck cancer radiation therapy: analysis of alignment trends with in-room cone-beam computed tomography scans
    Zachary Zumsteg
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Int J Radiat Oncol Biol Phys 83:712-9. 2012
    ..However, daily CBCT is time intensive and increases the overall radiation dose. We assessed the feasibility of using the average couch shifts from the first several CBCTs to estimate and correct for the presumed systematic setup error...
  83. doi request reprint Three-dimensional prostate position estimation with a single x-ray imager utilizing the spatial probability density
    Per Rugaard Poulsen
    Department of Radiation Oncology, Stanford University, Stanford, CA, USA
    Phys Med Biol 53:4331-53. 2008
    ..In conclusion, a method for estimation of the 3D target position from 2D projections has been developed and its use has been demonstrated in a simulation study of monoscopic prostate tracking...
  84. ncbi request reprint Collaborative engineering: 3-D optical imaging and gas exchange simulation of in-vitro alveolar constructs
    Jannick P Rolland
    CREOL, College of Optics and Photonics, University of Central Florida, Orlando, FL 32816, USA
    Stud Health Technol Inform 132:426-32. 2008
    ..Results show depth images of the alveolar tissue construct for a bilayer construct, as well as predictions of the gas exchange process in a simple model of a bio-reactor hosting the construct...
  85. ncbi request reprint Brain metastases from bladder carcinoma: presentation, treatment and survival
    Ashraf S Mahmoud-Ahmed
    Department of Radiation Oncology, Brain Tumor Institute, Taussig Cancer Center, 9500 Euclid Avenue, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Urol 167:2419-22. 2002
    ..We report the presentation of brain metastases from bladder carcinoma. We investigated the role of whole brain radiation therapy for treating this disease...
  86. ncbi request reprint Validation study of the accuracy of a postoperative nomogram for recurrence after radical prostatectomy for localized prostate cancer
    Markus Graefen
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:951-6. 2002
    ..We evaluated the predictive accuracy of the nomogram when applied to patients of four international institutions...
  87. ncbi request reprint Evaluation of two tomotherapy-based techniques for the delivery of whole-breast intensity-modulated radiation therapy
    Victor J Gonzalez
    Florida State University College of Medicine, Tallahassee, FL, USA
    Int J Radiat Oncol Biol Phys 65:284-90. 2006
    ..To evaluate two different techniques for whole-breast treatments delivered using the Hi-ART II tomotherapy device...
  88. ncbi request reprint Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy
    Weiguo Lu
    TomoTherapy Inc, 1240 Deming Way, Madison, WI 53717, USA
    Phys Med Biol 51:4357-74. 2006
    ..The applications of deformable registration in ART, including 'deformable dose accumulation', 'automatic re-contouring' and 'tumour growth/regression evaluation' throughout the course of radiotherapy are also studied...
  89. ncbi request reprint Salvage radiotherapy for recurrent prostate cancer after radical prostatectomy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    JAMA 291:1325-32. 2004
    ..Salvage radiotherapy may potentially cure patients with disease recurrence after radical prostatectomy, but previous evidence has suggested that it is ineffective in patients at the highest risk of metastatic disease progression...
  90. ncbi request reprint Increasing external beam dose for T1-T2 prostate cancer: effect on risk groups
    Howard D Thames
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, and Department of Radiation Oncology, William Beaumont Hospital, Deroit, MI, USA
    Int J Radiat Oncol Biol Phys 65:975-81. 2006
    ....
  91. ncbi request reprint Pretreatment nomogram that predicts 5-year probability of metastasis following three-dimensional conformal radiation therapy for localized prostate cancer
    Michael W Kattan
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 27, New York, NY 10021, USA
    J Clin Oncol 21:4568-71. 2003
    ..The goal of this study was to create and to externally validate a nomogram for predicting the probability that a patient will develop metastasis within 5 years after three-dimensional conformal radiation therapy (CRT)...
  92. ncbi request reprint Comparison of ultrasound and implanted seed marker prostate localization methods: Implications for image-guided radiotherapy
    Todd J Scarbrough
    MIMA Cancer Center, Melbourne, FL 32901, USA
    Int J Radiat Oncol Biol Phys 65:378-87. 2006
    ..To analyze two methods of image-guided radiotherapy (IGRT) for external beam radiotherapy of prostate cancer...
  93. ncbi request reprint Defining sexual outcomes after treatment for localized prostate carcinoma
    Leslie R Schover
    Department of Behavioral Science, The University of Texas M D Anderson Cancer Center, Houston, Texas77030 4009, USA
    Cancer 95:1773-85. 2002
    ..The objective of this survey was to identify factors associated with good sexual outcomes in a large group of survivors of localized prostate carcinoma...
  94. ncbi request reprint The use of treatments for erectile dysfunction among survivors of prostate carcinoma
    Leslie R Schover
    Department of Behavioral Science, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 95:2397-407. 2002
    ....