Research Topics
| F F HahnSummaryAffiliation: Lovelace Respiratory Research Institute Country: USA Publications
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Detail Information
Publications
Comparative stochastic effects of alpha, beta or x-irradiation of the lung of ratsFletcher F Hahn
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Health Phys 99:363-6. 2010..The incidence of lung tumors in the PuO(2) groups was 21 times higher than that of the groups exposed to the lower LET radiations. These results support a radiation-weighting factor of 20, as recommended by ICRP 60...
Implanted depleted uranium fragments cause soft tissue sarcomas in the muscles of ratsFletcher F Hahn
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Environ Health Perspect 110:51-9. 2002..These results indicate that DU fragments of sufficient size cause localized proliferative reactions and soft tissue sarcomas that can be detected with radiography in the muscles of rats...
Plutonium microdistribution in the lungs of Mayak workersF F Hahn
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Radiat Res 161:568-81. 2004..Thus the prolonged retention of plutonium in lung scars may not increase the dose or risk for lung cancer...- Distribution of plutonium particles in the lungs of Mayak workersF F Hahn
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive S E, Albuquerque, New Mexico 87108, USA
Radiat Prot Dosimetry 105:81-4. 2003..These results support the hypothesis that Pu activity is not uniformly distributed in the lung, with long-term retained particles concentrated in scars of the lung. The results may significantly affect estimates of dose from inhaled Pu... - Comparative oncology of lung tumorsFletcher F Hahn
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Toxicol Pathol 35:130-5. 2007..For example, the molecular changes in lung tumors of mice and humans have a number of similarities that may be important in evaluating the significance of compound-induced lung tumors in mice... - A review of the histopathology of cigarette smoke-induced lung cancer in rats and miceFletcher F Hahn
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, New Mexico 87108, USA
Int J Toxicol 26:307-13. 2007..These studies in rats and mice allow new approaches to the study of cigarette smoke-induced changes in the lung... - Biological effects of inhaled 144CeCl3 in beagle dogsF F Hahn
Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87185, USA
Radiat Res 147:92-108. 1997..The property of 144Ce in depositing on and remaining associated with bone surfaces for long times may be an important factor in the radiation dose to bone marrow and epithelium adjacent to bone... - Comparative deterministic effects of inhaled, insoluble alpha- and beta-particle-emitting radionuclides in dogsB A Muggenburg
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Radiat Res 152:S23-6. 1999..The greater tissue penetration of the beta-particle emissions from the cerium resulted in more uniform dose distribution over the lung and the atria of the heart than from the alpha-particle emissions from plutonium... - Comparative stochastic effects of inhaled alpha- and beta-particle-emitting radionuclides in beagle dogsF F Hahn
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Radiat Res 152:S19-22. 1999..In addition, inhaled beta-particle emitters can also induce cancers in lung-associated lymph nodes and heart at these larger absorbed radiation doses... - Assessing the uniformity of plutonium alpha radiation dose in human lung: the Mayak experienceR A Guilmette
Lovelace Respiratory Research Institute (LRRI, P.O. Box 5890, Albuquerque, New Mexico 87185, USA
Radiat Prot Dosimetry 99:457-61. 2002..Concentrations of Pu particles in conducting airways are uniformly low, thus indicating that long-term-retained Pu particles are non-uniformly distributed in human lung, mostly in the parenchyma... - Carcinogenic responses of transgenic heterozygous p53 knockout mice to inhaled 239PuO2 or metallic berylliumG L Finch
Inhalation Toxicology Laboratory, Lovelace Biomedical and Environmental Research Institute, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Toxicol Pathol 26:484-91. 1998.... - Carcinogenicity of inhaled butadiene diepoxide in female B6C3F1 mice and Sprague-Dawley ratsR F Henderson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185 5890, USA
Toxicol Sci 52:33-44. 1999..The results indicate that the site of formation of the BDO2 is important for tumor induction... - Cigarette smoke exposure produces more evidence of emphysema in B6C3F1 mice than in F344 ratsT H March
Inhalation Toxicology Laboratory, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Toxicol Sci 51:289-99. 1999..Furthermore, the type of inflammatory response may be a determining factor for species differences in susceptibility to emphysema induction by CS exposure... - Dose responses from inhaled monodisperse aerosols of 244Cm2O3 in the lung, liver and skeleton of F344 rats and comparison with 239PuO2D L Lundgren
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico 87185, USA
Radiat Res 147:598-612. 1997..Inhaled 244Cm2O3 appeared to be about 50% less effective as a lung carcinogen in rats compared to 239PuO2 at similar doses... - Animal models of beryllium-induced lung diseaseG L Finch
Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87185, USA
Environ Health Perspect 104:973-9. 1996..Taken together, this research program constitutes a coordinated effort to understand beryllium-induced lung disease in experimental animal models... - The toxicity of insoluble cerium-144 inhaled by beagle dogs: non-neoplastic effectsF F Hahn
Inhalation Toxicology Laboratory, Lovelace Respiratory Research Institute, P O Box 5890, Albuquerque, New Mexico 87185, USA
Radiat Res 155:95-112. 2001.... - Influence of exposure concentration or dose on the distribution of particulate material in rat and human lungsK J Nikula
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Environ Health Perspect 109:311-8. 2001..This difference in distribution may bring different lung cells into contact with the retained particles or particle-containing macrophages in rats and humans and may account for differences in species response to inhaled particles... - Effects of subchronic inhalation exposure of rats to emissions from a diesel engine burning soybean oil-derived biodiesel fuelG L Finch
