B Wolozin

Summary

Affiliation: Loyola University Chicago
Country: USA

Publications

  1. ncbi request reprint Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    B Wolozin
    Department of Pharmacology, Loyola University Medical Center, Bldg 102, Room 3634, 2160 S First Ave, Maywood, IL 60153
    Arch Neurol 57:1439-43. 2000
  2. ncbi request reprint Iron and Parkinson's disease
    Benjamin Wolozin
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois, USA
    Neuroscientist 8:22-32. 2002
  3. ncbi request reprint SEPT5_v2 is a parkin-binding protein
    P Choi
    Department of Pharmacology, Loyola University Medical Center, Bldg 102 3634, 2160 S 1st Ave, Maywood, IL 60153, USA
    Brain Res Mol Brain Res 117:179-89. 2003
  4. pmc LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
    C H Hsu
    Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA
    Neurodegener Dis 7:68-75. 2010
  5. ncbi request reprint Re-assessing the relationship between cholesterol, statins and Alzheimer's disease
    B Wolozin
    Department of Pharmacology, Boston University School of Medicine, MA 02118, USA
    Acta Neurol Scand Suppl 185:63-70. 2006
  6. ncbi request reprint Beta-amyloid augments platelet aggregation: reduced activity of familial angiopathy-associated mutants
    B Wolozin
    Section on Geriatric Psychiatry, NIMH, Bethesda, MD 20892, USA
    Mol Psychiatry 3:500-7. 1998
  7. ncbi request reprint Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein
    M Frasier
    Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA
    Exp Neurol 192:274-87. 2005
  8. ncbi request reprint Regulation of apoptosis by presenilin 1
    B Wolozin
    Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA
    Neurobiol Aging 19:S23-7. 1998
  9. ncbi request reprint Cholesterol and Alzheimer's disease
    B Wolozin
    Department of Pharmacology, Loyola University Medical Center, Bldg 102, Rm 3634, 2160 South First Avenue, Maywood, IL 60153, USA
    Biochem Soc Trans 30:525-9. 2002
  10. ncbi request reprint alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
    N Ostrerova
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:5782-91. 1999

Collaborators

  • L Petrucelli
  • Y Zhang
  • R C Green
  • J Hardy
  • C H Hsu
  • L D'ADAMIO
  • G Siegel
  • D Chan
  • K Lim
  • M Racchi
  • A Takashima
  • M P Murphy
  • V Calabrese
  • D A Butterfield
  • Mark R Cookson
  • SERGE E PRZEDBORSKI
  • T E Golde
  • Heather Snyder
  • P Choi
  • Mark Frasier
  • J M Lee
  • H Fai Poon
  • Rina Ved
  • M Frasier
  • Andreas Matouschek
  • Kwame Mensah
  • Catherine Theisler
  • H Snyder
  • Bong Hyun Ahn
  • E Cochran
  • M Chong
  • Natalie Golts
  • J J Palacino
  • N Ostrerova
  • Clifford Steer
  • Aixa Alfonso
  • D Magnuson
  • Barry Festoff
  • Celine Perier
  • Makoto Hashimoto
  • Andrei Surguchov
  • L McCarthy
  • Shamol Saha
  • Cecilia M P Rodrigues
  • M Walzer
  • P Kahle
  • Anne Sluder
  • Beth Westlund
  • Marius Hoener
  • C Haas
  • Lucinda Burnam
  • Irina G Surgucheva
  • Nathan Shreve
  • Leo Liu
  • Eliazer Masliah
  • T M Dawson
  • K K K Chung
  • R Bowser
  • K Kehoe
  • C Theisler
  • Jack Lee
  • Young Mo Sung
  • Jong Soo Chang
  • Mun Yong Lee
  • Do Sik Min
  • Ju Youn Choi
  • Yang Hyeok Jo
  • Sang June Hahn
  • Kwang Chul Chung
  • Hyangshuk Rhim
  • Shin Hee Yoon
  • Taeg Kyu Kwon
  • Peter Choi
  • Myung Suk Kim
  • Shi Yeon Kim
  • Young Han Lee
  • O Murayama
  • K Iwasaki
  • D Sparkman
  • N Golts
  • M Fujiwara
  • N Mehta
  • M Farrer

