R Cooper

Summary

Affiliation: Loyola University Chicago
Country: USA

Publications

  1. ncbi request reprint The role of genetic and environmental factors in cardiovascular disease in African Americans
    R Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University, Stritch School of Medicine, Maywood, Illinois 60153, USA
    Am J Med Sci 317:208-13. 1999
  2. ncbi request reprint Prevalence of NIDDM among populations of the African diaspora
    R S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    Diabetes Care 20:343-8. 1997
  3. ncbi request reprint Hypertension in blacks
    R Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    Am J Hypertens 10:804-12. 1997
  4. ncbi request reprint Angiotensinogen levels and obesity in four black populations. ICSHIB Investigators
    R Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Hypertens 16:571-5. 1998
  5. ncbi request reprint Hypertension, serum angiotensinogen, and molecular variants of the angiotensinogen gene among Nigerians
    C Rotimi
    Department of Preventive Medicine and Epidemiology, Loyola University, Chicago, Ill, USA
    Circulation 95:2348-50. 1997
  6. ncbi request reprint The distribution and mortality impact of chronic energy deficiency among adult Nigerian men and women
    C Rotimi
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
    Eur J Clin Nutr 53:734-9. 1999
  7. ncbi request reprint Psychosocial correlates of chest pain among African-American women
    S G Fisher
    Department of Preventive Medicine and Epidemiology, Loyola University Chicago, Maywood, IL, USA
    Women Health 24:19-35. 1996
  8. ncbi request reprint An association study of angiotensinogen polymorphisms with serum level and hypertension in an African-American population
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Hypertens 21:1847-52. 2003
  9. pmc An international comparative study of blood pressure in populations of European vs. African descent
    Richard S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL, USA
    BMC Med 3:2. 2005
  10. ncbi request reprint Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Obesity, Metabolic Syndrome, and Hypertension Writing Group
    Sidney C Smith
    Circulation 111:e134-9. 2005

Collaborators

Detail Information

Publications62

  1. ncbi request reprint The role of genetic and environmental factors in cardiovascular disease in African Americans
    R Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University, Stritch School of Medicine, Maywood, Illinois 60153, USA
    Am J Med Sci 317:208-13. 1999
    ....
  2. ncbi request reprint Prevalence of NIDDM among populations of the African diaspora
    R S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    Diabetes Care 20:343-8. 1997
    ..K. Increases in risk have likewise been observed in the island nations of the Caribbean and in urban West Africa. To date, however, no systematic comparison of the geographic variation of NIDDM among black populations has been undertaken...
  3. ncbi request reprint Hypertension in blacks
    R Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    Am J Hypertens 10:804-12. 1997
    ..In the absence of evidence to support the hypothesis, it is perhaps surprising that credence continues to be given to the notion of black exceptionalism. Am J..
  4. ncbi request reprint Angiotensinogen levels and obesity in four black populations. ICSHIB Investigators
    R Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Hypertens 16:571-5. 1998
    ..Recent findings related to the association between hypertension and polymorphisms of the angiotensinogen gene have generated new interest in this potential pathway to hypertension...
  5. ncbi request reprint Hypertension, serum angiotensinogen, and molecular variants of the angiotensinogen gene among Nigerians
    C Rotimi
    Department of Preventive Medicine and Epidemiology, Loyola University, Chicago, Ill, USA
    Circulation 95:2348-50. 1997
    ..We evaluated the association among the M235T and T174M variants of the angiotensinogen (AGT) gene, plasma AGT, and hypertension status in a sample of Nigerians...
  6. ncbi request reprint The distribution and mortality impact of chronic energy deficiency among adult Nigerian men and women
    C Rotimi
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA
    Eur J Clin Nutr 53:734-9. 1999
    ..To determine the prevalence of chronic energy deficiency (CED) and associated mortality risk in a cohort of adult Nigerians followed from 1992 to 1997...
  7. ncbi request reprint Psychosocial correlates of chest pain among African-American women
    S G Fisher
    Department of Preventive Medicine and Epidemiology, Loyola University Chicago, Maywood, IL, USA
    Women Health 24:19-35. 1996
    ..These results confirm the high rates of chest pain experienced among black women, and provide insight into the role of psychological factors that should be considered in the identification of treatment options...