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Inhal Toxicol 14:1017-48. 2002..This study demonstrated modest adverse effects at the highest exposure level, and none other than the expected physiological macrophage response to repeated particle exposure at the intermediate level... - Dosimetry and acute toxicity of inhaled butadiene diepoxide in rats and miceR F Henderson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Toxicol Sci 51:146-52. 1999..Therefore, the final design selected for the carcinogenesis study comprised exposing the rats and mice for 6 h/day, 5 days/week for 6 weeks to 0, 2.5, or 5.0 ppm BDO2... - Animal models of emphysema and their relevance to studies of particle-induced diseaseT H March
Lovelace Respiratory Research Institute, PO Box 5890, Albuquerque, NM 87185, USA
Inhal Toxicol 12:155-87. 2000..Thus, the emphysema model must be selected carefully in order to answer specific questions about the interactive effects of particles and emphysema... - Radiotoxicity of inhaled (239)PuO(2) in dogsBruce A Muggenburg
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Radiat Res 170:736-57. 2008..No primary tumors were found in the tracheobronchial and mediastinal lymph nodes despite the high alpha-particle radiation doses to these lymph nodes, and no cases of leukemia were observed... - Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the ratS A Belinsky
Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87185, USA
Radiat Res 145:449-56. 1996..No alterations in electrophoretic mobility were detected. The results of this investigation indicate that alterations in the K-ras and p53 pathways do not play a major role in the genesis of X-ray-induced lung tumors in the rat... - Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in ratsJoe L Mauderly
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Toxicol Sci 81:280-92. 2004..3%, C = 0.4% for combined genders). These results demonstrate that chronic whole-body exposure of rats to cigarette smoke can induce lung cancer... - Health effects of subchronic exposure to low levels of wood smoke in ratsYohannes Tesfaigzi
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, New Mexico 87108, USA
Toxicol Sci 65:115-25. 2002..Further studies are needed to establish whether exposure to wood smoke exacerbates asthmalike symptoms that resemble those described for children living in homes using wood stoves for heating and cooking... - Low-level subchronic exposure to wood smoke exacerbates inflammatory responses in allergic ratsYohannes Tesfaigzi
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Toxicol Sci 88:505-13. 2005..Therefore, this animal model may be useful to elucidate the mechanisms of the decline in pulmonary function caused by environmental pollutants when asthmatics are exposed to allergen... - Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathwaysJulie A Hutt
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Carcinogenesis 26:1999-2009. 2005..These results emphasize the importance of the activation of K-ras and silencing of DAP-kinase and RAR-beta in lung cancer development, and confirm the relevance of this mouse model for studying lung tumorigenesis... - Inhalation toxicity of brevetoxin 3 in rats exposed for twenty-two daysJanet M Benson
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Environ Health Perspect 113:626-31. 2005..Results indicate that the immune system is the primary target for toxicity in rats after repeated inhalation exposure to relatively high concentrations of brevetoxins... - Carcinogenic interactions between a single inhalation of 239PuO2 and chronic exposure to cigarette smoke in ratsJoe L Mauderly
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Radiat Res 173:665-76. 2010..The synergy for malignant lung tumors is consistent with findings from uranium miners and nuclear weapons production workers. These results bolster confidence in the epidemiological findings and have implications for risk assessment... - Hepatic neoplasms from internally deposited 144CeCl3F F Hahn
Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87185, USA
Toxicol Pathol 24:281-9. 1996..Biliary cystadenomas were associated with degenerative lesions in the liver but not with other neoplasms in the liver. These results indicate that the liver is an important target organ for effects from internally deposited 144Ce... - Radiological risk assessment of Capstone depleted uranium aerosolsFletcher F Hahn
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87105, USA
Health Phys 96:352-62. 2009..35%. These risks can be significantly reduced by using an existing ventilation system (if operable) and by reducing personnel time in the vehicle immediately after perforation... - A biphasic response to silica: I. Immunostimulation is restricted to the early stage of silicosis in lewis ratsRaymond J Langley
Immunology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
Am J Respir Cell Mol Biol 30:823-9. 2004..Thus, in the early stages of silicosis, silica activates the immune system; however, the progression of lung granulomas does not depend on a continually activated adaptive immune system... - Chronic nicotine inhibits inflammation and promotes influenza infectionSeddigheh Razani-Boroujerdi
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
Cell Immunol 230:1-9. 2004..Thus, because nicotine suppresses leukocyte migration, it might contribute to the delayed wound healing and increased incidence of respiratory infections among smokers... - Chromatin clearance in C57Bl/10 mice: interaction with heparan sulphate proteoglycans and receptors on Kupffer cellsT W Du Clos
Department of Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
Clin Exp Immunol 117:403-11. 1999..These data suggest that chromatin clearance is mediated by charge interactions with cell surface HSPG and by DNA receptors. Clearance and degradation of chromatin require functional macrophages in the liver and spleen... - Role of muscarinic receptors in the regulation of immune and inflammatory responsesSeddigheh Razani-Boroujerdi
Immunology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, United States
J Neuroimmunol 194:83-8. 2008..Thus, activation of nicotinic and muscarinic receptors has opposite effects on the immune/inflammatory responses... - Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in utero to 3'-azido-3'-deoxythymidineDale M Walker
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Cardiovasc Toxicol 4:133-53. 2004.... - Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 ratsDale M Walker
Experimental Pathology Laboratories, Inc, Herndon, Virginia, USA
Environ Mol Mutagen 48:283-98. 2007.... - Comparative pathology of environmental lung disease: an overviewFrancis H Y Green
Respiratory Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada
Toxicol Pathol 35:136-47. 2007..These differences may account for differences between the 2 species in carcinogenic response to nonfibrous particulates...