Brian Nickoloff

Summary

Affiliation: Loyola University Medical Center
Country: USA

Publications

  1. ncbi Id-1 delays senescence but does not immortalize keratinocytes
    B J Nickoloff
    Department of Pathology and the Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 275:27501-4. 2000
  2. pmc Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
    Brian J Nickoloff
    Skin Disease Research Laboratory and Cardinal Bernardin Cancer Center, Loyola University of Chicago, Medical Center, Maywood, Illinois 60153, USA
    J Clin Invest 113:1664-75. 2004
  3. ncbi Life and death signaling pathways contributing to skin cancer
    Brian J Nickoloff
    Loyola University Medical Center, Department of Pathology, Skin Cancer Research Laboratory, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
    J Investig Dermatol Symp Proc 7:27-35. 2002
  4. ncbi Notch and NOXA-related pathways in melanoma cells
    Brian J Nickoloff
    Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois 60153 5385, USA
    J Investig Dermatol Symp Proc 10:95-104. 2005
  5. ncbi Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations
    Jian Zhong Qin
    Loyola University Medical Center, Skin Cancer Research Laboratory, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
    Exp Dermatol 11:573-83. 2002
  6. ncbi Keratinocytes regain momentum as instigators of cutaneous inflammation
    Brian J Nickoloff
    Skin Cancer Research Program, Loyola University of Chicago Medical Center, Cardinal Bernardin Cancer Center, 2160 South First Avenue, Building 112, Room 301, Maywood, IL 60153, USA
    Trends Mol Med 12:102-6. 2006
  7. ncbi Cutaneous dendritic cells in the crossfire between innate and adaptive immunity
    Brian J Nickoloff
    Department of Pathology, Skin Cancer Research Laboratories, Cardinal Bernardin Cancer Center, Loyola University of Chicago Medical Center, Building 112, Room 301, 2160 South First Avenue, Maywood, IL 60153, USA
    J Dermatol Sci 29:159-65. 2002
  8. ncbi The cytokine and chemokine network in psoriasis
    Brian J Nickoloff
    Department of Pathology and Skin Disease Research Program, Oncology Institute and Cardinal Bernardin Cancer Center, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
    Clin Dermatol 25:568-73. 2007
  9. ncbi Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
    B J Nickoloff
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 South First Avenue, Building 112, Room 301, Maywood, IL 60153, USA
    Cell Death Differ 9:842-55. 2002
  10. ncbi Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity
    Brian J Nickoloff
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Cancer Res 64:2956-61. 2004

Research Grants

  1. PHENOTYPE AND FUNCTION OF SENESCENT KERATINOCYTES
    Brian Nickoloff; Fiscal Year: 2005
  2. Cell Death in Normal and Diseased Human Epidermis
    Brian Nickoloff; Fiscal Year: 2006
  3. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2007
  4. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2002
  5. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2009

