Research Topics
Genomes and Genes | Yong LinSummaryAffiliation: Lovelace Respiratory Research Institute Country: USA Publications
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Publications
The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activationYong Lin
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Biol Chem 281:23525-32. 2006..Taken together, our results indicate that RIP, a key factor in tumor necrosis factor signaling, also plays a pivotal role in IGF-I-induced JNK activation and cell proliferation...
Luteolin, a flavonoid with potential for cancer prevention and therapyYong Lin
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr, SE, Albuquerque, NM 87108, USA
Curr Cancer Drug Targets 8:634-46. 2008..In this review, we summarize the progress of recent research on luteolin, with a particular focus on its anticancer role and molecular mechanisms underlying this property of luteolin...- The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapyYong Lin
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Expert Opin Ther Targets 14:45-55. 2010..Elucidating the roles of NF-kappaB in cancer facilitates developing approaches for cancer prevention and therapy... - IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cellsLang Bai
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA
Mol Cancer Ther 8:1636-45. 2009.... - Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cellsLang Bai
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, New Mexico 87108, USA
J Cell Biochem 108:1125-31. 2009..The results suggest that combination of SMC3 and luteolin is an effective approach for improving the anticancer value of SMC3, which has implications in cancer prevention and therapy... - Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell deathLang Bai
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
Apoptosis 16:45-54. 2011..The results suggest that concurrent targeting c-IAP1 and Hsp90 by combination of SMC3 and Hsp90 inhibitors is an effective approach for improving the anticancer value of SMC3... - A superoxide-mediated mitogen-activated protein kinase phosphatase-1 degradation and c-Jun NH(2)-terminal kinase activation pathway for luteolin-induced lung cancer cytotoxicityLang Bai
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Mol Pharmacol 81:549-55. 2012.... - Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosisWenjie Chen
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr, SE, Albuquerque, NM 87108, USA
Mol Pharmacol 77:416-23. 2010..Our results establish a novel pathway that consists of Akt, COX-2, and Mcl-1 for acquired apoptosis resistance, which could be a molecular target for circumventing acquired chemoresistance in lung cancer... - Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cellsWenshu Chen
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Cell Biochem 105:554-61. 2008.... - A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cellsWei Ju
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Mol Pharmacol 71:1381-8. 2007..Taken together, these results suggest that the accumulation of ROS induced by luteolin plays a pivotal role in suppression of NF-kappaB and potentiation of JNK to sensitize lung cancer cells to undergo TNF-induced apoptosis... 
Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogenWenshu Chen
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr, SE Albuquerque, NM 87108, USA
Carcinogenesis 33:1368-74. 2012..These results suggest that LDR inhibits cigarette smoke-induced lung carcinogenesis by suppressing secretion of cytokines such as IL-6 from fibroblasts in lung tumor-prone microenvironment...- Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cellsXia Wang
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA
Mol Cancer Ther 7:1156-63. 2008..Taken together, these results identify c-FLIP(L) and Mcl-1(L) as the major determinants of acquired TRAIL resistance and could be molecular targets for improving the therapeutic value of TRAIL against lung cancer... - MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activationXiuling Xu
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
PLoS ONE 7:e33846. 2012.... - Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cellsWenshu Chen
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA
Carcinogenesis 28:2114-21. 2007..The potentiation of TRAIL-induced NSCLC cell death could be implicated in lung cancer therapy and prevention... - Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathwaysXia Wang
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Biochem Biophys Res Commun 355:807-12. 2007.... - Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cellsZi Li
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Biol Chem 286:21164-72. 2011..Because TGM2 couples TRAIL resistance and cell migration, it could be a molecular target for circumventing acquired chemoresistance and metastasis in lung cancer... - NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy targetWenshu Chen
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
Front Biosci 16:1172-85. 2011..In this review, we summarize progresses in understanding the NF-kappaB pathway in lung cancer development as well as in modulating NF-kappaB for lung cancer prevention and therapy... - Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateauShuguang Leng
Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Carcinogenesis 34:1044-50. 2013..Together, these findings substantiate genetic variation in SIRT1 as a risk modifier for developing SCC in miners and suggest that SIRT1 may also play a tumor suppressor role in radon-induced cancer in miners... - 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathwayXia Wang
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Cancer Res 66:1089-95. 2006.... - Cigarette smoke synergizes lipopolysaccharide-induced interleukin-1β and tumor necrosis factor-α secretion from macrophages via substance P-mediated nuclear factor-κB activationJunyang Xu
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Am J Respir Cell Mol Biol 44:302-8. 2011..Our findings suggest that CS amplifies the LPS-induced macrophages' secretion of IL-1β and TNF-α through synergizing SP secretion, which activates NF-κB via binding with NK1R... - Glucose up-regulates HIF-1 alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox statusShuhong Guo
College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