Detail Information

Publications23

  1. ncbi request reprint Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    B Wolozin
    Department of Pharmacology, Loyola University Medical Center, Bldg 102, Room 3634, 2160 S First Ave, Maywood, IL 60153
    Arch Neurol 57:1439-43. 2000
    ..Increasing evidence suggests that cholesterol plays a role in the pathophysiology of Alzheimer disease (AD). For instance, an elevated serum cholesterol level has been shown to be a risk factor for AD...
  2. ncbi request reprint Iron and Parkinson's disease
    Benjamin Wolozin
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois, USA
    Neuroscientist 8:22-32. 2002
    ..Recent studies suggest that an additional mechanism by which iron might contribute to PD is by inducing aggregation of the alpha-synuclein, which is a protein that accumulates in Lewy bodies in PD...
  3. ncbi request reprint SEPT5_v2 is a parkin-binding protein
    P Choi
    Department of Pharmacology, Loyola University Medical Center, Bldg 102 3634, 2160 S 1st Ave, Maywood, IL 60153, USA
    Brain Res Mol Brain Res 117:179-89. 2003
    ..These findings suggest that an important relationship exists between parkin and septins...
  4. pmc LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
    C H Hsu
    Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA
    Neurodegener Dis 7:68-75. 2010
    ..These results are consistent with a putative role of LRRK2 in regulating the stress kinase cascade...
  5. ncbi request reprint Re-assessing the relationship between cholesterol, statins and Alzheimer's disease
    B Wolozin
    Department of Pharmacology, Boston University School of Medicine, MA 02118, USA
    Acta Neurol Scand Suppl 185:63-70. 2006
    ..These results suggest that the primary action of statins in humans with AD might be to reduce inflammation rather than decrease Abeta load...
  6. ncbi request reprint Beta-amyloid augments platelet aggregation: reduced activity of familial angiopathy-associated mutants
    B Wolozin
    Section on Geriatric Psychiatry, NIMH, Bethesda, MD 20892, USA
    Mol Psychiatry 3:500-7. 1998
    ..These results suggest that A beta interacts with platelets in a highly specific manner and may play a role in regulating platelet function...
  7. ncbi request reprint Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein
    M Frasier
    Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA
    Exp Neurol 192:274-87. 2005
    ..These results suggest that alpha-synuclein pathology can stimulate early pathological changes in tau...
  8. ncbi request reprint Regulation of apoptosis by presenilin 1
    B Wolozin
    Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA
    Neurobiol Aging 19:S23-7. 1998
    ..We also observed that wild-type and the H115Y mutant form of PS1 differentially regulate Jun Kinase, an important enzyme regulating apoptosis...
  9. ncbi request reprint Cholesterol and Alzheimer's disease
    B Wolozin
    Department of Pharmacology, Loyola University Medical Center, Bldg 102, Rm 3634, 2160 South First Avenue, Maywood, IL 60153, USA
    Biochem Soc Trans 30:525-9. 2002
    ..70% lower risk of developing AD. Since statins are widely used by doctors, their ability to reduce A beta offers a putative therapeutic strategy for treating AD by using medicines that have already been proved safe to use in humans...
  10. ncbi request reprint alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
    N Ostrerova
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:5782-91. 1999
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases...
  11. ncbi request reprint Co-association of parkin and alpha-synuclein
    P Choi
    Department of Pharmacology, Loyola University Medical Center, Bldg 102, Rm 3634, 2160 S 1st Ave, Maywood, IL 60153, USA
    Neuroreport 12:2839-43. 2001
    ..These results suggest that parkin interacts with alpha-synuclein and could contribute to the pathophysiology of PD more generally than was previously considered...
  12. ncbi request reprint Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion
    J J Palacino
    Department of Pharmacology and Neuroscience Program, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 276:38563-9. 2001
    ..These data show that PS1 interacts with multiple components of the beta-catenin signaling cascade and suggest that PS1 regulates beta-catenin in a manner independent of GSK 3beta activity...
  13. pmc Investigating convergent actions of genes linked to familial Parkinson's disease
    Benjamin Wolozin
    Department of Pharmacology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Neurodegener Dis 5:182-5. 2008
    ..Mutations in LRRK2 are among the most frequent genetic changes identified in Parkinson's disease (PD), but how LRRK2 contributes to the pathophysiology of PD is not known...
  14. pmc Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease
    Benjamin Wolozin
    Boston University School of Medicine, Boston, MA, USA
    BMC Med 5:20. 2007
    ..We used a large database to compare the action of several different statins to investigate whether some statins might be differentially associated with a reduction in the incidence of dementia and Parkinson's disease...
  15. ncbi request reprint Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
    Rina Ved
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    J Biol Chem 280:42655-68. 2005
    ..These results show that diverse PD-related genetic modifications disrupt the mitochondrial function in C. elegans, and they raise the possibility that mitochondrial disruption is a pathway shared in common by many types of familial PD...
  16. ncbi request reprint Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Dis 18:492-8. 2005
    ..Our findings suggest that proteins associated with impaired energy metabolism and mitochondria are particularly prone to oxidative stress associated with A30P-mutant alpha-synuclein...
  17. ncbi request reprint Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein
    Natalie Golts
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 277:16116-23. 2002
    ..These data suggest that the conformation of alpha-synuclein can be modulated by metals, with iron promoting aggregation and magnesium inhibiting aggregation...
  18. ncbi request reprint Pathological proteins in Parkinson's disease: focus on the proteasome
    Heather Snyder
    Boston University School of Medicine, 715 Albany Street, Room L 603, Boston, MA 02118 2526, USA
    J Mol Neurosci 24:425-42. 2004
    ..These models are very helpful in elucidating the pathophysiology of PD but do not completely recapitulate the disease process. The relationship between these transgenic models and PD is a subject of intense investigation...
  19. ncbi request reprint beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein
    Heather Snyder
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 280:7562-9. 2005
    ..Based on these data, we hypothesize that the alpha- and gamma-synucleins regulate proteasomal function and that beta-synuclein acts as a negative regulator of alpha-synuclein...
  20. ncbi request reprint Following the leader: fibrillization of alpha-synuclein and tau
    Mark Frasier
    Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA
    Exp Neurol 187:235-9. 2004
  21. ncbi request reprint alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells
    Bong Hyun Ahn
    Department of Physiology, Research Institute of Molecular Genetics, and Anatomy, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    J Biol Chem 277:12334-42. 2002
    ..These results suggest that the association of alpha-synuclein with PLD, and modulation of PLD activity, is biologically important, but PLD does not appear to play an essential role in the pathophysiology of alpha-synuclein...
  22. ncbi request reprint Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
    Leonard Petrucelli
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neuron 36:1007-19. 2002
    ..Therefore, parkin and alpha-synuclein are linked by common effects on a pathway associated with selective cell death in catecholaminergic neurons...
  23. ncbi request reprint Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function
    Heather Snyder
    Department of Pharmacology and Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 278:11753-9. 2003
    ..These studies suggest that proteasomal inhibition by aggregated alpha-synuclein could be mediated by interaction with S6'...