E Perez-Reyes

Summary

Affiliation: Loyola University Chicago
Country: USA

Publications

  1. ncbi Molecular characterization of a neuronal low-voltage-activated T-type calcium channel
    E Perez-Reyes
    Department of Physiology, and Cardiovascular Institute, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Nature 391:896-900. 1998
  2. ncbi Molecular characterization of two members of the T-type calcium channel family
    E Perez-Reyes
    Department of Physiology, Loyola University Medical Center, Maywood, Ilinois 60153, USA
    Ann N Y Acad Sci 868:131-43. 1999
  3. ncbi Three for T: molecular analysis of the low voltage-activated calcium channel family
    E Perez-Reyes
    Department of Physiology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Cell Mol Life Sci 56:660-9. 1999
  4. ncbi Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family
    L L Cribbs
    Department of Physiology, Cardiovascular Institute, Loyola University Medical Center, Maywood, Ill 60153, USA
    Circ Res 83:103-9. 1998
  5. ncbi Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family
    J H Lee
    Department of Physiology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:1912-21. 1999
  6. ncbi Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels
    J H Lee
    Department of Physiology, Loyola University Medical Center, Maywood, IL 60153, USA
    FEBS Lett 445:231-6. 1999
  7. ncbi Molecular cloning and functional expression of Ca(v)3.1c, a T-type calcium channel from human brain
    L L Cribbs
    Department of Physiology and the Cardiovascular Institute, Loyola University Medical Center, Maywood, IL, USA
    FEBS Lett 466:54-8. 2000
  8. ncbi Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release
    D M Bers
    Department of Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Cardiovasc Res 42:339-60. 1999
  9. ncbi Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1
    R Vajna
    Institute of Neurophysiology, University of Cologne, Koln, Germany
    Eur J Biochem 268:1066-75. 2001
  10. ncbi Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells
    J Barclay
    Department of Paediatrics and Child Health, Royal Free and University College Medical School, The Rayne Institute, London, WC1E 6JJ, United Kingdom
    J Neurosci 21:6095-104. 2001

