Diana L Williams

Summary

Affiliation: Louisiana State University
Country: USA

Publications

  1. pmc Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis
    D L Williams
    Gillis W Long Hansen s Disease Research Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70894, USA
    Antimicrob Agents Chemother 42:1853-7. 1998
  2. pmc Implications of high level pseudogene transcription in Mycobacterium leprae
    Diana L Williams
    HRSA, BPHC, Division of National Hansen s Disease Programs, Laboratory Research Branch, Molecular Biology Research Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    BMC Genomics 10:397. 2009
  3. pmc Molecular basis of the defective heat stress response in Mycobacterium leprae
    Diana L Williams
    Molecular Biology Research Dept, Laboratory Research Branch, Division of the National Hansen s Disease Programs at LSU SVM, Baton Rouge, LA 70803, USA
    J Bacteriol 189:8818-27. 2007
  4. ncbi request reprint Biological implications of Mycobacterium leprae gene expression during infection
    Diana L Williams
    Laboratory Research Branch, Division of the National Hansen s Disease Programs at LSU SVM, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA
    J Mol Microbiol Biotechnol 8:58-72. 2004
  5. ncbi request reprint Molecular detection of drug resistance in Mycobacterium leprae
    Diana L Williams
    Molecular Biology Research Department, Laboratory Research Branch, Division of the National Hansen s Disease Programs, Baton Rouge, LA, USA
    Lepr Rev 75:118-30. 2004
  6. ncbi request reprint Purification of Mycobacterium leprae RNA for gene expression analysis from leprosy biopsy specimens
    Diana L Williams
    Molecular Biology Research Department, Laboratory Research Branch, National Hansen s Disease Programs at LSU SVM, Rm 3517W, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Biotechniques 35:534-6, 538, 540-1. 2003
  7. pmc Simultaneous detection of Mycobacterium leprae and its susceptibility to dapsone using DNA heteroduplex analysis
    D L Williams
    Molecular Biology Research Department, Laboratory Research Branch, National Hansen s Disease Programs at the School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70894, USA
    J Clin Microbiol 39:2083-8. 2001
  8. pmc Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance
    D L Williams
    Laboratory Research Branch, National Hansen s Disease Programs at Louisiana State University, Baton Rouge, Louisiana 70894, USA
    Antimicrob Agents Chemother 44:1530-7. 2000
  9. pmc Increased CXC ligand 10 levels and gene expression in type 1 leprosy reactions
    David M Scollard
    National Hansen s Disease Programs, 1770 Physician Park Dr, Baton Rouge, LA 70816, USA
    Clin Vaccine Immunol 18:947-53. 2011
  10. pmc The armadillo: a model for the neuropathy of leprosy and potentially other neurodegenerative diseases
    Rahul Sharma
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Dis Model Mech 6:19-24. 2013

Detail Information

Publications11

  1. pmc Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis
    D L Williams
    Gillis W Long Hansen s Disease Research Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70894, USA
    Antimicrob Agents Chemother 42:1853-7. 1998
    ....
  2. pmc Implications of high level pseudogene transcription in Mycobacterium leprae
    Diana L Williams
    HRSA, BPHC, Division of National Hansen s Disease Programs, Laboratory Research Branch, Molecular Biology Research Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    BMC Genomics 10:397. 2009
    ..Preliminary evidence suggests that some pseudogenes are expressed. Therefore, defining pseudogene transcriptional and translational potentials of this genome should increase our understanding of their impact on M. leprae physiology...
  3. pmc Molecular basis of the defective heat stress response in Mycobacterium leprae
    Diana L Williams
    Molecular Biology Research Dept, Laboratory Research Branch, Division of the National Hansen s Disease Programs at LSU SVM, Baton Rouge, LA 70803, USA
    J Bacteriol 189:8818-27. 2007
    ..leprae to survive at elevated temperatures results from the lack of a functional transcriptional response to heat shock and the absence of a full repertoire of heat stress response genes, including sigH...
  4. ncbi request reprint Biological implications of Mycobacterium leprae gene expression during infection
    Diana L Williams
    Laboratory Research Branch, Division of the National Hansen s Disease Programs at LSU SVM, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA
    J Mol Microbiol Biotechnol 8:58-72. 2004
    ..leprae gene expression profiling. Identifying genes associated with growth and survival during infection should lead to a more comprehensive understanding of the ability of M. leprae to cause disease...
  5. ncbi request reprint Molecular detection of drug resistance in Mycobacterium leprae
    Diana L Williams
    Molecular Biology Research Department, Laboratory Research Branch, Division of the National Hansen s Disease Programs, Baton Rouge, LA, USA
    Lepr Rev 75:118-30. 2004
  6. ncbi request reprint Purification of Mycobacterium leprae RNA for gene expression analysis from leprosy biopsy specimens
    Diana L Williams
    Molecular Biology Research Department, Laboratory Research Branch, National Hansen s Disease Programs at LSU SVM, Rm 3517W, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Biotechniques 35:534-6, 538, 540-1. 2003
    ..This represents a major advancement in the ability to study M. leprae gene expression directly from biopsy material and should help to define genes that are associated with intracellular survival of this human pathogen...
  7. pmc Simultaneous detection of Mycobacterium leprae and its susceptibility to dapsone using DNA heteroduplex analysis
    D L Williams
    Molecular Biology Research Department, Laboratory Research Branch, National Hansen s Disease Programs at the School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70894, USA
    J Clin Microbiol 39:2083-8. 2001
    ..The assay should prove useful for drug resistance surveillance in leprosy control programs when combined with similar molecular tests developed for other drug resistance markers...
  8. pmc Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance
    D L Williams
    Laboratory Research Branch, National Hansen s Disease Programs at Louisiana State University, Baton Rouge, Louisiana 70894, USA
    Antimicrob Agents Chemother 44:1530-7. 2000
    ..leprae strains were identical, indicating that this gene does not encode a functional DHPS and is not involved in dapsone resistance in M. leprae...
  9. pmc Increased CXC ligand 10 levels and gene expression in type 1 leprosy reactions
    David M Scollard
    National Hansen s Disease Programs, 1770 Physician Park Dr, Baton Rouge, LA 70816, USA
    Clin Vaccine Immunol 18:947-53. 2011
    ..CXCL10 measurement offers new possibilities for laboratory diagnosis and monitoring of T1R. Studies of the regulation of CXCL10 may provide insight into the mechanisms of T1R and identify potential new drug targets for treatment...
  10. pmc The armadillo: a model for the neuropathy of leprosy and potentially other neurodegenerative diseases
    Rahul Sharma
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Dis Model Mech 6:19-24. 2013
    ..These advances will facilitate the use of armadillos in piloting new therapies and diagnostic regimens, and will provide new insights into the oldest known infectious neurodegenerative disorder...
  11. ncbi request reprint A new model for studying the effects of Mycobacterium leprae on Schwann cell and neuron interactions
    Deanna A Hagge
    Biological Sciences Department, Louisiana State University, Baton Rouge, Louisana 70803, USA
    J Infect Dis 186:1283-96. 2002
    ..leprae retained 53% viability. This article describes a new model for studying the effects of M. leprae on Schwann cells...