Research Topics
Species | Ping WangSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Detail Information
Publications
A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformansPing Wang
Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
Curr Genet 46:247-55. 2004..Our findings support a model in which Sch9 modulates capsule formation and contributes to the virulence of C. neoformans both independently of and in conjunction with the cAMP-PKA pathway...
The cyclophilinsPing Wang
The Research Institute for Children, Children s Hospital, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
Genome Biol 6:226. 2005..Recent studies have implicated a diverse array of additional cellular functions for cyclophilins, including roles as chaperones and in cell signaling...
The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathwaysPing Wang
The Research Institute for Children, New Orleans, Louisiana, USA
Med Mycol 49:449-57. 2011..neoformans. An understanding of intracellular trafficking mechanisms as they relate to pathogenesis will likely reveal the identity of novel antifungal targets...- Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell proteinVenkatadri Kolla
Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Physiol Lung Cell Mol Physiol 296:L1019-30. 2009..Because CEACAM6 acts as an antiapoptotic factor and stabilizes surfactant function, in addition to a putative role in innate defense against bacteria, we propose that it is a multifunctional alveolar protein... - The RGS protein Crg2 regulates pheromone and cyclic AMP signaling in Cryptococcus neoformansGui Shen
The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
Eukaryot Cell 7:1540-8. 2008.... - Canonical heterotrimeric G proteins regulating mating and virulence of Cryptococcus neoformansLie Li
Department of Pediatrics, The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
Mol Biol Cell 18:4201-9. 2007.... - Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformansGui Shen
The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Eukaryot Cell 11:471-81. 2012..Collectively, our studies suggest novel ways in which this pathogenic fungus has adapted conserved signaling pathways to control vesicle transport and actin organization, likely benefiting survival within infected hosts... - Wsp1, a GBD/CRIB domain-containing WASP homolog, is required for growth, morphogenesis, and virulence of Cryptococcus neoformansGui Shen
The Research Institute for Children, LSU Health Sciences Center, New Orleans, LA 70118, USA
Eukaryot Cell 10:521-9. 2011..Our studies reveal divergent evolution of WASP proteins in the fungal phylum and suggest that the conserved function of WASP proteins in the actin cytoskeleton may also impact fungal virulence... - The RGS protein Crg2 is required for establishment and progression of murine pulmonary cryptococcosisAmy Whittington
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Med Mycol 49:263-75. 2011.... - Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformansGui Shen
The Research Institute for Children, Louisiana State University Health Sciences Center, New Orleans, LA 70118, USA
Mol Microbiol 76:662-76. 2010..Our study presents the first evidence of a multi-modular protein whose function in intracellular transport underlies the growth, differentiation and virulence of a pathogenic microorganism... - Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformansGillian M Olson
Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
Eukaryot Cell 6:222-34. 2007..Taken together, these results indicate a central role for Pmt4-mediated protein O mannosylation in growth, cell wall integrity, and virulence of C. neoformans... - Gib2, a novel Gbeta-like/RACK1 homolog, functions as a Gbeta subunit in cAMP signaling and is essential in Cryptococcus neoformansDaniel A Palmer
Research Institute for Children, Department of Pediatrics, Louisiana State University Health Sciences Center, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
J Biol Chem 281:32596-605. 2006..Finally, Gib2 is shown to also physically interact with a downstream target of Gpa1-cAMP signaling, Smg1, and the protein kinase C homolog Pkc1, indicating that Gib2 is also a multifunctional RACK1-like protein... - Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformansPing Wang
Department of Pediatrics, Research Institute for Children, Children s Hospital, 200 Henry Clay Ave, New Orleans, LA 70118, USA
Eukaryot Cell 3:1028-35. 2004..Interestingly, crg1 mutants of MATalpha cells produced dark melanin pigment under normally inhibitory conditions, which may relate to the mechanism for increased virulence... - Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genesVenkatadri Kolla
Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
