Eugene A Woltering

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc Development of a novel in vitro human tissue-based angiogenesis assay to evaluate the effect of antiangiogenic drugs
    Eugene A Woltering
    Department of Surgery, Section of Surgical Endocrinology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA
    Ann Surg 237:790-8; discussion 798-800. 2003
  2. pmc Clinical value of monitoring plasma octreotide levels during chronic octreotide long-acting repeatable therapy in carcinoid patients
    Eugene A Woltering
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 37:94-100. 2008
  3. ncbi request reprint Validation of serum versus plasma measurements of chromogranin a levels in patients with carcinoid tumors: lack of correlation between absolute chromogranin a levels and symptom frequency
    Eugene A Woltering
    Section of Surgical Endocrinology, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 33:250-4. 2006
  4. ncbi request reprint Effect of octreotide LAR dose and weight on octreotide blood levels in patients with neuroendocrine tumors
    Eugene A Woltering
    Department of Surgery, Sections of Surgical Endocrinology and Oncology, Louisiana State University and The Veterans Administration Medical Center, New Orleans, LA 70012, USA
    Pancreas 31:392-400. 2005
  5. ncbi request reprint Development of targeted somatostatin-based antiangiogenic therapy: a review and future perspectives
    Eugene A Woltering
    Louisiana State University Health Sciences Center, Department of Surgery, LSUHSC Stanley S Scott Cancer Center, LSUHSC Neuroscience Center of Excellence, and the Veterans Affairs Medical Center, New Orleans, Louisiana 70112, USA
    Cancer Biother Radiopharm 18:601-9. 2003
  6. doi request reprint An extended phase II trial of iodine-125 methylene blue for sentinel lymph node identification in women with breast cancer
    William W Harkrider
    Louisiana State University Health Sciences Center, University Medical Center, Lafayette, LA, USA
    J Am Coll Surg 216:599-605; discussion 605-6. 2013
  7. ncbi request reprint A single institution's experience with surgical cytoreduction of stage IV, well-differentiated, small bowel neuroendocrine tumors
    J Philip Boudreaux
    Louisiana State University Health Sciences Center, University Medical Center, New Orleans, LA
    J Am Coll Surg 218:837-44. 2014
  8. pmc A prospective trial on the effect of body mass index and sex on plasma octreotide levels in patients undergoing long-term octreotide LAR therapy
    Saju Joseph
    Sections of Surgical Endocrinology and Hepatobiliary Surgery, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 39:964-6. 2010
  9. doi request reprint Neurokinin A levels predict survival in patients with stage IV well differentiated small bowel neuroendocrine neoplasms
    Anne E Diebold
    Department of Surgery, Section of Surgical Endocrinology, The Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Surgery 152:1172-6. 2012
  10. doi request reprint Cervical and upper mediastinal lymph node metastasis from gastrointestinal and pancreatic neuroendocrine tumors: true incidence and management
    Yi Zarn Wang
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Am Coll Surg 214:1017-22. 2012

Collaborators

Detail Information

Publications41

  1. pmc Development of a novel in vitro human tissue-based angiogenesis assay to evaluate the effect of antiangiogenic drugs
    Eugene A Woltering
    Department of Surgery, Section of Surgical Endocrinology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA
    Ann Surg 237:790-8; discussion 798-800. 2003
    ..To describe a novel in vitro human tissue-based angiogenic model that can predict an individual tumor's response to antiangiogenic drugs...
  2. pmc Clinical value of monitoring plasma octreotide levels during chronic octreotide long-acting repeatable therapy in carcinoid patients
    Eugene A Woltering
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 37:94-100. 2008
    ..However, plasma octreotide levels have decreased over time in patients receiving these doses of LAR...
  3. ncbi request reprint Validation of serum versus plasma measurements of chromogranin a levels in patients with carcinoid tumors: lack of correlation between absolute chromogranin a levels and symptom frequency
    Eugene A Woltering
    Section of Surgical Endocrinology, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 33:250-4. 2006
    ....
  4. ncbi request reprint Effect of octreotide LAR dose and weight on octreotide blood levels in patients with neuroendocrine tumors
    Eugene A Woltering
    Department of Surgery, Sections of Surgical Endocrinology and Oncology, Louisiana State University and The Veterans Administration Medical Center, New Orleans, LA 70012, USA
    Pancreas 31:392-400. 2005
    ..At identical monthly LAR doses, patients with higher weights will require more medication to achieve similar plasma octreotide levels than individuals with lower body weights...
