Elizabeth R Rhoades

Summary

Affiliation: Lovelace Respiratory Research Institute
Country: USA

Publications

  1. ncbi request reprint Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial components
    Elizabeth R Rhoades
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Tuberculosis (Edinb) 85:159-76. 2005
  2. pmc Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infection
    Kaori Sakamoto
    Department of Pathology, College of Veterinary Medicine, 501 D W Brooks Dr, University of Georgia, Athens, GA 30602 7388, USA
    Infect Immun 78:1004-11. 2010
  3. pmc Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases
    Kaori Sakamoto
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
    Infect Immun 81:764-76. 2013
  4. ncbi request reprint In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolates
    Rachel E Geisel
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 174:5007-15. 2005
  5. pmc Characterization of sulfolipids of Mycobacterium tuberculosis H37Rv by multiple-stage linear ion-trap high-resolution mass spectrometry with electrospray ionization reveals that the family of sulfolipid II predominates
    Elizabeth R Rhoades
    Department of Microbiology and Immunology, C5 109 Vet Medical Center, Cornell University, Ithaca, New York 14853, United States
    Biochemistry 50:9135-47. 2011
  6. doi request reprint Mycobacterium abscessus Glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-alpha by preventing interaction with TLR2
    Elizabeth R Rhoades
    Cornell Nanoscale Science and Technology Facility, Cornell University, Ithaca, NY 14853, USA
    J Immunol 183:1997-2007. 2009
  7. ncbi request reprint Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 4:167-76. 2002
  8. pmc Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guérin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. I. PIMs and lyso-PIMs
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 18:466-78. 2007
  9. pmc Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Gúerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. II. Monoacyl- and diacyl-PIMs
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 18:479-92. 2007
  10. ncbi request reprint Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosis
    Henry C Mwandumba
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Box 30096, Blantyre 3, Malawi
    Tuberculosis (Edinb) 88:58-63. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial components
    Elizabeth R Rhoades
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Tuberculosis (Edinb) 85:159-76. 2005
    ..We submit that the matrix model presents pertinent features of the murine granulomatous response that will prove to be an adaptable method for study of this complex response...
  2. pmc Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infection
    Kaori Sakamoto
    Department of Pathology, College of Veterinary Medicine, 501 D W Brooks Dr, University of Georgia, Athens, GA 30602 7388, USA
    Infect Immun 78:1004-11. 2010
    ..In this model, fibrin(ogen) was not required for cell recruitment, cytokine response, or response to infection, but it promoted granulation tissue formation and suppressed leukocyte necrosis...
  3. pmc Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases
    Kaori Sakamoto
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
    Infect Immun 81:764-76. 2013
    ..Given that MMPs likely play an important role in both the construction and breakdown of tuberculous granulomas, our results suggest that TDM may drive MMP expression during TB pathogenesis...
  4. ncbi request reprint In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolates
    Rachel E Geisel
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 174:5007-15. 2005
    ..These results demonstrate that the trehalose mycolates, particularly trehalose dimycolate, are the most bioactive lipids in the BCG extract, inducing a proinflammatory cascade that influences granuloma formation...
  5. pmc Characterization of sulfolipids of Mycobacterium tuberculosis H37Rv by multiple-stage linear ion-trap high-resolution mass spectrometry with electrospray ionization reveals that the family of sulfolipid II predominates
    Elizabeth R Rhoades
    Department of Microbiology and Immunology, C5 109 Vet Medical Center, Cornell University, Ithaca, New York 14853, United States
    Biochemistry 50:9135-47. 2011
    ..We redefined the structure of this important lipid family that was misassigned using the traditional methods 40 years ago...
  6. doi request reprint Mycobacterium abscessus Glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-alpha by preventing interaction with TLR2
    Elizabeth R Rhoades
    Cornell Nanoscale Science and Technology Facility, Cornell University, Ithaca, NY 14853, USA
    J Immunol 183:1997-2007. 2009
    ..Conversely spontaneous "unmasking" of cell wall lipids may promote airway inflammation...
  7. ncbi request reprint Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 4:167-76. 2002
    ..Infection of macrophages from gal-3-deficient mice indicated that the protein did not play a role in infection in vitro. In contrast, infection of gal-3-deficient mice revealed a reduced capacity to clear late but not early infection...
  8. pmc Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guérin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. I. PIMs and lyso-PIMs
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 18:466-78. 2007
    ..The combined structural information from the MS(2) and MS(3) product-ion spectra permit the complex structures of PIMs that consist of various isomers to be unveiled in detail...
  9. pmc Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Gúerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. II. Monoacyl- and diacyl-PIMs
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 18:479-92. 2007
    ..bovis Bacillus Calmette Guérin...
  10. ncbi request reprint Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosis
    Henry C Mwandumba
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Box 30096, Blantyre 3, Malawi
    Tuberculosis (Edinb) 88:58-63. 2008
    ..The local immune responses may affect the clinical presentation of active pulmonary TB in HIV-infected patients...