Ping Wang

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans
    Ping Wang
    Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Curr Genet 46:247-55. 2004
  2. pmc The cyclophilins
    Ping Wang
    The Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Genome Biol 6:226. 2005
  3. pmc The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways
    Ping Wang
    The Research Institute for Children, New Orleans, Louisiana, USA
    Med Mycol 49:449-57. 2011
  4. pmc Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein
    Venkatadri Kolla
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1019-30. 2009
  5. pmc The RGS protein Crg2 regulates pheromone and cyclic AMP signaling in Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Eukaryot Cell 7:1540-8. 2008
  6. pmc Canonical heterotrimeric G proteins regulating mating and virulence of Cryptococcus neoformans
    Lie Li
    Department of Pediatrics, The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Mol Biol Cell 18:4201-9. 2007
  7. pmc Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Eukaryot Cell 11:471-81. 2012
  8. pmc Wsp1, a GBD/CRIB domain-containing WASP homolog, is required for growth, morphogenesis, and virulence of Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, LSU Health Sciences Center, New Orleans, LA 70118, USA
    Eukaryot Cell 10:521-9. 2011
  9. pmc Noncanonical Gβ Gib2 is a scaffolding protein promoting cAMP signaling through functions of Ras1 and Cac1 proteins in Cryptococcus neoformans
    Yanli Wang
    From the Research Institute for Children, Children s Hospital, New Orleans, Louisiana 70118
    J Biol Chem 289:12202-16. 2014
  10. pmc Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Mol Microbiol 76:662-76. 2010

Collaborators

  • Philip L Ballard
  • JOSEPH B HEITMAN
  • Yanli Wang
  • Gillian M Olson
  • J Alspaugh
  • G M Cox
  • Christina M Hull
  • John Perfect
  • Kejing Song
  • Deborah S Fox
  • Marco Conti
  • Gui Shen
  • Amy Whittington
  • Venkatadri Kolla
  • Lie Li
  • Jin fu Yuan
  • Ping Xu
  • Wei Li
  • Feng Ni
  • Haichao Wang
  • Wito Richter
  • Dmitri Tolkatchev
  • Sreedevi Angampalli
  • Linda W Gonzales
  • Michael Miksa
  • Rongqian Wu
  • Maria Zoudilova
  • Surajit Bhattacharjya
  • John C Fyfe
  • Youxiang Zhou
  • Huan Yang
  • Lihong Yang
  • Andrew E Sama
  • Jianhua Li
  • Kevin J Tracey
  • Mala Ashok
  • Jill K Thompson
  • Daniel A Palmer
  • Urs Giger
  • Mark E Haskins
  • Zhong yi Ji
  • Monn Monn Myat
  • Cheng xiang Lei
  • Rebecca To
  • Qiu Xia Wang
  • Xinchun Lin
  • Deborah C Silverstein Dombrowski
  • Li Min Luo
  • Kirsten Nielsen
  • Kajsa Paulsson
  • Marlies E J Reinders
  • Robert C Davidson
  • Erxun Zhou
  • Muniswamy Madesh
  • Marye H Godinez
  • Nicole A Bailey
  • Andrew J Patterson
  • Anna Vinogradova
  • Sebastien Granier
  • Matthew D Bruss
  • Peter Day
  • Hugh P J Bennett
  • Rani Agrawal
  • Zhigang Chen
  • Tao Lei
  • Brian Kobilka
  • Andrew Bateman
  • Kathleen Horner
  • Suneil Malik
  • Søren G F Rasmussen
  • H Hank Simms
  • Jiajia Wu
  • Fusheng Chen
  • Zheng Guang Zhang
  • John Gonzales
  • Donald F Patterson
  • Bijun Xie
  • Kathryn A DeFea
  • Sheldon I Feinstein
  • Thomas J Van Winkle
  • Ying Xu
  • Gary M Bokoch
  • Paula S Henthorn
  • Michelle G Hawkins
  • Weifeng Dong
  • Michael J Osborne
  • Naoya Yuhki
  • DaZhi Chen
  • Puneet Kumar
  • Xiaoxuan Cui

Detail Information

Publications42

  1. ncbi request reprint A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans
    Ping Wang
    Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Curr Genet 46:247-55. 2004
    ..Our findings support a model in which Sch9 modulates capsule formation and contributes to the virulence of C. neoformans both independently of and in conjunction with the cAMP-PKA pathway...