  8. ncbi request reprint An association study of angiotensinogen polymorphisms with serum level and hypertension in an African-American population
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Hypertens 21:1847-52. 2003
    ..To evaluate the association of angiotensinogen (AGT) gene with AGT level and hypertension based on the overall genetic variation of the AGT gene in among African-Americans...
  9. pmc An international comparative study of blood pressure in populations of European vs. African descent
    Richard S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL, USA
    BMC Med 3:2. 2005
    ..Large surveys now provide new information on this issue...
  10. ncbi request reprint Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Obesity, Metabolic Syndrome, and Hypertension Writing Group
    Sidney C Smith
    Circulation 111:e134-9. 2005
  11. ncbi request reprint Genetic effects on blood pressure localized to chromosomes 6 and 7
    Adebowale Adeyemo
    Department of Pediatrics Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Hypertens 23:1367-73. 2005
    ..To identify quantitative trait loci (QTL) contributing to the variation in blood pressure in a west African population...
  12. ncbi request reprint Ethnicity, education, and blood pressure in Cuba
    Pedro Ordunez
    Department of Public Health, Faculty of Medical Sciences, University Hospital Dr Gustavo Aldereguía Lima, Cienfuegos, Cuba
    Am J Epidemiol 162:49-56. 2005
    ....
  13. ncbi request reprint Meta-analysis of genome-wide scans for blood pressure in African American and Nigerian samples. The National Heart, Lung, and Blood Institute GeneLink Project
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Hypertens 19:270-4. 2006
    ..However, the combined linkage evidence across several studies can be synthesized using meta-analysis with the aim of providing more definitive support of linkage...
  14. pmc Voluntary participation and informed consent to international genetic research
    Patricia A Marshall
    Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4976, USA
    Am J Public Health 96:1989-95. 2006
    ..We compared voluntary participation and comprehension of informed consent among individuals of African ancestry enrolled in similarly designed genetic studies of hypertension in the United States and Nigeria...
  15. ncbi request reprint A genome-wide scan of loci linked to serum adiponectin in two populations of African descent
    Chindo Hicks
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 1219 Roosevelt Road, Maywood, IL 60153, USA
    Obesity (Silver Spring) 15:1207-14. 2007
    ..The objectives were to identify quantitative trait loci linked to serum adiponectin concentration and to estimate heritability in two populations of African descent...
  16. pmc Body size and blood pressure: an analysis of Africans and the African diaspora
    Francesco P Cappuccio
    Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
    Epidemiology 19:38-46. 2008
    ..Blood pressure is directly and causally associated with body mass index (BMI) in populations worldwide. However, the relationship may vary across BMI in populations of African origin...
  17. ncbi request reprint A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans
    Bonnie A Thiel
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Hypertens 16:151-3. 2003
    ..0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large...
  18. ncbi request reprint A genome-wide scan for obesity in African-Americans
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA
    Diabetes 51:541-4. 2002
    ..The replication of linkage evidence using different ethnic groups reinforces the potential significance of this latter candidate region...
  19. ncbi request reprint Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19
    Richard S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola Medical School, Maywood, Ill 60153, USA
    Hypertension 40:629-33. 2002
    ..Study designs that make it possible to confirm these results with association analysis and narrow the genomic interval are needed in order to make progress in this field...
  20. pmc A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Hum Genet 70:1247-56. 2002
    ....
  21. ncbi request reprint Activity energy expenditure and adiposity among black adults in Nigeria and the United States
    Amy Luke
    Department of Preventive Medicine and Epidemiology, Loyola University School of Medicine, Maywood, IL 60153, USA
    Am J Clin Nutr 75:1045-50. 2002
    ..The prevalence of obesity is higher among populations in industrialized than in developing countries...
  22. ncbi request reprint Hypertension detection and control: population and policy implications
    Richard S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Medical School, 2160 S First Ave, Maywood, IL 60153, USA
    Cardiol Clin 20:187-94. 2002
    ..Improvement in information technology, including an electronic medical record and on-line risk equations, will also be required before its full value can be realized...
