D Neil Granger

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Leukocyte-mediated Tissue Injury in Ischemic Stroke
    S F Rodrigues
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA, USA
    Curr Med Chem 21:2130-7. 2014
  2. pmc Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis
    Christoph Anthoni
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Exp Med 204:1595-601. 2007
  3. pmc Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide
    C F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Exp Med 194:1207-18. 2001
  4. ncbi request reprint Synergistic effects of high blood cholesterol and hypertension on leukocyte and platelet recruitment in the cerebral microcirculation
    Stephen F Rodrigues
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932
    Hypertension 63:747-52. 2014
  5. pmc Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction
    Georg Singer
    Department of Pediatric Surgery, Medical University of Graz, Graz, Austria
    Inflamm Res 62:155-64. 2013
  6. pmc Leukocyte-dependent responses of the microvasculature to chronic angiotensin II exposure
    Alper Yildirim
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, Shreveport, LA 71130 3932, USA
    Hypertension 60:1503-9. 2012
  7. pmc Induction of neuro-protective/regenerative genes in stem cells infiltrating post-ischemic brain tissue
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, LA, USA
    Exp Transl Stroke Med 2:11. 2010
  8. ncbi request reprint Modulation of the inflammatory response in cardiovascular disease
    D Neil Granger
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Hypertension 43:924-31. 2004
  9. pmc Microvascular responses to cardiovascular risk factors
    D Neil Granger
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Microcirculation 17:192-205. 2010
  10. pmc Angiotensin II-mediated microvascular thrombosis
    Elena Y Senchenkova
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, 1501 Kings Hwy, Shreveport, LA 71130 3932
    Hypertension 56:1089-95. 2010

Research Grants

  1. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 2003
  2. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2004
  3. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2005
  4. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2005
  5. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2006
  6. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2006
  7. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2007
  8. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2007
  9. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2009
  10. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 2002

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Leukocyte-mediated Tissue Injury in Ischemic Stroke
    S F Rodrigues
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA, USA
    Curr Med Chem 21:2130-7. 2014
    ..Recently tested compounds that afford protection against the neurological deficits and tissue injury induced by stroke are addressed within the context of potential development of novel strategies for stroke treatment. ..
  2. pmc Tissue factor: a mediator of inflammatory cell recruitment, tissue injury, and thrombus formation in experimental colitis
    Christoph Anthoni
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Exp Med 204:1595-601. 2007
    ..These findings implicate TF in intestinal inflammation and support an interaction between inflammation and coagulation in experimental colitis...
  3. pmc Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide
    C F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Exp Med 194:1207-18. 2001
    ..Interestingly, SOD(Tg) mice exhibited more severe colitis than their WT littermates. These findings reveal divergent roles for superoxide and iNOS-derived NO in intestinal inflammation...
  4. ncbi request reprint Synergistic effects of high blood cholesterol and hypertension on leukocyte and platelet recruitment in the cerebral microcirculation
    Stephen F Rodrigues
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932
    Hypertension 63:747-52. 2014
    ..Our findings indicate that the combination of hypertension and large increases in plasma cholesterol concentration results in a severe, but reversible, inflammatory and thrombogenic phenotype in the cerebral microvasculature. ..
  5. pmc Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction
    Georg Singer
    Department of Pediatric Surgery, Medical University of Graz, Graz, Austria
    Inflamm Res 62:155-64. 2013
    ..Hepatic microvascular dysfunction is a critical event in the development of liver failure during sepsis. Activated blood cells and reactive oxygen and nitrogen species (RONS) have been implicated in the pathogenesis of sepsis...
  6. pmc Leukocyte-dependent responses of the microvasculature to chronic angiotensin II exposure
    Alper Yildirim
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, Shreveport, LA 71130 3932, USA
    Hypertension 60:1503-9. 2012
    ..These findings implicate leukocyte-associated AT(1)r and gp91(phox) in the induction of the pro-oxidative, proinflammatory, and prothrombogenic phenotype assumed by microvessels that is chronically exposed to elevated Ang II...
