H Yu

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi Role of the insulin-like growth factor family in cancer development and progression
    H Yu
    Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    J Natl Cancer Inst 92:1472-89. 2000
  2. ncbi Clinical implications of prostate-specific antigen in men and women
    H Yu
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, 1501 Kings Hwy, PO Box 33932, Shreveport, LA 71130 3932, USA
    J Gend Specif Med 3:45-8, 53. 2000
  3. ncbi Do insulin-like growth factors mediate the effect of alcohol on breast cancer risk?
    H Yu
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Med Hypotheses 52:491-6. 1999
  4. ncbi Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation
    H Yu
    Feist Weiller Cancer Center, Section of Cancer Prevention and Control, Louisiana State University Medical Center, Shreveport 71130, USA
    J Clin Lab Anal 13:166-72. 1999
  5. ncbi Free insulin-like growth factor-I and breast cancer risk
    B D Li
    Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Int J Cancer 91:736-9. 2001
  6. ncbi Levels of insulin-like growth factor I (IGF-I) and IGF binding proteins 2 and 3 in serial postoperative serum samples and risk of prostate cancer recurrence
    H Yu
    Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71104, USA
    Urology 57:471-5. 2001
  7. pmc Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination
    H Yu
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, Shreveport 71130, USA
    Br J Cancer 81:490-5. 1999
  8. pmc Insulin-like growth factor-I and prostate cancer: a meta-analysis
    R Shi
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, LSUHSC Shreveport, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Br J Cancer 85:991-6. 2001
  9. pmc Patient compliance is critical for equivalent clinical outcomes for breast cancer treated by breast-conservation therapy
    B D Li
    Department of Surgery, Division of Radiation Oncology, Louisiana State University Health Science Center in Shreveport, Shreveport, Louisiana 71103, USA
    Ann Surg 231:883-9. 2000
  10. ncbi Polymorphic CA repeats in the IGF-I gene and breast cancer
    H Yu
    Feist Weiller Cancer Center and Department of Medicine, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Breast Cancer Res Treat 70:117-22. 2001

Collaborators

  • B D Li
  • I Kato
  • A Juul
  • J C McDonald
  • J Trachtenberg
  • Mitsunori Ikeda
  • Akira Sawa
  • Lili Wang
  • E P Diamandis
  • GLORIA YF HO
  • D Katsaros
  • J Qian
  • Z Tang
  • G Fang
  • S Fracchioli
  • L Mu
  • A C Beeghly
  • A Wiley
  • X Luo
  • I A Rigault de la Longrais
  • M Puopolo
  • H Chen
  • M W Kirschner
  • M Massobrio
  • R Bharadwaj
  • H R Luo
  • A Al-Haddad
  • J Lin
  • R Shi
  • M Gerstein
  • G Zhang
  • J Min
  • P G Trivedi
  • S A Kuznetsov
  • L L Ong
  • M Preti
  • C Wang
  • A Durando
  • G Levesque
  • R Arisio
  • L Lu
  • T J Rutherford
  • A L Wiley
  • A T Prescott
  • D N Melegos
  • R Piccinno
  • R Jansen
  • M A Shonn
  • T S Jung
  • X Guan
  • W G Krebs
  • C A Wilson
  • S Danese
  • A Diamandi
  • J Deisenhofer
  • M Dolled-Filhart
  • A Blocker
  • K Ye
  • J Park
  • E Nagata
  • S H Snyder
  • V Alexandrov
  • H Liu
  • X Zhou
  • J A Hammer
  • M J Khosravi
  • M Trumbauer
  • N Echols
  • K Hakala
  • L H Van der Ploeg
  • W Steffen
  • J K Burkhardt
  • G Gordini
  • B Stenger
  • Q Xie
  • M Yao
  • A Saiardi
  • S Jain
  • H Yan
  • C Zhao
  • H Zhu
  • G Griffiths
  • F Genta
  • H J Berkel
  • B Redlich
  • S A Teichmann
  • E Ozkan
  • D G Weiss
  • G Richiardi
  • M A Levesque

Detail Information

Publications36

  1. ncbi Role of the insulin-like growth factor family in cancer development and progression
    H Yu
    Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    J Natl Cancer Inst 92:1472-89. 2000
    ....
