Yung-Sung Cheng

Summary

Affiliation: Lovelace Respiratory Research Institute
Country: USA

Publications

  1. doi request reprint Thoracic fraction of inhaled fiber aerosol
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    J Occup Environ Hyg 10:194-202. 2013
  2. pmc Exposing animals to oxidant gases: nose only vs. whole body
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA
    Proc Am Thorac Soc 7:264-8. 2010
  3. doi request reprint Personal exposure to aerosolized red tide toxins (brevetoxins)
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Occup Environ Hyg 7:326-31. 2010
  4. pmc Characterization of Florida red tide aerosol and the temporal profile of aerosol concentration
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Toxicon 55:922-9. 2010
  5. doi request reprint Physicochemical characterization of Capstone depleted uranium aerosols II: particle size distributions as a function of time
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Health Phys 96:266-75. 2009
  6. ncbi request reprint Lung deposition of droplet aerosols in monkeys
    Y S Cheng
    Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico 87108, USA
    Inhal Toxicol 20:1029-36. 2008
  7. ncbi request reprint Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica
    Y S Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    J Aerosol Med 14:255-66. 2001
  8. ncbi request reprint Evaluation of respirator filters for asbestos fibers
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Occup Environ Hyg 3:26-35. 2006
  9. pmc Concentration and particle size of airborne toxic algae (brevetoxin) derived from ocean red tide events
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest, SE, Albuquerque, New Mexico 87108, USA
    Environ Sci Technol 39:3443-9. 2005
  10. ncbi request reprint Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway
    Y S Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    J Aerosol Med 14:267-80. 2001