J Neurochem 105:1849-60. 2008..The results imply that hypoxia only may not be sufficient to stabilize HIF-1alpha and that a reducing environment is required to stabilize HIF-1alpha in neurons exposed to hypoxia... - Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulationYong Lin
Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:10822-8. 2004..These results suggest that RIP, TRAF2, and FADD are crucial in mediating ROS accumulation in TNF-induced necrotic cell death... - The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinasesAnne Devin
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
EMBO Rep 4:623-7. 2003..The activation of these kinases by interleukin-1 is normal in Rip(-/-) cells. More importantly, we showed that the kinase activity of RIP is needed for ERK activation... - The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activationGang Min Hur
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
Genes Dev 17:873-82. 2003..We also found that RIP forms a complex with IKK in response to DNA damage. Therefore, our study provides a possible mechanism for the initiation of the cytoplasmic signaling to activate NF-kappaB in response to DNA damage... - TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLFYong Lin
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 23:5849-56. 2003..These results reveal a novel aspect of TRAF2 function: by regulating the expression of genes, such as LKLF, TRAF2 controls cell sensitivity to apoptosis... - Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatinGang Lu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Clin Cancer Res 14:4981-8. 2008.... - Inhibitory effect of voluntary running wheel exercise on the growth of human pancreatic Panc-1 and prostate PC-3 xenograft tumors in immunodeficient miceXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Oncol Rep 19:1583-8. 2008..The present study demonstrated an inhibitory effect of voluntary exercise on the growth of pancreas and prostate tumors in a SCID mouse xenograft model... - Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP)Wenxiang Wei
National Key Laboratory of Medical Neurobiology, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
Cell Res 13:111-20. 2003..The interaction between RMP and TFIIF may be an additional passway for RMP to regulate the transcription, or alternatively TFIIF may cooperate with RPB5 and TFIIB for the corepressor function of RMP... - [Proliferation of hepatocytes after delivery of exogenous hepatocyte growth factor gene]Yong Lin
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Zhonghua Gan Zang Bing Za Zhi 11:331-3. 2003..It may be an effective tool for hepatocyte transplantation by gene modified donor hepatocytes... - Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3Qiaojia Huang
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Nat Immunol 5:98-103. 2004..Note: In the version of this article originally published online, the third author's name was incorrect. The correct author name should be Yong Lin. This error has been corrected for the HTML and print versions of this article. - Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell deathHan Ming Shen
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 24:5914-22. 2004..Therefore, our study uncovers a novel signaling pathway regulating oxidative stress-induced cell death... - Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient miceGina E Avila
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Pharmacol Exp Ther 315:170-87. 2005..The inhibitory effects of TPA on tumor growth occurred at clinically achievable blood levels... - Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptorQingFeng Yang
Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 102:9631-6. 2005..All other antiinflammatory effects of digitoxin on NF-kappaB and c-Jun N-terminal kinase pathways appear to follow from the blockade of this initial upstream signaling event... - [Transcriptional regulation on proliferation and differentiation of transplanted hepatocytes]Zhi-qing He
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Zhonghua Gan Zang Bing Za Zhi 13:712-4. 2005 - Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green teaJihyeung Ju
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Cancer Res 65:10623-31. 2005.... - Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNKQingFeng Yang
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
EMBO Rep 7:622-7. 2006..We also found that TNFR1 functions downstream of IRE1 and that IRE1 is present in the same complex with TNFR1 under ER stress condition. Therefore, our study shows a novel role of TNFR1 in mediating ER stress-induced JNK activation... - Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesisHui Qiang
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, Shanghai, China
Liver Int 26:1126-37. 2006..Selective targeting of ERK1 inhibitors to HSC might present as a novel strategy for the treatment of hepatic fibrosis... - Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient miceXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854, USA
Clin Cancer Res 12:3444-51. 2006..Clinical trials with TPA alone or in combination with paclitaxel in patients with prostate cancer may be warranted... - Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient miceXi Zheng
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Clin Cancer Res 13:5480-7. 2007..To investigate the effects and mechanisms of atorvastatin and celecoxib administered individually or in combination on human prostate cancer PC-3 cells cultured in vitro or grown as xenograft tumors in immunodeficient mice... - Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancerXuesong Ouyang
Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
Cancer Res 68:2132-44. 2008..This study provides a striking example of how accurate mouse models can provide insights on molecular processes involved in progression and recurrence of human cancer... - Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutaseMartin Weinzierl
Department of Neurological Surgery, RWTH Aachen, Germany
Neurosci Lett 336:13-6. 2003..Together, these findings suggest that lysed blood preferentially induces HO-1 in glia and macrophages through the generation of oxidative stress...
Research Grants
- Nutrient Flavonoids and Lung Cancer PreventionYong Lin; Fiscal Year: 2007....
- Bridging Inflammation and Cigarette Smoke-associated Lung Carcinogenesis by MUC1Yong Lin; Fiscal Year: 2010..The outcome from this study may lead to new strategies for lung cancer prevention and therapy. ..