Jovanny Zabaleta

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc Transcriptional profiling of gastric epithelial cells infected with wild type or arginase-deficient Helicobacter pylori
    Songhee H Kim
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA 71130, USA
    BMC Microbiol 12:175. 2012
  2. pmc Multifactorial etiology of gastric cancer
    Jovanny Zabaleta
    Department of Pediatrics and Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Methods Mol Biol 863:411-35. 2012
  3. doi request reprint Interactions of cytokine gene polymorphisms in prostate cancer risk
    Jovanny Zabaleta
    Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, CSRB 455, New Orleans, LA 70112, USA
    Carcinogenesis 29:573-8. 2008
  4. pmc Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians
    Jovanny Zabaleta
    Department of Pediatrics, LSUHSC, New Orleans, LA 70112, USA
    Int J Cancer 128:668-75. 2011
  5. pmc Cytokine genetic polymorphisms and prostate cancer aggressiveness
    Jovanny Zabaleta
    Department of Pediatrics and Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, Clinical Sciences Research Building, New Orleans, LA 70112, USA
    Carcinogenesis 30:1358-62. 2009
  6. ncbi request reprint Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development
    Jovanny Zabaleta
    Stanley S Scott Cancer Center, LSUHSC, New Orleans, LA, USA
    Cancer Immunol Immunother 57:107-14. 2008
  7. ncbi request reprint Association of interleukin-1beta gene polymorphisms with precancerous gastric lesions in African Americans and Caucasians
    Jovanny Zabaleta
    Department of Pathology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Am J Gastroenterol 101:163-71. 2006
  8. ncbi request reprint Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment
    Arnold H Zea
    Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Infect Dis 194:1385-93. 2006
  9. ncbi request reprint Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes
    Liviu A Sicinschi
    Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Int J Cancer 118:649-57. 2006
  10. pmc L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 185:5198-204. 2010