Am J Respir Cell Mol Biol 36:213-25. 2007..In addition, knockdown of TTF-1 inhibited 72 of 274 other genes induced by hormones. We conclude that 42-kD TTF-1 is required for induction of a subset of regulated genes during type II cell differentiation... - Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformansPing Wang
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Eukaryot Cell 1:257-72. 2002.... - Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolatesKirsten Nielsen
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Infect Immun 71:4831-41. 2003..Our studies highlight a role for sexual recombination in the evolution of a human fungal pathogen and provide a robust genetic platform to establish the molecular determinants of virulence... - A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila tracheaMonn Monn Myat
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Dev Biol 281:38-52. 2005..These studies support a model in which both the Dpp- and the FGF-signaling pathways control expression of knirps and knirps-related, thereby regulating cell migration during dorsal branch formation... - Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestinsPing Wang
Division of Biomedical Sciences, Cell, Molecular and Developmental Biology Program and Biochemistry and Molecular Biology Program, University of California, Riverside, CA 92521, USA
Biochem J 408:221-30. 2007.... - [Preparation and characterization of anti-human IL-15 monoclonal antibody]Ping Wang
Department of Immunology, Institute of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:183-5. 2004..A sandwich ELISA for detecting rhIL-15 protein was established and its sensitivity was as low as 10 microg/L. CONCLUSION: The anti-hIL-15 mAb was prepared successfully. A sandwich ELISA for the detection of hIL-15 was established... - Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gammaMichael Miksa
Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
J Immunol 179:6263-72. 2007..We conclude that AM/AMBP-1 is protective in sepsis due to its vasoactive properties and direct anti-inflammatory effects mediated through both the cAMP-dependent pathway and Pyk-2-ERK1/2-dependent induction of PPAR-gamma... - Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4Wito Richter
Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
EMBO J 27:384-93. 2008.... - Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activitiesDmitri Tolkatchev
Bio NMR and Protein Research Laboratory, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
Protein Sci 17:711-24. 2008..The functionally active and structurally well-characterized human hGrnA offers a unique opportunity for detailed structure-function studies of these important GEM proteins as novel members of mammalian growth factors... - A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic functionPing Wang
The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 24:4518-29. 2004..Given the behavioral similarities between disruptions of PGK function in Drosophila and humans, the analysis of nubian animals may reveal conserved neuronal responses associated with altered ATP generation within the brain... - Mucopolysaccharidosis type VII in a German Shepherd DogDeborah C Silverstein Dombrowski
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA
J Am Vet Med Assoc 224:553-7, 532-3. 2004..Furthermore, there are specific blood enzyme and DNA-based tests to distinguish the forms of mucopolysaccharidosis in affected and carrier animals... - Proinflammatory functions of vascular endothelial growth factor in alloimmunityMarlies E J Reinders
Division of Nephrology, Department of Medicine, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Clin Invest 112:1655-65. 2003..Thus, VEGF appears to be functional in acute allograft rejection via its effects on leukocyte trafficking. Together, these observations provide mechanistic insight into the proinflammatory function of VEGF in immunity... - Chaperones and folding of MHC class I molecules in the endoplasmic reticulumKajsa Paulsson
The Institution of Tumour Immunology, Lund University, BMC I12, S 223 62, Lund, Sweden
Biochim Biophys Acta 1641:1-12. 2003..Late stage MHC class I maturation with focus on the dedicated chaperone tapasin is also discussed... - Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2Maria Zoudilova
Cell, Molecular, and Developmental Biology Program and Biomedical Sciences Division, University of California Riverside, B605 Statistics Road, Riverside, CA 92521, USA
J Biol Chem 282:20634-46. 2007..These findings identify cofilin as a novel target of beta-arrestin-dependent scaffolding and suggest that many PAR-2-induced processes may be independent of Galpha(q/11) protein coupling... - Conformational analyses of a partially-folded bioactive prodomain of human furinSurajit Bhattacharjya
Biomolecular NMR and Protein Research Laboratory, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec, Canada
