Research Topics
Species | Stephen PruettSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Publications
Toxicology of metam sodiumS B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Medical Center, Shreveport, Louisiana, USA
J Toxicol Environ Health B Crit Rev 4:207-22. 2001..However, further studies are needed to relate specific molecular or cellular actions to specific health effects...- TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effectsGyongyi Szabo
University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 178:1243-9. 2007..EtOH provides an example of an immunomodulatory drug that acts at least in part by modifying lipid rafts, and it could represent a model to probe the relationships between rafts, receptor complexes, and signaling... 
Urinary corticosterone as an indicator of stress-mediated immunological changes in ratsStephen Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
J Immunotoxicol 5:17-22. 2008..Because these results can be obtained reliably during routine preclinical evaluations, they should be useful for the weight-of-evidence approaches often used in regulatory settings...- Differences in IL-10 and IL-12 production patterns and differences in the effects of acute ethanol treatment on macrophages in vivo and in vitroStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
Alcohol 37:1-8. 2005..This suggests that results for cytokine studies and probably signaling studies as well that are conducted in vitro should be interpreted with caution and confirmed in vivo, particularly if they involve IL-10 and IL-12... - Involvement of three mechanisms in the alteration of cytokine responses by sodium methyldithiocarbamateStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, 71130, USA
Toxicol Appl Pharmacol 213:172-8. 2006..This treatment partially prevented the action of SMD on IL-10 and IL-12 in the peritoneal fluid. The results suggest that all of the proposed mechanisms have some role in the alteration of cytokine production by SMD... - Sodium methyldithiocarbamate inhibits MAP kinase activation through toll-like receptor 4, alters cytokine production by mouse peritoneal macrophages, and suppresses innate immunityStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Toxicol Sci 87:75-85. 2005..Treatment of mice with SMD decreased survival following challenge with non-pathogenic Escherichia coli within 24-48 h, demonstrating suppression of innate immunity... - Acute exposure to ethanol affects Toll-like receptor signaling and subsequent responses: an overview of recent studiesStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Alcohol 33:235-9. 2004..Thus, ethanol alters responses through most or all mouse TLRs, and this suppresses expression of a wide range of innate immune mediators... - Ethanol suppresses cytokine responses induced through Toll-like receptors as well as innate resistance to Escherichia coli in a mouse model for binge drinkingStephen B Pruett
Department of Cellular Biology and Anatomy, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Alcohol 33:147-55. 2004..Ethanol significantly decreased host resistance to E. coli peritonitis. Thus, ethanol suppresses responses induced by TLR receptors in mice and in the same experimental system it suppresses resistance to infection... 
Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouseStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA
BMC Immunol 5:24. 2004..Reversal of the increased number of thymocytes caused by adrenalectomy following restoration of physiological corticosterone concentrations would indicate that corticosterone is the major adrenal product involved in thymic homeostasis...- Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3Stephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
J Immunol 173:2715-24. 2004.... - Characterization of glucocorticoid receptor translocation, cytoplasmic IkappaB, nuclear NFkappaB, and activation of NFkappaB in T lymphocytes exposed to stress-inducible concentrations of corticosterone in vivoStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Int Immunopharmacol 3:1-16. 2003..Additionally, upregulation of IkappaB and consequent inhibition of NFkappaB activation are not prominent in vivo, in contrast to results obtained in vitro or with a synthetic glucocorticoid... - Acute ethanol administration profoundly alters poly I:C-induced cytokine expression in mice by a mechanism that is not dependent on corticosteroneStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130, USA
Life Sci 72:1825-39. 2003..These results plus previously published findings are consistent with the idea that EtOH may be a generalized suppressor of toll-like receptor signaling... - Modeling and predicting immunological effects of chemical stressors: characterization of a quantitative biomarker for immunological changes caused by atrazine and ethanolStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Toxicol Sci 75:343-54. 2003..One of the parameters (MHC class II expression) was evaluated as a predictive biomarker for stress-related immunosuppression, and the results suggest it could be suitable for that purpose... 