Collaborators

Detail Information

Publications32

  1. ncbi Molecular characterization of a neuronal low-voltage-activated T-type calcium channel
    E Perez-Reyes
    Department of Physiology, and Cardiovascular Institute, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Nature 391:896-900. 1998
    ..Based on the channel's distinctive voltage dependence, slow deactivation kinetics, and 7.5-pS single-channel conductance, we conclude that this channel is a low-voltage-activated T-type calcium channel...
  2. ncbi Molecular characterization of two members of the T-type calcium channel family
    E Perez-Reyes
    Department of Physiology, Loyola University Medical Center, Maywood, Ilinois 60153, USA
    Ann N Y Acad Sci 868:131-43. 1999
    ..The currents generated by alpha 1G and alpha 1H are nearly identical in terms of their voltage dependence and kinetics. We present preliminary evidence that nickel may serve as a valuable tool in discriminating between these subtypes...
  3. ncbi Three for T: molecular analysis of the low voltage-activated calcium channel family
    E Perez-Reyes
    Department of Physiology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Cell Mol Life Sci 56:660-9. 1999
    ....
  4. ncbi Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family
    L L Cribbs
    Department of Physiology, Cardiovascular Institute, Loyola University Medical Center, Maywood, Ill 60153, USA
    Circ Res 83:103-9. 1998
    ..4 micromol/L, consistent with the reported potency of mibefradil for T-type Ca2+ channels. Together with alpha1G, a rat brain T-type Ca2+ channel also cloned in our laboratory, these genes define a unique family of Ca2+ channels...
  5. ncbi Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family
    J H Lee
    Department of Physiology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:1912-21. 1999
    ..Based on its brain distribution and novel gating properties, we suggest that alpha1I plays important roles in determining the electroresponsiveness of neurons, and hence, may be a novel drug target...
  6. ncbi Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels
    J H Lee
    Department of Physiology, Loyola University Medical Center, Maywood, IL 60153, USA
    FEBS Lett 445:231-6. 1999
    ..Despite extensive expression attempts, currents from the putative channel were not detected. Based on its sequence, we propose that the novel protein might be a voltage-activated cation channel with unique gating properties...
  7. ncbi Molecular cloning and functional expression of Ca(v)3.1c, a T-type calcium channel from human brain
    L L Cribbs
    Department of Physiology and the Cardiovascular Institute, Loyola University Medical Center, Maywood, IL, USA
    FEBS Lett 466:54-8. 2000
    ..The resulting currents were analyzed for their voltage- and time-dependent properties. These properties identify this gene as encoding a T-type Ca(2+) channel...
  8. ncbi Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release
    D M Bers
    Department of Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Cardiovasc Res 42:339-60. 1999
    ..The Ca released from the SR can also feedback on several sarcolemmal ion currents and alter action potential configuration as well as contribute to arrhythmogenesis...
  9. ncbi Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1
    R Vajna
    Institute of Neurophysiology, University of Cologne, Koln, Germany
    Eur J Biochem 268:1066-75. 2001
    ....
  10. ncbi Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells
    J Barclay
    Department of Paediatrics and Child Health, Royal Free and University College Medical School, The Rayne Institute, London, WC1E 6JJ, United Kingdom
    J Neurosci 21:6095-104. 2001
    ..Our observations document the first mammalian alpha2delta mutation and complete the association of each of the major classes of voltage-dependent Ca(2+) channel subunits with a phenotype of ataxia and epilepsy in the mouse...
  11. ncbi Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide
    S M Todorovic
    Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA
    Mol Pharmacol 60:603-10. 2001
    ..2 currents in HEK cells at subanesthetic concentrations. Blockade of T currents may contribute to the anesthetic and/or analgesic effects of N(2)O...
  12. ncbi Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)
    B Gao
    Hamon Center for Therapeutic Oncology Research, Departments of Internal Medicine, Pharmacology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:12237-42. 2000
    ..The homologous location on mouse chromosome 9 is also the site of the mouse neurologic mutant ducky (du), and thus, CACNA2D2 is also a candidate gene for this inherited idiopathic generalized epilepsy syndrome...
  13. ncbi Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel
    E Perez-Reyes
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 267:1792-7. 1992
    ..These results indicate that the cardiac L-type Ca2+ channel has a similar subunit structure as in skeletal muscle, and provides evidence for the modulatory role of the beta subunit...
  14. ncbi Block of cloned human T-type calcium channels by succinimide antiepileptic drugs
    J C Gomora
    Department of Pharmacology, University of Virginia, Charlottesville, 22908, USA
    Mol Pharmacol 60:1121-32. 2001
    ..We conclude that succinimide antiepileptic drugs are capable of blocking human T-type channels at therapeutically relevant concentrations...
  15. ncbi Gating kinetics of the alpha1I T-type calcium channel
    C J Frazier
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Gen Physiol 118:457-70. 2001
