Y Wang

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies
    Robin S Bowen
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Soc Gynecol Investig 12:428-32. 2005
  2. ncbi request reprint Endothelial barrier function in preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA
    Front Biosci 12:2412-24. 2007
  3. pmc Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, PO Box 33932, Shreveport, Louisiana 71130, USA
    J Clin Endocrinol Metab 93:260-6. 2008
  4. ncbi request reprint Role of chymase in preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130
    Curr Vasc Pharmacol 11:606-15. 2013
  5. pmc Differential miRNA expression profiles between the first and third trimester human placentas
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, LA 71130, USA
    Am J Physiol Endocrinol Metab 304:E836-43. 2013
  6. pmc Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies
    Rong Ma
    Dept of Obstetrics and Gynecology, LSUHSC Shreveport, P O Box 33932, Shreveport, LA 71130, USA
    Am J Physiol Endocrinol Metab 303:E928-35. 2012
  7. doi request reprint Increased urinary excretion of nephrin, podocalyxin, and βig-h3 in women with preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Am J Physiol Renal Physiol 302:F1084-9. 2012
  8. pmc Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro
    Tomoaki Ando
    Nagoya City Medical University, 1 Kawasumi Mizuho, Nagoya, 467 8601, Japan
    BMC Physiol 7:10. 2007
  9. pmc Prostacyclin and thromboxane levels in women with severe preeclampsia undergoing magnesium sulfate therapy during antepartum and postpartum periods
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 70030, USA
    Hypertens Pregnancy 27:17-27. 2008
  10. ncbi request reprint Placental tissue levels of nonesterified polyunsaturated fatty acids in normal and preeclamptic pregnancies
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Hypertens Pregnancy 24:235-45. 2005

Research Grants

  1. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
  2. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
  3. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2007
  4. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2007
  5. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2004
  6. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2003
  7. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies
    Robin S Bowen
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Soc Gynecol Investig 12:428-32. 2005
    ..The objective of this study was to determine whether hypoxia could modify interleukin (IL)-6, IL-8, and IL-10 production by placental trophoblast cells (TCs) from normal and preeclamptic (PE) pregnancies...
  2. ncbi request reprint Endothelial barrier function in preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA
    Front Biosci 12:2412-24. 2007
    ..Insights gained from the characterization of the endothelial cell phenotype assumed by the preeclamptic microvasculature may lead to novel therapeutic strategies for the management of this syndrome...
  3. pmc Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, PO Box 33932, Shreveport, Louisiana 71130, USA
    J Clin Endocrinol Metab 93:260-6. 2008
    ..Increased production of antiangiogenic factors soluble endoglin (sEng) and soluble fms-like tyrosine kinase receptor-1 (sFlt-1) by the placenta contributes to the pathophysiology in preeclampsia (PE)...
  4. ncbi request reprint Role of chymase in preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130
    Curr Vasc Pharmacol 11:606-15. 2013
    ..The effects of chymase on inflammatory responses associated with endothelial activation/dysfunction in preeclampsia are also discussed. ..
  5. pmc Differential miRNA expression profiles between the first and third trimester human placentas
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, LA 71130, USA
    Am J Physiol Endocrinol Metab 304:E836-43. 2013
    ..These results indicate that miRNAs play critical roles in placental development...
  6. pmc Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies
    Rong Ma
    Dept of Obstetrics and Gynecology, LSUHSC Shreveport, P O Box 33932, Shreveport, LA 71130, USA
    Am J Physiol Endocrinol Metab 303:E928-35. 2012
    ....
  7. doi request reprint Increased urinary excretion of nephrin, podocalyxin, and βig-h3 in women with preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Am J Physiol Renal Physiol 302:F1084-9. 2012
    ..The finding of urinary βig-h3 excretion in preeclampsia suggests that increased transforming growth factor activity might also be involved in the kidney lesion in this pregnancy disorder...
  8. pmc Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro
    Tomoaki Ando
    Nagoya City Medical University, 1 Kawasumi Mizuho, Nagoya, 467 8601, Japan
    BMC Physiol 7:10. 2007
    ..Therefore, this study measured MAdCAM-1 expression, regulation, and function in cultured murine hepatic endothelial cells...