  2. pmc The cyclophilins
    Ping Wang
    The Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Genome Biol 6:226. 2005
    ..Recent studies have implicated a diverse array of additional cellular functions for cyclophilins, including roles as chaperones and in cell signaling...
  3. pmc The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways
    Ping Wang
    The Research Institute for Children, New Orleans, Louisiana, USA
    Med Mycol 49:449-57. 2011
    ..neoformans. An understanding of intracellular trafficking mechanisms as they relate to pathogenesis will likely reveal the identity of novel antifungal targets...
  4. pmc Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein
    Venkatadri Kolla
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1019-30. 2009
    ..Because CEACAM6 acts as an antiapoptotic factor and stabilizes surfactant function, in addition to a putative role in innate defense against bacteria, we propose that it is a multifunctional alveolar protein...
  5. pmc The RGS protein Crg2 regulates pheromone and cyclic AMP signaling in Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Eukaryot Cell 7:1540-8. 2008
    ....
  6. pmc Canonical heterotrimeric G proteins regulating mating and virulence of Cryptococcus neoformans
    Lie Li
    Department of Pediatrics, The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Mol Biol Cell 18:4201-9. 2007
    ....
  7. pmc Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Eukaryot Cell 11:471-81. 2012
    ..Collectively, our studies suggest novel ways in which this pathogenic fungus has adapted conserved signaling pathways to control vesicle transport and actin organization, likely benefiting survival within infected hosts...
  8. pmc Wsp1, a GBD/CRIB domain-containing WASP homolog, is required for growth, morphogenesis, and virulence of Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, LSU Health Sciences Center, New Orleans, LA 70118, USA
    Eukaryot Cell 10:521-9. 2011
    ..Our studies reveal divergent evolution of WASP proteins in the fungal phylum and suggest that the conserved function of WASP proteins in the actin cytoskeleton may also impact fungal virulence...
  9. pmc Noncanonical Gβ Gib2 is a scaffolding protein promoting cAMP signaling through functions of Ras1 and Cac1 proteins in Cryptococcus neoformans
    Yanli Wang
    From the Research Institute for Children, Children s Hospital, New Orleans, Louisiana 70118
    J Biol Chem 289:12202-16. 2014
    ..Our study reveals Gib2 as an essential component in deciphering the complexity of regulatory networks that control growth and virulence in C. neoformans. ..
  10. pmc Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans
    Gui Shen
    The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
    Mol Microbiol 76:662-76. 2010
    ..Our study presents the first evidence of a multi-modular protein whose function in intracellular transport underlies the growth, differentiation and virulence of a pathogenic microorganism...
  11. pmc The RGS protein Crg2 is required for establishment and progression of murine pulmonary cryptococcosis
    Amy Whittington
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Med Mycol 49:263-75. 2011
    ....
  12. pmc Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans
    Gillian M Olson
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Eukaryot Cell 6:222-34. 2007
    ..Taken together, these results indicate a central role for Pmt4-mediated protein O mannosylation in growth, cell wall integrity, and virulence of C. neoformans...
  13. ncbi request reprint Gib2, a novel Gbeta-like/RACK1 homolog, functions as a Gbeta subunit in cAMP signaling and is essential in Cryptococcus neoformans
    Daniel A Palmer
    Research Institute for Children, Department of Pediatrics, Louisiana State University Health Sciences Center, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    J Biol Chem 281:32596-605. 2006
    ..Finally, Gib2 is shown to also physically interact with a downstream target of Gpa1-cAMP signaling, Smg1, and the protein kinase C homolog Pkc1, indicating that Gib2 is also a multifunctional RACK1-like protein...
  14. pmc Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans
    Ping Wang
    Department of Pediatrics, Research Institute for Children, Children s Hospital, 200 Henry Clay Ave, New Orleans, LA 70118, USA
    Eukaryot Cell 3:1028-35. 2004
    ..Interestingly, crg1 mutants of MATalpha cells produced dark melanin pigment under normally inhibitory conditions, which may relate to the mechanism for increased virulence...
  15. pmc Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genes
    Venkatadri Kolla
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    Am J Respir Cell Mol Biol 36:213-25. 2007
    ..In addition, knockdown of TTF-1 inhibited 72 of 274 other genes induced by hormones. We conclude that 42-kD TTF-1 is required for induction of a subset of regulated genes during type II cell differentiation...