  7. pmc Induction of neuro-protective/regenerative genes in stem cells infiltrating post-ischemic brain tissue
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, LA, USA
    Exp Transl Stroke Med 2:11. 2010
    ..These genes are relevant to the neuroprotection, regeneration and angiogenesis previously described following stem cell therapy in animal models of ischemic stroke...
  8. ncbi request reprint Modulation of the inflammatory response in cardiovascular disease
    D Neil Granger
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Hypertension 43:924-31. 2004
    ..These factors also hold the promise of offering multiple sites for therapeutic intervention in CVD...
  9. pmc Microvascular responses to cardiovascular risk factors
    D Neil Granger
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Microcirculation 17:192-205. 2010
    ..Future efforts to develop therapies that prevent the harmful effects of risk factor-induced inflammation should focus on the microcirculation...
  10. pmc Angiotensin II-mediated microvascular thrombosis
    Elena Y Senchenkova
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, 1501 Kings Hwy, Shreveport, LA 71130 3932
    Hypertension 56:1089-95. 2010
    ....
  11. pmc Role of blood cell-associated angiotensin II type 1 receptors in the cerebral microvascular response to ischemic stroke during angiotensin-induced hypertension
    Mutsumi Nagai
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Exp Transl Stroke Med 3:15. 2011
    ..abstract:..
  12. ncbi request reprint Cerebral microvascular responses to hypercholesterolemia: roles of NADPH oxidase and P-selectin
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circ Res 94:239-44. 2004
    ....
  13. pmc CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation
    Karen Y Stokes
    Dept of Molecular and Cellular Physiology, LSU Health Sciences Ctr, 1501 E Kings Hwy, Shreveport, LA 71130 3932, USA
    Am J Physiol Heart Circ Physiol 296:H689-97. 2009
    ....
  14. ncbi request reprint Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction
    Anitaben Tailor
    Department of Molecular and Cellular Physiology, Health Sciences Center, Louisiana State University, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Am J Physiol Heart Circ Physiol 293:H3636-42. 2007
    ..Platelet- and endothelial cell-associated COX-1 promote microvascular inflammation and thrombogenesis during hypercholesterolemia, yet nitric oxide-releasing aspirin directly inhibits platelets independent of COX-1...
  15. ncbi request reprint Molecular determinants of the prothrombogenic and inflammatory phenotype assumed by the postischemic cerebral microcirculation
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
    Stroke 34:1777-82. 2003
    ..The objective of this study was to define the magnitude and molecular determinants of the platelet- and leukocyte-endothelial cell adhesive interactions induced by I/R in the mouse brain...
  16. ncbi request reprint Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brain
    Vidula Vachharajani
    Department of Critical Care Medicine, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Microcirculation 12:183-94. 2005
    ..The authors examined the inflammatory and thrombogenic responses of the cerebral microvasculature to sepsis induced by cecal ligation and perforation in obese and lean wild-type mice...
  17. ncbi request reprint Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic mice
    Katherine C Wood
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Heart Circ Physiol 286:H1608-14. 2004
    ..These findings indicate that betaS mice assume both an inflammatory and prothrombogenic phenotype, with endothelial cell P-selectin playing a major role in mediating these microvascular responses...
  18. ncbi request reprint Role of blood cell-associated AT1 receptors in the microvascular responses to hypercholesterolemia
    Thomas Petnehazy
    Department of Molecular and Cellular Physiology, Louisiana State University, Health Sciences Center, Shreveport, LA 71130 3932, USA
    Arterioscler Thromb Vasc Biol 26:313-8. 2006
    ..The objective of this study was to determine the relative contributions of blood cell-associated versus endothelium-associated AT1a-R to these hypercholesterolemia-induced microvascular alterations...
