R Roskoski

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi Src protein-tyrosine kinase structure and regulation
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 324:1155-64. 2004
  2. ncbi Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic
    R Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    Biochemistry 40:9329-35. 2001
  3. ncbi Protein prenylation: a pivotal posttranslational process
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 303:1-7. 2003
  4. ncbi STI-571: an anticancer protein-tyrosine kinase inhibitor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 309:709-17. 2003
  5. ncbi The ErbB/HER receptor protein-tyrosine kinases and cancer
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 319:1-11. 2004
  6. ncbi Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 338:1307-15. 2005
  7. ncbi Src kinase regulation by phosphorylation and dephosphorylation
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 331:1-14. 2005
  8. ncbi Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 337:1-13. 2005
  9. ncbi Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase
    R Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70119, USA
    Arch Biochem Biophys 356:167-76. 1998
  10. ncbi Vascular endothelial growth factor (VEGF) signaling in tumor progression
    Robert Roskoski
    Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116A, Box 19, Horse Shoe, NC 28742, USA
    Crit Rev Oncol Hematol 62:179-213. 2007

Detail Information

Publications11

  1. ncbi Src protein-tyrosine kinase structure and regulation
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 324:1155-64. 2004
    ..Amino acid residues in the alphaD helix near the catalytic loop in the large lobe of C-terminal Src kinase serve as a docking site for the physiological substrate (Src) but not for an artificial substrate (polyGlu(4)Tyr)...
  2. ncbi Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic
    R Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    Biochemistry 40:9329-35. 2001
    ..Furthermore, BZA-4B, with a leucine specificity determinant, was a classical competitive inhibitor of GGTase-I and not a time-dependent inhibitor...
  3. ncbi Protein prenylation: a pivotal posttranslational process
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 303:1-7. 2003
  4. ncbi STI-571: an anticancer protein-tyrosine kinase inhibitor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 309:709-17. 2003
    ..Resistance to STI-571 is often the result of mutations in residues of the Bcr-Abl kinase that ordinarily bind to the drug. Inhibition of target protein kinases represents an emerging therapeutic strategy for the treatment of cancer...
  5. ncbi The ErbB/HER receptor protein-tyrosine kinases and cancer
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 319:1-11. 2004
    ..An ErbB2/HER2 ectodomain directed antibody (trastuzumab, or Herceptin) has also been approved for the treatment of breast cancer. Current research promises to produce additional agents based upon these approaches...
  6. ncbi Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 338:1307-15. 2005
    ..STI-571 binds to Kit and Bcr-Abl (the oncoprotein of chronic myelogenous leukemia) at their ATP-binding sites...
  7. ncbi Src kinase regulation by phosphorylation and dephosphorylation
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 331:1-14. 2005
    ....
  8. ncbi Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 337:1-13. 2005
    ..Kit has the potential to participate in multiple signal transduction pathways as a result of interaction with several enzymes and adaptor proteins...
  9. ncbi Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase
    R Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70119, USA
    Arch Biochem Biophys 356:167-76. 1998
    ..Our studies indicate that the substrate and inhibitor binding specificities of protein geranylgeranyltransferase was much more restricted than those of protein farnesyltransferase...
  10. ncbi Vascular endothelial growth factor (VEGF) signaling in tumor progression
    Robert Roskoski
    Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116A, Box 19, Horse Shoe, NC 28742, USA
    Crit Rev Oncol Hematol 62:179-213. 2007
    ..Owing to the importance of angiogenesis in tumor progression, inhibition of VEGF signaling represents an attractive cancer treatment...
  11. ncbi VEGF receptor protein-tyrosine kinases: structure and regulation
    Robert Roskoski
    Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116A, Box 19, Horse Shoe, NC 28742, USA
    Biochem Biophys Res Commun 375:287-91. 2008
    ..Interaction between VEGFR1 and VEGFR2 or VEGFR2 and VEGFR3 alters receptor tyrosine phosphorylation...