  9. pmc Prostacyclin and thromboxane levels in women with severe preeclampsia undergoing magnesium sulfate therapy during antepartum and postpartum periods
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 70030, USA
    Hypertens Pregnancy 27:17-27. 2008
    ..To study effects of magnesium sulfate (MgSO(4)) on prostacyclin (PGI(2)) and thromboxane A(2) (TXA(2)) levels in women with severe preeclampsia during antepartum and postpartum periods...
  10. ncbi request reprint Placental tissue levels of nonesterified polyunsaturated fatty acids in normal and preeclamptic pregnancies
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Hypertens Pregnancy 24:235-45. 2005
    ..Polyunsaturated fatty acids of the n-6 and n-3 families are essential dietary fatty acids. The n-6 polyunsaturated fatty acids are involved in inflammatory reactions, whereas n-3 polyunsaturated fatty acids protect against inflammation...
  11. ncbi request reprint Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 28:263-9. 2007
    ..Since chymase is a potent non-ACE angiotensin II producing enzyme, our data suggest that if placenta-derived CLP/chymase is released into the maternal circulation, it may contribute to the cardiovascular complications associated with PE...
  12. doi request reprint Endothelial angiotensin II generation induced by placenta-derived factors from preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Reprod Sci 15:932-8. 2008
    ....
  13. pmc Digibind attenuates cytokine TNFalpha-induced endothelial inflammatory response: potential benefit role of digibind in preeclampsia
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Perinatol 29:195-200. 2009
    ..This study was undertaken to determine if Digibind could attenuate increased endothelial inflammatory response induced by tumor necrosis factor-alpha (TNFalpha)...
  14. pmc Elevated plasma chymotrypsin-like protease (chymase) activity in women with preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University, Health Sciences Center Shreveport, Shreveport, Louisiana 71130, USA
    Hypertens Pregnancy 29:253-61. 2010
    ..Chymase, a chymotrypsin-like protease, is a non-ACE angiotensin II (Ang II) generating enzyme. We determined if maternal chymotrypsin-like protease/chymase activity was increased in women with preeclampsia (PE)...
  15. pmc D2-40/podoplanin expression in the human placenta
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Placenta 32:27-32. 2011
    ....
  16. doi request reprint Digoxin immune fab protects endothelial cells from ouabain-induced barrier injury
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center LSUHSC, Shreveport, USA
    Am J Reprod Immunol 67:66-72. 2012
    ....
  17. doi request reprint Analysis of endothelial barrier function in vitro
    Yuping Wang
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Methods Mol Biol 763:253-64. 2011
    ..Here, we describe methods for both visualizing and quantifying junctional permeability and barrier changes in endothelial monolayers in vitro...
  18. ncbi request reprint Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase expression is associated with increased cell permeability in endothelial cells from preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Am J Obstet Gynecol 190:817-24. 2004
    ....
  19. ncbi request reprint Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130, USA
    Placenta 22:206-12. 2001
    ..These findings support the notion of increased oxidative stress in the pre-eclamptic placenta, which may contribute to the pathophysiology of this pregnancy disorder...
  20. ncbi request reprint Protease chymotrypsin mediates the endothelial expression of P- and E-selectin, but not ICAM and VCAM, induced by placental trophoblasts from pre-eclamptic pregnancies
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 24:851-61. 2003
    ..We also examined whether proteases released by placental cells induce the endothelial cell surface molecule expression in PE...
  21. ncbi request reprint Endothelial junctional protein redistribution and increased monolayer permeability in human umbilical vein endothelial cells isolated during preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shrevport, LA 71130, USA
    Am J Obstet Gynecol 186:214-20. 2002
    ..We hypothesized that increased endothelial monolayer permeability in preeclampsia reflects altered monolayer barrier properties produced by disorganization of endothelial cell junction proteins...
  22. ncbi request reprint Placental trophoblast-derived factors diminish endothelial barrier function
    Yuping Wang
    Departments of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Clin Endocrinol Metab 89:2421-8. 2004
    ..these results implicate trophoblast-derived factors in the increased vascular permeability associated with preeclampsia...
  23. ncbi request reprint Neutrophil activation induced by placental factors in normal and pre-eclamptic pregnancies in vitro
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 22:560-5. 2001
    ..Upregulation of surface adhesion molecule CD11 expression may be responsible for the increased neutrophil-endothelial adhesion induced by factors derived from pre-eclamptic placentae...
