Research Topics
| J M BensonSummaryAffiliation: Lovelace Respiratory Research Institute Country: USA Publications
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Detail Information
Publications
Uptake, tissue distribution, and excretion of brevetoxin 3 administered to rats by intratracheal instillationJ M Benson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
J Toxicol Environ Health A 57:345-55. 1999....- The acute toxicity, tissue distribution, and histopathology of inhaled ricin in Sprague Dawley rats and BALB/c miceJanet M Benson
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Inhal Toxicol 23:247-56. 2011..Results of this study demonstrate differences exist in pulmonary deposition, clearance rates, and tissue dose and histopathological changes between rats and mice inhaling ricin... - Chronic carcinogenicity study of gasoline vapor condensate (GVC) and GVC containing methyl tertiary-butyl ether in F344 ratsJanet M Benson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Toxicol Environ Health A 74:638-57. 2011.... - Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injuryJanet M Benson
CounterAct Research Center of Excellence, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Wound Repair Regen 19:348-57. 2011..Erythema, edema, and histologic changes are consistent with findings among human victims of SM attack. This model, with observations to 2 weeks, will be useful in assessing the efficacy of countermeasures against SM... - Brevetoxin inhalation alters the pulmonary response to influenza A in the male F344 ratJanet M Benson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Toxicol Environ Health A 74:313-24. 2011..These results suggest that repeated inhalation exposure to brevetoxin may delay virus particle clearance and recovery from influenza A infection in the rat lung... - Placental transport of brevetoxin-3 in CD-1 miceJanet M Benson
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque NM 87108, USA
Toxicon 48:1018-26. 2006..The consequences of these findings for pregnant women exposed to brevetoxins by inhalation or ingestion remain to be determined... - Uptake, tissue distribution, and excretion of 14C-sulfur mustard vapor following inhalation in F344 rats and cutaneous exposure in hairless guinea pigsJanet M Benson
CounterAct Research Center of Excellence, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
J Toxicol Environ Health A 74:875-85. 2011..Urine was the primary route of excretion for both species. Results indicate inhaled SM is rapidly absorbed from the lung and distributed throughout the body while there is limited systemic distribution following cutaneous exposure... - Inhalation toxicity of brevetoxin 3 in rats exposed for twenty-two daysJanet M Benson
Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
Environ Health Perspect 113:626-31. 2005..Results indicate that the immune system is the primary target for toxicity in rats after repeated inhalation exposure to relatively high concentrations of brevetoxins... - The toxicity of microcystin LR in mice following 7 days of inhalation exposureJanet M Benson
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
Toxicon 45:691-8. 2005..While these proteins have not been positively identified, they may be useful in the future as biomarkers of microcystin exposure in humans... - Uptake, tissue distribution, and fate of inhaled carbon tetrachloride: comparison of rat, mouse, and hamsterJ M Benson
Lovelace Respiratory Research Institute, PO Box 5890, Albuquerque, NM 87185 5890, USA
Inhal Toxicol 13:207-17. 2001..The results indicate that ranking of species sensitivity to the hepatotoxic effects of inhaled CCl(4) correlates with CE dose to liver and with the ability to metabolize CCl(4)... - Particle clearance and histopathology in lungs of C3H/HeJ mice administered beryllium/copper alloy by intratracheal instillationJ M Benson
Lovelace Respiratory Research Institute, PO Box 5890, Albuquerque, NM 87185 5890, USA
Inhal Toxicol 12:733-49. 2000..The results of tissue analyses also indicate that, while the Cu component of the alloy clears the lung rapidly, Be is retained and may accumulate upon repeated exposure... - The uptake, distribution, metabolism, and excretion of methyl tertiary-butyl ether inhaled alone and in combination with gasoline vaporJanet M Benson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Toxicol Environ Health A 66:1029-52. 2003.... - Dosimetry and acute toxicity of inhaled butadiene diepoxide in rats and miceR F Henderson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Toxicol Sci 51:146-52. 1999..Therefore, the final design selected for the carcinogenesis study comprised exposing the rats and mice for 6 h/day, 5 days/week for 6 weeks to 0, 2.5, or 5.0 ppm BDO2... - Carcinogenicity of inhaled butadiene diepoxide in female B6C3F1 mice and Sprague-Dawley ratsR F Henderson
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185 5890, USA
Toxicol Sci 52:33-44. 1999..The results indicate that the site of formation of the BDO2 is important for tumor induction... - Uptake, tissue distribution, and excretion of brevetoxin-3 administered to mice by intratracheal instillationBrad M Tibbetts
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
J Toxicol Environ Health A 69:1325-35. 2006..These results are consistent with earlier reports of rapid absorption and widespread tissue distribution of brevetoxins in rats... - Particle size distribution and inhalation dose of shower water under selected operating conditionsYue Zhou
Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
Inhal Toxicol 19:333-42. 2007..Alveolar deposition was 6-10% and 0.9% assuming oral and nasal breathing, respectively. The consequences deposition of shower water droplets will depend on the nature and extent of any pollutants in the source water... - Cardiovascular effects of inhaled diesel exhaust in spontaneously hypertensive ratsMatthew J Campen
Lovelace Respiratory Research Institute, National Environmental Respiratory Center, Albuquerque, NM, USA
Cardiovasc Toxicol 3:353-61. 2003..These results concur with previous reports suggesting that realistic exposure concentrations of air pollution affect the pacemaking system of rats... - Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injuryWaylon M Weber
Lovelace CounterACT Center of Excellence, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
Toxicol Mech Methods 20:14-24. 2010..Intratracheal inhalation of SM vapors at a concentration of 5400 mg x min/m(3) resulted in homogeneous lung injury with no nasal degeneration... - Short-term inhalation of particulate transition metals has little effect on the electrocardiograms of dogs having preexisting cardiac abnormalitiesB A Muggenburg
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
Inhal Toxicol 15:357-71. 2003.... - Cochlear function in mice following inhalation of brevetoxin-3Janet M Benson
Lovelace Respiratory Research Institute, Albuquerque, NM, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:619-26. 2005..Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels... - A biphasic response to silica: I. Immunostimulation is restricted to the early stage of silicosis in lewis ratsRaymond J Langley
Immunology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
Am J Respir Cell Mol Biol 30:823-9. 2004..Thus, in the early stages of silicosis, silica activates the immune system; however, the progression of lung granulomas does not depend on a continually activated adaptive immune system... - A review of whole animal bioassays of the carcinogenic potential of naphthaleneD Warner North
NorthWorks, Inc, 1002 Misty Lane, Belmont, CA 94002 3651, USA
Regul Toxicol Pharmacol 51:S6-14. 2008.... - Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brainXiuzhen Yan
Department of Physiology and Pharmacology, University of Georgia Athens, Georgia, USA
Inhal Toxicol 18:1109-16. 2006..These results suggest that subacute exposure to PbTx-3 for 2 days is sufficient to induce neuronal degeneration in a discrete region of the mouse cerebral cortex... - Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of actionKenneth T Bogen
Exponent Health and Environmental, 500 12th Street, Suite 220, Oakland, CA 94607, USA
Regul Toxicol Pharmacol 51:S27-36. 2008....