Research Topics
| Ashok K PullikuthSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Detail Information
Publications
Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasionSiyi Hu
Stanley S Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Mol Cancer 9:30. 2010..PSAP is the lysosomal precursor of saposins, which serve as activators for lysosomal hydrolases involved in the degradation of ceramide (Cer) and other sphingolipids...- Differential requirement for MEK Partner 1 in DU145 prostate cancer cell migrationElecta R Park
Department of Pharmacology, LSU Health Sciences Center New Orleans, LA, USA
Cell Commun Signal 7:26. 2009..MP1 may function by regulating the stability or expression of paxillin, a key regulator of motility... - Extracellular signal-regulated kinase promotes Rho-dependent focal adhesion formation by suppressing p190A RhoGAPAshok K Pullikuth
Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Mol Cell Biol 30:3233-48. 2010..These observations reveal a novel role for ERK signaling in adhesion assembly in addition to its established role in adhesion disassembly... - Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspectiveAshok K Pullikuth
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Cell Signal 19:1621-32. 2007..Here we review data supporting the view that localized ERK signaling mediated through recently identified scaffold proteins may regulate cell migration... 
Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegyptiAshok K Pullikuth
Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521 0146, USA
J Exp Biol 209:3529-44. 2006....- NHE8 mediates amiloride-sensitive Na+/H+ exchange across mosquito Malpighian tubules and catalyzes Na+ and K+ transport in reconstituted proteoliposomesWanyoike Kang'ethe
Graduate Program in Environmental Toxicology, University of California, Riverside, California 92521, USA
Am J Physiol Renal Physiol 292:F1501-12. 2007..We propose that AeNHE8 may be coupled to the inward H(+) gradient across the Malpighian tubules and plays a role in the extrusion of excess sodium and potassium while maintaining steady intracellular pH in the principal cells... - Phylogeny and cloning of ion transporters in mosquitoesAshok K Pullikuth
Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
J Exp Biol 206:3857-68. 2003..Ion transport mechanisms will be discussed from a comparative physiology perspective to gain appreciation of the exquisite mechanisms of mosquito ion regulation... 
ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cellsShyamal D Desai
Department of Biochemistry and Molecular Biology, LSU Health Sciences Center School of Medicine, 1901 Perdido Street, New Orleans, LA 70112, USA
Exp Biol Med (Maywood) 237:38-49. 2012....- In vivo membrane trafficking role for an insect N-ethylmaleimide-sensitive factor which is developmentally regulated in endocrine cellsAshok K Pullikuth
Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
J Exp Biol 205:911-26. 2002..This underscores the utility of our approach to delineate functional roles for proteins from systems that are not currently amenable to in vitro reconstitution... - Trypanosomatid RACK1 orthologs show functional differences associated with translation despite similar roles in Leishmania pathogenesisKohelia Choudhury
Department of Microbiology Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
PLoS ONE 6:e20710. 2011..While biochemically distinguishable, both LACK/LACK and LACK/TbRACK1 lines were more tolerant of elevated temperatures, resistant to translation inhibitors, and displayed robust pathogenesis in vivo, contrasting to LACK/- parasites... - Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2Ashok K Pullikuth
Department of Pharmacology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Int J Mol Sci 14:3595-620. 2013..These data suggest that ERK phosphorylation of IC-2 regulates dynein function through mechanisms other than its interaction with dynactin... - Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transportDavid J Mitchell
Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
J Neurosci 32:15495-510. 2012..These results demonstrate that neurotrophin binding to Trk initiates the recruitment of cytoplasmic dynein to signaling endosomes through ERK1/2 phosphorylation of intermediate chains for their subsequent retrograde transport in axons... - Heliothis virescens and Manduca sexta lipid rafts are involved in Cry1A toxin binding to the midgut epithelium and subsequent pore formationMeibao Zhuang
Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, University of California, Riverside, California 92521, USA
J Biol Chem 277:13863-72. 2002..Our study strongly suggests that these microdomains might be involved in Cry1A toxin aggregation and pore formation...