  24. ncbi request reprint Expression of thrombin receptors in endothelial cells and neutrophils from normal and preeclamptic pregnancies
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Clin Endocrinol Metab 87:3728-34. 2002
    ..Factors released from the placenta are likely candidates in regulating PAR expression in ECs and may contribute to the platelet activation and vascular endothelial dysfunction in PE...
  25. pmc Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, LSUHSC Shreveport, Shreveport, LA 71130, USA
    Hypertension 57:336-42. 2011
    ..Thus, reduced gp130 and SOCS-3 expressions may offer, at least in part, a plausible explanation of reduced antiinflammatory protection in the maternal vascular system in preeclampsia...
  26. ncbi request reprint Homogeneity of mesothelial cells with lymphatic endothelium: expression of lymphatic endothelial markers by mesothelial cells
    T Ando
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Lymphat Res Biol 3:117-25. 2005
    ..In the present study, a stable pleural mesothelial cell line (MIM) was isolated and characterized, and the expression of several lymphatic specific markers by these cells examined...
  27. ncbi request reprint Increased neutrophil-endothelial adhesion induced by placental factors is mediated by platelet-activating factor in preeclampsia
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Medical Center, Shreveport 71130, USA
    J Soc Gynecol Investig 6:136-41. 1999
    ..In this study, the effect of placental factor(s) on neutrophil-endothelial adhesion and the possible role of platelet-activating factor (PAF) in mediating the response have been examined...
  28. ncbi request reprint Isolation and characterization of a novel mouse lymphatic endothelial cell line: SV-LEC
    T Ando
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Lymphat Res Biol 3:105-15. 2005
    ..g., Prox-1, LYVE-1, Flt-4). SV-LEC also expresses MAdCAM-1 in response to TNF-alpha, an effect seen in VEC, but not AEC...
  29. pmc Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia
    S Zhao
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 29:1024-8. 2008
    ....
  30. ncbi request reprint Activation of endothelial cells in preeclampsia: increased neutrophil-endothelial adhesion correlates with up-regulation of adhesion molecule P-selectin in human umbilical vein endothelial cells isolated from preeclampsia
    Y Wang
    Department of Obstetrics and Gynecology, Louisiana State University Medical Center, Shreveport, USA
    J Soc Gynecol Investig 5:237-43. 1998
    ..Our objective was to examine whether in preeclampsia neutrophil adherence to endothelial cells is increased and whether endothelial cell-surface adhesion molecule expression is up-regulated...
  31. pmc Proteases and sFlt-1 release in the human placenta
    S Zhao
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 31:512-8. 2010
    ..These results suggest chymotrypsin-like serine protease and ADAM10, but not cysteine protease and metalloendopeptidase, may play a role in inducing sFlt-1 release in PE placentas...
  32. pmc Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnancies
    S Zhao
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 29:81-8. 2008
    ..To investigate apical and basal releases of thromboxane (TX) and prostacyclin (PGI2) by trophoblasts (TCs) from normal and preeclamptic (PE) placentas...
  33. pmc Contractility of placental vascular smooth muscle cells in response to stimuli produced by the placenta: roles of ACE vs. non-ACE and AT1 vs. AT2 in placental vessel cells
    C Benoit
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 29:503-9. 2008
    ..These results also suggest the potential role of increased chymase activity and altered AT2 receptor function in placental related pregnancy disorders such as preeclampsia and IUGR...
  34. ncbi request reprint Placental isoprostane is significantly increased in preeclampsia
    S W Walsh
    Departments of Obstetrics and Gynecology, and Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0034, USA
    FASEB J 14:1289-96. 2000
    ....
  35. doi request reprint PAR-2 triggers placenta-derived protease-induced altered VE-cadherin reorganization at endothelial junctions in preeclampsia
    Y Gu
    Departments of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 33:803-9. 2012
    ..These results strongly suggest that proteases produced by the placenta elicit endothelial barrier dysfunction via a PAR-2 signaling regulatory mechanism in PE...
  36. ncbi request reprint AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta
    S W Walsh
    Departments of Obstetrics and Gynecology, and Physiology, Virginia Commonwealth University, Medical College of Virginia, Richmond, Virginia, USA
    J Pharmacol Exp Ther 290:220-6. 1999
    ....
