Virginia M Sanders

Summary

Affiliation: Loyola University Medical Center
Country: USA

Publications

  1. ncbi request reprint Norepinephrine, the beta-adrenergic receptor, and immunity
    Virginia M Sanders
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois 60153, USA
    Brain Behav Immun 16:290-332. 2002
  2. ncbi request reprint CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection
    Craig J Serpe
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, USA
    Brain Behav Immun 17:393-402. 2003
  3. ncbi request reprint Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury
    Kathryn J Jones
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Chicago, Maywood, IL 60153, USA
    Brain Behav Immun 19:12-9. 2005
  4. pmc CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation
    Susanna C Byram
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, Illinois 60153, USA
    J Neurosci 24:4333-9. 2004
  5. ncbi request reprint Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4/STAT6 signaling pathway in CD4(+) T cells
    Cynthia A Deboy
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, 2160 S 1st Avenue, Maywood, IL 60153, USA
    Exp Neurol 201:212-24. 2006
  6. pmc Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy
    Junping Xin
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    Brain Behav Immun 22:528-37. 2008
  7. ncbi request reprint CD4+CD25+ regulatory T cells and CD1-restricted NKT cells do not mediate facial motoneuron survival after axotomy
    Cynthia A Deboy
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, IL 60153, and Research and Development Service, Hines VA Hospital 60141, USA
    J Neuroimmunol 176:34-8. 2006
  8. pmc Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice
    Derek A Wainwright
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    J Neuroimmunol 216:66-75. 2009
  9. pmc Functional recovery and facial motoneuron survival are influenced by immunodeficiency in crush-axotomized mice
    Taylor Beahrs
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    Exp Neurol 221:225-30. 2010
  10. pmc Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy
    Derek A Wainwright
    Dept of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, United States
    Neurosci Lett 471:10-4. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Norepinephrine, the beta-adrenergic receptor, and immunity
    Virginia M Sanders
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois 60153, USA
    Brain Behav Immun 16:290-332. 2002
    ....
  2. ncbi request reprint CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection
    Craig J Serpe
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, USA
    Brain Behav Immun 17:393-402. 2003
    ..5 and 63%+/-1.0, respectively). It is concluded that, of the population of FMN that do not survive injury, CD4+ T lymphocytes, but not CD8+ T lymphocytes or B cells, mediate FMN survival after peripheral nerve injury...
  3. ncbi request reprint Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury
    Kathryn J Jones
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Chicago, Maywood, IL 60153, USA
    Brain Behav Immun 19:12-9. 2005
    ....
  4. pmc CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation
    Susanna C Byram
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, Illinois 60153, USA
    J Neurosci 24:4333-9. 2004
    ..This is the first in vivo report demonstrating a neuroprotective mechanism requiring APC functions by resident (i.e., parenchymal) microglial cells...
  5. ncbi request reprint Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4/STAT6 signaling pathway in CD4(+) T cells
    Cynthia A Deboy
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, 2160 S 1st Avenue, Maywood, IL 60153, USA
    Exp Neurol 201:212-24. 2006
    ..Collectively, these data suggest that STAT6-mediated CD4(+) T cell differentiation into the Th2 subset is necessary for FMN survival. A hypothesis relevant to motoneuron disease progression is presented...
  6. pmc Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy
    Junping Xin
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    Brain Behav Immun 22:528-37. 2008
    ....
  7. ncbi request reprint CD4+CD25+ regulatory T cells and CD1-restricted NKT cells do not mediate facial motoneuron survival after axotomy
    Cynthia A Deboy
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, IL 60153, and Research and Development Service, Hines VA Hospital 60141, USA
    J Neuroimmunol 176:34-8. 2006
    ....
  8. pmc Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice
    Derek A Wainwright
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    J Neuroimmunol 216:66-75. 2009
    ..Differences in the number of CCL11- and CXCL11-expressing cells were observed between WT and mSOD1 mice after facial nerve axotomy...
  9. pmc Functional recovery and facial motoneuron survival are influenced by immunodeficiency in crush-axotomized mice
    Taylor Beahrs
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    Exp Neurol 221:225-30. 2010
    ....
  10. pmc Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy
    Derek A Wainwright
    Dept of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, United States
    Neurosci Lett 471:10-4. 2010
    ..These data contribute to understanding the role of innate immunity after FMN death and may be relevant to motoneuron diseases, such as amyotrophic lateral sclerosis (ALS)...
  11. ncbi request reprint Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice
    Craig J Serpe
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Brain Behav Immun 16:808-12. 2002
    ..5+/-0.3 and 10.0+/-0.0 days, respectively. These results suggest that the delayed behavioral recovery time observed in scid mice may be due to the absence of T and B lymphocytes...
  12. ncbi request reprint Natural killer cells do not mediate facial motoneuron survival after facial nerve transection
    Susanna C Byram
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Brain Behav Immun 17:417-25. 2003
    ..Thus, NK cells appear to not be a component of immune cell-mediated rescue of motoneurons from axotomy induced cell death...
  13. pmc Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy
    Nichole A Mesnard
    Neuroscience Program, Loyola University Medical Center, Maywood, IL 60153, USA
    Exp Neurol 225:94-103. 2010
    ....
  14. ncbi request reprint B cell receptor- and beta 2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells
    Adam P Kohm
    Department of Cell Biology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
    J Immunol 168:6314-22. 2002
    ..Thus, this study provides additional insight into the signaling intermediates and molecular mechanisms by which stimulation of the BCR and beta(2)AR may regulate B cell-associated B7-2 expression...
  15. ncbi request reprint Adaptive immunity in mice lacking the beta(2)-adrenergic receptor
    Virginia M Sanders
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    Brain Behav Immun 17:55-67. 2003
    ....
  16. ncbi request reprint It takes nerve to tell T and B cells what to do
    Nicholas W Kin
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Leukoc Biol 79:1093-104. 2006
    ..We will also discuss how dysregulation of this line of communication between the nervous and immune systems might contribute to disease development and progression...
  17. ncbi request reprint Role of immunity in recovery from a peripheral nerve injury
    Virginia M Sanders
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University School of Medicine and Public Health, 2194 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA
    J Neuroimmune Pharmacol 1:11-9. 2006
    ....
  18. ncbi request reprint Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice
    Craig J Serpe
    Rehabilitation, Research and Development Service, Hines VA Hospital, 5th and Roosevelt Road, Hines, IL 60141, USA
    Brain Behav Immun 19:173-80. 2005
    ..3) 4 wpo. These data lend support to the hypothesis that CD4+ T cells produce NTF that support motoneuron survival before target reconnection occurs...
  19. ncbi request reprint CD86 regulates IgG1 production via a CD19-dependent mechanism
    Nicholas W Kin
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210
    J Immunol 179:1516-23. 2007
    ..Thus, our findings suggest that CD86 plays a key role in regulating the level of IgG(1) produced in vitro and in vivo, and that Lyn and CD19 may be the signaling intermediates activated by CD86 proximal to PI3K...
  20. pmc Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation
    Kurt M Lucin
    The Integrated Biomedical Science Graduate Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Exp Neurol 207:75-84. 2007
    ..These data illustrate the immunosuppressive effects of the SNS after high-level SCI and indicate that immune deficits may be overcome using beta-blockers...
  21. ncbi request reprint Spinal cord injury triggers systemic autoimmunity: evidence for chronic B lymphocyte activation and lupus-like autoantibody synthesis
    Daniel P Ankeny
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Neurochem 99:1073-87. 2006
    ..We show a similar pathologic potential for the autoantibodies produced after SCI. Thus, mammalian SCI produces marked dysregulation of B cell function (i.e. autoimmunity) with pathological potential...
  22. ncbi request reprint CXCR3-/- mice mount an efficient Th1 response but fail to control Leishmania major infection
    Lucia E Rosas
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43221, USA
    Eur J Immunol 35:515-23. 2005
    ..major is due to impaired CD4+ and CD8+ T cell trafficking and decreased production of IFN-gamma at the site of infection rather than to their inability to mount a parasite-specific Th1 response...
  23. ncbi request reprint Interdisciplinary research: noradrenergic regulation of adaptive immunity
    Virginia M Sanders
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH, USA
    Brain Behav Immun 20:1-8. 2006
    ..And finally, this review will discuss how the lessons from the past can help us to attain a vision of interdisciplinary research for the future...
  24. pmc Autonomic innervation and regulation of the immune system (1987-2007)
    Dwight M Nance
    Susan Samueli Center for Integrative Medicine, University of California Irvine, Orange, CA 92868 4283, USA
    Brain Behav Immun 21:736-45. 2007
    ....
  25. ncbi request reprint The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner
    Georg Pongratz
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    J Immunol 177:2926-38. 2006
    ....
  26. ncbi request reprint CD86 and beta2-adrenergic receptor stimulation regulate B-cell activity cooperatively
    Joseph R Podojil
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Trends Immunol 26:180-5. 2005
    ..This finding suggests that signaling pathways that are activated by an immunoreceptor (CD86) and a neuroreceptor (beta2AR) converge to regulate the IgG1 response...
  27. ncbi request reprint CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways
    Nicholas W Kin
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 176:6727-35. 2006
    ..These results identify a previously unknown signaling pathway induced by CD86 to regulate the level of B cell gene expression and activity...
  28. ncbi request reprint CD86 and beta2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B Expression and binding to the 3'-IgH enhancer in B cells
    Joseph R Podojil
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 279:23394-404. 2004
    ....
  29. ncbi request reprint Selective regulation of mature IgG1 transcription by CD86 and beta 2-adrenergic receptor stimulation
    Joseph R Podojil
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    J Immunol 170:5143-51. 2003
    ..These results provide the first evidence that CD86 and/or beta(2)AR stimulation on a CD40 ligand/IL-4-activated B cell increases the level of IgG1 protein produced per cell by increasing the rate of mature IgG1 transcription...
  30. ncbi request reprint Epigenetic regulation of Th1 and Th2 cell development
    Virginia M Sanders
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH, USA
    Brain Behav Immun 20:317-24. 2006
    ..This article will review basic epigenetic mechanisms and what is known about how these mechanisms influence cytokine gene expression in a naïve CD4+ T cell as it develops into a Th1 or Th2 cell...