Affiliation: Loyola University Medical Center
- Id-1 delays senescence but does not immortalize keratinocytesB J Nickoloff
Department of Pathology and the Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA
J Biol Chem 275:27501-4. 2000..Thus, while no immortalization was observed, Id-1 could delay the onset of replicative senescence in unselected human keratinocyte populations...
- Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunitiesBrian J Nickoloff
Skin Disease Research Laboratory and Cardinal Bernardin Cancer Center, Loyola University of Chicago, Medical Center, Maywood, Illinois 60153, USA
J Clin Invest 113:1664-75. 2004..Such strategic transition from serendipity to the use of novel selective agents aimed at defined targets in psoriatic lesions is moving rapidly from research benches to the bedsides of patients with this chronic and debilitating disease...
- Life and death signaling pathways contributing to skin cancerBrian J Nickoloff
Loyola University Medical Center, Department of Pathology, Skin Cancer Research Laboratory, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
J Investig Dermatol Symp Proc 7:27-35. 2002....
- Notch and NOXA-related pathways in melanoma cellsBrian J Nickoloff
Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois 60153 5385, USA
J Investig Dermatol Symp Proc 10:95-104. 2005..g. Notch signaling), and anti-cancer agents that achieve tumor selectivity (e.g., GSI-induced NOXA), this experimental approach provides a useful framework for future therapeutic strategies in cutaneous oncology...
- Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparationsJian Zhong Qin
Loyola University Medical Center, Skin Cancer Research Laboratory, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
Exp Dermatol 11:573-83. 2002....
- Keratinocytes regain momentum as instigators of cutaneous inflammationBrian J Nickoloff
Skin Cancer Research Program, Loyola University of Chicago Medical Center, Cardinal Bernardin Cancer Center, 2160 South First Avenue, Building 112, Room 301, Maywood, IL 60153, USA
Trends Mol Med 12:102-6. 2006....
- Cutaneous dendritic cells in the crossfire between innate and adaptive immunityBrian J Nickoloff
Department of Pathology, Skin Cancer Research Laboratories, Cardinal Bernardin Cancer Center, Loyola University of Chicago Medical Center, Building 112, Room 301, 2160 South First Avenue, Maywood, IL 60153, USA
J Dermatol Sci 29:159-65. 2002
- The cytokine and chemokine network in psoriasisBrian J Nickoloff
Department of Pathology and Skin Disease Research Program, Oncology Institute and Cardinal Bernardin Cancer Center, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
Clin Dermatol 25:568-73. 2007..These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions...
- Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgammaB J Nickoloff
Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 South First Avenue, Building 112, Room 301, Maywood, IL 60153, USA
Cell Death Differ 9:842-55. 2002..These results indicate that activation of Notch signaling is necessary for maturation of human epidermis, and activation by a soluble Notch ligand is sufficient to trigger complete KC differentiation including cornification...
- Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activityBrian J Nickoloff
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
Cancer Res 64:2956-61. 2004..These findings indicate that senescent KCs exert a paracrine antiangiogenic activity, and maspin is the principal contributor to this potentially tumor-suppressive effect of cellular senescence...
- Lessons learned from psoriatic plaques concerning mechanisms of tissue repair, remodeling, and inflammationBrian J Nickoloff
Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois 60153, USA
J Investig Dermatol Symp Proc 11:16-29. 2006..In summary, many lessons can be learned by focusing on complex processes involved in regulation of inflammation, tissue repair, and remodeling...
- Immunopathogenesis of psoriasisBrian J Nickoloff
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
Clin Rev Allergy Immunol 33:45-56. 2007....
- Immunobiology of acute cytotoxic drug reactionsBrian J Nickoloff
Department of Pathology, Loyola University Medical Center, Maywood, Chicago, IL 60153 5385, USA
Curr Dir Autoimmun 10:53-64. 2008..Clearly, many new insights are required at multiple levels of understanding to better manage and perhaps even prevent TENS...
- Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. ViewpointB J Nickoloff
Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
J Cutan Pathol 28:57-64. 2001..This paper explores the possible molecular mechanism for the tumor suppressor pathway in psoriatic lesions, with an emphasis on a putative senescence-switch involving p16...