  16. pmc Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans
    Ping Wang
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eukaryot Cell 1:257-72. 2002
    ....
  17. pmc Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates
    Kirsten Nielsen
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 71:4831-41. 2003
    ..Our studies highlight a role for sexual recombination in the evolution of a human fungal pathogen and provide a robust genetic platform to establish the molecular determinants of virulence...
  18. pmc Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4
    Wito Richter
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    EMBO J 27:384-93. 2008
    ....
  19. pmc Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
    Dmitri Tolkatchev
    Bio NMR and Protein Research Laboratory, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Protein Sci 17:711-24. 2008
    ..The functionally active and structurally well-characterized human hGrnA offers a unique opportunity for detailed structure-function studies of these important GEM proteins as novel members of mammalian growth factors...
  20. ncbi request reprint Preparation for aflatoxin B(1)-cationized bovine serum albumin based on Mannich-type reaction
    Youxiang Zhou
    College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China
    J Immunol Methods 328:79-88. 2007
    ..This suggests that the Mannich-type reaction might be an alternative method of preparation for AFB(1)-protein...
  21. ncbi request reprint Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    J Immunol 179:6263-72. 2007
    ..We conclude that AM/AMBP-1 is protective in sepsis due to its vasoactive properties and direct anti-inflammatory effects mediated through both the cAMP-dependent pathway and Pyk-2-ERK1/2-dependent induction of PPAR-gamma...
  22. pmc Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins
    Ping Wang
    Division of Biomedical Sciences, Cell, Molecular and Developmental Biology Program and Biochemistry and Molecular Biology Program, University of California, Riverside, CA 92521, USA
    Biochem J 408:221-30. 2007
    ....
  23. ncbi request reprint Mucopolysaccharidosis type VII in a German Shepherd Dog
    Deborah C Silverstein Dombrowski
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 224:553-7, 532-3. 2004
    ..Furthermore, there are specific blood enzyme and DNA-based tests to distinguish the forms of mucopolysaccharidosis in affected and carrier animals...
  24. ncbi request reprint Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2
    Maria Zoudilova
    Cell, Molecular, and Developmental Biology Program and Biomedical Sciences Division, University of California Riverside, B605 Statistics Road, Riverside, CA 92521, USA
    J Biol Chem 282:20634-46. 2007
    ..These findings identify cofilin as a novel target of beta-arrestin-dependent scaffolding and suggest that many PAR-2-induced processes may be independent of Galpha(q/11) protein coupling...
  25. ncbi request reprint Conformational analyses of a partially-folded bioactive prodomain of human furin
    Surajit Bhattacharjya
    Biomolecular NMR and Protein Research Laboratory, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec, Canada
    Biopolymers 86:329-44. 2007
    ..As such, this study provides valuable insights into the structural properties of the furin prodomain in relation to its role in the folding of the furin zymogen and its inhibitory action toward furin...
  26. pmc A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Immunol 178:3856-64. 2007
    ..Taken together, these data re-enforce the pathogenic role of HMGB1 in lethal sepsis, and support a therapeutic potential for TSNIIA-SS in the treatment of human sepsis...
  27. pmc A complex rearrangement in GBE1 causes both perinatal hypoglycemic collapse and late-juvenile-onset neuromuscular degeneration in glycogen storage disease type IV of Norwegian forest cats
    John C Fyfe
    Laboratory of Comparative Medical Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Mol Genet Metab 90:383-92. 2007
    ..The molecular characterization of feline GSD IV will enhance further studies of GSD IV pathophysiology and development of novel therapies in this unique animal model...
  28. pmc Proinflammatory functions of vascular endothelial growth factor in alloimmunity
    Marlies E J Reinders
    Division of Nephrology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:1655-65. 2003
    ..Thus, VEGF appears to be functional in acute allograft rejection via its effects on leukocyte trafficking. Together, these observations provide mechanistic insight into the proinflammatory function of VEGF in immunity...
  29. ncbi request reprint A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function
    Ping Wang
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 24:4518-29. 2004
    ..Given the behavioral similarities between disruptions of PGK function in Drosophila and humans, the analysis of nubian animals may reveal conserved neuronal responses associated with altered ATP generation within the brain...