  23. doi request reprint Neighborhood characteristics and hypertension
    Mahasin S Mujahid
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48104, USA
    Epidemiology 19:590-8. 2008
    ..The goal of this study was to investigate cross-sectional associations between features of neighborhoods and hypertension and to examine the sensitivity of results to various methods of estimating neighborhood conditions...
  24. pmc Multiple genes for essential-hypertension susceptibility on chromosome 1q
    YEN PEI CHRISTY CHANG
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 80:253-64. 2007
    ..Because the associated alleles in these genes are relatively common (frequency >5%), these three genes are important contributors to elevated BP in the population at large...
  25. ncbi request reprint RE: Hirsch C, Anderson ML, Newman A, Kop W, Jackson S, Gottdiener J, et al, for the Cardiovascular Health Study Research Group. The association of race with frailty: The Cardiovascular Health Study. Ann Epidemiol. 2006;16:545-553
    Jay S Kaufman
    Ann Epidemiol 17:157-8. 2007
  26. ncbi request reprint Heritability of blood pressure in Nigerian families
    Adebowale A Adeyemo
    College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Hypertens 20:859-63. 2002
    ..This study was undertaken to provide estimates of heritability for four blood pressure phenotypes: systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure...
  27. ncbi request reprint Isoprostanes, a marker of lipid peroxidation, may not be involved in the development of glucose intolerance
    Michael S Boyne
    Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica
    Diabetes Res Clin Pract 76:149-51. 2007
    ..Isoprostanes were not significantly associated with IS or BCF (p-values>0.1). We concluded that isoprostanes may not be causally involved in the development of glucose intolerance, insulin resistance or deteriorating BCF...
  28. ncbi request reprint Success in control of hypertension in a low-resource setting: the Cuban experience
    Pedro Orduñez-García
    Hospital Universitario Dr Gustavo Aldereguía Lima, Cienfuegos, Cuba
    J Hypertens 24:845-9. 2006
    ..Cuba has a well-organized primary-care system and has made reduction of cardiovascular diseases a priority, particularly through detection and treatment of hypertension...
  29. ncbi request reprint The feasibility of implementing a dietary sodium reduction intervention among free-living normotensive individuals in south west Nigeria
    Adebowale A Adeyemo
    College of Medicine, University of Ibadan, Nigeria
    Ethn Dis 12:207-12. 2002
    ....
  30. ncbi request reprint Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload
    J Eduardo Rame
    Division of Cardiology, University of California San Francisco, USA
    Hypertension 49:857-64. 2007
    ..These data suggest that the corin I555(P568) allele represents a cardiac hypertrophy-sensitizing genetic locus in systemic hypertension...
  31. ncbi request reprint Using public health indicators to measure the success of hypertension control
    Richard S Cooper
    Hypertension 49:773-4. 2007
  32. ncbi request reprint Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men
    Catarina D Campbell
    Program in Genomics and Division of Endocrinology, Children s Hospital, Boston, Massachusetts 021115, USA
    Diabetes 56:1460-7. 2007
    ..73 x 10(-4), OR = 1.36) and not in women. Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men...
  33. doi request reprint Blacks and whites have a similar prevalence of reduced left ventricular ejection fraction in the general population: the Dallas Heart Study (DHS)
    David W Markham
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Am Heart J 155:876-82. 2008
    ..Because of the higher prevalence of risk factors for heart failure in blacks, including hypertension, obesity, and LV hypertrophy, we hypothesized that LV dysfunction would also be more common in this ethnic group...
  34. pmc Rapid increases in obesity in Jamaica, compared to Nigeria and the United States
    Ramon A Durazo-Arvizu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, IL, USA
    BMC Public Health 8:133. 2008
    ..To examine the rate of change across the spectrum of low to high-income countries we compared rates of weight change in samples drawn from three countries, Nigeria, Jamaica and the United States...
  35. pmc Obesity reduction and its possible consequences: what can we learn from Cuba's Special Period?
    Manuel Franco
    Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    CMAJ 178:1032-4. 2008
  36. doi request reprint Risk factors associated with uncontrolled hypertension: findings from the baseline CARMEN survey in Cienfuegos, Cuba
    Pedro Ordunez
    Hospital Universitario Dr Gustavo Aldereguía Lima, Cienfuegos, Cuba
    J Hypertens 26:663-71. 2008
    ..The probability of having inadequate control varies widely in the population and better understanding of the factors responsible could help to focus treatment strategies...
