Kathy S Albain

Summary

Affiliation: Loyola University Medical Center
Country: USA

Publications

  1. ncbi request reprint PIONEER: a phase III randomized trial of paclitaxel poliglumex versus paclitaxel in chemotherapy-naive women with advanced-stage non-small-cell lung cancer and performance status of 2
    Kathy S Albain
    Loyola University, Chicago Medical Center, Maywood, IL 60153, USA
    Clin Lung Cancer 7:417-9. 2006
  2. pmc Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, Maywood, IL, USA
    Lancet Oncol 11:55-65. 2010
  3. doi request reprint Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153 5589, USA
    Lancet 374:379-86. 2009
  4. pmc Racial disparities in cancer survival among randomized clinical trials patients of the Southwest Oncology Group
    Kathy S Albain
    Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA
    J Natl Cancer Inst 101:984-92. 2009
  5. doi request reprint Gemcitabine plus Paclitaxel versus Paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, 2160 S First Ave, Maywood, IL 60153, USA
    J Clin Oncol 26:3950-7. 2008
  6. ncbi request reprint Reducing the global breast cancer burden: the importance of patterns of care research
    Kathy S Albain
    Loyola University Chicago Strich School of Medicine, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
    Clin Breast Cancer 6:412-20. 2005
  7. pmc Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a phase 3, open-label, randomised controlled trial
    Kathy S Albain
    Loyola University Stritch School of Medicine, Maywood, IL, USA
    Lancet 374:2055-63. 2009
  8. ncbi request reprint Concurrent cisplatin, etoposide, and chest radiotherapy in pathologic stage IIIB non-small-cell lung cancer: a Southwest Oncology Group phase II study, SWOG 9019
    Kathy S Albain
    Loyola University Stritch School of Medicine, Maywood, IL, USA
    J Clin Oncol 20:3454-60. 2002
  9. doi request reprint Prediction of adjuvant chemotherapy benefit in endocrine responsive, early breast cancer using multigene assays
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Division of Hematology Oncology, Maywood, IL 60153, USA
    Breast 18:S141-5. 2009
  10. ncbi request reprint Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    Mark G Kris
    Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University, New York, NY 10021, USA
    JAMA 290:2149-58. 2003