  2. ncbi Clinical implications of prostate-specific antigen in men and women
    H Yu
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, 1501 Kings Hwy, PO Box 33932, Shreveport, LA 71130 3932, USA
    J Gend Specif Med 3:45-8, 53. 2000
    ..Concentrations of PSA in serum are elevated in pregnant women as well as in women who have excess androgens. More studies are necessary to determine the clinical implications of the presence of PSA in amniotic fluid and female serum...
  3. ncbi Do insulin-like growth factors mediate the effect of alcohol on breast cancer risk?
    H Yu
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Med Hypotheses 52:491-6. 1999
    ..Therefore, compared to moderate drinkers, heavy alcohol users do not have a higher risk of breast cancer...
  4. ncbi Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation
    H Yu
    Feist Weiller Cancer Center, Section of Cancer Prevention and Control, Louisiana State University Medical Center, Shreveport 71130, USA
    J Clin Lab Anal 13:166-72. 1999
    ....
  5. ncbi Free insulin-like growth factor-I and breast cancer risk
    B D Li
    Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Int J Cancer 91:736-9. 2001
    ..The findings of this study suggest that measuring free IGF-I in circulation is more useful than measuring total IGF-I with respect to evaluation of an association between IGF-I and breast cancer risk...
  6. ncbi Levels of insulin-like growth factor I (IGF-I) and IGF binding proteins 2 and 3 in serial postoperative serum samples and risk of prostate cancer recurrence
    H Yu
    Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71104, USA
    Urology 57:471-5. 2001
    ..05). CONCLUSIONS: The study suggests that IGFBP-2 may play a role in the progression of prostate cancer, but serum levels of IGFBP-2 as well as IGF-I and IGFBP-3 have no predictive values in the prognosis of prostate cancer...
  7. pmc Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination
    H Yu
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, Shreveport 71130, USA
    Br J Cancer 81:490-5. 1999
    ....
  8. pmc Insulin-like growth factor-I and prostate cancer: a meta-analysis
    R Shi
    Section of Cancer Prevention and Control, Feist Weiller Cancer Center, LSUHSC Shreveport, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Br J Cancer 85:991-6. 2001
    ..Circulating levels of IGF-I and IGFBP-3 are likely to be higher in prostate cancer patients than in the controls. These findings support the suggestion that high IGF-I and IGFBP-3 are associated with an increased risk of prostate cancer...
  9. pmc Patient compliance is critical for equivalent clinical outcomes for breast cancer treated by breast-conservation therapy
    B D Li
    Department of Surgery, Division of Radiation Oncology, Louisiana State University Health Science Center in Shreveport, Shreveport, Louisiana 71103, USA
    Ann Surg 231:883-9. 2000
    ....
  10. ncbi Polymorphic CA repeats in the IGF-I gene and breast cancer
    H Yu
    Feist Weiller Cancer Center and Department of Medicine, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Breast Cancer Res Treat 70:117-22. 2001
    ..If our observations can be confirmed in larger studies, the findings will provide further evidence to support the role of IGF-I in breast cancer and the link between genetic polymorphism and cancer susceptibility...
  11. pmc Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motility
    A Al-Haddad
    , FB Biowissenschaften, , D-18051 Rostock, Germany
    Mol Biol Cell 12:2742-55. 2001
    ..We propose an "antagonistic/cooperative mechanism" to explain the saltatory phagosome movement toward the cell center in normal macrophages...
  12. ncbi GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase
    H R Luo
    Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuron 31:439-51. 2001
    ..The association of InsP6K1 with GRAB fits with a role for InsP7 in vesicle exocytosis...
  13. pmc cDNA sequence for human erythrocyte ankyrin
    S Lambert
    Department of Biomedical Research, Saint Elizabeth s Hospital of Boston, Tufts University Medical School, MA 02135
    Proc Natl Acad Sci U S A 87:1730-4. 1990
    ..An ankyrin message was also observed in RNA from the human cerebellum by the same method. The ankyrin gene is assigned to chromosome 8 using genomic DNA from a panel of sorted human chromosomes...