  19. ncbi request reprint Angiotensin II type-1 receptor antagonism attenuates the inflammatory and thrombogenic responses to hypercholesterolemia in venules
    Thomas Petnehazy
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 E Kings Highway, Shreveport, LA 71130 3932, USA
    Hypertension 45:209-15. 2005
    ..We propose that AT1-R engagement contributes to the prothrombogenic and proinflammatory state induced in venules by hypercholesterolemia...
  20. ncbi request reprint CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon
    Thorsten Vowinkel
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Gastroenterology 132:955-65. 2007
    ....
  21. ncbi request reprint Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules
    Mikiji Mori
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Gastrointest Liver Physiol 288:G920-6. 2005
    ..Our findings indicate that colonic inflammation is associated with the induction of a prothrombogenic phenotype in the colonic microcirculation, with P-selectin and its ligand PSGL-1 playing a major role in the recruitment of platelets...
  22. ncbi request reprint Role of interferon-gamma in hypercholesterolemia-induced leukocyte-endothelial cell adhesion
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 E Kings Highway, Shreveport, LA 71130 3932, USA
    Circulation 107:2140-5. 2003
    ..The objective of this study was to define the contribution of T-lymphocyte-derived interferon-gamma (IFN-gamma) to the leukocyte-endothelial cell adhesion induced by hypercholesterolemia...
  23. ncbi request reprint Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130 3932, USA
    Free Radic Biol Med 33:1026-36. 2002
    ..Agents that act to maintain the normal balance between NO and reactive oxygen species (ROS) in vascular endothelial cells may prove particularly useful in this regard...
  24. ncbi request reprint Role of platelets in hypercholesterolemia-induced leukocyte recruitment and arteriolar dysfunction
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Microcirculation 13:377-88. 2006
    ..To define the contribution of platelets, specifically platelet-associated P-selectin, to the altered venular and arteriolar responses induced by hypercholesterolemia...
  25. ncbi request reprint Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice
    Katherine C Wood
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    FASEB J 19:989-91. 2005
    ..These findings suggest that superoxide derived from endothelial cell NADPH-oxidase and catalytically active iron contribute to the proinflammatory and prothrombogenic responses associated with sickle cell disease...
  26. pmc Platelet-associated NAD(P)H oxidase contributes to the thrombogenic phenotype induced by hypercholesterolemia
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Free Radic Biol Med 43:22-30. 2007
    ....
  27. ncbi request reprint Leukocyte dependence of platelet adhesion in postcapillary venules
    Dianne Cooper
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Heart Circ Physiol 286:H1895-900. 2004
    ..These results are consistent with leukocytes playing a major role in supporting I/R-induced platelet adhesion...
  28. ncbi request reprint Hypertonic saline and the cerebral microcirculation in obese septic mice
    Vidula Vachharajani
    Critical Care Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Microcirculation 14:223-31. 2007
    ....
  29. ncbi request reprint Low venular shear rates promote leukocyte-dependent recruitment of adherent platelets
    Janice Russell
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Am J Physiol Gastrointest Liver Physiol 284:G123-9. 2003
    ....
  30. ncbi request reprint T-lymphocytes modulate the microvascular and inflammatory responses to intestinal ischemia-reperfusion
    Takeharu Shigematsu
    Department of Molecular Cellular Physiology, Center of Excellence in Arthritis Rheumatology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Microcirculation 9:99-109. 2002
    ..The overall objective of this study was to define the contribution of T-lymphocytes to the microvascular and inflammatory responses of the intestine to ischemia/reperfusion (I/R)...
  31. doi request reprint Inflammatory and injury responses to ischemic stroke in obese mice
    Satoshi Terao
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Stroke 39:943-50. 2008
    ..This study tested the hypothesis that obesity exacerbates the cerebrovascular dysfunction and tissue injury induced by brain ischemia and reperfusion...
  32. ncbi request reprint Differential expression of E- and P-selectin in the microvasculature of sickle cell transgenic mice
    Katherine Wood
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Microcirculation 11:377-85. 2004
    ....