Detail Information

Publications71

  1. ncbi Id-1 delays senescence but does not immortalize keratinocytes
    B J Nickoloff
    Department of Pathology and the Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 275:27501-4. 2000
    ..Thus, while no immortalization was observed, Id-1 could delay the onset of replicative senescence in unselected human keratinocyte populations...
  2. pmc Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
    Brian J Nickoloff
    Skin Disease Research Laboratory and Cardinal Bernardin Cancer Center, Loyola University of Chicago, Medical Center, Maywood, Illinois 60153, USA
    J Clin Invest 113:1664-75. 2004
    ..Such strategic transition from serendipity to the use of novel selective agents aimed at defined targets in psoriatic lesions is moving rapidly from research benches to the bedsides of patients with this chronic and debilitating disease...
  3. ncbi Life and death signaling pathways contributing to skin cancer
    Brian J Nickoloff
    Loyola University Medical Center, Department of Pathology, Skin Cancer Research Laboratory, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
    J Investig Dermatol Symp Proc 7:27-35. 2002
    ....
  4. ncbi Notch and NOXA-related pathways in melanoma cells
    Brian J Nickoloff
    Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois 60153 5385, USA
    J Investig Dermatol Symp Proc 10:95-104. 2005
    ..g. Notch signaling), and anti-cancer agents that achieve tumor selectivity (e.g., GSI-induced NOXA), this experimental approach provides a useful framework for future therapeutic strategies in cutaneous oncology...
  5. ncbi Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations
    Jian Zhong Qin
    Loyola University Medical Center, Skin Cancer Research Laboratory, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
    Exp Dermatol 11:573-83. 2002
    ....
  6. ncbi Keratinocytes regain momentum as instigators of cutaneous inflammation
    Brian J Nickoloff
    Skin Cancer Research Program, Loyola University of Chicago Medical Center, Cardinal Bernardin Cancer Center, 2160 South First Avenue, Building 112, Room 301, Maywood, IL 60153, USA
    Trends Mol Med 12:102-6. 2006
    ....
  7. ncbi Cutaneous dendritic cells in the crossfire between innate and adaptive immunity
    Brian J Nickoloff
    Department of Pathology, Skin Cancer Research Laboratories, Cardinal Bernardin Cancer Center, Loyola University of Chicago Medical Center, Building 112, Room 301, 2160 South First Avenue, Maywood, IL 60153, USA
    J Dermatol Sci 29:159-65. 2002
  8. ncbi The cytokine and chemokine network in psoriasis
    Brian J Nickoloff
    Department of Pathology and Skin Disease Research Program, Oncology Institute and Cardinal Bernardin Cancer Center, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
    Clin Dermatol 25:568-73. 2007
    ..These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions...
  9. ncbi Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
    B J Nickoloff
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 South First Avenue, Building 112, Room 301, Maywood, IL 60153, USA
    Cell Death Differ 9:842-55. 2002
    ..These results indicate that activation of Notch signaling is necessary for maturation of human epidermis, and activation by a soluble Notch ligand is sufficient to trigger complete KC differentiation including cornification...
  10. ncbi Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity
    Brian J Nickoloff
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Cancer Res 64:2956-61. 2004
    ..These findings indicate that senescent KCs exert a paracrine antiangiogenic activity, and maspin is the principal contributor to this potentially tumor-suppressive effect of cellular senescence...
  11. ncbi Lessons learned from psoriatic plaques concerning mechanisms of tissue repair, remodeling, and inflammation
    Brian J Nickoloff
    Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Investig Dermatol Symp Proc 11:16-29. 2006
    ..In summary, many lessons can be learned by focusing on complex processes involved in regulation of inflammation, tissue repair, and remodeling...
  12. ncbi Immunopathogenesis of psoriasis
    Brian J Nickoloff
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Clin Rev Allergy Immunol 33:45-56. 2007
    ....
  13. doi Immunobiology of acute cytotoxic drug reactions
    Brian J Nickoloff
    Department of Pathology, Loyola University Medical Center, Maywood, Chicago, IL 60153 5385, USA
    Curr Dir Autoimmun 10:53-64. 2008
    ..Clearly, many new insights are required at multiple levels of understanding to better manage and perhaps even prevent TENS...
  14. ncbi Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint
    B J Nickoloff
    Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
    J Cutan Pathol 28:57-64. 2001
    ..This paper explores the possible molecular mechanism for the tumor suppressor pathway in psoriatic lesions, with an emphasis on a putative senescence-switch involving p16...
  15. ncbi Characterization of lymphocyte-dependent angiogenesis using a SCID mouse: human skin model of psoriasis