  30. ncbi request reprint [Preparation and characterization of anti-human IL-15 monoclonal antibody]
    Ping Wang
    Department of Immunology, Institute of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:183-5. 2004
    ..To prepare monoclonal antibody (mAb) against human interleukin-15 (hIL-15) and identify its characterization...
  31. ncbi request reprint [Immunogenicity of a multiple epitope DNA vaccine against hepatitis B virus]
    Li Min Luo
    Institute of Tropic Diseases, First Military Medical University, Guangzhou 510515, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:517-21. 2004
    ..To study the immunogenicity of a multiple epitope DNA vaccine against hepatitis B virus(HBV)...
  32. ncbi request reprint A PCR-based strategy to generate integrative targeting alleles with large regions of homology
    Robert C Davidson
    Department of Molecular Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Microbiology 148:2607-15. 2002
    ..In combination with the availability of the complete genomic sequence, this gene-disruption technique should pave the way for higher throughput genetic analysis of this important pathogenic fungus...
  33. ncbi request reprint Stereoselective kinetic study of hexaconazole enantiomers in the rabbit
    Qiu Xia Wang
    Department of Applied Chemistry, China Agricultural University, Beijing 100094, China
    Chirality 17:186-92. 2005
    ..Other pharmacokinetic parameters of the enantiomers were also different. These results indicate substantial stereoselectivity in the kinetics of hexaconazole enantiomers in rabbits...
  34. pmc A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea
    Monn Monn Myat
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Biol 281:38-52. 2005
    ..These studies support a model in which both the Dpp- and the FGF-signaling pathways control expression of knirps and knirps-related, thereby regulating cell migration during dorsal branch formation...
  35. ncbi request reprint [A study on etiology and pathogenic mechanism of decompression sickness]
    Jin fu Yuan
    Naval Medical Research Institute, Shanghai, China
    Space Med Med Eng (Beijing) 18:19-24. 2005
    ..To explain the etiology of decompression sickness (DCS) and to elucidate its pathogenic mechanism...
  36. ncbi request reprint [Experimental study on mechanism of recompression therapy of decompression sickness]
    Jin fu Yuan
    Naval Medical Research Institute, Shanghai, China
    Space Med Med Eng (Beijing) 18:102-6. 2005
    ..To elucidate that recompression is the most efficient measure in removing the pathogenic factors...
  37. ncbi request reprint Macrophage migration inhibitory factor within the alveolar spaces induces changes in the heart during late experimental sepsis
    Xinchun Lin
    Department of Surgery, Institute for Medical Research at North Shore LIJ Health System, Manhasset, New York, NY 11030, USA
    Shock 24:556-63. 2005
    ....
  38. pmc The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Nutr 136:360-5. 2006
    ..sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1...
  39. ncbi request reprint [Quality standard for Xindi soft capsule]
    Yu Jie Wang
    College of Traditional Chinese Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611731, China
    Zhongguo Zhong Yao Za Zhi 31:552-4, 597. 2006
    ..To establish the quality control standard of Xindi soft capsule...
  40. ncbi request reprint Isolation of monomeric human V(H)s by a phage selection
    Rebecca To
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 280:41395-403. 2005
    ..These 15 V(H)s should serve as good scaffolds for developing immunotherapeutics, and the selection method employed here should have general utility for isolating proteins with desirable biophysical properties...
  41. ncbi request reprint Screening and analysis of the multiple absorbed bioactive components and metabolites of Dangguibuxue decoction by the metabolic fingerprinting technique and liquid chromatography/diode-array detection mass spectrometry
    Ping Wang
    College of Chemistry and Chemical Engineering, Research Center of Modernization of Chinese Medicines, Central South University, Changsha 410083, P R China
    Rapid Commun Mass Spectrom 21:99-106. 2007
    ..This is very important not only for the pharmaceutical discovery process and the quality control of crude drugs, but also to explain the curative mechanism of TCMs...
  42. ncbi request reprint Chaperones and folding of MHC class I molecules in the endoplasmic reticulum
    Kajsa Paulsson
    The Institution of Tumour Immunology, Lund University, BMC I12, S 223 62, Lund, Sweden
    Biochim Biophys Acta 1641:1-12. 2003
    ..Late stage MHC class I maturation with focus on the dedicated chaperone tapasin is also discussed...