Research Topics
Species | H YuSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Detail Information
Publications
Role of the insulin-like growth factor family in cancer development and progressionH Yu
Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
J Natl Cancer Inst 92:1472-89. 2000....- Clinical implications of prostate-specific antigen in men and womenH Yu
Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, 1501 Kings Hwy, PO Box 33932, Shreveport, LA 71130 3932, USA
J Gend Specif Med 3:45-8, 53. 2000..Concentrations of PSA in serum are elevated in pregnant women as well as in women who have excess androgens. More studies are necessary to determine the clinical implications of the presence of PSA in amniotic fluid and female serum... - Do insulin-like growth factors mediate the effect of alcohol on breast cancer risk?H Yu
Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, Shreveport 71130 3932, USA
Med Hypotheses 52:491-6. 1999..Therefore, compared to moderate drinkers, heavy alcohol users do not have a higher risk of breast cancer... - Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulationH Yu
Feist Weiller Cancer Center, Section of Cancer Prevention and Control, Louisiana State University Medical Center, Shreveport 71130, USA
J Clin Lab Anal 13:166-72. 1999.... - Free insulin-like growth factor-I and breast cancer riskB D Li
Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
Int J Cancer 91:736-9. 2001..The findings of this study suggest that measuring free IGF-I in circulation is more useful than measuring total IGF-I with respect to evaluation of an association between IGF-I and breast cancer risk... - Levels of insulin-like growth factor I (IGF-I) and IGF binding proteins 2 and 3 in serial postoperative serum samples and risk of prostate cancer recurrenceH Yu
Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71104, USA
Urology 57:471-5. 2001..05). CONCLUSIONS: The study suggests that IGFBP-2 may play a role in the progression of prostate cancer, but serum levels of IGFBP-2 as well as IGF-I and IGFBP-3 have no predictive values in the prognosis of prostate cancer... 
Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combinationH Yu
Section of Cancer Prevention and Control, Feist Weiller Cancer Center, Louisiana State University Medical Center, Shreveport 71130, USA
Br J Cancer 81:490-5. 1999....- Insulin-like growth factor-I and prostate cancer: a meta-analysisR Shi
Section of Cancer Prevention and Control, Feist Weiller Cancer Center, LSUHSC Shreveport, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
Br J Cancer 85:991-6. 2001..Circulating levels of IGF-I and IGFBP-3 are likely to be higher in prostate cancer patients than in the controls. These findings support the suggestion that high IGF-I and IGFBP-3 are associated with an increased risk of prostate cancer... - Patient compliance is critical for equivalent clinical outcomes for breast cancer treated by breast-conservation therapyB D Li
Department of Surgery, Division of Radiation Oncology, Louisiana State University Health Science Center in Shreveport, Shreveport, Louisiana 71103, USA
Ann Surg 231:883-9. 2000.... - Polymorphic CA repeats in the IGF-I gene and breast cancerH Yu
Feist Weiller Cancer Center and Department of Medicine, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
Breast Cancer Res Treat 70:117-22. 2001..If our observations can be confirmed in larger studies, the findings will provide further evidence to support the role of IGF-I in breast cancer and the link between genetic polymorphism and cancer susceptibility... - Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motilityA Al-Haddad
, FB Biowissenschaften, , D-18051 Rostock, Germany
Mol Biol Cell 12:2742-55. 2001..We propose an "antagonistic/cooperative mechanism" to explain the saltatory phagosome movement toward the cell center in normal macrophages... - GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinaseH R Luo
Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
Neuron 31:439-51. 2001..The association of InsP6K1 with GRAB fits with a role for InsP7 in vesicle exocytosis... - cDNA sequence for human erythrocyte ankyrinS Lambert
Department of Biomedical Research, Saint Elizabeth s Hospital of Boston, Tufts University Medical School, MA 02135
Proc Natl Acad Sci U S A 87:1730-4. 1990..An ankyrin message was also observed in RNA from the human cerebellum by the same method. The ankyrin gene is assigned to chromosome 8 using genomic DNA from a panel of sorted human chromosomes... - Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1Z Tang
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
Dev Cell 1:227-37. 2001..Because BubR1 also interacts with the mitotic motor CENP-E, the ability of BubR1 to inhibit APC may be regulated by kinetochore tension or occupancy... - APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complexZ Tang
Departments of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
Mol Biol Cell 12:3839-51. 2001..Surprisingly, with Ubc4 as the E2 enzyme, Zn(2+) ions alone are sufficient to catalyze the ubiquitination of cyclin B1. Therefore, the Zn(2+) ions of the RING finger family of ubiquitin ligases may be directly involved in catalysis... - Beyond synexpression relationships: local clustering of time-shifted and inverted gene expression profiles identifies new, biologically relevant interactionsJ Qian
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, PO Box 208114, New Haven, CT 06520-8114, USA
J Mol Biol 314:1053-66. 2001..Our clustering program and a detailed website of clustering results is available at http://www.bioinfo.mbb.yale.edu/expression/cluster (or http://www.genecensus.org/expression/cluster)... - [Expression and prognostic significance in epithelial ovarian cancer]D Katsaros
Dipartimento di Ostetricia e Ginecologia, , , Turin, Italy
Minerva Ginecol 54:15-24. 2002..An association between IGFBP-3 and overall survival was not shown. CONCLUSIONS: This study suggest that IGFBP-3 may play a role in the progression of epithelial ovarian cancer... - Levels of organochlorine pesticides in Beijing human milk, 1998H Yu
Beijing Center for Disease Prevention and Control, Hepingli Middle Street Number 16, Dongcheng District, People's Republic of China
Bull Environ Contam Toxicol 70:193-7. 2003 - Polymorphism of the insulin gene is associated with increased prostate cancer riskG Y F Ho
Department of Epidemiology and Social Medicine, Albert Eistein College of Medicine, Bronx, New York, NY 10461, USA