  33. pmc P-selectin contributes to severe experimental malaria but is not required for leukocyte adhesion to brain microvasculature
    Wun Ling Chang
    Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Infect Immun 71:1911-8. 2003
    ..berghei malaria was similar to that observed in control mice. Collectively, these results indicate that P-selectin is important for the development of malarial pathogenesis but is not required for leukocyte adhesion in brain...
  34. ncbi request reprint Exposure of brain to high-dose, focused gamma rays irradiation produces increase in leukocytes-adhesion and pavementing in small intracerebral blood vessels
    Katherine Wood
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Neurosurgery 57:1282-8; discussion 1282-8. 2005
    ..We hereby present our in vivo model to study the effects of single-session, high-dose radiation on the cerebral vessels that are targeted with radiosurgery using the Leksell Gamma Knife...
  35. ncbi request reprint Role of interleukin 12 in hypercholesterolemia-induced inflammation
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 E Kings Highway, Shreveport, LA 71130 3932, USA
    Am J Physiol Heart Circ Physiol 285:H2623-9. 2003
    ..These findings implicate IL-12 in the inflammatory responses observed in the venules of hypercholesterolemic mice...
  36. ncbi request reprint Intercellular adhesion molecule 1 is important for the development of severe experimental malaria but is not required for leukocyte adhesion in the brain
    Jie Li
    Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, USA
    J Investig Med 51:128-40. 2003
    ..berghei malaria. Leukocyte rolling and adhesion in the brain vasculature during P. berghei malaria use different ligands than observed during inflammation in other vascular beds...
  37. doi request reprint CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism
    Ryan M Wolfort
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Am J Physiol Heart Circ Physiol 294:H2619-26. 2008
    ....
  38. ncbi request reprint HMG-CoA reductase inhibitor attenuates platelet adhesion in intestinal venules of hypercholesterolemic mice
    Anitaben Tailor
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3982, USA
    Am J Physiol Heart Circ Physiol 286:H1402-7. 2004
    ..pravastatin treatment inhibits the prothrombogenic effects of hypercholesterolemia via an action on both endothelial cells and platelets; and 3). the protective effect of pravastatin is nitric oxide dependent...
  39. ncbi request reprint Hypercholesterolemia promotes leukocyte-dependent platelet adhesion in murine postcapillary venules
    Anitaben Tailor
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Microcirculation 11:597-603. 2004
    ..The study determined whether leukocytes contribute to the platelet adhesion induced by hypercholesterolemia in postcapillary venules...
  40. ncbi request reprint Time-dependent platelet-vessel wall interactions induced by intestinal ischemia-reperfusion
    Dianne Cooper
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Gastrointest Liver Physiol 284:G1027-33. 2003
    ....
  41. ncbi request reprint Inflammatory responses to ischemia and reperfusion in the cerebral microcirculation
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Front Biosci 9:1339-47. 2004
    ..The limited data available for the brain microcirculation support the potential of anti-leukocyte and anti-platelet strategies for stroke therapy...
  42. ncbi request reprint CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circulation 111:1690-6. 2005
    ..The purpose of this study was to investigate the role of CD40/CD40L signaling in cerebral microvascular dysfunction and tissue injury response to middle cerebral artery occlusion (MCAO) and reperfusion...
  43. ncbi request reprint Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    J Cereb Blood Flow Metab 24:907-15. 2004
    ..These findings implicate a major role for both platelet-associated and endothelial cell-associated P-selectin, as well as neutrophils in the inflammatory and prothrombogenic responses in the microcirculation after focal cerebral I/R...
  44. ncbi request reprint Differential expression and regulation of murine CD40 in regional vascular beds
    Thorsten Vowinkel
    Dept of Molecular and Cellular Physiology, LSU Health Sciences Ctr, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
    Am J Physiol Heart Circ Physiol 290:H631-9. 2006
    ..Platelet- and T-lymphocyte-associated CD40L appears to play a major role in regulating the density of CD40 expression on vascular endothelial cells in vivo...
