Michael A Collins

Summary

Affiliation: Loyola University Medical Center
Country: USA

Publications

  1. ncbi Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures
    Michael A Collins
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA
    Neurotox Res 23:105-10. 2013
  2. ncbi Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity
    Michael A Collins
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Front Biosci (Elite Ed) 4:1358-67. 2012
  3. ncbi Neuroinflammatory pathways in binge alcohol-induced neuronal degeneration: oxidative stress cascade involving aquaporin, brain edema, and phospholipase A2 activation
    Michael A Collins
    Department of Molecular Pharmacology and Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    Neurotox Res 21:70-8. 2012
  4. ncbi Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms
    Michael A Collins
    Biochemistry Division, Department of Pharmacology, Loyola University Medical School, Maywood, IL 60153, USA
    Mol Neurobiol 41:420-5. 2010
  5. ncbi Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies
    Michael A Collins
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Chicago Stritch School of Medicine, 2160 S 1st Avenue, Maywood, IL 60153, USA
    Alcohol Clin Exp Res 33:206-19. 2009
  6. ncbi Tetrahydropapaveroline in Parkinson's disease and alcoholism: a look back in honor of Merton Sandler
    Michael A Collins
    Biochemistry Division of the Department of Cell Biology and Neurobiology, Loyola University Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Neurotoxicology 25:117-20. 2004
  7. ncbi Potential neurotoxic "agents provocateurs" in Parkinson's disease
    Michael A Collins
    Department of Cell Biology, Neurobiology, and Anatomy, Division of Biochemistry, Loyola University School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Neurotoxicol Teratol 24:571-7. 2002
  8. ncbi Alkaloids, alcohol and Parkinson's disease
    Michael A Collins
    Department of Cell Biology, Neurobiology and Anatomy, Division of Biochemistry, Stritch School of Medicine, Loyola University, 2160 South First Avenue, Maywood, IL 60153, USA
    Parkinsonism Relat Disord 8:417-22. 2002
  9. ncbi Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteins
    Sreevidya Sivaswamy
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Eur J Neurosci 32:1800-12. 2010
  10. ncbi Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro
    Robert M Mitchell
    Department of Pharmacology, Division of Biochemistry, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Neurochem 111:580-8. 2009