Br J Cancer 88:263-9. 2003.... - Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancerA Wiley
Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
Int J Gynecol Cancer 16:210-8. 2006..These results suggest that IGFBP-3 promoter methylation may be a useful prognostic marker for disease progression and death in early-stage ovarian cancer... - IGF-II promoter methylation and ovarian cancer prognosisA C Beeghly
Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT, 06520 8034, USA
J Cancer Res Clin Oncol 133:713-23. 2007..Thus, we sought to examine if DNA methylation varies among IGF-II promoters in ovarian cancer and if methylation patterns are related to clinical features of the disease... - [The growth hormone and insulin-like growth factors axis in liver failure patients]J Min
Department of Digestive Diseases, Beijing Youan Hospital, Beijing 100054, China
Zhonghua Gan Zang Bing Za Zhi 9:76-8. 2001..CONCLUSIONS: The GH-IGFs axis is significantly abnormal in liver failure patients, suggesting the existence of GH resistance in these patients. Serum IGF-1 may act as a predictor for their prognosis... - PartsList: a web-based system for dynamically ranking protein folds based on disparate attributes, including whole-genome expression and interaction informationJ Qian
Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA
Nucleic Acids Res 29:1750-64. 2001..e. according to V(-b), for attribute value V and constant exponent b), with a few folds having large values and most having small values... - Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surfaceH Yu
Howard Hughes Medical Institute, Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138, USA
Nature 376:788-91. 1995..The Rab-binding surface of hMss4 has subsequently been delineated using chemical-shift perturbation experiments and site-directed mutagenesis. The active site of hMss4 involves the Zn(2+)-binding region and a neighbouring loop... - Dopamine transporter-dependent and -independent endogenous dopamine release from weaver mouse striatum in vitroJ A Richter
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202 4887
J Neurochem 64:191-8. 1995..These findings suggest that the reason for the difference in the responsiveness of the two genotypes to these release-inducing agents is not related to DA transporter function... - Cellular protein modulates effects of human immunodeficiency virus type 1 RevY Luo
Howard Hughes Medical Institute, San Francisco, California
J Virol 68:3850-6. 1994..Thus, YL2 or p32 is a cellular protein that modulates the function of human immunodeficiency virus type 1 Rev... - Prostate-specific antigen in female serum, a potential new marker of androgen excessD N Melegos
Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
J Clin Endocrinol Metab 82:777-80. 1997..Receiver operating characteristic (ROC) analysis revealed that 3 alpha-AG was a slightly better marker of androgen excess than PSA. We conclude that female serum PSA may be a new biochemical marker of androgen action in females... - The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiationG Fang
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 12:1871-83. 1998..We conclude that the checkpoint-mediated cell cycle arrest involves hMAD2 receiving an upstream signal to inhibit activation of APC... - Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1G Fang
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 2:163-71. 1998..The hCDH1 protein level remains constant during the cell cycle and may target specific substrates lacking the D-box in G1, such as polo-like kinase, for ubiquitination... - Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-cateninG Levesque
Centre for Research in Neurodegenerative Diseases, Department of Medicine Neurology, University of Toronto, and Toronto Hospital, Ontario, Canada
J Neurochem 72:999-1008. 1999..The latter residues contain a single arm-like domain and are highly conserved in the presenilins, suggesting that they form a functional armadillo protein binding site for the presenilins... - Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20X Luo
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Struct Biol 7:224-9. 2000..Mad2 and Cdc20 form a tight 1:1 heterodimeric complex in which the C-terminal segment of Mad2 becomes folded. These results provide the first structural insight into mechanisms of the spindle assembly checkpoint... - Kinectin-kinesin binding domains and their effects on organelle motilityL L Ong
National University Medical Institutes, Faculty of Medicine, National University of Singapore, Singapore 117597
J Biol Chem 275:32854-60. 2000..These data, when combined with other studies, suggest a role for kinectin in organelle motility... - mRNA and protein expression of Fas associated death domain protein in apoptosic hepatocyte induced by tumor necrosis factor-alphaG Zhang
Department of Infectious Diseases, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Zhonghua Gan Zang Bing Za Zhi 9:10-2. 2001..The expression of protein and mRNA of FADD were positively correlative with the apoptosic hepatocytes. CONCLUSION: TNF-alpha induces hepatocyte apoptosis by up regulation expression of FADD protein... - IGFBP-3 in epithelial ovarian carcinoma and its association with clinico-pathological features and patient survivalD Katsaros
Department of Obstetrics and Gynecology, Gynecologic Oncology and Breast Cancer Unit, University of Turin, Turin, Italy
Eur J Cancer 37:478-85. 2001..Findings of the study indicate that IGFBP-3 may play a role in the progression of epithelial ovarian cancer, but that it has no independent value in predicting either disease prognosis or the response of patients to chemotherapy... - Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out miceP G Trivedi
Department of Obesity Research, Merck Research Laboratories, 07065, Rahway, New Jersey, USA
Peptides 22:395-403. 2001..A similar increase in Y1 receptor binding was seen only in the hypothalamus. These results demonstrate the NPY receptor expression is altered in mice deficient for its natural ligand... - TGF-beta1 genotype and phenotype in breast cancer and their associations with IGFs and patient survivalL Mu
Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
Br J Cancer 99:1357-63. 2008..The study suggests a complex role of TGF-beta1 in breast cancer progression, which supports the finding of in vitro studies that TGF-beta1 has conflicting effects on tumour growth and metastasis...