    B J Nickoloff
    Department of Pathology, Skin Cancer Research Laboratories, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Investig Dermatol Symp Proc 5:67-73. 2000
    ....
  16. ncbi Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system
    B J Nickoloff
    Department of Pathology, Loyola University Medical Center, Boston, MA 60153 5385, USA
    J Dermatol Sci 24:212-25. 2000
    ..Thus, this pathogenic cell line provides evidence that T cells bearing NKRs can directly provoke a Th1 disease such as psoriasis...
  17. pmc Targeting TNFalpha rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiation
    Deborah J Marble
    Department of Medicine, Division of Dermatology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, United States
    J Dermatol Sci 48:87-101. 2007
    ..The cytokine network theory for psoriasis postulates a key role for TNFalpha in mediating inflammation and altered epidermal differentiation...
  18. ncbi Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosis
    Jian Zhong Qin
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Cell Physiol 200:155-66. 2004
    ....
  19. ncbi Innate immune-related receptors in normal and psoriatic skin
    Jonathan L Curry
    Department of Pathology, Skin Cancer Research Laboratories, Loyola University Cancer Center, Maywood, IL 60153, USA
    Arch Pathol Lab Med 127:178-86. 2003
    ..Surface receptors, including Toll-like receptors (TLRs) that recognize bacterial ligands and CD91, which recognizes heat shock proteins (HSPs), are implicated in both innate and adaptive immunity...
  20. ncbi Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence
    Hong Xin
    Departments of Pathology and Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4831-40. 2003
    ..Collectively, our observations support the idea that increased levels of IFI 16 in PrECs contribute to senescence-associated irreversible cell growth arrest...
  21. ncbi Knock down of p53 levels in human keratinocytes increases susceptibility to type I and type II interferon-induced apoptosis mediated by a TRAIL dependent pathway
    Vijaya Chaturvedi
    Department of Pathology, Loyola University Medical Center, USA
    J Dermatol Sci 41:31-41. 2006
    ..By contrast, in inflammatory pathological conditions featuring type I (IFN-alpha) and type II (IFN-gamma) interferons KCs undergo premature apoptosis...
  22. ncbi Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes
    Jian Zhong Qin
    Department of Pathology, Loyola University Medical Center, Illinois, USA
    Oncogene 21:2991-3002. 2002
    ..In conclusion, the sensitivity and resistance of KCs to apoptosis depends not only on the location within various layers of epidermis and levels of p53, but may also involve p53 activation via post-translational modifications...
  23. pmc 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo
    Tara M Kroll
    Department of Pathology Oncology Institute, Loyola University, Chicago, Illinois 60153, USA
    J Invest Dermatol 124:798-806. 2005
    ..Stressed melanocytes may mediate DC activation through release of HSP70, and DC effector functions appear to play a previously unappreciated role in progressive vitiligo...
  24. ncbi Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA
    Jian Zhong Qin
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Cancer Res 66:9636-45. 2006
    ....
  25. pmc Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes
    Vijaya Chaturvedi
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Am J Pathol 162:161-70. 2003
    ....
  26. ncbi Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma
    Vijaya Chaturvedi
    Department of Pathology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA
    Exp Dermatol 12:255-60. 2003
    ..Thus, dysregulated Id-1 may not only contribute to delaying the senescence program in keratinocytes, it may also contribute to the escape of the relatively undifferentiated tumor cells in BCC from immune surveillance...
  27. ncbi p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas
    Jian Zhong Qin
    Department of Pathology, Loyola University of Chicago Medical Center, Chicago, IL, USA
    Mol Cancer Ther 3:895-902. 2004
    ....
  28. ncbi Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis
    Vijaya Chaturvedi
    Department of Pathology, Oncology Institute, Loyola University Medical Center, Maywood, IL 60153, USA
    Oncogene 24:5299-312. 2005
    ....
  29. ncbi Digital epiluminescence microscopy monitoring of high-risk patients
    June K Robinson
    Department of Medicine, Division of Dermatology, Cardinal Bernardin Cancer Center, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
    Arch Dermatol 140:49-56. 2004
    ..To examine the outcome of digital epiluminescence microscopic (DELM) surveillance of atypical nevi in a high-risk population for 4 years...
  30. pmc Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells
    I Caroline Le Poole
    Department of Pathology, Skin Oncology Research Program, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Bldg 112, Rm 303, 2160 S 1st Ave, Maywood, IL 60153, USA
