Arnold H Zea

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion
    Arnold H Zea
    Stanley S Scott Cancer Center, Department of Immunology and Microbiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Cancer Res 65:3044-8. 2005
  2. pmc Interferon-gamma-induced nitric oxide inhibits the proliferation of murine renal cell carcinoma cells
    David J Tate
    Stanley S Scott Cancer Center, LSUHSC, New Orleans, LA, 70112, USA
    Int J Biol Sci 8:1109-20. 2012
  3. ncbi request reprint L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes
    Arnold H Zea
    Stanley S Scott Cancer Center, LSUHSC, New Orleans, LA, USA
    Cell Immunol 232:21-31. 2004
  4. ncbi request reprint Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment
    Arnold H Zea
    Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Infect Dis 194:1385-93. 2006
  5. ncbi request reprint Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    Augusto C Ochoa
    Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
    Clin Cancer Res 13:721s-726s. 2007
  6. ncbi request reprint L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 171:1232-9. 2003
  7. ncbi request reprint T cell CD3 receptor zeta (TCRzeta)-chain expression in children with idiopathic nephrotic syndrome
    Diego H Aviles
    Department of Pediatrics, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Nephrol 24:769-73. 2009
  8. ncbi request reprint Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta)
    Jovanny Zabaleta
    Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 173:586-93. 2004
  9. ncbi request reprint Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, Louisiana 70112, USA
    Cancer Res 64:5839-49. 2004
  10. ncbi request reprint Regulation of T cell receptor CD3zeta chain expression by L-arginine
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University, Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:21123-9. 2002

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion
    Arnold H Zea
    Stanley S Scott Cancer Center, Department of Immunology and Microbiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Cancer Res 65:3044-8. 2005
    ..In addition, it supports the concept that blocking arginase may be an important step in the success of immunotherapy...
  2. pmc Interferon-gamma-induced nitric oxide inhibits the proliferation of murine renal cell carcinoma cells
    David J Tate
    Stanley S Scott Cancer Center, LSUHSC, New Orleans, LA, 70112, USA
    Int J Biol Sci 8:1109-20. 2012
    ....
  3. ncbi request reprint L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes
    Arnold H Zea
    Stanley S Scott Cancer Center, LSUHSC, New Orleans, LA, USA
    Cell Immunol 232:21-31. 2004
    ..The replenishment of L-arginine recovers the expression of CD3zeta. The decreased expression of CD3zeta is not caused by a decreased CD3zeta mRNA, an increased CD3zeta degradation or T cell apoptosis...
  4. ncbi request reprint Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment
    Arnold H Zea
    Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Infect Dis 194:1385-93. 2006
    ..The decreased expression of CD3zeta reported in T cells from patients with either cancer or leprosy has provided possible explanations for the altered immune response observed in these diseases...
  5. ncbi request reprint Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    Augusto C Ochoa
    Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
    Clin Cancer Res 13:721s-726s. 2007
    ..Preliminary data suggest that prostaglandin E(2) produced by the tumor induces arginase I expression in MDSC. Therefore, blocking MDSC activity may enhance the therapeutic efficacy of immunotherapy in RCC...
  6. ncbi request reprint L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 171:1232-9. 2003
    ..These results may provide new insights into the mechanisms leading to T cell dysfunction and the down-regulation of CD3zeta in cancer and chronic infectious diseases...
  7. ncbi request reprint T cell CD3 receptor zeta (TCRzeta)-chain expression in children with idiopathic nephrotic syndrome
    Diego H Aviles
    Department of Pediatrics, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Nephrol 24:769-73. 2009
    ..Therefore, a decreased expression of the TCRzeta chain may explain the abnormal function of T cells in patients with INS, and it may also contribute to the increased risk for infections seen in these patients...
  8. ncbi request reprint Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta)
    Jovanny Zabaleta
    Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 173:586-93. 2004
    ..Furthermore, arginase inhibitors reversed these events. These results suggest that H. pylori arginase is not only important for urea production, but may also impair T cell function during infection...
  9. ncbi request reprint Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, Louisiana 70112, USA
    Cancer Res 64:5839-49. 2004
    ..Therefore, arginase I production by mature myeloid cells in the tumor microenvironment may be a central mechanism for tumor evasion and may represent a target for new therapies...
