Amy H Luke

..The prevalence of obesity is higher among populations in industrialized than in developing countries...

..However there are few empirical data to support the assertion that low levels of energy expenditure in activity is a causal factor in the current obesity epidemic are very limited...

..To examine the rate of change across the spectrum of low to high-income countries we compared rates of weight change in samples drawn from three countries, Nigeria, Jamaica and the United States...

..Large surveys now provide new information on this issue...

..These findings initiated much research on race as a primary biological determinant of obesity and energy expenditure as a potential pathway. Race is a difficult construct to use in biomedical research...

..In conclusion these data suggest that habitual levels of physical activity may have a generalizable relationship with BP in populations with widely different social and environmental characteristics...

..The interrelationship of REE with sympathetic tone, transmembrane ion exchange, or other metabolic processes that determine energy costs at rest could provide physiological explanations for this observation...

..The multiple replications of linkage evidence in the region on 3q27 strongly confirm its potential importance as a candidate region in the search for obesity-related genes...

..We sought to determine the relationship between activity energy expenditure (AEE), adiposity and weight change in an adult population undergoing rapid socio-economic transition...

..The relation between variation in interindividual levels of energy expenditure and weight gain remains controversial...

..The aims of the current study were to investigate the associations between objectively measured PA and cardiovascular disease risk factors and obesity...

..Evidence of the importance of energy expenditure in adult weight change has been limited to studies conducted in Pima Indians, in whom resting energy expenditure (REE) was found to be inversely associated with weight gain...

..NHB adolescents had significantly lower %BF for BMI and MA had higher than NHW. Our results indicate that BMI may not be an equivalent measure of %BF in a multi-ethnic population of US adolescents...

..We sought to assess the relative importance of resting energy expenditure (REE) and activity EE (AEE) in two populations with different rates of obesity...

..To evaluate the association of angiotensinogen (AGT) gene with AGT level and hypertension based on the overall genetic variation of the AGT gene in among African-Americans...

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..These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans...

..We determined racial differences in urinary incontinence prevalence using the 2001-2004 National Health and Nutrition Examination Survey...

..The replication of linkage evidence using different ethnic groups reinforces the potential significance of this latter candidate region...

..Body composition data are presented by gender and age group. BIA was validated for use among Nigerian children and adults and provides a potentially important tool for research...

..As a result of the survival advantage associated with obesity and decreased likelihood for transplantation, these trends most likely will influence the total number of patients who receive dialysis in the next decade...

..Study designs that make it possible to confirm these results with association analysis and narrow the genomic interval are needed in order to make progress in this field...

..In our earlier genome-wide linkage study for BP in this population, strong linkage evidence was noted on chromosomes 6 and 7...

..The aim of this study was to examine trends in average body mass index (BMI), waist circumference, and obesity prevalence among adults with and without Type 2 diabetes...

..These findings have implications for candidate-gene association studies and indicate that variation between populations of European and African origin in haplotype diversity is characteristic of most genes...

..Sugar-sweetened soda is a primary source of fructose. We therefore hypothesized that sugary soda consumption was associated with albuminuria, a sensitive marker for kidney disease...

..9 vs. 64.9+/-24.7 kJ x kg(-1) x d(-1); PAL, 1.40+/-0.12 vs. 1.57+/-0.18; P <0.005). Results suggest that these MA girls were expending less energy than EA children of comparable body size due to a reduced activity energy expenditure...

..However, epidemiological data supporting an association between overweight and obesity and risk for CKD currently are limited...

..These data suggest that ACE gene polymorphisms may influence the development of weight gain...

..Obesity is the number one preventable risk factor for chronic kidney disease. Obesity is, however, associated with improved survival in patients with end-stage renal disease (ESRD)...

..The objectives were to identify quantitative trait loci linked to serum adiponectin concentration and to estimate heritability in two populations of African descent...

..Our study confirms in an additional trait that rare variants can influence the distribution of complex traits; whether these variants can be captured by common SNPs or haplotypes requires further investigation...

..3) with a likelihood of odds of 2.96 (p = 0.08). Linkage evidence (likelihood of odds > 1) was detected on another three chromosomal regions, namely 2q12.1, 8q21.2, and 15p11.2...

..Thus, in this biracial population sample, we find evidence that interindividual variation in the renin-angiotensin system genes contributes to hypertension risk...

..There is an assumption that people in developing countries have a higher total energy expenditure (TEE) and physical activity level (PAL) than do people in developed nations, but few objective data for this assertion exist...

..46), which has been reported in two previous studies. Suggestive linkage (LOD>1) was found in another six regions in our combined analysis. Evidence for linkage for two of these regions (2p12, 20p11) has also been reported previously...

..This study was undertaken to provide estimates of heritability for four blood pressure phenotypes: systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure...

..The proposed study will not use an ecologic design, since conclusions will be based relationships defined among individuals, not the comparison of group means. ..

..To date, however, measurement of physical activity has been very crude. We propose to conduct a large international study to define the impact of daily activity level on the risk of weight gain and obesity. ..

..To date, however, measurement of physical activity has been very crude. We propose to conduct a large international study to define the impact of daily activity level on the risk of weight gain and obesity. ..