    Am J Pathol 160:521-8. 2002
    ..Reduced MART-1 expression was frequently observed in adjacent tumor cells. Consequently, IFN-gamma may enhance inflammatory responses yet hamper effective recognition of melanoma cells...
  31. ncbi Graft-versus-host disease of the skin: life and death on the epidermal edge
    Craig C Hofmeister
    Department of Medicine, Division of Hematology Oncology, Loyola University Medical Center Cardinal Bernardin Cancer Center, Maywood, Illinois 60153, USA
    Biol Blood Marrow Transplant 10:366-72. 2004
    ..With new insights designed to better predict and prevent GVHD and novel agents designed to treat GVHD, overcoming this current impediment to successful bone marrow transplantation should become increasingly feasible...
  32. ncbi The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells
    Sanne Weijzen
    Cancer Immunology and Skin Cancer Programs, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    J Immunol 169:4273-8. 2002
    ..These data may have important medical implications, since they provide new reagents to induce DC activity, which may be beneficial as adjuvants in situations where an immune response needs to be elicited, such as tumor immunotherapy...
  33. ncbi Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region
    Lawrence S Stennett
    Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA
    Pigment Cell Res 17:525-32. 2004
    ..The current study provides insight into transcriptional regulation of the PMel17 and CDK2 genes, important to identify strategies for modulating expression of gp100 and CDK2 proteins by melanoma cells...
  34. ncbi Inflammation and cancer: is the link as simple as we think?
    Brian J Nickoloff
    Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Chicago Medical Center, Chicago, Illinois, USA
    J Invest Dermatol 124:x-xiv. 2005
  35. ncbi Defining the caspase-containing apoptotic machinery contributing to cornification in human epidermal equivalents
    Vijaya Chaturvedi
    Department of Pathology, Loyola University Chicago, IL 60153, USA
    Exp Dermatol 15:14-22. 2006
    ..We conclude caspases function as important death effectors strategically positioned at intersection of intrinsic and extrinsic pathways in KCs undergoing stratum corneum formation...
  36. ncbi Reactivity of resident immunocytes in normal and prepsoriatic skin using an ex vivo skin-explant model system
    Jonathan L Curry
    Department of Pathology, Loyola University, Chicago Medical Center, Maywood, IL, USA
    Arch Pathol Lab Med 127:289-96. 2003
    ..Since acute tissue responses to stimuli involve both resident cells and immunocytes recruited rapidly from circulation, it is difficult to discern the contribution of endogenous cells normally present in skin...
  37. ncbi Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells
    Jian Zhong Qin
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153 5385, USA
    Cancer Res 65:6282-93. 2005
    ....
  38. ncbi Alefacept in corticosteroid refractory graft versus host disease: early results indicate promising activity
    Amir A Toor
    Bone Marrow Transplantation Program, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA
    J Dermatolog Treat 18:13-8. 2007
    ..The pathological and immunohistochemical findings of GVHD also improved, validating our clinical impression. These preliminary findings indicate that alefacept may have beneficial activity in GVHD warranting further study...
  39. doi Inhibition of PAX3 by TGF-beta modulates melanocyte viability
    Guang Yang
    Department of Medical Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 32:554-63. 2008
    ....
  40. ncbi Topical and light-based treatments for basal cell carcinoma
    June K Robinson
    Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
    Semin Cutan Med Surg 22:171-6. 2003
    ..It is hoped that further developments of the class of drugs will produce an agent with fewer side effects and improved efficacy for nodular BCC...
  41. ncbi Focal adhesion kinase promotes the aggressive melanoma phenotype
    Angela R Hess
    Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Cancer Res 65:9851-60. 2005
    ..Collectively, these data suggest a new mechanism involved in promoting the aggressive melanoma phenotype through FAK-mediated signal transduction pathways, thus providing new insights into possible therapeutic intervention strategies...
  42. ncbi Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells
    Christine L Curry
    Department of Pathology and Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153 5385, USA
    Oncogene 24:6333-44. 2005
    ..The results indicate that KS cells overexpress activated Notch and interruption of Notch signaling inhibits KS cell growth. Thus, targeting Notch signaling may be of therapeutic value in KS patients...
  43. ncbi Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment
    Elisabeth A Seftor
    Children s Memorial Research Center and Robert H Lurie Comprehensive Cancer Center at Northwestern University, Chicago, IL 60614, USA
    Cancer Res 65:10164-9. 2005