Collaborators

Detail Information

Publications28

  1. pmc Transcriptional profiling of gastric epithelial cells infected with wild type or arginase-deficient Helicobacter pylori
    Songhee H Kim
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA 71130, USA
    BMC Microbiol 12:175. 2012
    ....
  2. pmc Multifactorial etiology of gastric cancer
    Jovanny Zabaleta
    Department of Pediatrics and Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Methods Mol Biol 863:411-35. 2012
    ..pylori infection and gastric cancer, with big emphasis to the H. pylori role in the development of the disease due to the strong association between both...
  3. doi request reprint Interactions of cytokine gene polymorphisms in prostate cancer risk
    Jovanny Zabaleta
    Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, CSRB 455, New Orleans, LA 70112, USA
    Carcinogenesis 29:573-8. 2008
    ..92, 95% CI = 1.13-7.55) and the genotype combination of TNF-238GG plus IL10-592AA (OR = 2.14, 95% CI = 1.05-4.38). Our results highlight the importance of cytokine SNPs and their interactions in CaP risk...
  4. pmc Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians
    Jovanny Zabaleta
    Department of Pediatrics, LSUHSC, New Orleans, LA 70112, USA
    Int J Cancer 128:668-75. 2011
    ..Interestingly, carriage of IL1B+3954T allele seems to be the key factor, even though the role played by other polymorphisms cannot be excluded...
  5. pmc Cytokine genetic polymorphisms and prostate cancer aggressiveness
    Jovanny Zabaleta
    Department of Pediatrics and Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, Clinical Sciences Research Building, New Orleans, LA 70112, USA
    Carcinogenesis 30:1358-62. 2009
    ..With limited sample size, the results from this study suggest that SNPs in cytokine genes may be associated with PCa aggressiveness. More extensive studies are warranted to validate our findings...
  6. ncbi request reprint Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development
    Jovanny Zabaleta
    Stanley S Scott Cancer Center, LSUHSC, New Orleans, LA, USA
    Cancer Immunol Immunother 57:107-14. 2008
    ..We hypothesize that these dissimilarities may contribute to differences in the inflammatory response and cancer incidence and mortality between African-Americans and Caucasians in Louisiana...
  7. ncbi request reprint Association of interleukin-1beta gene polymorphisms with precancerous gastric lesions in African Americans and Caucasians
    Jovanny Zabaleta
    Department of Pathology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Am J Gastroenterol 101:163-71. 2006
    ..The aim of this study was to evaluate the relationship between IL1B and IL1 receptor antagonist gene polymorphisms and the risk of multifocal atrophic gastritis in African Americans and Caucasians...
  8. ncbi request reprint Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment
    Arnold H Zea
    Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Infect Dis 194:1385-93. 2006
    ..The decreased expression of CD3zeta reported in T cells from patients with either cancer or leprosy has provided possible explanations for the altered immune response observed in these diseases...
  9. ncbi request reprint Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes
    Liviu A Sicinschi
    Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Int J Cancer 118:649-57. 2006
    ..pylori. Our results support the identification of the IL1B-31 promoter polymorphism as a useful marker for risk of intestinal type gastric cancer in persons with CagA positive H. pylori infections...
  10. pmc L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 185:5198-204. 2010
    ..These data contribute to an understanding of a central mechanism by which diseases characterized by increased arginase I production may cause T cell dysfunction...
  11. ncbi request reprint L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes
    Arnold H Zea
    Stanley S Scott Cancer Center, LSUHSC, New Orleans, LA, USA
    Cell Immunol 232:21-31. 2004
    ..The replenishment of L-arginine recovers the expression of CD3zeta. The decreased expression of CD3zeta is not caused by a decreased CD3zeta mRNA, an increased CD3zeta degradation or T cell apoptosis...
  12. pmc Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    Paulo C Rodriguez
    Department of Microbiology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Cancer Res 69:1553-60. 2009
    ..These results may provide new insights on the mechanisms of tumor-induced anergy/tolerance and may help explain why some immunotherapies fail to induce an antitumor response...
  13. pmc Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, New Orleans, LA, USA
    J Exp Med 202:931-9. 2005
    ..Furthermore, an addition of arginase I represents a clinical approach to enhance the therapeutic potential of cancer immunotherapies...
  14. ncbi request reprint Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, Louisiana 70112, USA
    Cancer Res 64:5839-49. 2004
    ..Therefore, arginase I production by mature myeloid cells in the tumor microenvironment may be a central mechanism for tumor evasion and may represent a target for new therapies...
  15. ncbi request reprint Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion
    Arnold H Zea
    Stanley S Scott Cancer Center, Department of Immunology and Microbiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Cancer Res 65:3044-8. 2005
    ..In addition, it supports the concept that blocking arginase may be an important step in the success of immunotherapy...
  16. pmc Pegylated arginase I: a potential therapeutic approach in T-ALL
    Claudia P Hernandez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center LSU HSC, New Orleans, LA 70112, USA
    Blood 115:5214-21. 2010
    ..The results suggest the potential benefit of L-Arginine depletion by peg-Arg I in the treatment of T-cell malignancies...
  17. ncbi request reprint Citrulline can preserve proliferation and prevent the loss of CD3 zeta chain under conditions of low arginine
    Vishal Bansal
    Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    JPEN J Parenter Enteral Nutr 28:423-30. 2004
    ..We hypothesized that citrulline could substitute for arginine under conditions of increased arginase expression. Thus, the goal was to establish a possible mechanism of how citrulline could overcome arginine depletion caused by arginase...
  18. ncbi request reprint Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta)
    Jovanny Zabaleta
    Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 173:586-93. 2004
    ..Furthermore, arginase inhibitors reversed these events. These results suggest that H. pylori arginase is not only important for urea production, but may also impair T cell function during infection...
  19. ncbi request reprint L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 171:1232-9. 2003
    ..These results may provide new insights into the mechanisms leading to T cell dysfunction and the down-regulation of CD3zeta in cancer and chronic infectious diseases...
  20. ncbi request reprint Regulation of T cell receptor CD3zeta chain expression by L-arginine
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University, Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:21123-9. 2002
    ..Therefore, the regulation of L-Arg concentration in the microenvironment could represent an important mechanism to modulate the expression of CD3zeta and the T cell receptor and consequently of T cell function...
  21. pmc Cerebrospinal fluid miRNA profile in HIV-encephalitis
    Marco Pacifici
    LSU Health Sciences Center, School of Medicine, Stanley S Scott Cancer Center, Louisiana State University, New Orleans, LA 70112, USA
    J Cell Physiol 228:1070-5. 2013
    ..Although more clinical samples should be examined, this work represents the first report of CSF miRNAs in HIV-infection and offers the basis for future investigation...
  22. ncbi request reprint Low frequency of anticyclic citrullinated peptide antibodies in psoriatic arthritis but not in cutaneous psoriasis
    Liliana Candia
    Rheumatology Section, Department of Medicine and the Stanley S Scott Cancer Center, LSU Health Sciences Center, New Orleans, Louisiana, USA
    J Clin Rheumatol 12:226-9. 2006
    ..Seven percent to 40% of patients with longstanding psoriasis will develop PsA at some point. Therefore, it is important to study the positivity of these antibodies in these two interrelated populations...
  23. ncbi request reprint Cytokine polymorphisms and gastric cancer risk: an evolving view
    Barbara G Schneider
    Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Biol Ther 7:157-62. 2008
    ..In this review, we discuss challenges in experimental design of gene association studies in gastric cancer, with attention to gene-environment interactions that may lead to inconsistency in findings across populations...
  24. ncbi request reprint IL1B polymorphisms and gastric cancer risk
    M Constanza Camargo
    Cancer Epidemiol Biomarkers Prev 16:635; author reply 635-6. 2007
  25. ncbi request reprint Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis
    M Constanza Camargo
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, 2215 Garland Avenue, 1005 MRB IV, Nashville, TN 37232 0252, USA
    Cancer Epidemiol Biomarkers Prev 15:1674-87. 2006
    ..Polymorphisms of interleukin-1B (IL1B) and its receptor antagonist (IL1RN) genes have been inconsistently associated with gastric cancer risk. We examined these associations by performing meta-analyses...
  26. pmc In vitro and in vivo complementation of the Helicobacter pylori arginase mutant using an intergenic chromosomal site
    Melanie L Langford
    Biology Department, University of South Alabama, Mobile, AL 36688, USA
    Helicobacter 11:477-93. 2006
    ..pylori at relatively low frequencies, and chromosomally based approaches. Chromosomal complementation strategies are susceptible to polar effects and disruption of other H. pylori genes, leading to unwanted pleiotropic effects...
  27. ncbi request reprint Purification and characterization of Helicobacter pylori arginase, RocF: unique features among the arginase superfamily
    David J McGee
    Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Eur J Biochem 271:1952-62. 2004
    ..The results indicate that H. pylori RocF is necessary and sufficient for arginase activity and has unparalleled features among the arginase superfamily, which may reflect the unique gastric ecological niche of this organism...
  28. ncbi request reprint CD14 gene promoter polymorphism in different clinical forms of tuberculosis
    Eugenia Pacheco
    Grupo de Inmunologia Celular e Inmunogenetica, Facultad de Medicina, Universidad de Antioquia, Cra 51 D No 62 29 Lab 283 Medellín, Colombia
    FEMS Immunol Med Microbiol 40:207-13. 2004
    ..Measuring sCD14 in tuberculosis may help monitor anti-tuberculosis treatment...