  37. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  38. pmc Admixture mapping provides evidence of association of the VNN1 gene with hypertension
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 2:e1244. 2007
    ..Despite these encouraging results, susceptibility loci for hypertension have been exceptionally difficult to localize and confirmation by independent studies will be necessary to establish these findings...
  39. pmc Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
    ..These changes could have a significant impact on the risk of obesity-related morbidity in the general population...
  40. pmc An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension
    Gen Wen
    Department of Medicine, Moores UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Hum Mol Genet 16:1752-64. 2007
    ..These results identify a common regulatory variation in SCG2 and implicate granin gene expression in the control of human blood pressure and susceptibility to hypertension...
  41. ncbi request reprint An updated meta-analysis of genome scans for hypertension and blood pressure in the NHLBI Family Blood Pressure Program (FBPP)
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola University Chicago Medical Center, 2160 S First Avenue, Maywood, IL 60153, USA
    Am J Hypertens 19:122-7. 2006
    ..Strong evidence for linkage at two of these regions, 2p14 and 3p14.1, have also been published in previous meta-analyses, making them good candidate locations for susceptibility variants...
  42. ncbi request reprint Epithelial sodium channel allele T594M is not associated with blood pressure or blood pressure response to amiloride
    John M Hollier
    Division of Hypertension, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
    Hypertension 47:428-33. 2006
    ..8). We conclude that the T594M allele does not contribute significantly to BP in blacks and does not predict a significantly superior response to amiloride therapy...
  43. ncbi request reprint Positional identification of hypertension susceptibility genes on chromosome 2
    Ruth Ann Barkley
    Human Genetics Center and Institute of Molecular Medicine, of Texas Health Science Center at Houston, USA
    Hypertension 43:477-82. 2004
    ..Moreover, the present study validates previous evidence for one or more genes on chromosome 2 that influence hypertension-related phenotypes in the population-at-large...
  44. ncbi request reprint Hypertension treatment and control in five European countries, Canada, and the United States
    Katharina Wolf-Maier
    Department of Preventive Medicine and Epidemiology, Stritch School of Medicine, Loyola University, 2160 S First Ave, Maywood, Ill 60153, USA
    Hypertension 43:10-7. 2004
    ..Low treatment and control rates in Europe, combined with a higher prevalence of hypertension, could contribute to a higher burden of cardiovascular disease risk attributable to elevated blood pressure compared with that in North America...
  45. ncbi request reprint Task force #1--magnitude of the prevention problem: opportunities and challenges. 33rd Bethesda Conference
    Emelia J Benjamin
    Boston University School of Medicine, The Framingham Heart Study, MA 01702 5827, USA
    J Am Coll Cardiol 40:588-603. 2002
  46. ncbi request reprint High blood pressure: the foundation for epidemic cardiovascular disease in African populations
    Richard S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    Ethn Dis 13:S48-52. 2003
    ..It will be critical to obtain investments in improved surveillance and program-relevant research to provide the evidence base for policy development and effective hypertension prevention and control...
  47. ncbi request reprint Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States
    Katharina Wolf-Maier
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
    JAMA 289:2363-9. 2003
    ..Geographic variations in cardiovascular disease (CVD) and associated risk factors have been recognized worldwide. However, little attention has been directed to potential differences in hypertension between Europe and North America...
  48. ncbi request reprint Combined analysis of genomewide scans for adult height: results from the NHLBI Family Blood Pressure Program
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA
    Eur J Hum Genet 11:271-4. 2003
    ..46), which has been reported in two previous studies. Suggestive linkage (LOD>1) was found in another six regions in our combined analysis. Evidence for linkage for two of these regions (2p12, 20p11) has also been reported previously...
  49. pmc Linkage disequilibrium and haplotype diversity in the genes of the renin-angiotensin system: findings from the family blood pressure program
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Maywood, Illinois 60153, USA
    Genome Res 13:173-81. 2003
    ..These findings have implications for candidate-gene association studies and indicate that variation between populations of European and African origin in haplotype diversity is characteristic of most genes...
  50. ncbi request reprint A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program
    Michael A Province
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hypertens 16:144-7. 2003
    ..The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives)...