Detail Information

Publications32

  1. doi request reprint Thoracic fraction of inhaled fiber aerosol
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    J Occup Environ Hyg 10:194-202. 2013
    ..The thoracic curve as defined for spherical particles, therefore, may not include some fibers that could penetrate to the thoracic region...
  2. pmc Exposing animals to oxidant gases: nose only vs. whole body
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA
    Proc Am Thorac Soc 7:264-8. 2010
    ..Considerations such as animal number, exposure duration, end points of study, and availability of test material should influence the selection of a particular exposure system...
  3. doi request reprint Personal exposure to aerosolized red tide toxins (brevetoxins)
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Occup Environ Hyg 7:326-31. 2010
    ..Results showed that the personal sample might provide an estimate of individual exposure level. Nasal swab samples showed that brevetoxins indeed were inhaled and deposited in the nasal passage during the March 2005 red tide event...
  4. pmc Characterization of Florida red tide aerosol and the temporal profile of aerosol concentration
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Toxicon 55:922-9. 2010
    ..The temporal profile of the Florida red tide aerosol during a sampling period could be explained generally with the variation of wind direction...
  5. doi request reprint Physicochemical characterization of Capstone depleted uranium aerosols II: particle size distributions as a function of time
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Health Phys 96:266-75. 2009
    ..The AMADs generally decreased over time because of settling. Additionally, the median diameter of the larger size mode decreased with time. These results were used to estimate the dosimetry of inhaled DU particles...
  6. ncbi request reprint Lung deposition of droplet aerosols in monkeys
    Y S Cheng
    Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico 87108, USA
    Inhal Toxicol 20:1029-36. 2008
    ..3- and 5.1-microm particle aerosols, respectively, whereas the deposition in the deep lung was 12% and 8%, respectively. This information will be useful in developing animal models for inhaled infectious agents...
  7. ncbi request reprint Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica
    Y S Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    J Aerosol Med 14:255-66. 2001
    ..Comparison of oropharyngeal deposition and those predicted by artificial throats used in the impactor measurements showed that, in general, the artificial throat predicted a lower deposition...
  8. ncbi request reprint Evaluation of respirator filters for asbestos fibers
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Occup Environ Hyg 3:26-35. 2006
    ..For charged-neutralized, low-efficiency filter cartridges, asbestos fibers may penetrate more than spherical particles with a mean particle size of 0.3 microm diameter...
  9. pmc Concentration and particle size of airborne toxic algae (brevetoxin) derived from ocean red tide events
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest, SE, Albuquerque, New Mexico 87108, USA
    Environ Sci Technol 39:3443-9. 2005
    ..The particle size indicated the likelihood of high deposition efficiency in the respiratory tract with the majority of aerosol deposited in the upper airways and small but not insignificant deposition in the lower airways...
  10. ncbi request reprint Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway
    Y S Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    J Aerosol Med 14:267-80. 2001
    ..Larger droplets and a wider spray angle increased deposition in the anterior region of the nasal airway, which prevented more material from depositing in the turbinate region...
  11. ncbi request reprint Dose estimate of inhaled hafnium tritide using the ICRP 66 lung model
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Health Phys 82:817-24. 2002
    ..The ICRP estimate did not include a self-absorption factor and thus might have overestimated the dose. This finding has significant implications for current health protection guidelines...
  12. ncbi request reprint Particle characteristics and lung deposition patterns in a human airway replica of a dry powder formulation of polylactic acid produced using supercritical fluid technology
    Y S Cheng
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Aerosol Med 16:65-73. 2003
    ..Our results showed that L-PLA particles as manufactured by the supercritical technology could be used in a DPI that does not require the use of carrier particles to facilitate aerosol delivery...
  13. ncbi request reprint Characterization of plutonium aerosol collected during an accident
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87115, USA
    Health Phys 87:596-605. 2004
    ....
  14. pmc Characterization of marine aerosol for assessment of human exposure to brevetoxins
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Environ Health Perspect 113:638-43. 2005
    ..The deposition pattern correlated with the observed increase of upper airway symptoms in healthy lifeguards during the exposure periods...
  15. doi request reprint Aerosol sampling system for collection of Capstone depleted uranium particles in a high-energy environment
    Thomas D Holmes
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Health Phys 96:221-37. 2009
    ..The aerosol sampling arrays and control systems for the Capstone study provided the needed aerosol samples for physicochemical analysis, and the resultant data were used for risk assessment of exposure to DU aerosol...
  16. ncbi request reprint Influence of impactor operating flow rate on particle size distribution of four jet nebulizers
    Yue Zhou
    Lovelace Respiratory Research Institute, Albuquerque, NM, USA
    Pharm Dev Technol 12:353-9. 2007
    ..3 L/min. The higher MMAD and GSD could cause the patient to inhale less of the drug than expected if the nebulizer was evaluated by the ACI at the operating flow rate of 28.3 L/min...
  17. ncbi request reprint Medical nebulizer performance: effects of cascade impactor temperature
    Yue Zhou
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque NM 87108, USA
    Respir Care 50:1077-82. 2005
    ..However, when the cascade impactor is operated at ambient room temperature, the droplets could evaporate because of the temperature difference between the nebulizer outlet and the body of the impactor...
  18. pmc Particle size distribution and inhalation dose of shower water under selected operating conditions
    Yue Zhou
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Inhal Toxicol 19:333-42. 2007
    ..Alveolar deposition was 6-10% and 0.9% assuming oral and nasal breathing, respectively. The consequences deposition of shower water droplets will depend on the nature and extent of any pollutants in the source water...