    ..This suggests that T-channels share a common gating mechanism, but with considerable quantitative variability...
  16. ncbi Inactivation determinants in segment IIIS6 of Ca(v)3.1
    R Marksteiner
    , Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria
    J Physiol 537:27-34. 2001
    ..1 (Hering et al. 1998) have a significant role in Ca(v)3.1 inactivation. These data suggest common elements in the molecular architecture of the inactivation mechanism in high and low threshold Ca(2+) channels...
  17. ncbi New isoform of the neuronal Ca2+ channel alpha1E subunit in islets of Langerhans and kidney--distribution of voltage-gated Ca2+ channel alpha1 subunits in cell lines and tissues
    R Vajna
    Institute of Neurophysiology, University of Cologne, Germany
    Eur J Biochem 257:274-85. 1998
    ....
  18. ncbi Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes
    E Perez-Reyes
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 265:20430-6. 1990
    ..These results demonstrate that calcium channel diversity is created by both the expression of distinct genes and the alternate splicing of these genes...
  19. ncbi Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels
    M De Leon
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 270:1502-6. 1995
    ..Donation of the alpha 1C EF-hand region to the alpha 1E channel conferred the Ca(2+)-inactivating phenotype. These results strongly suggest that Ca2+ binding to the alpha 1C subunit initiates Ca2+ inactivation...
  20. ncbi Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit
    T Schneider
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030
    Receptors Channels 2:255-70. 1994
    ..1% crude funnel web spider venom and 100% by Ni2+ (IC50 = 30 nM). Single-channel records show a complex activity pattern with several apparent conductance states, the largest having a conductance of 14 pS...
  21. ncbi Cloning and expression of a third calcium channel beta subunit
    A Castellano
    Department of Molecular Physiology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 268:3450-5. 1993
    ..In addition, beta 3 accelerates the rate of inactivation at positive test potentials...
  22. ncbi Cloning and expression of a neuronal calcium channel beta subunit
    A Castellano
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 268:12359-66. 1993
    ....
  23. ncbi Molecular cloning and functional expression of a skeletal muscle dihydropyridine receptor from Rana catesbeiana
    J Zhou
    Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois 60612, USA
    J Biol Chem 273:25503-9. 1998
    ..and Tanabe, T. (1997) J. Gen. Physiol. 110, 379-389). This molecule constitutes a new tool for studies of excitation-contraction coupling, gating, modulation, and gene expression...
  24. ncbi Molecular pharmacology of T-type Ca2+ channels
    T N Heady
    Department of Chemistry, University of Virginia, Charlottesville 22904, USA
    Jpn J Pharmacol 85:339-50. 2001
    ....
  25. ncbi The role of T-type calcium channels in epilepsy and pain
    M T Nelson
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
    Curr Pharm Des 12:2189-97. 2006
    ..Considering the important role T-channels play in the thalamus, it is likely that T-channel mutations also contribute to a wider range of disorders characterized by thalamocortical dysrhythmia...
  26. ncbi Molecular characterization of T-type calcium channels
    E Perez-Reyes
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Cell Calcium 40:89-96. 2006
    ..This section reviews the structure of T-channels, how splicing affects structure and function, how SNPs alter channel activity, and how high voltage-activated auxiliary subunits affect T-channels...
  27. ncbi T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates
    M Uebachs
    Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany
    J Physiol 571:519-36. 2006
    ..These data provide a novel mechanism for cellular short-term plasticity on the millisecond to second time scale that relies on biophysical properties of specific T-type Ca2+ channel subunits...
  28. ncbi Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide
    J Chemin
    IGH-CNRS UPR, 1142-141 rue de la Cardonille, F-34396 Montpellier cedex 05, France
    EMBO J 20:7033-40. 2001
    ..Our data demonstrate that anandamide inhibition of T-channels can regulate neuronal excitability and account for CB receptor-independent effects of this signaling molecule...
  29. ncbi Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype
    F O Levy
    Department of Cell Biology and Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 267:7553-62. 1992
    ..7 to 1.2 nM). We propose that the human S12 serotonin receptor is a receptor of the 5-hydroxytryptamine1D subtype...
  30. ncbi Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel
    A E Lacerda
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    Nature 352:527-30. 1991
    ....
  31. ncbi alpha1H T-type Ca2+ channel is the predominant subtype expressed in bovine and rat zona glomerulosa
    A D Schrier
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Cell Physiol 280:C265-72. 2001
    ..4 +/- 0.2 microM. Because the alpha1H subtype exhibits similar NiCl2 sensitivity, we propose that the alpha1H subtype is the predominant T-type Ca2+ channel present in the adrenal zona glomerulosa...
  32. ncbi Molecular biology of T-type calcium channels
    E Perez-Reyes
    Departments of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    CNS Neurol Disord Drug Targets 5:605-9. 2006
    ....