  51. ncbi request reprint Association between blood pressure and resting energy expenditure independent of body size
    Amy Luke
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA
    Hypertension 43:555-60. 2004
    ..The interrelationship of REE with sympathetic tone, transmembrane ion exchange, or other metabolic processes that determine energy costs at rest could provide physiological explanations for this observation...
  52. ncbi request reprint Angiotensin I-converting enzyme polymorphisms, ACE level and blood pressure among Nigerians, Jamaicans and African-Americans
    Nourdine Bouzekri
    Department of Biological Anthropology, University of Oxford, Oxford, UK
    Eur J Hum Genet 12:460-8. 2004
    ..We did observe, however, that the overtransmitted haplotypes among hypertensives were drawn from a single clade, suggesting that susceptibility may cluster in patterns not captured directly by our markers...
  53. ncbi request reprint A genome scan among Nigerians linking resting energy expenditure to chromosome 16
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola Medical School, Maywood, Illinois 60153, USA
    Obes Res 12:577-81. 2004
    ..3) with a likelihood of odds of 2.96 (p = 0.08). Linkage evidence (likelihood of odds > 1) was detected on another three chromosomal regions, namely 2q12.1, 8q21.2, and 15p11.2...
  54. ncbi request reprint Should ethnicity serve as the basis for clinical trial design? Diversity and inclusiveness should remain the guiding principles for clinical trials
    Richard S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Maywood, IL 60153, USA
    Circulation 112:3660-5; discussion 3665-6. 2005
  55. ncbi request reprint Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension
    Daniel L Dries
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas at Southwestern Medical Center, Dallas, USA
    Circulation 112:2403-10. 2005
    ..The natriuretic peptide system contributes to blood pressure regulation. Atrial and brain natriuretic peptides are cleaved into smaller biologically active molecules by corin, a transmembrane serine protease expressed in cardiomyocytes...
  56. ncbi request reprint Efficacy of angiotensin-converting enzyme inhibition in reducing progression from asymptomatic left ventricular dysfunction to symptomatic heart failure in black and white patients
    Daniel L Dries
    Heart Failure Research Group, Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9034, USA
    J Am Coll Cardiol 40:311-7. 2002
    ..This study was undertaken to determine whether enalapril had comparable efficacy in black and white patients with asymptomatic left ventricular dysfunction (ALVD) in preventing the development of symptomatic heart failure (HF)...
  57. ncbi request reprint Left ventricular hypertrophy is more prevalent in blacks than whites in the general population: the Dallas Heart Study
    Mark H Drazner
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Hypertension 46:124-9. 2005
    ..The ethnic differences in left ventricular mass are independent of differences in body composition...
  58. ncbi request reprint Isosorbide dinitrate and hydralazine in blacks with heart failure
    Andrew E Moran
    N Engl J Med 352:1041-3; author reply 1041-3. 2005
  59. ncbi request reprint Admixture mapping for hypertension loci with genome-scan markers
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S First Ave, Maywood, Illinois 60153, USA
    Nat Genet 37:177-81. 2005
    ..These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans...
  60. ncbi request reprint Predicting incident diabetes in Jamaica: the role of anthropometry
    Lincoln A Sargeant
    Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica
    Obes Res 10:792-8. 2002
    ..To evaluate the performance of the body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), and waist-to-height ratio (WHTR) in predicting incident diabetes in Jamaica...
  61. ncbi request reprint Association between evolutionary history of angiotensinogen haplotypes and plasma levels
    Laura Fejerman
    Department of Biological Anthropology, Oxford University, Oxford, UK
    Hum Genet 115:310-8. 2004
    ..A significant linear correlation was detected between haplogroup genetic distance and AGT levels, suggesting a nonrandom accumulation of risk-associated mutations during the evolutionary history of the AGT gene...
  62. ncbi request reprint Linkage disequilibrium analysis of the renin-angiotensin system genes
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, 2160 S First Ave, Maywood, IL 60153, USA
    Curr Hypertens Rep 5:40-6. 2003
    ..In this review, the linkage disequilibrium among the polymorphisms within the four RAS genes and current association analyses involving the RAS are discussed, as well as some of the gaps of knowledge and possible solutions...