J Seagrave

Summary

Affiliation: Lovelace Respiratory Research Institute
Country: USA

Publications

  1. pmc Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
    Respir Res 13:98. 2012
  2. doi request reprint Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Exp Lung Res 37:606-14. 2011
  3. pmc Sulfur mustard vapor effects on differentiated human lung cells
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Inhal Toxicol 22:896-902. 2010
  4. pmc Mechanisms and implications of air pollution particle associations with chemokines
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
    Toxicol Appl Pharmacol 232:469-77. 2008
  5. doi request reprint Oxidative stress, inflammation, and pulmonary function assessment in rats exposed to laboratory-generated pollutant mixtures
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Toxicol Environ Health A 71:1352-62. 2008
  6. ncbi request reprint Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air-liquid interface
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Exp Lung Res 33:27-51. 2007
  7. pmc Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Environ Health Perspect 114:1387-93. 2006
  8. ncbi request reprint In vitro versus in vivo exposure to combustion emissions
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA
    Exp Toxicol Pathol 57:233-8. 2005
  9. ncbi request reprint Composition, toxicity, and mutagenicity of particulate and semivolatile emissions from heavy-duty compressed natural gas-powered vehicles
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, New Mexico 87108, USA
    Toxicol Sci 87:232-41. 2005
  10. ncbi request reprint Mutagenicity and in vivo toxicity of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, New Mexico 87108, USA
    Toxicol Sci 70:212-26. 2002

