Gary E Wise


Affiliation: Louisiana State University
Country: USA


  1. Wise G. Cellular and molecular basis of tooth eruption. Orthod Craniofac Res. 2009;12:67-73 pubmed publisher
    ..Conclusion - The osteoclastogenesis and osteogenesis needed for eruption are regulated by differential gene expression in the DF both chronologically and spatially. ..
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    Wise G, Yao S. Expression of vascular endothelial growth factor in the dental follicle. Crit Rev Eukaryot Gene Expr. 2003;13:173-80 pubmed
    ..Treatment with PMA also increased the protein level of VEGF. Thus, VEGF may be involved in promoting the secondary burst of osteoclastogenesis, and activation of PKC may upregulate its expression. ..
  3. Wise G, Yao S, Odgren P, Pan F. CSF-1 regulation of osteoclastogenesis for tooth eruption. J Dent Res. 2005;84:837-41 pubmed
    ..Thus, these studies support our hypothesis that the down-regulation of OPG needed for tooth eruption is mediated by CSF-1. ..
  4. Wise G, He H, Gutierrez D, Ring S, Yao S. Requirement of alveolar bone formation for eruption of rat molars. Eur J Oral Sci. 2011;119:333-8 pubmed publisher
    ..These studies show that alveolar bone growth at the base of the crypt is required for tooth eruption and that Bmp6 may be essential for promoting this growth. ..
  5. Rezai Rad M, Liu D, He H, Brooks H, Xiao M, Wise G, et al. The role of dentin matrix protein 1 (DMP1) in regulation of osteogenic differentiation of rat dental follicle stem cells (DFSCs). Arch Oral Biol. 2015;60:546-56 pubmed publisher
    ..DMP1 is highly expressed in the DFSCs, but minimally expressed in non-stem cell DFC. DMP1 appears to play an important role for osteogenic differentiation of the DFSCs. ..
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    Wise G, Ren Y, Yao S. Regulation of osteoprotegerin gene expression in dental follicle cells. J Dent Res. 2003;82:298-302 pubmed
    ..The PKC-alpha isoform may be critical in OPG regulation because PKC-alpha gene expression is enhanced by PMA and reduced by either CSF-1 or PTHrP...
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    Wise G, Ding D, Yao S. Regulation of secretion of osteoprotegerin in rat dental follicle cells. Eur J Oral Sci. 2004;112:439-44 pubmed
    ..Thus, a reduction in secretion of the OPG protein at defined times may promote the osteoclastogenesis and alveolar bone resorption needed for eruption, and enhancement of OPG secretion at other times may promote alveolar bone formation...
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    Wise G, Yao S, Liu D. Injections of osteoprotegerin and PMA delay tooth eruption. Clin Anat. 2006;19:19-24 pubmed
    ..Consequently, regulation of OPG production by the dental follicle likely affects the alveolar bone resorption needed for tooth eruption. ..
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    Wise G, Yao S. Regional differences of expression of bone morphogenetic protein-2 and RANKL in the rat dental follicle. Eur J Oral Sci. 2006;114:512-6 pubmed

More Information


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    Wise G, Yao S, Henk W. Bone formation as a potential motive force of tooth eruption in the rat molar. Clin Anat. 2007;20:632-9 pubmed
    ..Thus, SEM indicates that the motive force of tooth eruption likely is bone formation at the base of the alveolar crypt and this osteogenesis may relate to BMP-2 production in the dental follicle. ..