    ..This novel approach identifies specific genes involved in the transdifferentiation of melanocytes to a more aggressive phenotype, which may offer significant therapeutic value...
  44. ncbi Estimation of size of clonal unit for keratinocytes in normal human skin
    Vijaya Chaturvedi
    Department of Pathology, Loyola University Medical Center, Maywood, IL, USA
    Arch Pathol Lab Med 126:420-4. 2002
    ..To estimate the territory or surface area covered by a single stem-cell-derived KC population in human skin, clonal skin maps were created from 3 healthy adult women and from normal skin of a psoriatic patient...
  45. ncbi Uncovering histologic criteria with prognostic significance in toxic epidermal necrolysis
    Adam M Quinn
    Departments of Pathology, Surgery, Internal Medicine, and Preventive Medicine and Epidemiology, Loyola University, Maywood, IL 60153, USA
    Arch Dermatol 141:683-7. 2005
    ..To identify histologic criteria and prognostic significance in patients with toxic epidermal necrolysis (TEN), a frequently lethal disease that usually represents an adverse drug reaction...
  46. doi Ecthyma gangrenosum following toxic epidermal necrolysis syndrome in a 3-year-old boy-a survivable series of events
    Christine M Gresik
    Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
    J Burn Care Res 29:555-8. 2008
    ..To our knowledge, this is the first reported case of TENS/EG in the pediatric population, and the first report of survivability following these illnesses...
  47. ncbi Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways
    Mei Shiang Jang
    Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, USA
    J Cell Physiol 199:418-33. 2004
    ..The relevance of these findings to the role of Notch signaling in differentiation and cancer are discussed...
  48. doi Treatment strategies in toxic epidermal necrolysis syndrome: where are we at?
    Gerard J Abood
    Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Burn Care Res 29:269-76. 2008
    ..Given the rare nature of this syndrome, multi-institutional studies will be necessary and essential in improving the understanding and treatment of TENS...
  49. ncbi The helix-loop-helix protein id-1 delays onset of replicative senescence in human endothelial cells
    Jun Tang
    Department of Pathology and Skin Cancer Research Laboratories, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois 60153 5385, USA
    Lab Invest 82:1073-9. 2002
    ..These findings may have implications in the development of endothelial cell-derived tumors...
  50. ncbi Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents
    Brian J Nickoloff
    Department of Pathology, Loyola University, Chicago, USA
    Oncogene 22:6598-608. 2003
    ....
  51. ncbi The skin cancer paradox of psoriasis: a matter of life and death decisions in the epidermis
    Brian J Nickoloff
    Arch Dermatol 140:873-5. 2004
  52. doi 56th annual Montagna Symposium on the Biology of Skin: Epidermal T-cell interactions--clinicopathological and basic mechanisms
    Kevin D Cooper
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA
    J Invest Dermatol 128:1351-3. 2008
  53. ncbi Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determination
    Mary J C Hendrix
    Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242, USA
    Cancer Res 62:665-8. 2002
    ....
  54. pmc Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha
    Onur Boyman
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH 8091, Switzerland
    J Exp Med 199:731-6. 2004
    ..These findings underline the importance of resident immune cells in psoriasis and will have implications for new therapeutic strategies for psoriasis and other T cell-mediated diseases...
  55. ncbi Characterization of tissue specific expression of Notch-1 in human tissues
    Alfonso Baldi
    Department of Biochemistry and Biophysics F Cedrangolo, Section of Pathologic Anatomy, Second University of Naples, Italy
    Biol Cell 96:303-11. 2004
    ....
  56. pmc Deepening our understanding of immune sentinels in the skin
    Frank O Nestle
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London School of Medicine, London, United Kingdom
    J Clin Invest 117:2382-5. 2007
    ..These studies provide the basis for better insight into the role of important immune sentinels contributing to the maintenance of skin tissue homeostasis and lay the foundation for future studies of the skin immune system...
  57. ncbi The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation
    Barbara Bedogni
    Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305, USA
    Cancer Cell 8:443-54. 2005
    ..Taken together, these findings demonstrate that Akt hyperactivation and HIF1alpha induction by normally occurring hypoxia in the skin significantly contribute to melanoma development...
  58. pmc The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
    Samudra K Dissanayake
    Laboratory of Immunology, Gerontology Research Center, NIA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
    J Biol Chem 282:17259-71. 2007