Biopolymers 86:329-44. 2007..As such, this study provides valuable insights into the structural properties of the furin prodomain in relation to its role in the folding of the furin zymogen and its inhibitory action toward furin... - [A study on etiology and pathogenic mechanism of decompression sickness]Jin fu Yuan
Naval Medical Research Institute, Shanghai, China
Space Med Med Eng (Beijing) 18:19-24. 2005..To explain the etiology of decompression sickness (DCS) and to elucidate its pathogenic mechanism... - [Experimental study on mechanism of recompression therapy of decompression sickness]Jin fu Yuan
Naval Medical Research Institute, Shanghai, China
Space Med Med Eng (Beijing) 18:102-6. 2005..To elucidate that recompression is the most efficient measure in removing the pathogenic factors... - Stereoselective kinetic study of hexaconazole enantiomers in the rabbitQiu Xia Wang
Department of Applied Chemistry, China Agricultural University, Beijing 100094, China
Chirality 17:186-92. 2005..Other pharmacokinetic parameters of the enantiomers were also different. These results indicate substantial stereoselectivity in the kinetics of hexaconazole enantiomers in rabbits... - Isolation of monomeric human V(H)s by a phage selectionRebecca To
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
J Biol Chem 280:41395-403. 2005..These 15 V(H)s should serve as good scaffolds for developing immunotherapeutics, and the selection method employed here should have general utility for isolating proteins with desirable biophysical properties... - Macrophage migration inhibitory factor within the alveolar spaces induces changes in the heart during late experimental sepsisXinchun Lin
Department of Surgery, Institute for Medical Research at North Shore-LIJ Health System, Manhasset, New York, NY 11030, USA
Shock 24:556-63. 2005.... - The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsisHaichao Wang
Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
J Nutr 136:360-5. 2006..sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1... - [Quality standard for Xindi soft capsule]Yu Jie Wang
College of Traditional Chinese Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611731, China
Zhongguo Zhong Yao Za Zhi 31:552-4, 597. 2006..To establish the quality control standard of Xindi soft capsule... - A PCR-based strategy to generate integrative targeting alleles with large regions of homologyRobert C Davidson
Department of Molecular Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
Microbiology 148:2607-15. 2002..In combination with the availability of the complete genomic sequence, this gene-disruption technique should pave the way for higher throughput genetic analysis of this important pathogenic fungus... - [Immunogenicity of a multiple epitope DNA vaccine against hepatitis B virus]Li Min Luo
Institute of Tropic Diseases, First Military Medical University, Guangzhou 510515, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:517-21. 2004..To study the immunogenicity of a multiple epitope DNA vaccine against hepatitis B virus(HBV)... - Screening and analysis of the multiple absorbed bioactive components and metabolites of Dangguibuxue decoction by the metabolic fingerprinting technique and liquid chromatography/diode-array detection mass spectrometryPing Wang
College of Chemistry and Chemical Engineering, Research Center of Modernization of Chinese Medicines, Central South University, Changsha 410083, P R China
Rapid Commun Mass Spectrom 21:99-106. 2007..This is very important not only for the pharmaceutical discovery process and the quality control of crude drugs, but also to explain the curative mechanism of TCMs... - A complex rearrangement in GBE1 causes both perinatal hypoglycemic collapse and late-juvenile-onset neuromuscular degeneration in glycogen storage disease type IV of Norwegian forest catsJohn C Fyfe
Laboratory of Comparative Medical Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
Mol Genet Metab 90:383-92. 2007..The molecular characterization of feline GSD IV will enhance further studies of GSD IV pathophysiology and development of novel therapies in this unique animal model... - A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1Wei Li
Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
J Immunol 178:3856-64. 2007..Taken together, these data re-enforce the pathogenic role of HMGB1 in lethal sepsis, and support a therapeutic potential for TSNIIA-SS in the treatment of human sepsis... - Preparation for aflatoxin B(1)-cationized bovine serum albumin based on Mannich-type reactionYouxiang Zhou
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China
J Immunol Methods 328:79-88. 2007..This suggests that the Mannich-type reaction might be an alternative method of preparation for AFB(1)-protein...