  45. pmc Apolipoprotein A-IV inhibits experimental colitis
    Thorsten Vowinkel
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    J Clin Invest 114:260-9. 2004
    ..This anti-inflammatory effect likely involves the inhibition of P-selectin-mediated leukocyte and platelet adhesive interactions...
  46. pmc Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
    Guohong Li
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, United States
    Atherosclerosis 208:358-65. 2010
    ..These results reveal a mechanism whereby PN mediates vascular SMC migration through an interaction with alphaV-integrins (mainly alphanubeta3) and subsequent activation of FAK pathway...
  47. ncbi request reprint Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules
    Wolfgang H Cerwinka
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Heart Circ Physiol 282:H1111-7. 2002
    ..These findings indicate that 1) eNOS-derived NO attenuates endotoxin-induced P/E adhesion and 2) sGC is responsible for the antiadhesive action of NO...
  48. ncbi request reprint Endothelial junctional protein redistribution and increased monolayer permeability in human umbilical vein endothelial cells isolated during preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shrevport, LA 71130, USA
    Am J Obstet Gynecol 186:214-20. 2002
    ..We hypothesized that increased endothelial monolayer permeability in preeclampsia reflects altered monolayer barrier properties produced by disorganization of endothelial cell junction proteins...
  49. pmc Elevated plasma chymotrypsin-like protease (chymase) activity in women with preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University, Health Sciences Center Shreveport, Shreveport, Louisiana 71130, USA
    Hypertens Pregnancy 29:253-61. 2010
    ..Chymase, a chymotrypsin-like protease, is a non-ACE angiotensin II (Ang II) generating enzyme. We determined if maternal chymotrypsin-like protease/chymase activity was increased in women with preeclampsia (PE)...
  50. pmc Blood cell-derived RANTES mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusion
    Satoshi Terao
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Stroke 39:2560-70. 2008
    ....
  51. pmc Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis
    John H Chidlow
    Department of Pathology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana 71130, USA
    Gastroenterology 136:575-84.e2. 2009
    ..Caveolin-1 (Cav-1), the major structural protein of caveolae in endothelial cells, is involved in the regulation of angiogenesis, so we investigated its role in experimental colitis...
  52. ncbi request reprint Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules
    Wolfgang H Cerwinka
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Am J Physiol Heart Circ Physiol 284:H535-41. 2003
    ..These findings indicate that neutrophil-derived superoxide plays a major role in the modulation of endotoxin-induced P/E adhesion...
  53. pmc Lymphocyte-derived interferon-gamma mediates ischemia-reperfusion-induced leukocyte and platelet adhesion in intestinal microcirculation
    Mohammad Osman
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Am J Physiol Gastrointest Liver Physiol 296:G659-63. 2009
    ..These findings implicate both T and B cells and lymphocyte-derived IFN-gamma as mediators of the proinflammatory and prothrombogenic phenotype assumed by intestinal microvessels after I/R...
  54. pmc Leukocyte recruitment and ischemic brain injury
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuromolecular Med 12:193-204. 2010
    ..Evidence implicating regulatory T-cells as cerebroprotective modulators of the inflammatory and tissue injury responses to brain I/R support a continued focus on leukocytes as a target for therapeutic intervention in ischemic stroke...
  55. pmc Role of blood cells in ischaemia-reperfusion induced endothelial barrier failure
    Stephen F Rodrigues
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Cardiovasc Res 87:291-9. 2010
    ..e. hypertension, diabetes, hypercholesterolaemia, and obesity, influence the vascular permeability response to I/R. Areas of uncertainty and controversy in this field of investigation are also identified...
  56. ncbi request reprint Hypercholesterolemia promotes P-selectin-dependent platelet-endothelial cell adhesion in postcapillary venules
    Anitaben Tailor
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130 3982, USA
    Arterioscler Thromb Vasc Biol 23:675-80. 2003
    ....