    ..Furthermore, inhibition of PKC before Wnt5A treatment blocked Snail expression, implying that Wnt5A can potentiate melanoma metastasis via the induction of EMT in a PKC-dependent manner...
  59. pmc Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Clin Invest 117:719-29. 2007
    ..Akt thus serves as a molecular switch that increases angiogenesis and the generation of superoxide, fostering more aggressive tumor behavior. Targeting Akt and ROS may be of therapeutic importance in treatment of advanced melanoma...
  60. ncbi Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
    Shigetoshi Sano
    Department of Carcinogenesis, University of Texas, M D Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, PO Box 389, Smithville, Texas 78957, USA
    Nat Med 11:43-9. 2005
    ..Finally, abrogation of Stat3 function by a decoy oligonucleotide inhibits the onset and reverses established psoriatic lesions in K5.Stat3C mice. Thus, targeting Stat3 may be potentially therapeutic in the treatment of psoriasis...
  61. ncbi A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer
    Alfred E Chang
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109 0932, USA
    Clin Cancer Res 8:1021-32. 2002
    ..The objectives of this study were to assess the toxicity and immunological response induced by the intradermal (i.d) administration of tumor lysate-pulsed dendritic cells (DCs)...
  62. ncbi Defining the transcriptome of accelerated and replicatively senescent keratinocytes reveals links to differentiation, interferon signaling, and Notch related pathways
    Ranjan J Perera
    Keck Graduate Institute, Claremont, California, USA
    J Cell Biochem 98:394-408. 2006
    ..Integrating all of the transcriptional data revealed a key role for Notch receptor mediated signaling in the confluency induced differentiation phenotype using this model system...
  63. ncbi What have we learned in dermatology from the biologic therapies?
    Brian J Nickoloff
    J Am Acad Dermatol 54:S143-51. 2006
    ..Here, we review the history of our understanding of inflammatory dermatoses, traditional and new treatment approaches, and future directions for research and therapy in this area...
  64. ncbi Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cells
    Christine L Curry
    Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153 5385, USA
    Lab Invest 86:842-52. 2006
    ..This is the first report, to our knowledge, that JNK signaling can modulate Hes-1 expression in a Notch-independent manner...
  65. ncbi Clonal persistence and evolution during a decade of recurrent melanoma
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Invest Dermatol 126:1372-7. 2006
    ..Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies...
  66. ncbi Senescent human keratinocytes suppress colony formation of HeLa cells
    Patricia Bacon
    J Dermatol Sci 38:64-6. 2005
  67. doi Cross-validation of murine UV signal transduction pathways in human skin
    Janine G Einspahr
    Department of Medicine, University of Arizona, Tucson, AZ, USA
    Photochem Photobiol 84:463-76. 2008
    ..Validation of murine models in human skin will aid in development of effective skin cancer chemoprevention and prevention strategies...
  68. doi Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesis
    Marianna Sabatino
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Warren G Magnuson Clinical Center, Biometrics Research Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892 1184, USA
    Cancer Res 68:122-31. 2008
    ..Our study provides important insights about the dynamics of cancer progression and supports the development of targeted anticancer therapies aimed against stable genetic factors that are maintained throughout the end stage of disease...
  69. ncbi Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness
    Jolanta M Topczewska
    Program in Developmental Biology, Children s Memorial Research Center, Feinberg School of Medicine Northwestern University, 2300 Children s Plaza, Box 222, Chicago Illinois, 60614, USA
    Nat Med 12:925-32. 2006
    ..These data suggest that Nodal signaling has a key role in melanoma cell plasticity and tumorigenicity, thereby providing a previously unknown molecular target for regulating tumor progression...
  70. ncbi Cracking the cytokine code in psoriasis
    Brian J Nickoloff
    Nat Med 13:242-4. 2007
  71. ncbi Proliferating cultured human keratinocytes are more susceptible to apoptosis compared with mouse keratinocytes
    Vijaya Chaturvedi
    J Invest Dermatol 123:1200-3. 2004

Research Grants21

  1. PHENOTYPE AND FUNCTION OF SENESCENT KERATINOCYTES
    Brian Nickoloff; Fiscal Year: 2005
    ....
  2. Cell Death in Normal and Diseased Human Epidermis
    Brian Nickoloff; Fiscal Year: 2006
    ..abstract_text> ..
  3. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2007
    ....
  4. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2002
    ..The applicants expect that these studies will enhance our understanding of the causation of psoriasis and provide a basis for developing new and more effective treatments for this common and chronic disease. ..
  5. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2009
    ....