Research Grants

  1. Diesel Exhaust Particle Modulation of Inflammation
    Jeanclare Seagrave; Fiscal Year: 2005

Detail Information

Publications30

  1. pmc Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
    Respir Res 13:98. 2012
    ..We examined the effects of guaifenesin (GGE), N-acetylcysteine (NAC) and ambroxol (Amb) on differentiated human airway epithelial cells stimulated with IL-13 to produce additional MUC5AC...
  2. doi request reprint Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Exp Lung Res 37:606-14. 2011
    ..Viability of the cultures was not significantly affected. These results suggest that guaifenesin could improve mucociliary clearance in humans by reducing the release and/or production of mucins, thereby altering mucus rheology...
  3. pmc Sulfur mustard vapor effects on differentiated human lung cells
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Inhal Toxicol 22:896-902. 2010
    ..Animal studies are critical to understanding mechanisms, but differences between animals and humans must be addressed. Studies of cultured human cells can bridge animal studies and humans...
  4. pmc Mechanisms and implications of air pollution particle associations with chemokines
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
    Toxicol Appl Pharmacol 232:469-77. 2008
    ..In contrast to silica particles, which do not bind the chemokine, the presence of diesel exhaust particles, which bind the chemokine, prolonged the retention of the chemokine...
  5. doi request reprint Oxidative stress, inflammation, and pulmonary function assessment in rats exposed to laboratory-generated pollutant mixtures
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Toxicol Environ Health A 71:1352-62. 2008
    ..Overall, the toxicological effects from exposure to these pollutant mixtures were subtle, but the results show differences in the effects of atmospheres having different physical/chemical characteristics...
  6. ncbi request reprint Responses of differentiated primary human lung epithelial cells to exposure to diesel exhaust at an air-liquid interface
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Exp Lung Res 33:27-51. 2007
    ..Some exposure-related effects were similar among donors, whereas others were affected by the donor, consistent with human population heterogeneity. This model may be useful for mechanistic and comparative toxicology studies...
  7. pmc Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Environ Health Perspect 114:1387-93. 2006
    ..Exposure to air pollution and, more specifically, particulate matter (PM) is associated with adverse health effects. However, the specific PM characteristics responsible for biological effects have not been defined...
  8. ncbi request reprint In vitro versus in vivo exposure to combustion emissions
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA
    Exp Toxicol Pathol 57:233-8. 2005
    ..This article discusses relevant parallels and discrepancies between exposures of cells and living animals...
  9. ncbi request reprint Composition, toxicity, and mutagenicity of particulate and semivolatile emissions from heavy-duty compressed natural gas-powered vehicles
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, New Mexico 87108, USA
    Toxicol Sci 87:232-41. 2005
    ..While mutagenic potencies for the CNG emission samples were similar to the range observed in the gasoline and diesel emission samples, lung toxicity potency factors were generally lower than those for the gasoline and diesel samples...
  10. ncbi request reprint Mutagenicity and in vivo toxicity of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, New Mexico 87108, USA
    Toxicol Sci 70:212-26. 2002
    ....
  11. ncbi request reprint Oxidative mechanisms in tobacco smoke-induced emphysema
    J Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    J Toxicol Environ Health A 61:69-78. 2000
    ..Finally, oxidative damage to structural proteins may potentiate their degradation by the increased proteolytic burden...
  12. ncbi request reprint Multiple modes of responses to air pollution particulate materials in A549 alveolar type II cells
    J C Seagrave
    Lovelace Respiratory Research Institute, PO Box 5890, Albuquerque, NM 87185, USA
    Inhal Toxicol 12:247-60. 2000
    ..These results suggest multiple modes of responses to toxic materials and imply that a toxicological screening process should address these and possibly other endpoints...
  13. ncbi request reprint Diesel particulate material binds and concentrates a proinflammatory cytokine that causes neutrophil migration
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Inhal Toxicol 16:93-8. 2004
    ..DPM-induced inflammatory responses may therefore be more focused or sustained as a result of this binding of inflammatory mediators by DPM...
  14. ncbi request reprint In vitro relative toxicity screening of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Toxicol Environ Health A 66:1113-32. 2003
    ..Thus, while the in vitro assays may provide mechanistic information, revealing cell type-specific responses, they did not accurately reflect in vivo comparative toxicity in their current form...
  15. ncbi request reprint Effects of cigarette smoke exposure and cessation on inflammatory cells and matrix metalloproteinase activity in mice
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Exp Lung Res 30:1-15. 2004
    ..These results support a role for MMPs in CS-induced emphysema and indicate that smoking cessation allows restoration toward normal homeostasis...
  16. ncbi request reprint Responses to subchronic inhalation of low concentrations of diesel exhaust and hardwood smoke measured in rat bronchoalveolar lavage fluid
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Inhal Toxicol 17:657-70. 2005
    ..Furthermore, effects may be nonmonotonic functions of exposure levels, with maximal responses in environmentally or occupationally relevant exposure ranges...
  17. pmc Inhalation toxicity of brevetoxin 3 in rats exposed for 5 days
    Janet Benson
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Toxicol Environ Health A 67:1443-56. 2004
    ..Results suggest that the immune system may be a target of toxicity following brevetoxin inhalation. Future studies will focus on identification of a no-effect level and mechanisms underlying brevetoxin-induced immune suppression...
  18. pmc Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(-/-) mice
    Matthew J Campen
    Toxicology Division, Lovelace Respiratory Research Institute, Albuquerque, NM, USA
    Toxicol Appl Pharmacol 242:310-7. 2010
    ..Combined with previous studies, these results indicate that whole emissions from mobile sources may have a significant role in promoting chronic vascular disease...
  19. ncbi request reprint Animal models of asthma: potential usefulness for studying health effects of inhaled particles
    D E Bice
    Lovelace Respiratory Research Institute, PO Box 5890, Albuquerque, NM 87185, USA
    Inhal Toxicol 12:829-62. 2000
    ..Finally, economic issues as well as reagent availability limit the utility of horses, sheep, and primates...
  20. ncbi request reprint Health effects of inhaled gasoline engine emissions
    Jacob D McDonald
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87109, USA
    Inhal Toxicol 19:107-16. 2007
    ....
  21. pmc Relationship between composition and toxicity of motor vehicle emission samples
    Jacob D McDonald
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Environ Health Perspect 112:1527-38. 2004
    ....
  22. doi request reprint Cardiopulmonary response to inhalation of biogenic secondary organic aerosol
    Jacob D McDonald
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Inhal Toxicol 22:253-65. 2010
    ..Overall, alpha-pinene-derived SOA, including SOA that included organosulfate compounds, revealed limited biological response after short-term inhalation exposures...
  23. doi request reprint Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies
    Gavin Pickett
    Keck UNM Genomic Resource Facility, Cancer Center, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Toxicol Sci 114:79-89. 2010
    ..These studies lay the foundation for future investigations to analyze differences in the responses of in vivo systems to tobacco products marketed with claims of reduced exposure or reduced harm...
  24. pmc Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions
    Jacob D McDonald
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Environ Health Perspect 112:1307-12. 2004
    ..Baseline DEE produced statistically significant biological effects for all measured parameters. The use of low sulfur fuel and a catalyzed trap either completely or nearly eliminated the effects...
  25. ncbi request reprint Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice
    Thomas H March
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Toxicol Sci 92:545-59. 2006
    ..The similarities of this model to the human disease make it promising for studying disease pathogenesis and assessing new therapeutic interventions...
  26. ncbi request reprint Fresh gasoline emissions, not paved road dust, alter cardiac repolarization in ApoE-/- mice
    Matthew J Campen
    Division of Toxicology, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, USA
    Cardiovasc Toxicol 6:199-210. 2006
    ..The absence of ECG effects for both very high concentrations of road dust PM and equivalent concentrations of the vapor/gas phase of gasoline engine exhaust further indicate the specific risk conferred by fresh vehicular PM...
  27. ncbi request reprint Bcl-2 in LPS- and allergen-induced hyperplastic mucous cells in airway epithelia of Brown Norway rats
    Y Tesfaigzi
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    Am J Physiol Lung Cell Mol Physiol 279:L1210-7. 2000
    ..These data demonstrate Bcl-2 expression in hyperplastic mucous cells of Brown Norway rats regardless of the type of inflammatory response and indicate that apoptotic mechanisms may be involved in the resolution of MCHs...
  28. doi request reprint Cytoskeletal modulation and tyrosine phosphorylation of tight junction proteins are associated with mainstream cigarette smoke-induced permeability of airway epithelium
    Dorian Olivera
    Division of Pathophysiology, Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA
    Exp Toxicol Pathol 62:133-43. 2010
    ..These results indicate that MS exposure causes alterations in cytoskeletal and TJ structure and function, resulting in increased macromolecular permeability that may contribute to the adverse health effects of MS...
  29. pmc Effect of specific allergen inhalation on serum adiponectin in human asthma
    Akshay Sood
    Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
    Chest 135:287-94. 2009
    ..We sought to evaluate whether allergen inhalation affects serum adiponectin in human asthma...
  30. ncbi request reprint STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma
    Barbara A Stout
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87185, USA
    J Immunol 178:8107-16. 2007
    ..Collectively, these observations suggest that STAT1-dependent translocation of Bax to the ER is crucial for IFN-gamma-induced cell death of AECs and the resolution of allergen-induced mucous cell hyperplasia...

Research Grants1

  1. Diesel Exhaust Particle Modulation of Inflammation
    Jeanclare Seagrave; Fiscal Year: 2005
    ....