- Characterization of lymphocyte-dependent angiogenesis using a SCID mouse: human skin model of psoriasisB J Nickoloff
Department of Pathology, Skin Cancer Research Laboratories, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois 60153, USA
J Investig Dermatol Symp Proc 5:67-73. 2000....
- Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model systemB J Nickoloff
Department of Pathology, Loyola University Medical Center, Boston, MA 60153 5385, USA
J Dermatol Sci 24:212-25. 2000..Thus, this pathogenic cell line provides evidence that T cells bearing NKRs can directly provoke a Th1 disease such as psoriasis...
- Targeting TNFalpha rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiationDeborah J Marble
Department of Medicine, Division of Dermatology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, United States
J Dermatol Sci 48:87-101. 2007..The cytokine network theory for psoriasis postulates a key role for TNFalpha in mediating inflammation and altered epidermal differentiation...
- Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosisJian Zhong Qin
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
J Cell Physiol 200:155-66. 2004....
- Innate immune-related receptors in normal and psoriatic skinJonathan L Curry
Department of Pathology, Skin Cancer Research Laboratories, Loyola University Cancer Center, Maywood, IL 60153, USA
Arch Pathol Lab Med 127:178-86. 2003..CONCLUSIONS: These data demonstrate distinctive patterns of innate immune-related receptors by specific subsets of cells in normal and psoriatic skin, suggesting functional roles for HSPs and DCs in psoriasis...
- Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescenceHong Xin
Departments of Pathology and Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Mail Code 114B, Maywood, IL 60153, USA
Oncogene 22:4831-40. 2003..Collectively, our observations support the idea that increased levels of IFI 16 in PrECs contribute to senescence-associated irreversible cell growth arrest...
- Knock down of p53 levels in human keratinocytes increases susceptibility to type I and type II interferon-induced apoptosis mediated by a TRAIL dependent pathwayVijaya Chaturvedi
Department of Pathology, Loyola University Medical Center, USA
J Dermatol Sci 41:31-41. 2006..By contrast, in inflammatory pathological conditions featuring type I (IFN-alpha) and type II (IFN-gamma) interferons KCs undergo premature apoptosis...
- Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytesJian Zhong Qin
Department of Pathology, Loyola University Medical Center, Illinois, USA
Oncogene 21:2991-3002. 2002..In conclusion, the sensitivity and resistance of KCs to apoptosis depends not only on the location within various layers of epidermis and levels of p53, but may also involve p53 activation via post-translational modifications...
- 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligoTara M Kroll
Department of Pathology/Oncology Institute, Loyola University, Chicago, Illinois 60153, USA
J Invest Dermatol 124:798-806. 2005..Stressed melanocytes may mediate DC activation through release of HSP70, and DC effector functions appear to play a previously unappreciated role in progressive vitiligo...
- Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXAJian-Zhong Qin
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
Cancer Res 66:9636-45. 2006....
- Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytesVijaya Chaturvedi
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
Am J Pathol 162:161-70. 2003....
- Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinomaVijaya Chaturvedi
Department of Pathology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA
Exp Dermatol 12:255-60. 2003..Thus, dysregulated Id-1 may not only contribute to delaying the senescence program in keratinocytes, it may also contribute to the escape of the relatively undifferentiated tumor cells in BCC from immune surveillance...
- p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomasJian Zhong Qin
Department of Pathology, Loyola University of Chicago Medical Center, Chicago, IL, USA
Mol Cancer Ther 3:895-902. 2004....
- Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosisVijaya Chaturvedi
Department of Pathology, Oncology Institute, Loyola University Medical Center, Maywood, IL 60153, USA
Oncogene 24:5299-312. 2005....
- Digital epiluminescence microscopy monitoring of high-risk patientsJune K Robinson
Department of Medicine, Division of Dermatology, Cardinal Bernardin Cancer Center, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
Arch Dermatol 140:49-56. 2004..To examine the outcome of digital epiluminescence microscopic (DELM) surveillance of atypical nevi in a high-risk population for 4 years...
- Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cellsI Caroline Le Poole
Department of Pathology, Skin Oncology Research Program, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Bldg 112, Rm 303, 2160 S 1st Ave, Maywood, IL 60153, USA
Am J Pathol 160:521-8. 2002..Reduced MART-1 expression was frequently observed in adjacent tumor cells. Consequently, IFN-gamma may enhance inflammatory responses yet hamper effective recognition of melanoma cells...
- Graft-versus-host disease of the skin: life and death on the epidermal edgeCraig C Hofmeister
Department of Medicine, Division of Hematology/Oncology, Loyola University Medical Center/Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, USA
Biol Blood Marrow Transplant 10:366-72. 2004..With new insights designed to better predict and prevent GVHD and novel agents designed to treat GVHD, overcoming this current impediment to successful bone marrow transplantation should become increasingly feasible...
- The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cellsSanne Weijzen
Cancer Immunology and Skin Cancer Programs, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
J Immunol 169:4273-8. 2002..These data may have important medical implications, since they provide new reagents to induce DC activity, which may be beneficial as adjuvants in situations where an immune response needs to be elicited, such as tumor immunotherapy...
- Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter regionLawrence S Stennett
Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA
Pigment Cell Res 17:525-32. 2004..The current study provides insight into transcriptional regulation of the PMel17 and CDK2 genes, important to identify strategies for modulating expression of gp100 and CDK2 proteins by melanoma cells...
- Inflammation and cancer: is the link as simple as we think?Brian J Nickoloff
Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Chicago Medical Center, Chicago, Illinois, USA
J Invest Dermatol 124:x-xiv. 2005
- Defining the caspase-containing apoptotic machinery contributing to cornification in human epidermal equivalentsVijaya Chaturvedi
Department of Pathology, Loyola University Chicago, IL 60153, USA
Exp Dermatol 15:14-22. 2006..We conclude caspases function as important death effectors strategically positioned at intersection of intrinsic and extrinsic pathways in KCs undergoing stratum corneum formation...
- Reactivity of resident immunocytes in normal and prepsoriatic skin using an ex vivo skin-explant model systemJonathan L Curry
Department of Pathology, Loyola University, Chicago Medical Center, Maywood, IL, USA
Arch Pathol Lab Med 127:289-96. 2003..These results demonstrate the utility of this skin-explant assay system to further investigate quantitative and qualitative immune responses of NN and PN skin...
- Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cellsJian-Zhong Qin
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153-5385, USA
Cancer Res 65:6282-93. 2005....
- Alefacept in corticosteroid refractory graft versus host disease: early results indicate promising activityAmir A Toor
Bone Marrow Transplantation Program, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA
J Dermatolog Treat 18:13-8. 2007..The pathological and immunohistochemical findings of GVHD also improved, validating our clinical impression. These preliminary findings indicate that alefacept may have beneficial activity in GVHD warranting further study...
- Inhibition of PAX3 by TGF-beta modulates melanocyte viabilityGuang Yang
Department of Medical Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Mol Cell 32:554-63. 2008....
- Topical and light-based treatments for basal cell carcinomaJune K Robinson
Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
Semin Cutan Med Surg 22:171-6. 2003..It is hoped that further developments of the class of drugs will produce an agent with fewer side effects and improved efficacy for nodular BCC...
- Focal adhesion kinase promotes the aggressive melanoma phenotypeAngela R Hess
Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614-3394, USA
Cancer Res 65:9851-60. 2005..Collectively, these data suggest a new mechanism involved in promoting the aggressive melanoma phenotype through FAK-mediated signal transduction pathways, thus providing new insights into possible therapeutic intervention strategies...
- Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cellsChristine L Curry
Department of Pathology and Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153-5385, USA
Oncogene 24:6333-44. 2005..The results indicate that KS cells overexpress activated Notch and interruption of Notch signaling inhibits KS cell growth. Thus, targeting Notch signaling may be of therapeutic value in KS patients...
- Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironmentElisabeth A Seftor
Children's Memorial Research Center and Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, IL 60614, USA
Cancer Res 65:10164-9. 2005..This novel approach identifies specific genes involved in the transdifferentiation of melanocytes to a more aggressive phenotype, which may offer significant therapeutic value...