  37. ncbi request reprint Increased endothelial monolayer permeability is induced by serum from women with preeclampsia but not by serum from women with normal pregnancy or that are not pregnant
    Yanping Zhang
    Obstetrics and Gynecology Department, Louisiana State University Health Sciences Center, Shreveport, Lousiana 71130, USA
    Hypertens Pregnancy 22:99-108. 2003
    ..To determine if endothelial monolayer permeability could be altered by serum from preeclampsia (PE)...
  38. ncbi request reprint Antioxidant superoxide dismutase attenuates increased endothelial permeability induced by platelet-activating factor
    Yanping Zhang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    J Soc Gynecol Investig 10:5-10. 2003
    ..Superoxide dismutase partially attenuated the PAF-induced increased endothelial monolayer permeability, which suggests that oxidative stress might be involved in the process of PAF-induced disturbances of endothelial barrier function...
  39. pmc Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Reprod Sci 16:479-88. 2009
    ..We conclude that chymotrypsin-like protease released by the placenta is at least one important mediator responsible for disrupting endothelial cell integrity and inducing endothelial permeability in preeclampsia...
  40. ncbi request reprint Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta
    H Li
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 26:210-7. 2005
    ..The aim of this study was to investigate whether hypoxia mediates TC sFlt-1 production and whether increased sFlt-1 production correlates with increased oxidative stress in placental TCs...
  41. pmc Differential cytokine responses in human and mouse lymphatic endothelial cells to cytokines in vitro
    G V Chaitanya
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Lymphat Res Biol 8:155-64. 2010
    ....
  42. pmc Over-expression of SOCS-3 gene promotes IL-10 production by JEG-3 trophoblast cells
    Q Dong
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 30:11-4. 2009
    ....
  43. ncbi request reprint PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies
    Y Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 27:744-9. 2006
    ..The aim of this study was to determine: (1) platelet-activating factor (PAF) levels and PAF-acetylhydrolase (PAF-AH) activities in normal and preeclamptic placentas; (2) lipid peroxide production by placental tissues stimulated with PAF...
  44. ncbi request reprint MAdCAM-1 expression and regulation in murine colonic endothelial cells in vitro
    T Ando
    LSU Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Inflamm Bowel Dis 11:258-64. 2005
    ..This study measured the expression of MAdCAM-1 in a novel colon endothelial line MJC-1, as well as MAdCAM-1 regulation and function in vitro...
  45. pmc Elevated maternal IL-16 levels, enhanced IL-16 expressions in endothelium and leukocytes, and increased IL-16 production by placental trophoblasts in women with preeclampsia
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA 71130, USA
    J Immunol 181:4418-22. 2008
    ....
  46. ncbi request reprint Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia
    Yanping Zhang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Soc Gynecol Investig 12:586-92. 2005
    ..This study was to determine if oxidative stress elicited by peroxynitrite could lead to an increase in endothelial permeability...
  47. doi request reprint 1,25(OH)2D3 suppresses COX-2 up-regulation and thromboxane production in placental trophoblast cells in response to hypoxic stimulation
    J Sun
    Dept of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, PO Box 33932, Shreveport, LA 71130, USA Dept of Obstetrics and Gynecology, First Hospital, Harbin Medical University, Harbin, China
    Placenta 35:143-5. 2014
    ..These results provide evidence of the beneficial effects of vitamin D on placental trophoblasts. ..
  48. ncbi request reprint Detection of interleukin-6 in maternal plasma predicts neonatal and infectious complications in preterm premature rupture of membranes
    D F Lewis
    Department of Obstetrics and Gynecology and Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Am J Perinatol 18:387-91. 2001
    ..These correlations persisted when the data were stratified for those patients who received corticosteroids. It also predicted infectious complications...
  49. pmc Hospitalized late preterm mild preeclamptic patients with mature lung testing: what are the risks of delivery?
    D F Lewis
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    J Perinatol 29:413-5. 2009
    ..To evaluate the risk of elective delivery of hospitalized patients with isolated mild preeclampsia with mature fetal lung profile compared with a cohort of patients who had preeclampsia with indicated delivery matched for gestational age...
  50. pmc Vasoreactivity of chorionic plate arteries in response to vasoconstrictors produced by preeclamptic placentas
    C Benoit
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, PO Box 33932, 1501 Kings Highway, Shreveport, LA 71130, USA
    Placenta 28:498-504. 2007
    ..Our data demonstrate increased vasocontractility in PE placentas and suggest that the non-ACE pathway is probably a major source of ANG II produced in the human placenta...