  19. ncbi request reprint Fiber deposition in the tracheobronchial region: experimental measurements
    Yue Zhou
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Inhal Toxicol 19:1071-8. 2007
    ..This demonstrates, again, the importance of using a realistic airway model, including larynx, to simulate the airway geometry and flow pattern of the human respiratory tract...
  20. doi request reprint Dissolution rate and biokinetic model of zirconium tritide particles in rat lungs
    Yue Zhou
    Lovelace Respiratory Research Institute, Albuquerque, NM, USA
    Health Phys 98:672-82. 2010
    ..The predicted retention curves with various phases of tritium in each organ agreed very well with the experimental data. The result can be used to estimate the human annual limit of intake and derived air concentration of ZrT particles...
  21. ncbi request reprint Fiber deposition pattern in two human respiratory tract replicas
    Wei Chung Su
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Inhal Toxicol 18:749-60. 2006
    ..When comparing the results between the two replicas, fiber length, inspiratory flow rate, and the geometry of the oral airway were found to be factors that might affect the fiber deposition pattern in the human respiratory tract...
  22. pmc Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury
    Waylon M Weber
    Lovelace CounterACT Center of Excellence, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Toxicol Mech Methods 20:14-24. 2010
    ..Intratracheal inhalation of SM vapors at a concentration of 5400 mg x min/m(3) resulted in homogeneous lung injury with no nasal degeneration...
  23. doi request reprint Evaluation of IOM personal sampler at different flow rates
    Yue Zhou
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    J Occup Environ Hyg 7:88-93. 2010
    ..The test results indicate that the IOM sampler can be used at higher flow rates...
  24. ncbi request reprint Fiber deposition in the tracheobronchial region: deposition equations
    Yue Zhou
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Inhal Toxicol 20:1191-8. 2008
    ....
  25. doi request reprint Physicochemical characterization of Capstone depleted uranium aerosols IV: in vitro solubility analysis
    Raymond A Guilmette
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Health Phys 96:292-305. 2009
    ..Nevertheless, these data provide a useful experimental basis for modeling the intake-dose relationships for inhaled DU aerosols arising from penetrator impact on armored vehicles...
  26. pmc Characterization of aerosols containing microcystin
    Yung Sung Cheng
    Lovelace Respiratory Research Institute, 2425 Ridgecrest, SE, Albuquerque, NM, 87111, USA E mails for Yue Zhou C Mitch Irvin
    Mar Drugs 5:136-50. 2007
    ..4 and 27.8 mum. The sampling and analysis methods were successfully used in a pilot field study to measure microcystin aerosol in situ...
  27. doi request reprint Aerosol fabrication of hollow mesoporous silica nanoparticles and encapsulation of L-methionine as a candidate drug cargo
    Xingmao Jiang
    Department of Chemical and Nuclear Engineering and Center for Micro Engineered Materials, The University of New Mexico, Albuquerque, NM 87131, USA
    Chem Commun (Camb) 46:3019-21. 2010
    ..The model drug, L-methionine, was encapsulated within the spherical void at high loadings by repeated crystallization...
  28. ncbi request reprint A quantitative analysis of aerosols inside an armored vehicle perforated by a kinetic energy penetrator containing tungsten, nickel, and cobalt
    Kenneth Gold
    U S Army Research, Development and Engineering Command, Armament Research, Development and Engineering Center, Armaments Engineering and Technology Center, Environmental Technology Division, Picatinny Arsenal, NJ 07806 5000, USA
    Mil Med 172:393-8. 2007
    ....
  29. pmc Occupational exposure to aerosolized brevetoxins during Florida red tide events: effects on a healthy worker population
    Lorraine C Backer
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS F 46, Chamblee, GA 30341, USA
    Environ Health Perspect 113:644-9. 2005
    ..We did not observe any impact of exposure to aerosolized brevetoxins, with or without mild exercise, on pulmonary function...
  30. pmc Initial evaluation of the effects of aerosolized Florida red tide toxins (brevetoxins) in persons with asthma
    Lora E Fleming
    National Institute of Environmental Health Sciences Marine and Freshwater Biomedical Sciences Center, University of Miami Rosenstiel School of Marine and Atmospheric Sciences, Miami, FL 33136, USA
    Environ Health Perspect 113:650-7. 2005
    ..Future studies will examine the possible chronic effects of these toxins among persons with asthma and other chronic respiratory impairment...
  31. pmc Aerosolized red-tide toxins (brevetoxins) and asthma
    Lora E Fleming
    National Institute of Environmental Health Sciences Marine and Freshwater Biomedical Sciences Center, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL, USA
    Chest 131:187-94. 2007
    ..In humans, a significant increase in self-reported respiratory symptoms has been described after recreational and occupational exposures to Florida red-tide aerosols, particularly among individuals with asthma...
  32. ncbi request reprint Balloon-based in vitro MDI aerosol deposition experiments on the effects of mouthpiece diameter
    Ahmed Fadl
    Department of Mechanical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, USA
    Inhal Toxicol 19:505-15. 2007
    ..Expansion balloons were used to induce airflow as well as to collect the penetrated particles through an airway cast. The potential advantages of the balloon-based experimental system are simplicity, accuracy, and cost-effectiveness...

Research Grants10

  1. Development of a Personal Sampler for Nanoparticles
    Yung Sung Cheng; Fiscal Year: 2010
    ..It can be used to assess personal exposure to nanoparticles in terms of mass concentration and physicochemical characteristics. ..
  2. Development of a Highly Efficient Personal Sampler to collect Viable Bioaerosols
    Yung Sung Cheng; Fiscal Year: 2009
    ..The new device will not only be beneficial in occupational settings, but may also have future potential in high risk areas such as those following any possible biological attack. ..
  3. Inhalation Dosimetry/Exposure Index of Fiber Aerosol
    Yung Sung Cheng; Fiscal Year: 2006
    ..Sampling devices based on this size-selection definition can be developed in the future for improved assessment of worker exposure. ..
  4. Development of a Highly Efficient Personal Sampler to collect Viable Bioaerosols
    Yung Sung Cheng; Fiscal Year: 2010
    ..The new device will not only be beneficial in occupational settings, but may also have future potential in high risk areas such as those following any possible biological attack. ..