The role of stress mediators in modulation of cytokine production by ethanolMitzi Glover
LSU Health Sciences Center, Department of Cellular Biology and Anatomy, Shreveport, LA 71130, USA
Toxicol Appl Pharmacol 239:98-105. 2009....- Role of corticosterone in immunosuppressive effects of acute ethanol exposure on Toll-like receptor mediated cytokine productionMitzi Glover
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, LSUHSC-S, 1501 Kings Highway, Shreveport, LA 71130, USA
J Neuroimmune Pharmacol 1:435-42. 2006.... - Oxidative stress and sodium methyldithiocarbamate-induced modulation of the macrophage response to lipopolysaccharide in vivoStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA
Toxicol Sci 109:237-46. 2009..However, oxidative stress alone cannot explain the increased IL-10 production caused by SMD... - Ethanol inhibits LPS-induced signaling and modulates cytokine production in peritoneal macrophages in vivo in a model for binge drinkingStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
BMC Immunol 10:49. 2009.... - Characterization of the action of drug-induced stress responses on the immune system: evaluation of biomarkers for drug-induced stress in ratsStephen Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
J Immunotoxicol 4:25-38. 2007..However, the good correlation between urine and serum corticosterone levels suggest that urine corticosterone may be a potential biomarker of stress induced changes to the immune response... - The role of glucocorticoids in the immediate vs. delayed effects of acute ethanol exposure on cytokine production in a binge drinking modelMitzi Glover
LSU Health Sciences Center, Shreveport, Louisiana, USA
Int Immunopharmacol 11:755-61. 2011..The purpose of this study was to determine the role of corticosterone on these effects. Also, since gender differences occur in immune responses, separate experiments were performed using male and female mice... - Ethanol suppresses polyinosinic:polycytidylic acid-induced activation of natural killer cells primarily by acting on natural killer cells, not through effects on other cell typesPamela Hebert
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Alcohol 28:75-81. 2002..1 monoclonal antibody, were used instead of perforin knockout mice. These results indicate that ethanol suppresses activation of NK cells primarily by suppressing the NK cell response to poly I:C, not by acting on another cell type... - Patterns of immunotoxicity associated with chronic as compared with acute exposure to chemical or physical stressors and their relevance with regard to the role of stress and with regard to immunotoxicity testingStephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Toxicol Sci 109:265-75. 2009..These results indicate that the nature of the stressor determines whether mice become tolerant with regard to the stress response and consequent immunological effects. This finding has practical implications for safety testing in mice... - Ethanol suppresses LPS-induced Toll-like receptor 4 clustering, reorganization of the actin cytoskeleton, and associated TNF-alpha productionQun Dai
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, USA
Alcohol Clin Exp Res 30:1436-44. 2006.... - Ethanol alters cellular activation and CD14 partitioning in lipid raftsQun Dai
Department of Cellular Biology and Anatomy, Louisiana State University Health Science Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Biochem Biophys Res Commun 332:37-42. 2005..This membrane action of EtOH might be one of the mechanisms by which EtOH acts as a generalized suppressor for TLR signaling... - Ethanol decreases natural killer cell activation but only minimally affects anatomical distribution after administration of polyinosinic:polycytidylic acid: role in resistance to B16F10 melanomaPamela Hebert
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Alcohol Clin Exp Res 27:1622-31. 2003..This effect is reduced after administration of ethanol (EtOH; 6 g/kg by oral gavage). The present study was conducted to determine whether decreased resistance is due to alteration of the distribution and/or the activation of NK cells... - Modeling and predicting stress-induced immunosuppression in mice using blood parametersCarlton L Schwab
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
Toxicol Sci 83:101-13. 2005..Nevertheless, MHC class II expression seems to provide a reasonably consistent indication of stress exposure in blood and spleen... - Assessment of immunologic mechanisms for flare reactions to SynviscAndrew A Marino
Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
Clin Orthop Relat Res 442:187-94. 2006..Flares that sometimes occur after treatment with Synvisc are probably not Type-1 (antibody-mediated) hypersensitivity reactions, but may be Type-4 (cell-mediated) hypersensitivity reactions... - An explanation for the paradoxical induction and suppression of an acute phase response by ethanolBrandon S Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Alcohol 39:105-10. 2006..These results provide a resolution for the apparently paradoxical pro- and anti-inflammatory actions of EtOH with regard to acute phase responses... - Thalidomide enhances both primary and secondary host resistances to Listeria monocytogenes infection by a neutrophil-related mechanism in female B6C3F1 miceTai L Guo
Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, Virginia 23298 6013, USA
Toxicol Appl Pharmacol 209:244-54. 2005..In conclusion, thalidomide enhanced host resistance to both primary and secondary L. monocytogenes infections by a neutrophil-related mechanism in female B6C3F1 mice... - Natural killer cells do not mediate facial motoneuron survival after facial nerve transectionSusanna C Byram
Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
Brain Behav Immun 17:417-25. 2003..Thus, NK cells appear to not be a component of immune cell-mediated rescue of motoneurons from axotomy induced cell death...