Research Grants

  1. HIV-1 protein neurotoxicity and ethanol pre-conditioning
    Michael Collins; Fiscal Year: 2006

Collaborators

Detail Information

Publications17

  1. ncbi Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures
    Michael A Collins
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA
    Neurotox Res 23:105-10. 2013
    ....
  2. ncbi Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity
    Michael A Collins
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Front Biosci (Elite Ed) 4:1358-67. 2012
    ....
  3. ncbi Neuroinflammatory pathways in binge alcohol-induced neuronal degeneration: oxidative stress cascade involving aquaporin, brain edema, and phospholipase A2 activation
    Michael A Collins
    Department of Molecular Pharmacology and Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    Neurotox Res 21:70-8. 2012
    ..We present the argument that such neuroimmune activation could be associated with or even dependent on increased aquaporin-4 and glial swelling as well...
  4. ncbi Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms
    Michael A Collins
    Biochemistry Division, Department of Pharmacology, Loyola University Medical School, Maywood, IL 60153, USA
    Mol Neurobiol 41:420-5. 2010
    ....
  5. ncbi Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies
    Michael A Collins
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Chicago Stritch School of Medicine, 2160 S 1st Avenue, Maywood, IL 60153, USA
    Alcohol Clin Exp Res 33:206-19. 2009
    ..Thus to a certain extent, moderate alcohol exposure appears to trigger analogous mild stress-associated, anti-inflammatory mechanisms in the heart, vasculature, and brain that tend to promote cellular survival pathways...
  6. ncbi Tetrahydropapaveroline in Parkinson's disease and alcoholism: a look back in honor of Merton Sandler
    Michael A Collins
    Biochemistry Division of the Department of Cell Biology and Neurobiology, Loyola University Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Neurotoxicology 25:117-20. 2004
    ..As reviewed here, that study provided the groundwork for and indeed stimulated many later investigations of mammalian alkaloids in numerous laboratories around the world...
  7. ncbi Potential neurotoxic "agents provocateurs" in Parkinson's disease
    Michael A Collins
    Department of Cell Biology, Neurobiology, and Anatomy, Division of Biochemistry, Loyola University School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Neurotoxicol Teratol 24:571-7. 2002
    ....
  8. ncbi Alkaloids, alcohol and Parkinson's disease
    Michael A Collins
    Department of Cell Biology, Neurobiology and Anatomy, Division of Biochemistry, Stritch School of Medicine, Loyola University, 2160 South First Avenue, Maywood, IL 60153, USA
    Parkinsonism Relat Disord 8:417-22. 2002
    ..In that regard, specific arguments for N-methylated 'MPP(+)-like' cationic alkaloids that can be generated centrally from beta-carbolines derived from the environment and diet are summarized...
  9. ncbi Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteins
    Sreevidya Sivaswamy
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Eur J Neurosci 32:1800-12. 2010
    ....
  10. ncbi Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro
    Robert M Mitchell
    Department of Pharmacology, Division of Biochemistry, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Neurochem 111:580-8. 2009
    ..The results indicate that ethanol preconditioning-dependent neuroprotection is associated with early increases in NR subunits concomitant with enhancement of synaptic localization and activity of NMDAR...
  11. ncbi Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA)
    James Brown
    Department of Cell Biology, Neurobiology and Anatomy, Loyola University Stritch School of Medicine, 2160 S First Avenue, Maywood, IL 60153, USA
    Neurochem Res 34:260-7. 2009
    ..g., oxidative stress); however, other DHA mechanisms could be important in subdueing ethanol-induced PLA2-dependent and independent neuroinflammatory processes...
  12. ncbi Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by moderate ethanol preconditioning
    Abdelhak Belmadani
    Division of Biochemistry, Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA
    Neuroreport 15:2093-6. 2004
    ..Our results suggest possible molecular mechanisms underlying the protective effect of moderate drinking against Alzheimer's dementia...
  13. ncbi Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation
    Nuzhath F Tajuddin
    Department of Molecular Pharmacology and Therapeutics, Stritch School of Medicine, Loyola University Chicago, 2160 S First Avenue, Maywood, IL 60153, USA
    Alcohol 47:39-45. 2013
    ..The data provide insights into mechanisms of binge ethanol abuse that might suggest new therapeutic approaches to counter neurodegeneration and dementia...
  14. ncbi Moderate alcohol consumption and cognitive risk
    Edward J Neafsey
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA
    Neuropsychiatr Dis Treat 7:465-84. 2011
    ..Overall, light to moderate drinking does not appear to impair cognition in younger subjects and actually seems to reduce the risk of dementia and cognitive decline in older subjects...
  15. ncbi Alcohol-induced neurodegeneration: when, where and why?
    Fulton T Crews
    University at Buffalo, SUNY, NY, USA
    Alcohol Clin Exp Res 28:350-64. 2004
    ..Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal...
  16. ncbi Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake
    Alexander Storch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurochem 89:685-94. 2004
    ..Our data suggest that DAT-mediated cellular uptake of 2[N]-methylated betaCs represents a potential mechanism for selective toxicity towards dopaminergic neurons and may be relevant for the pathogenesis of Parkinson's disease...
  17. ncbi Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease
    Debra A Gearhart
    Department of Cellular Biology and Anatomy, Veterans Affairs Medical Center, Medical College of Georgia, Augusta 30912 2000, USA
    Neurochem Int 40:611-20. 2002
    ....

Research Grants4

  1. HIV-1 protein neurotoxicity and ethanol pre-conditioning
    Michael Collins; Fiscal Year: 2006
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