- Estimation of size of clonal unit for keratinocytes in normal human skinVijaya Chaturvedi
Department of Pathology, Loyola University Medical Center, Maywood, IL, USA
Arch Pathol Lab Med 126:420-4. 2002..However, in lesion-free skin from a psoriatic patient, there may be clonal expansion of KCs due to perturbation in epidermopoiesis and/or stem cell distribution...
- Uncovering histologic criteria with prognostic significance in toxic epidermal necrolysisAdam M Quinn
Departments of Pathology, Surgery, Internal Medicine, and Preventive Medicine and Epidemiology, Loyola University, Maywood, IL 60153, USA
Arch Dermatol 141:683-7. 2005..Future clinical trials should consider the possibility that various patient subsets exist within the TEN population, and a role for immunocytes needs to be critically reevaluated in this devastating disease...
- Ecthyma gangrenosum following toxic epidermal necrolysis syndrome in a 3-year-old boy-a survivable series of eventsChristine M Gresik
Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
J Burn Care Res 29:555-8. 2008..To our knowledge, this is the first reported case of TENS/EG in the pediatric population, and the first report of survivability following these illnesses...
- Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathwaysMei-Shiang Jang
Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, USA
J Cell Physiol 199:418-33. 2004..The relevance of these findings to the role of Notch signaling in differentiation and cancer are discussed...
- Treatment strategies in toxic epidermal necrolysis syndrome: where are we at?Gerard J Abood
Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA
J Burn Care Res 29:269-76. 2008..Given the rare nature of this syndrome, multi-institutional studies will be necessary and essential in improving the understanding and treatment of TENS...
- The helix-loop-helix protein id-1 delays onset of replicative senescence in human endothelial cellsJun Tang
Department of Pathology and Skin Cancer Research Laboratories, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois 60153-5385, USA
Lab Invest 82:1073-9. 2002..These findings may have implications in the development of endothelial cell-derived tumors...
- Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agentsBrian J Nickoloff
Department of Pathology, Loyola University, Chicago, USA
Oncogene 22:6598-608. 2003....
- The skin cancer paradox of psoriasis: a matter of life and death decisions in the epidermisBrian J Nickoloff
Arch Dermatol 140:873-5. 2004
- 56th annual Montagna Symposium on the Biology of Skin: Epidermal T-cell interactions--clinicopathological and basic mechanismsKevin D Cooper
Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA
J Invest Dermatol 128:1351-3. 2008
- Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determinationMary J C Hendrix
Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242, USA
Cancer Res 62:665-8. 2002....
- Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alphaOnur Boyman
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH 8091, Switzerland
J Exp Med 199:731-6. 2004..These findings underline the importance of resident immune cells in psoriasis and will have implications for new therapeutic strategies for psoriasis and other T cell-mediated diseases...
- Characterization of tissue specific expression of Notch-1 in human tissuesAlfonso Baldi
Department of Biochemistry and Biophysics F. Cedrangolo, Section of Pathologic Anatomy, Second University of Naples, Italy
Biol Cell 96:303-11. 2004....
- Deepening our understanding of immune sentinels in the skinFrank O Nestle
St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, London, United Kingdom
J Clin Invest 117:2382-5. 2007..These studies provide the basis for better insight into the role of important immune sentinels contributing to the maintenance of skin tissue homeostasis and lay the foundation for future studies of the skin immune system...
- The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformationBarbara Bedogni
Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305, USA
Cancer Cell 8:443-54. 2005..Taken together, these findings demonstrate that Akt hyperactivation and HIF1alpha induction by normally occurring hypoxia in the skin significantly contribute to melanoma development...
- The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transitionSamudra K Dissanayake
Laboratory of Immunology, Gerontology Research Center, NIA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
J Biol Chem 282:17259-71. 2007..Furthermore, inhibition of PKC before Wnt5A treatment blocked Snail expression, implying that Wnt5A can potentiate melanoma metastasis via the induction of EMT in a PKC-dependent manner...
- Overexpression of Akt converts radial growth melanoma to vertical growth melanomaBaskaran Govindarajan
Department of Dermatology, Emory University School of Medicine, and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
J Clin Invest 117:719-29. 2007..Akt thus serves as a molecular switch that increases angiogenesis and the generation of superoxide, fostering more aggressive tumor behavior. Targeting Akt and ROS may be of therapeutic importance in treatment of advanced melanoma...
- Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse modelShigetoshi Sano
Department of Carcinogenesis, University of Texas, M D Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, PO Box 389, Smithville, Texas 78957, USA
Nat Med 11:43-9. 2005..Finally, abrogation of Stat3 function by a decoy oligonucleotide inhibits the onset and reverses established psoriatic lesions in K5.Stat3C mice. Thus, targeting Stat3 may be potentially therapeutic in the treatment of psoriasis...
- A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancerAlfred E Chang
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109 0932, USA
Clin Cancer Res 8:1021-32. 2002..The objectives of this study were to assess the toxicity and immunological response induced by the intradermal (i.d) administration of tumor lysate-pulsed dendritic cells (DCs)...
- Defining the transcriptome of accelerated and replicatively senescent keratinocytes reveals links to differentiation, interferon signaling, and Notch related pathwaysRanjan J Perera
Keck Graduate Institute, Claremont, California, USA
J Cell Biochem 98:394-408. 2006..Integrating all of the transcriptional data revealed a key role for Notch receptor mediated signaling in the confluency induced differentiation phenotype using this model system...
- What have we learned in dermatology from the biologic therapies?Brian J Nickoloff
J Am Acad Dermatol 54:S143-51. 2006..Here, we review the history of our understanding of inflammatory dermatoses, traditional and new treatment approaches, and future directions for research and therapy in this area...
- Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cellsChristine L Curry
Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153-5385, USA
Lab Invest 86:842-52. 2006..This is the first report, to our knowledge, that JNK signaling can modulate Hes-1 expression in a Notch-independent manner...
- Clonal persistence and evolution during a decade of recurrent melanomaEna Wang
Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
J Invest Dermatol 126:1372-7. 2006..Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies...
- Senescent human keratinocytes suppress colony formation of HeLa cellsPatricia Bacon
J Dermatol Sci 38:64-6. 2005
- Cross-validation of murine UV signal transduction pathways in human skinJanine G Einspahr
Department of Medicine, University of Arizona, Tucson, AZ, USA
Photochem Photobiol 84:463-76. 2008..Validation of murine models in human skin will aid in development of effective skin cancer chemoprevention and prevention strategies...
- Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesisMarianna Sabatino
Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Warren G Magnuson Clinical Center, Biometrics Research Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892 1184, USA
Cancer Res 68:122-31. 2008..Our study provides important insights about the dynamics of cancer progression and supports the development of targeted anticancer therapies aimed against stable genetic factors that are maintained throughout the end stage of disease...
- Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressivenessJolanta M Topczewska
Program in Developmental Biology, Children s Memorial Research Center, Feinberg School of Medicine Northwestern University, 2300 Children s Plaza, Box 222, Chicago Illinois, 60614, USA
Nat Med 12:925-32. 2006..These data suggest that Nodal signaling has a key role in melanoma cell plasticity and tumorigenicity, thereby providing a previously unknown molecular target for regulating tumor progression...
- Cracking the cytokine code in psoriasisBrian J Nickoloff
Nat Med 13:242-4. 2007
- Proliferating cultured human keratinocytes are more susceptible to apoptosis compared with mouse keratinocytesVijaya Chaturvedi
J Invest Dermatol 123:1200-3. 2004
- PHENOTYPE AND FUNCTION OF SENESCENT KERATINOCYTESBrian Nickoloff; Fiscal Year: 2005....
- Cell Death in Normal and Diseased Human EpidermisBrian Nickoloff; Fiscal Year: 2006..abstract_text> ..
- IMMUNOPATHOGENESIS OF PSORIASISBrian Nickoloff; Fiscal Year: 2007....
- IMMUNOPATHOGENESIS OF PSORIASISBrian Nickoloff; Fiscal Year: 2002..The applicants expect that these studies will enhance our understanding of the causation of psoriasis and provide a basis for developing new and more effective treatments for this common and chronic disease. ..
- IMMUNOPATHOGENESIS OF PSORIASISBrian Nickoloff; Fiscal Year: 2009....