  5. ncbi request reprint Development of targeted somatostatin-based antiangiogenic therapy: a review and future perspectives
    Eugene A Woltering
    Louisiana State University Health Sciences Center, Department of Surgery, LSUHSC Stanley S Scott Cancer Center, LSUHSC Neuroscience Center of Excellence, and the Veterans Affairs Medical Center, New Orleans, Louisiana 70112, USA
    Cancer Biother Radiopharm 18:601-9. 2003
    ..This manuscript reviews the development of somatostatin analogs as antiangiogenics in both their unlabeled and radiolabeled forms and postulates on future developments in this field...
  6. doi request reprint An extended phase II trial of iodine-125 methylene blue for sentinel lymph node identification in women with breast cancer
    William W Harkrider
    Louisiana State University Health Sciences Center, University Medical Center, Lafayette, LA, USA
    J Am Coll Surg 216:599-605; discussion 605-6. 2013
    ..The aim of this study was to determine if an intraoperative injection of iodine-125-labeled methylene blue ((125)I-MB) is a sensitive and effective method for detecting SLNs in women with breast cancer...
  7. ncbi request reprint A single institution's experience with surgical cytoreduction of stage IV, well-differentiated, small bowel neuroendocrine tumors
    J Philip Boudreaux
    Louisiana State University Health Sciences Center, University Medical Center, New Orleans, LA
    J Am Coll Surg 218:837-44. 2014
    ..Clinical outcomes in a group of stage IV, well-differentiated patients with NETs with small bowel primaries undergoing cytoreductive surgery and multidisciplinary management at a single center were evaluated...
  8. pmc A prospective trial on the effect of body mass index and sex on plasma octreotide levels in patients undergoing long-term octreotide LAR therapy
    Saju Joseph
    Sections of Surgical Endocrinology and Hepatobiliary Surgery, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 39:964-6. 2010
    ..Previous work has shown that body weight and monthly LAR dose will significantly affect circulating plasma octreotide levels in patients undergoing therapy...
  9. doi request reprint Neurokinin A levels predict survival in patients with stage IV well differentiated small bowel neuroendocrine neoplasms
    Anne E Diebold
    Department of Surgery, Section of Surgical Endocrinology, The Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Surgery 152:1172-6. 2012
    ..We hypothesized that American patients with persistently elevated plasma neurokinin A levels (>50 pg/mL) will also have a poor short-term survival...
  10. doi request reprint Cervical and upper mediastinal lymph node metastasis from gastrointestinal and pancreatic neuroendocrine tumors: true incidence and management
    Yi Zarn Wang
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Am Coll Surg 214:1017-22. 2012
    ..Historically, cervical nodes have been regarded as asymptomatic and ignored. We hypothesized that these lesions have clinical implications and should be removed surgically...
  11. doi request reprint Neuroendocrine tumors: current recommendations for diagnosis and surgical management
    Saju Joseph
    Section of Endocrine Surgery, Department of Surgery, Louisiana State University Health Sciences Center, 200 West Esplanade Avenue, Suite 200, Kenner, LA 70065, USA
    Endocrinol Metab Clin North Am 40:205-31, x. 2011
    ....
  12. doi request reprint A novel assay to assess the effectiveness of antiangiogenic drugs in human breast cancer
    John M Lyons
    Department of Surgery, Sections of Surgical Oncology and Surgical Endocrinology, Louisiana State University Health Sciences Center, Kenner, LA 70065, USA
    Ann Surg Oncol 15:3407-14. 2008
    ..We used a fibrin-thrombin clot-based angiogenesis model to evaluate the angiogenic response of human breast cancer to various cytotoxic agents commonly used in its treatment...
  13. pmc A phase I/II trial of 125I methylene blue for one-stage sentinel lymph node biopsy
    Jason David Cundiff
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, USA
    Ann Surg 245:290-6. 2007
    ..To avoid these problems, we developed a novel radiolabeled blue dye that can be injected intraoperatively...
  14. doi request reprint A study of pipeline drugs in neuroendocrine tumors
    Catherine T Anthony
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Gastrointest Cancer 43:296-304. 2012
    ..We tested a series of investigational agents to determine their ability to inhibit angiogenesis in our in vitro human angiogenesis model...
  15. ncbi request reprint Effect of human Angiostatin protein on human angiogenesis in vitro
    Sung Pil Jung
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Angiogenesis 6:233-40. 2003
    ....
  16. ncbi request reprint In vitro modeling of the clinical interactions between octreotide and 111In-pentetreotide: is there evidence of somatostatin receptor downregulation?
    Susan H Gunn
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Nucl Med 47:354-9. 2006
    ....