  51. pmc Erythrocyte sodium/potassium ATPase activity in severe preeclampsia
    C D Adair
    Section on Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Perinatol 29:280-3. 2009
    ..As the highest EDLF levels might be expected in severe preeclampsia, we investigated sodium pump activity in that group of patients...
  52. ncbi request reprint Heme oxygenase-1 mediates up-regulation of adhesion molecule expression induced by peroxynitrite in endothelial cells
    Shuang Zhao
    Departments of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Soc Gynecol Investig 11:465-71. 2004
    ..This study was to test whether EC oxidative stress induced by peroxynitrite could up-regulate EC CAM expression, and whether heme oxygenase-1 (HO-1) has protective effects on this peroxynitrite-induced cellular response...
  53. ncbi request reprint Effects of nicotine on intercellular adhesion molecule expression in endothelial cells and integrin expression in neutrophils in vitro
    Paul Speer
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Am J Obstet Gynecol 186:551-6. 2002
    ....
  54. pmc Increased superoxide generation and decreased stress protein Hsp90 expression in human umbilical cord vein endothelial cells (HUVECs) from pregnancies complicated by preeclampsia
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Hypertens Pregnancy 25:169-82. 2006
    ..In this study, we sought to determine whether increased oxidative stress was also present in primary cultured HUVECs from women with PE...
  55. ncbi request reprint Reduced cellular glutathione reductase activity and increased adhesion molecule expression in endothelial cells cultured with maternal plasma from women with preeclampsia
    Yanping Zhang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Soc Gynecol Investig 13:412-7. 2006
    ..The purpose of the current study was to determine whether maternal circulating components could regulate oxidative status of glutathione redox cycle and adhesion molecule expression in endothelial cells (ECs)...
  56. pmc Increased neutrophil numbers account for leukocytosis in women with preeclampsia
    Bernard J Canzoneri
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Am J Perinatol 26:729-32. 2009
    ..No statistical differences for monocyte and lymphocyte counts were observed between normal and PE groups. Increased neutrophil numbers account for the leukocytosis in women with PE...
  57. pmc ADAM17 regulates TNFα production by placental trophoblasts
    R Ma
    Dept of Gynecology, The Third Hospital of Harbin Medical University, Harbin, China
    Placenta 32:975-80. 2011
    ..These results suggest that oxidative stress-induced increased ADAM17 expression could contribute to the increased TNFα production in preeclamptic placentas...
  58. pmc Maternal circulating TNF-alpha levels are highly correlated with IL-10 levels, but not IL-6 and IL-8 levels, in women with pre-eclampsia
    David F Lewis
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, USA
    Am J Reprod Immunol 62:269-74. 2009
    ..In this study, we determined whether these cytokine levels are correlated before and after delivery in patients with PE...
  59. ncbi request reprint Increased phospholipase A2 and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia condition
    Robin S Bowen
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, PO Box 33932, Shreveport, LA 71130, USA
    Placenta 26:402-9. 2005
    ..Relative hypoxia could contribute to the increase in TX production and result in vasoconstriction in placental vasculature in preeclampsia...
  60. ncbi request reprint Dexamethasone potently enhances phorbol ester-induced IL-1beta gene expression and nuclear factor NF-kappaB activation
    Y Wang
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, OH 45267, USA
    J Immunol 159:534-7. 1997
    ..Our results indicate that glucocorticoids can be positive regulators of inflammatory cytokine gene expression during monocytic cell differentiation...
  61. pmc Differential expression of vascular endothelial growth factor (VEGF), endocrine gland derived-VEGF, and VEGF receptors in human placentas from normal and preeclamptic pregnancies
    Jin Young Chung
    Departments of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Clin Endocrinol Metab 89:2484-90. 2004
    ....
  62. pmc Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta
    Baihan Gu
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    Lymphat Res Biol 4:11-7. 2006
    ..Currently, little is known about the lymphatic character within the human placenta. This study therefore determined LYVE-1 and other lymphatic markers in human placentas...
  63. ncbi request reprint High glucose levels down-regulate glucose transporter expression that correlates with increased oxidative stress in placental trophoblast cells in vitro
    Hui Li
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Soc Gynecol Investig 11:75-81. 2004
    ..To study glucose transporter expression and oxidative stress in placental trophoblasts under hyperglycemic conditions in vitro...