Detail Information

Publications40

  1. ncbi request reprint PIONEER: a phase III randomized trial of paclitaxel poliglumex versus paclitaxel in chemotherapy-naive women with advanced-stage non-small-cell lung cancer and performance status of 2
    Kathy S Albain
    Loyola University, Chicago Medical Center, Maywood, IL 60153, USA
    Clin Lung Cancer 7:417-9. 2006
  2. pmc Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, Maywood, IL, USA
    Lancet Oncol 11:55-65. 2010
    ....
  3. doi request reprint Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153 5589, USA
    Lancet 374:379-86. 2009
    ..We therefore did this phase III trial to compare concurrent chemotherapy and radiotherapy followed by resection with standard concurrent chemotherapy and definitive radiotherapy without resection...
  4. pmc Racial disparities in cancer survival among randomized clinical trials patients of the Southwest Oncology Group
    Kathy S Albain
    Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA
    J Natl Cancer Inst 101:984-92. 2009
    ..Our objective was to determine whether racial disparities in survival exist among patients enrolled in consecutive trials conducted by the Southwest Oncology Group (SWOG)...
  5. doi request reprint Gemcitabine plus Paclitaxel versus Paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, 2160 S First Ave, Maywood, IL 60153, USA
    J Clin Oncol 26:3950-7. 2008
    ..It was designed as a pivotal study for the approval of G for a breast cancer treatment indication...
  6. ncbi request reprint Reducing the global breast cancer burden: the importance of patterns of care research
    Kathy S Albain
    Loyola University Chicago Strich School of Medicine, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA
    Clin Breast Cancer 6:412-20. 2005
    ..This unique international effort would allow the development of strategies to improve diagnostic and treatment-related standards of care and survival outcomes, thus reducing the breast cancer burden worldwide...
  7. pmc Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a phase 3, open-label, randomised controlled trial
    Kathy S Albain
    Loyola University Stritch School of Medicine, Maywood, IL, USA
    Lancet 374:2055-63. 2009
    ..We assessed the benefit of adding chemotherapy to adjuvant tamoxifen and whether tamoxifen should be given concurrently or after chemotherapy...
  8. ncbi request reprint Concurrent cisplatin, etoposide, and chest radiotherapy in pathologic stage IIIB non-small-cell lung cancer: a Southwest Oncology Group phase II study, SWOG 9019
    Kathy S Albain
    Loyola University Stritch School of Medicine, Maywood, IL, USA
    J Clin Oncol 20:3454-60. 2002
    ....
  9. doi request reprint Prediction of adjuvant chemotherapy benefit in endocrine responsive, early breast cancer using multigene assays
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Division of Hematology Oncology, Maywood, IL 60153, USA
    Breast 18:S141-5. 2009
    ..This literature-based review summarizes these data and provides a perspective on the limitations and clinical utility of these assays...
  10. ncbi request reprint Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    Mark G Kris
    Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University, New York, NY 10021, USA
    JAMA 290:2149-58. 2003
    ....
  11. ncbi request reprint Multimodality therapy for stage III non-small-cell lung cancer
    Daniel Farray
    Loyola University Medical Center, Cardinal Bernardin Cancer Center, 2160 South First Avenue, Maywood, IL 60153 5589, USA
    J Clin Oncol 23:3257-69. 2005
    ..Furthermore, how to incorporate radiation therapy, as well as whether it should be given at all in this subset of patients, are other important issues actively under study in ongoing trials...
  12. ncbi request reprint Phase IIa trial of trastuzumab emtansine with pertuzumab for patients with human epidermal growth factor receptor 2-positive, locally advanced, or metastatic breast cancer
    Kathy D Miller
    Kathy D Miller, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN Reshma L Mahtani, Sylvester Comprehensive Cancer Center, Miami, FL Kathy S Albain, Loyola University Chicago Stritch School of Medicine, Maywood, IL Liang Fang, Glenn Michelson, Genentech, South San Francisco, CA Howard A Burris, Sarah Cannon Research Institute, Nashville, TN Véronique Diéras, Institut Curie, Paris Fabrice Andre, Institut Gustave Roussy, Villejuif, France Nadia Harbeck, Interdisciplinary Breast Cancer, University of Cologne, Cologne Nadia Harbeck, Breast Cancer University of Munich, Germany Luca Gianni, San Raffaele Hospital, Milan Diana Crivellari, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy Sanne L de Haas, F Hoffmann La Roche, Basel, Switzerland
    J Clin Oncol 32:1437-44. 2014
    ..Our phase IIa study characterized the safety and efficacy of two human epidermal growth factor receptor 2 (HER2) -targeted agents, trastuzumab emtansine (T-DM1) and pertuzumab, in patients with HER2-positive metastatic breast cancer (MBC)...
  13. pmc Multicenter, double-blind, placebo-controlled, randomized phase II trial of gemcitabine/cisplatin plus bevacizumab or placebo in patients with malignant mesothelioma
    Hedy L Kindler
    University of Chicago ComprehensiveCancer Center, Chicago, IL, USA
    J Clin Oncol 30:2509-15. 2012
    ..We added the anti-VEGF antibody bevacizumab to gemcitabine/cisplatin in a multicenter, double-blind, placebo-controlled randomized phase II trial in patients with previously untreated, unresectable MM...
  14. doi request reprint Proceedings of the First Global Workshop on Breast Cancer: pathways to the evaluation and clinical development of novel agents for breast cancer