  17. doi request reprint A prospective evaluation of the effect of chronic proton pump inhibitor use on plasma biomarker levels in humans
    Daniel Raines
    Section of Gastroenterology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 41:508-11. 2012
    ..Pancreastatin, a fragment of CGA, is also commonly used to diagnose and follow NETs. We hypothesized that chronic PPI use would increase circulating plasma gastrin, CGA, and pancreastatin levels...
  18. ncbi request reprint Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni)
    Conrad A Hornick
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Angiogenesis 6:143-9. 2003
    ..In tumor explants which did show capillary sprouting, the vessels rapidly degenerated (2-3 days) in those exposed to media supplemented with 10% noni...
  19. doi request reprint The effect of AlloDerm on the initiation and growth of human neovessels
    Sean R Weiss
    Department of Otorhinolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Laryngoscope 120:443-9. 2010
    ..We hypothesized that AlloDerm would enhance angiogenesis and might be altered with autologous blood products to enhance initiation of the angiogenic response...
  20. ncbi request reprint Development of a human cardiac tissue-based angiogenesis model
    James M Lewis
    Department of Surgery Sections of Surgical Endocrinology, Louisiana State University Health Sciences Center LSUHSC, New Orleans, Louisiana 70112, USA
    J Surg Res 135:34-7. 2006
    ..Previous angiogenesis models use animal tissues such as the chicken chorioallantoic membrane (CAM) or the rabbit cornea. These models may not accurately reflect the mechanisms responsible for human angiogenesis...
  21. doi request reprint Do primary neuroendocrine tumors and metastasis have the same characteristics?
    Erika B Lindholm
    Louisiana State University Health Sciences Center, Department of Surgery, Section of Surgical Endocrinology, New Orleans, Louisiana, USA
    J Surg Res 174:200-6. 2012
    ..We also hypothesized that limited tumor sampling could lead to erroneous assumptions about the tumor's histologic characteristics and clinical behavior...
  22. pmc Metronomic dosing enhances the anti-angiogenic effect of epothilone B
    Mark W Stalder
    Department of Surgery, Section of Endocrine Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70006, USA
    J Surg Res 169:247-56. 2011
    ..We hypothesized that epothilone B would be an effective anti-angiogenic agent when administered at very low doses over an extended period of time...
  23. doi request reprint The role of angiogenesis in neuroendocrine tumors
    John Lyons
    Department of Surgery, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
    Endocrinol Metab Clin North Am 39:839-52. 2010
    ..This article describes the evolution of methods to assess in vitro angiogenesis in neuroendocrine tumors and describes some of the clinical data...
  24. doi request reprint Percutaneous localisation of pulmonary nodules prior to video-assisted thoracoscopic surgery using methylene blue and TC-99
    Yi Zarn Wang
    Louisiana State University, Department of Surgery, New Orleans, LA 70112, USA
    Eur J Cardiothorac Surg 37:237-8. 2010
    ..This modified dual agent's preoperative localisation is logical, practical and easy to be adopted into the clinical setting for surgeons who choose to use the VATS technique in addressing these lung nodules...
  25. ncbi request reprint The effect of drug dose and drug exposure time on the binding, internalization, and cytotoxicity of radiolabeled somatostatin analogs
    Catherine T Anthony
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    J Surg Res 119:1-13. 2004
    ..We hypothesized that the ability of a radiolabeled peptide to bind to a cell, be internalized, and induce cytotoxicity is proportional to both the radioligand concentration and the exposure time...
  26. ncbi request reprint Effect of human recombinant Endostatin protein on human angiogenesis
    Sung P Jung
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Angiogenesis 5:111-8. 2002
    ..Human endostatin can inhibit the initiation of a human angiogenic response and inhibit the subsequent proliferation of human neovessels when used at high doses in a continuous exposure model...
  27. doi request reprint Lymphatic mapping helps to define resection margins for midgut carcinoids
    Yi Zarn Wang
    Louisiana State University Health Sciences Center, Department of Surgery, Section of Surgical Oncology and Endocrine Surgery, New Orleans, LA, USA
    Surgery 146:993-7. 2009
    ..We hypothesized that altered lymphatic drainage makes traditional determination of resection margins inadequate...
  28. doi request reprint In vitro chemoresistance testing in well-differentiated carcinoid tumors
    John M Lyons
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Ann Surg Oncol 16:649-55. 2009
    ..We hypothesized that tumor specimens from well-differentiated carcinoid tumors would be highly resistant to the effects of chemotherapy when tested against a variety of antineoplastic agents in vitro...
  29. doi request reprint Resolution of pulsatile tinnitus following an upper mediastinal lymph node resection
    Yi Zarn Wang
    Ochsner Medical Center Kenner, Kenner, LA 70065, USA
    South Med J 103:374-7. 2010
    ..We believe a careful search for nodal metastases compressing vascular structures in such patients is warranted as debilitating pulsatile tinnitus may be cured by a simple surgical procedure...