  64. ncbi request reprint A prospective randomized trial of magnesium sulfate in severe preeclampsia: use of diuresis as a clinical parameter to determine the duration of postpartum therapy
    M Todd Fontenot
    Florida Perinatal Associates, Tampa, USA
    Am J Obstet Gynecol 192:1788-93; discussion 1793-4. 2005
    ..The purpose of this study was to assess the use of the onset of diuresis in the determination of the duration of postpartum magnesium sulfate therapy among patients with severe preeclampsia...
  65. ncbi request reprint Event-related potential N270 and its distribution in adults and school-age children
    Liping Li
    Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, 100053, PR China
    Brain Dev 25:507-13. 2003
    ..In school-age children, ERP N270 is elicited under the control of attention. Its distribution on the scalp depends on the attributes of stimulus pairs...
  66. ncbi request reprint A B-lectin receptor kinase gene conferring rice blast resistance
    Xuewei Chen
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant J 46:794-804. 2006
    ..Because of its novel extracellular domain, Pi-d2 represents a new class of plant resistance genes...
  67. doi request reprint Direct enzymatic assay for %HbA1c in human whole blood samples
    Limin Liu
    Diazyme Laboratories, 12889 Gregg Court, Poway, CA 92064, USA
    Clin Biochem 41:576-83. 2008
    ..Development and validation of a direct enzymatic HbA1c assay that utilizes a single channel on chemistry auto-analyzers without the need to run separate glycated hemoglobin and total hemoglobin assays...
  68. ncbi request reprint Involvement of hydrogen peroxide and nitric oxide in salt resistance in the calluses from Populus euphratica
    Feng Zhang
    Gansu Key Laboratory of Crop Genetic and Germplasm Enhancement, College of Life Sciences and Technology, Gansu Agricultural University, Lanzhou 730070, China
    Plant Cell Environ 30:775-85. 2007
    ..euphratica under slat stress by increasing the K/Na ratio, which was dependent on the increased PM H+ -ATPase activity...
  69. ncbi request reprint Whole-brain voxel-based morphometry of white matter in medial temporal lobe epilepsy
    Aihong Yu
    Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
    Eur J Radiol 65:86-90. 2008
    ..The purpose of this study was to analyze whole-brain white matter changes in medial temporal lobe epilepsy (MTLE)...
  70. ncbi request reprint Early detection of cognitive impairment in patients with obstructive sleep apnea syndrome: an event-related potential study
    Xi Zhang
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100050, PR China
    Neurosci Lett 325:99-102. 2002
    ..Conflict ERPs associated with processing of conflicting information are more vulnerable than no-conflict ERPs to hypoxic cerebral damage...
  71. ncbi request reprint The active inhibition for the processing of visual irrelevant conflict information
    Wei Mao
    Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
    Int J Psychophysiol 67:47-53. 2008
    ..Due to the limited capacity of the conflict processing system, the decrement of the N270 in the conjunction conflict condition is deduced to reflect an active inhibition for the processing of the irrelevant conflict...
  72. doi request reprint Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential
    Wei Sun
    Department of Neurology, Capital Medical University Xuanwu Hospital, Beijing, 100053, People s Republic of China
    Int J Psychophysiol 68:235-41. 2008
    ..The imperative effects of TPM on visual perception function reflected by N170 were more obvious than that of VPA. Attention reflected by N270 was impaired after TPM treatment...
  73. doi request reprint Mechanisms of lumbrokinase in protection of cerebral ischemia
    Hongrui Ji
    Institute of Clinical Pharmacology of Second Hospital, Harbin Medical University, Harbin, PR China
    Eur J Pharmacol 590:281-9. 2008
    ....
  74. ncbi request reprint Antiepileptic drugs and the significance of event-related potentials
    Wei Sun
    Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, PR China
    J Clin Neurophysiol 24:271-6. 2007
    ..These results indicate that antiepileptic drugs, especially VPA, might enhance the impairment of cognitive processing. N270 is more sensitive than P300 in the early detection of minor cognitive impairment in epileptics...

Research Grants16

  1. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  2. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  3. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2007
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  4. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2007
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  5. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2004
    ....
  6. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2003
    ..abstract_text> ..
  7. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..