    Kathy S Albain
    Loyola University Medical Center, Maywood, IL
    Clin Breast Cancer 10:421-39. 2010
    ..This summary highlights selected challenges in the current management of breast cancer and discusses expert perspectives, key questions, areas of debate, and future directions...
  15. ncbi request reprint Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation
    Peter Grudzien
    Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA
    Anticancer Res 30:3853-67. 2010
    ..One approach may be targeting signaling pathways, like Notch, that are involved in stem cell self-renewal and survival...
  16. doi request reprint Prevalence of secondary causes of bone loss among breast cancer patients with osteopenia and osteoporosis
    Pauline M Camacho
    Division of Endocrinology and Metabolism, Hematology Oncology Institute, Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
    J Clin Oncol 26:5380-5. 2008
    ..To determine the prevalence of secondary causes of bone loss among patients with breast cancer with osteopenia and osteoporosis...
  17. ncbi request reprint Clinical factors used to support prophylactic mastectomy for a male BRCA2 mutation carrier
    Maryam Guiahi
    Department of Surgery, Cardinal Bernardin, Cancer Center, Loyola University Medical Center, IL 60153, USA
    Surgery 139:704-6. 2006
  18. ncbi request reprint Acute lung injury associated with vinorelbine
    Tawee Tanvetyanon
    Division of Hematology Oncology, and Lung Transplantation Program, Division of Pulmonary and Critical Care Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA
    J Clin Oncol 24:1952-3. 2006
  19. ncbi request reprint Correlation of nipple aspiration and ductal lavage cytology with histopathologic findings for patients before scheduled breast biopsy examination
    Kristine E West
    Department of Surgery, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153, USA
    Am J Surg 191:57-60. 2006
    ..The purpose of this study was to correlate ductal lavage cytologic findings with the corresponding histology...
  20. doi request reprint Prospective multicenter study of the impact of the 21-gene recurrence score assay on medical oncologist and patient adjuvant breast cancer treatment selection
    Shelly S Lo
    Loyola University Medical Center, Cardinal Bernardin Cancer Center, 2160 S First Ave, Maywood, IL 60153, USA
    J Clin Oncol 28:1671-6. 2010
    ..This multicenter study was designed to prospectively examine whether RS affects physician and patient adjuvant treatment selection and satisfaction...
  21. ncbi request reprint Quantification of chemotherapeutic target gene mRNA expression in human breast cancer biopsies: comparison of real-time reverse transcription-PCR vs. relative quantification reverse transcription-PCR utilizing DNA sequencer analysis of PCR products
    Agnes Juhasz
    Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    J Clin Lab Anal 17:184-94. 2003
    ..By allowing the measurement of intratumoral target gene expression, these new methods may prove useful in predicting the clinical utility of gemcitabine- and platinum-containing chemotherapy programs in patients with solid tumors...
  22. ncbi request reprint Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group Study S9504
    David R Gandara
    University of California, Davis Cancer Center, Sacramento, USA
    J Clin Oncol 21:2004-10. 2003
    ..Results were compared with those of the predecessor study (S9019) with identical eligibility, staging criteria, and treatment, excepting docetaxel consolidation...
  23. doi request reprint Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023
    Karen Kelly
    University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Clin Oncol 26:2450-6. 2008
    ..Early clinical studies with gefitinib showed promising efficacy and mild toxicity in patients with advanced non-small-cell lung cancer (NSCLC). Thus, gefitinib was an ideal agent to evaluate in a maintenance setting in stage III disease...
  24. ncbi request reprint The potential role of surgery after induction treatment
    Dominique H Grunenwald
    Thoracic Department, Institut Mutualiste Montsouris, Paris, France
    Semin Radiat Oncol 14:335-9. 2004
    ..Finally, we conclude that mediastinal nodal downstaging after induction therapy significantly improves the survival of patients who are surgically resected after induction...
  25. ncbi request reprint Improving survival and reducing toxicity with chemotherapy in advanced non-small cell lung cancer : a realistic goal?
    Fiona H Blackhall
    Christie Hospital NHS Trust, Manchester, England, United Kingdom
    Treat Respir Med 4:71-84. 2005
    ....
  26. ncbi request reprint Current standards and ongoing controversies in the management of locally advanced non-small cell lung cancer
    Howard West
    Swedish Cancer Institute, Seattle, WA 98104, USA
    Semin Oncol 32:284-92. 2005
    ..While there exists a range of acceptable standard approaches to the treatment of stage III NSCLC, this review will describe several conclusions that have emerged and how they evolved...
  27. ncbi request reprint Gemcitabine in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: a phase II California cancer consortium trial
    Primo N Lara
    University of California Davis Cancer Center, Sacramento, CA 95817, USA
    Clin Lung Cancer 6:102-7. 2004
    ..06). We concluded that salvage gemcitabine in this dose and schedule is safe and tolerable in previously platinum-treated patients with NSCLC...
  28. ncbi request reprint Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancer
    Lori J Pierce
    Southwest Oncology Group, San Antonio, TX, USA
    J Clin Oncol 23:24-9. 2005
    ..An exploratory analysis was undertaken to evaluate the optimal sequencing of TAM and radiotherapy (RT) after breast-conserving surgery...
  29. ncbi request reprint Impact of a peer-delivered telephone intervention for women experiencing a breast cancer recurrence
    Carolyn Cook Gotay
    Cancer Research Center of Hawaii, Honolulu, HI 96822, USA
    J Clin Oncol 25:2093-9. 2007
    ..The Southwest Oncology Group conducted a phase III randomized trial to evaluate the effectiveness of a brief telephone intervention...
  30. ncbi request reprint Adjuvant chemotherapy for lymph node-negative, estrogen receptor-negative breast cancer: a tale of three trials
    Kathy S Albain
    J Natl Cancer Inst 96:1801-4. 2004
  31. ncbi request reprint Time from treatment to subsequent diagnosis of brain metastases in stage III non-small-cell lung cancer: a retrospective review by the Southwest Oncology Group
    Laurie E Gaspar
    MBA, University of Colorado Health Sciences Center, Department of Radiation Oncology, 1665 N Ursula St, Box F 706, Ste 1032, Aurora, CO 80010 0510, USA
    J Clin Oncol 23:2955-61. 2005
    ..CONCLUSION Brain metastases often develop early in the course of treatment for stage IIIA/B NSCLC. The statistical designs of ongoing trials of prophylactic cranial irradiation in stage III NSCLC have taken this into account...
  32. ncbi request reprint The global breast cancer burden: variations in epidemiology and survival
    Gabriel N Hortobagyi
    The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Clin Breast Cancer 6:391-401. 2005
    ..This will aid the development of tailored strategies to improve outcomes in general as well as the standard of care for underserved populations and reduce the burden of breast cancer worldwide...
  33. ncbi request reprint Therapeutic strategies for combined-modality therapy of locally advanced non-small-cell lung cancer: rationale for consolidation docetaxel therapy
    David R Gandara
    Department of Hematology Oncology, University of California Davis Cancer Center, Sacramento, CA 95817 2229, USA
    Clin Lung Cancer 7:S93-7. 2005
    ..Herein, we review the rationale for a treatment paradigm employing consolidation docetaxel therapy after concurrent chemotherapy/RT and the results of recent clinical trials using this approach...
  34. ncbi request reprint American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer
    Bruce E Hillner
    J Clin Oncol 21:4042-57. 2003
    ..To update the 2000 ASCO guidelines on the role of bisphosphonates in women with breast cancer and address the subject of bone health in these women...
  35. ncbi request reprint Long-term survival with concurrent chemoradiation therapy followed by consolidation docetaxel in stage IIIB non-small-cell lung cancer: a phase II Southwest Oncology Group Study (S9504)
    David R Gandara
    University of California, Davis Cancer Center, Sacramento, CA 95817, USA
    Clin Lung Cancer 8:116-21. 2006
    ..Survival outcomes were compared with a predecessor study (S9019) with identical eligibility, staging criteria, and treatment, excepting docetaxel consolidation...
  36. ncbi request reprint Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulator
    Carol J Fabian
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Clin Cancer Res 10:5403-17. 2004
    ..We performed a multi-institutional evaluation of arzoxifene in women with newly diagnosed ductal carcinoma in situ or T1/T2 invasive cancer...
  37. pmc p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy
    Peggy L Porter
    Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Natl Cancer Inst 98:1723-31. 2006
    ..We studied these markers in a clinical trial setting with patients with breast cancer treated by a uniform drug regimen so that treatment was not associated with variability in outcome...
  38. doi request reprint Phase III randomized placebo-controlled trial of two doses of megestrol acetate as treatment for menopausal symptoms in women with breast cancer: Southwest Oncology Group Study 9626
    J Wendall Goodwin
    Cancer Research for the Ozarks, 1730 E Republic Rd, Suite V, Springfield, MO 65804, USA
    J Clin Oncol 26:1650-6. 2008
    ..Prior progestin studies treating hot flashes in women have been short duration and single dose. This study tests the progestin megestrol acetate (MA) at two doses versus placebo over 6 months...
  39. doi request reprint Late cardiac effects of adjuvant chemotherapy in breast cancer survivors treated on Southwest Oncology Group protocol s8897
    Patricia A Ganz
    School of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr South, Room A2 125 CHS, Los Angeles, CA 90095 6900, USA
    J Clin Oncol 26:1223-30. 2008
    ..The late cardiac effects of adjuvant anthracycline therapy in survivors of early-stage breast cancer have had limited study. Subclinical and clinical cardiac late effects may contribute to added comorbidity over time...
  40. ncbi request reprint A phase II study of cisplatin preceded by a 12-h continuous infusion of concurrent hydroxyurea and cytosine arabinoside (Ara-C) for adult patients with malignant gliomas (Southwest Oncology Group S9149)
    Lode J Swinnen
    Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, CRB 2M88, 1650 Orleans Street, Baltimore, MD 21231, USA
    J Neurooncol 86:353-8. 2008
    ..Although benefit might be possible in a more platinum-sensitive tumor type, further clinical trials with this regimen for patients with glioblastoma multiforme or anaplastic astrocytoma are not justified...