  30. ncbi request reprint Development of 125I-methylene blue for sentinel lymph node biopsy
    Shawn J Stafford
    Department of Surgery, The Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Surg Oncol 94:293-7. 2006
    ..We hypothesize that 125I-labeled methylene blue will be rapidly absorbed into the lymphatics and transported to the drainage basin containing the sentinel nodes...
  31. doi request reprint A single fasting plasma 5-HIAA value correlates with 24-hour urinary 5-HIAA values and other biomarkers in midgut neuroendocrine tumors (NETs)
    Maria R Tellez
    Inter Science Institute, Inglewood, CA, USA
    Pancreas 42:405-10. 2013
    ..5-Hydroxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs) but currently requires a 24-hour urine collection...
  32. ncbi request reprint Indium-111-pentetreotide prolongs survival in gastroenteropancreatic malignancies
    Lowell B Anthony
    Louisiana State University Medical Center, Department of Medicine, the Louisiana State University Health Sciences Center LSUHSC, Stanley S Scott Cancer Center, New Orleans, LA 70112, USA
    Semin Nucl Med 32:123-32. 2002
    ..The maximal tolerated dose of (111)In-pentetreotide and the optimal dosing schedules remain under investigation...
  33. doi request reprint The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum
    J Philip Boudreaux
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 39:753-66. 2010
    ..Further studies of novel approaches such as peptide receptor radiotherapy are also warranted...
  34. ncbi request reprint Sentinel nodal assessment in patients with carcinoma of the lung
    Frank E Schmidt
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Ann Thorac Surg 74:870-4; discussion 874-5. 2002
    ..This study tested whether injection of isosulfan blue and technetium-99 could identify mediastinal sentinel nodes in patients with lung carcinoma and determine whether sentinel node histology predicts distal nodal metastases...
  35. ncbi request reprint A new in vitro assay for human tumor angiogenesis: three-dimensional human tumor angiogenesis assay
    Seza A Gulec
    John Wayne Cancer Institute, Santa Monica, California, USA
    Ann Surg Oncol 11:99-104. 2004
    ..A human tissue-based angiogenesis assay is needed to study the biology of angiogenesis in human tumor tissue and to tailor drug selection for patients...
  36. ncbi request reprint Gamma probe-guided lymph node dissection ('gamma picking') in differentiated thyroid carcinoma
    Seza A Gulec
    John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Nucl Med 27:859-61. 2002
    ..6 cm. Two of the four hot spots proved to be metastatic foci in small lymph nodes measuring less than 0.5 cm. The other two hot spots were thyroid remnants with no associated nodal tissue...
  37. ncbi request reprint Role of somatostatin analogs in the clinical management of non-neuroendocrine solid tumors
    Larry K Kvols
    Inter Disciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Anticancer Drugs 17:601-8. 2006
    ....
  38. ncbi request reprint Black raspberry extract and fractions contain angiogenesis inhibitors
    Zhijun Liu
    Louisiana State University Agricultural Center, 227 Renewable Natural Resources Building, Baton Rouge, Louisiana 70803, USA
    J Agric Food Chem 53:3909-15. 2005
    ..These extracts contain multiple active ingredients that may be additive or synergistic in their antiangiogenic effects. These observations warrant further investigations in animals and human trials...
  39. ncbi request reprint A multi-tyrosinated sst1/2 receptor preferring somatostatin agonist inhibits reflex and immune-mediated secretion in the guinea pig colon
    Helen J Cooke
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Regul Pept 114:51-60. 2003
    ..The results suggest that WOC 3B, a somatostatin analogue containing three tyrosine residues, has anti-secretory effects due to activation of somatostatin sst1 and sst2 receptors on enteric neurons...
  40. ncbi request reprint An assay to measure angiogenesis in human fat tissue
    Frank L Greenway
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Obes Surg 17:510-5. 2007
    ..Inhibition of angiogenesis reverses rodent obesity. A validated assay in human fat tissue is needed to study the role of angiogenesis in human obesity...
  41. ncbi request reprint Gallic acid is partially responsible for the antiangiogenic activities of Rubus leaf extract
    Zhijun Liu
    School of Renewable Natural Resources, LSU Agricultural Center, Louisiana State University, Baton Rouge, LA 70803, USA
    Phytother Res 20:806-13. 2006
    ..1% w/w caused a 41% inhibition of angiogenesis compared with saline injected controls. These preliminary results warrant further bioassay directed identification of other responsible compounds...