  14. ncbi Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1
    Z Tang
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Dev Cell 1:227-37. 2001
    ..Because BubR1 also interacts with the mitotic motor CENP-E, the ability of BubR1 to inhibit APC may be regulated by kinetochore tension or occupancy...
  15. pmc APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex
    Z Tang
    Departments of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
    Mol Biol Cell 12:3839-51. 2001
    ..Surprisingly, with Ubc4 as the E2 enzyme, Zn(2+) ions alone are sufficient to catalyze the ubiquitination of cyclin B1. Therefore, the Zn(2+) ions of the RING finger family of ubiquitin ligases may be directly involved in catalysis...
  16. ncbi Beyond synexpression relationships: local clustering of time-shifted and inverted gene expression profiles identifies new, biologically relevant interactions
    J Qian
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, PO Box 208114, New Haven, CT 06520-8114, USA
    J Mol Biol 314:1053-66. 2001
    ..Our clustering program and a detailed website of clustering results is available at http://www.bioinfo.mbb.yale.edu/expression/cluster (or http://www.genecensus.org/expression/cluster)...
  17. ncbi [Expression and prognostic significance in epithelial ovarian cancer]
    D Katsaros
    Dipartimento di Ostetricia e Ginecologia, Unità di Ginecologia Oncologica, Universita degli Studi, Turin, Italy
    Minerva Ginecol 54:15-24. 2002
    ..Epithelial ovarian cancer (EOC) tissues express IGFBP-3, IGFs and IGF-IR. Moreover, high levels of IGF-I and IGF-IR have been shown in epithelial ovarian cancer, and IGF-I stimulates the growth of ovarian cancer...
  18. ncbi Levels of organochlorine pesticides in Beijing human milk, 1998
    H Yu
    Beijing Center for Disease Prevention and Control, Hepingli Middle Street Number 16, Dongcheng District, People s Republic of China
    Bull Environ Contam Toxicol 70:193-7. 2003
  19. pmc Polymorphism of the insulin gene is associated with increased prostate cancer risk
    G Y F Ho
    Department of Epidemiology and Social Medicine, Albert Eistein College of Medicine, Bronx, New York, NY 10461, USA
    Br J Cancer 88:263-9. 2003
    ....
  20. ncbi Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer
    A Wiley
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Int J Gynecol Cancer 16:210-8. 2006
    ..These results suggest that IGFBP-3 promoter methylation may be a useful prognostic marker for disease progression and death in early-stage ovarian cancer...
  21. ncbi IGF-II promoter methylation and ovarian cancer prognosis
    A C Beeghly
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT, 06520 8034, USA
    J Cancer Res Clin Oncol 133:713-23. 2007
    ..Thus, we sought to examine if DNA methylation varies among IGF-II promoters in ovarian cancer and if methylation patterns are related to clinical features of the disease...
  22. ncbi [The growth hormone and insulin-like growth factors axis in liver failure patients]
    J Min
    Department of Digestive Diseases, Beijing Youan Hospital, Beijing 100054, China
    Zhonghua Gan Zang Bing Za Zhi 9:76-8. 2001
    ..CONCLUSIONS: The GH-IGFs axis is significantly abnormal in liver failure patients, suggesting the existence of GH resistance in these patients. Serum IGF-1 may act as a predictor for their prognosis...
  23. pmc PartsList: a web-based system for dynamically ranking protein folds based on disparate attributes, including whole-genome expression and interaction information
    J Qian
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA
    Nucleic Acids Res 29:1750-64. 2001
    ..e. according to V(-b), for attribute value V and constant exponent b), with a few folds having large values and most having small values...
  24. ncbi Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface
    H Yu
    Howard Hughes Medical Institute, Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 376:788-91. 1995
    ..The Rab-binding surface of hMss4 has subsequently been delineated using chemical-shift perturbation experiments and site-directed mutagenesis. The active site of hMss4 involves the Zn(2+)-binding region and a neighbouring loop...