  10. ncbi request reprint Regulation of T cell receptor CD3zeta chain expression by L-arginine
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University, Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:21123-9. 2002
    ..Therefore, the regulation of L-Arg concentration in the microenvironment could represent an important mechanism to modulate the expression of CD3zeta and the T cell receptor and consequently of T cell function...
  11. pmc Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma
    David J Tate
    Stanley S, Scott Cancer Center, LSUHSC, New Orleans, USA
    J Hematol Oncol 1:14. 2008
    ..Therefore, we studied in murine renal cell carcinoma (RCC) cell lines, the effect of arginase II on tumor cell proliferation and L-arginine depletion. The effect of arginase inhibitors on cell proliferation was also tested...
  12. pmc Morphologic and molecular evaluation of Chlamydia trachomatis growth in human endocervix reveals distinct growth patterns
    Maria E Lewis
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center New Orleans, LA, USA
    Front Cell Infect Microbiol 4:71. 2014
    ....
  13. ncbi request reprint Decreased expression of T-cell NF-kappaB p65 subunit in steroid-resistant nephrotic syndrome
    Diego H Aviles
    LSU Health Sciences Center Department of Pediatrics and The Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Kidney Int 66:60-7. 2004
    ..Steroid resistance is considered a poor prognostic sign but the mechanism of the resistance is unknown. The study examined the potential role of T-cell nuclear transcription factors in the steroid resistance...
  14. ncbi request reprint Toll-like receptor-2 expression is upregulated in antigen-presenting cells from patients with psoriatic arthritis: a pathogenic role for innate immunity?
    Liliana Candia
    Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2822, USA
    J Rheumatol 34:374-9. 2007
    ..To study Toll-like receptor-2 (TLR-2) and TLR-4 expression in antigen-presenting cells from patients with psoriatic arthritis (PsA)...
  15. doi request reprint Effect of L-arginine supplementation on immune responsiveness in patients with sickle cell disease
    Arnette Scavella
    Department of Pediatrics, Pediatric Hematology Oncology, Louisiana State University Health Sciences Centers LSUHC NO, New Orleans, Louisiana, USA
    Pediatr Blood Cancer 55:318-23. 2010
    ..L-arginine (L-Arg) is deficient in sickle cell disease (SSD) during vasoocclusion. We investigated possible causal relationship between L-Arg deficiency and immune dysfunction in SSD in steady-state...
  16. pmc Influence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections
    Ashok Aiyar
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center New Orleans, LA, USA
    Front Cell Infect Microbiol 4:72. 2014
    ..trachomatis. ..
  17. doi request reprint The great mimicker: IgG4-related disease
    Rodolfo Pérez Alamino
    Section of Rheumatology, Department of Internal Medicine, LSU Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112 2822, USA
    Clin Rheumatol 32:1267-73. 2013
    ..Glucocorticoids are considered the treatment of choice for remission induction of IgG4-related disease manifestations; however, concerns regarding duration of therapy and management of refractory disease remained to be elucidated. ..
  18. ncbi request reprint Mechanisms of tumor evasion from the immune response
    Paulo C Rodriguez
    Stanley S Scott Cancer Center, Pediatrics Department, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Cancer Chemother Biol Response Modif 21:351-64. 2003
    ....
  19. pmc Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JC
    Anna Wilk
    Neurological Cancer Research at Stanley S Scott Cancer Center, New Orleans, Louisiana, USA
    J Cell Physiol 228:2127-38. 2013
    ..Our results indicate for the first time carcinogenic synergy in which oil-PAHs trigger oxidative DNA damage and JCV T-antigen compromises DNA repair fidelity...
  20. pmc Optimal transactivation by Epstein-Barr nuclear antigen 1 requires the UR1 and ATH1 domains
    Gyanendra Singh
    Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Virol 83:4227-35. 2009
    ..Our data strongly indicate a role for AT-hooks in EBNA1's ability to transactivate, a function necessary for EBV to immortalize naïve B-cells...
  21. pmc Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells
    Joyce A Ibana
    Department of Microbiology, Immunology and Parasitiology, Medical Education Building, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Infect Immun 79:4425-37. 2011
    ..Our findings suggest that IDO1 inhibitors such as L-1MT might provide a novel means to investigate, and potentially target, persistent chlamydial forms, particularly in conjunction with conventional therapeutics...