  25. ncbi Dopamine transporter-dependent and -independent endogenous dopamine release from weaver mouse striatum in vitro
    J A Richter
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202 4887
    J Neurochem 64:191-8. 1995
    ..These findings suggest that the reason for the difference in the responsiveness of the two genotypes to these release-inducing agents is not related to DA transporter function...
  26. pmc Cellular protein modulates effects of human immunodeficiency virus type 1 Rev
    Y Luo
    Howard Hughes Medical Institute, San Francisco, California
    J Virol 68:3850-6. 1994
    ..Thus, YL2 or p32 is a cellular protein that modulates the function of human immunodeficiency virus type 1 Rev...
  27. ncbi Prostate-specific antigen in female serum, a potential new marker of androgen excess
    D N Melegos
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 82:777-80. 1997
    ..Receiver operating characteristic (ROC) analysis revealed that 3 alpha-AG was a slightly better marker of androgen excess than PSA. We conclude that female serum PSA may be a new biochemical marker of androgen action in females...
  28. pmc The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
    G Fang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 12:1871-83. 1998
    ..We conclude that the checkpoint-mediated cell cycle arrest involves hMAD2 receiving an upstream signal to inhibit activation of APC...
  29. ncbi Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
    G Fang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:163-71. 1998
    ..The hCDH1 protein level remains constant during the cell cycle and may target specific substrates lacking the D-box in G1, such as polo-like kinase, for ubiquitination...
  30. ncbi Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin
    G Levesque
    Centre for Research in Neurodegenerative Diseases, Department of Medicine Neurology, University of Toronto, and Toronto Hospital, Ontario, Canada
    J Neurochem 72:999-1008. 1999
    ..The latter residues contain a single arm-like domain and are highly conserved in the presenilins, suggesting that they form a functional armadillo protein binding site for the presenilins...
  31. ncbi Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20
    X Luo
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Struct Biol 7:224-9. 2000
    ..Mad2 and Cdc20 form a tight 1:1 heterodimeric complex in which the C-terminal segment of Mad2 becomes folded. These results provide the first structural insight into mechanisms of the spindle assembly checkpoint...
  32. ncbi Kinectin-kinesin binding domains and their effects on organelle motility
    L L Ong
    National University Medical Institutes, Faculty of Medicine, National University of Singapore, Singapore 117597
    J Biol Chem 275:32854-60. 2000
    ..These data, when combined with other studies, suggest a role for kinectin in organelle motility...
  33. ncbi mRNA and protein expression of Fas associated death domain protein in apoptosic hepatocyte induced by tumor necrosis factor-alpha
    G Zhang
    Department of Infectious Diseases, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Gan Zang Bing Za Zhi 9:10-2. 2001
    ..The expression of protein and mRNA of FADD were positively correlative with the apoptosic hepatocytes. CONCLUSION: TNF-alpha induces hepatocyte apoptosis by up regulation expression of FADD protein...
  34. ncbi IGFBP-3 in epithelial ovarian carcinoma and its association with clinico-pathological features and patient survival
    D Katsaros
    Department of Obstetrics and Gynecology, Gynecologic Oncology and Breast Cancer Unit, University of Turin, Turin, Italy
    Eur J Cancer 37:478-85. 2001
    ..Findings of the study indicate that IGFBP-3 may play a role in the progression of epithelial ovarian cancer, but that it has no independent value in predicting either disease prognosis or the response of patients to chemotherapy...
  35. ncbi Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out mice
    P G Trivedi
    Department of Obesity Research, Merck Research Laboratories, 07065, Rahway, New Jersey, USA
    Peptides 22:395-403. 2001
    ..A similar increase in Y1 receptor binding was seen only in the hypothalamus. These results demonstrate the NPY receptor expression is altered in mice deficient for its natural ligand...
  36. pmc TGF-beta1 genotype and phenotype in breast cancer and their associations with IGFs and patient survival
    L Mu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Br J Cancer 99:1357-63. 2008
    ..The study suggests a complex role of TGF-beta1 in breast cancer progression, which supports the finding of in vitro studies that TGF-beta1 has conflicting effects on tumour growth and metastasis...