  57. ncbi request reprint Hypercholesterolemia: its impact on ischemia-reperfusion injury
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Expert Rev Cardiovasc Ther 3:1061-70. 2005
    ..These common pathways of inflammation offer attractive targets for the development of drugs to combat cardiovascular disease and the associated ischemic disorders...
  58. ncbi request reprint Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion
    Thiruma V Arumugam
    Dept of Molecular and Cellular Physiology, Louisiana State Univ Health Sciences Center, 1500 Kings Highway, Shreveport, LA 71130, USA
    Am J Physiol Heart Circ Physiol 287:H2555-60. 2004
    ..These findings indicate that both alpha-subunits of the beta2-integrins contribute to the brain injury and blood cell-vessel wall interactions that are associated with transient focal cerebral ischemia...
  59. ncbi request reprint Placental trophoblast-derived factors diminish endothelial barrier function
    Yuping Wang
    Departments of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Clin Endocrinol Metab 89:2421-8. 2004
    ..these results implicate trophoblast-derived factors in the increased vascular permeability associated with preeclampsia...
  60. pmc Mediators of CD18/P-selectin-dependent constriction of venule-paired arterioles in hypercholesterolemia
    Min Ho Kim
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Microvasc Res 73:150-5. 2007
    ..These findings indicate that the mechanism of blood cell-dependent arteriolar constriction during hypercholesterolemia may be dependent on thromboxane, a decrease in NO, and the proximity of the arterioles to postcapillary venules...
  61. ncbi request reprint Endothelial barrier function in preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA
    Front Biosci 12:2412-24. 2007
    ..Insights gained from the characterization of the endothelial cell phenotype assumed by the preeclamptic microvasculature may lead to novel therapeutic strategies for the management of this syndrome...
  62. ncbi request reprint Glucocorticoids inhibit the cerebral microvascular dysfunction associated with sepsis in obese mice
    Vidula Vachharajani
    Critical Care Medicine, Louisiana State University Health Sciences Centre, Shreveport, Louisiana 71130, USA
    Microcirculation 13:477-87. 2006
    ..The objective of this study was to determine whether low-dose steroid therapy, which has proven effective in clinical setting, affords any benefit in the increased morbidity to sepsis in genetically obese (ob/ob) mice...
  63. ncbi request reprint Role of NADPH oxidase in the brain injury of intracerebral hemorrhage
    Jiping Tang
    Department of Molecular and Cellular Physiology, Lousiana State University Health Science Center, Shrevenport, Louisiana, USA
    J Neurochem 94:1342-50. 2005
    ..In conclusion, the oxidative stress resulting from activation of NADPH oxidase contributes to ICH induced by collagenase and promotes brain injury...
  64. ncbi request reprint Regulation of endothelial cell adhesion molecule expression in an experimental model of cerebral malaria
    Phillipe R Bauer
    Departments of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Microcirculation 9:463-70. 2002
    ....
  65. pmc Role of the protein C pathway in the extraintestinal thrombosis associated with murine colitis
    Hideo Yoshida
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 33932, USA
    Gastroenterology 135:882-8. 2008
    ..The objective of this study was to determine whether the protein C pathway contributes to the enhanced extraintestinal thrombosis that is associated with dextran sodium sulfate (DSS)-induced colitis in mice...
  66. ncbi request reprint The role of T-lymphocytes in hypercholesterolemia-induced leukocyte-endothelial interactions
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Microcirculation 9:407-17. 2002
    ..This study assesses the contribution of CD4(+) and CD8(+) T-cells to acute inflammatory responses observed in the microcirculation of hypercholesterolemic mice...
  67. ncbi request reprint Mechanisms of platelet and leukocyte recruitment in experimental colitis
    Thorsten Vowinkel
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130 3932, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1054-60. 2007
    ..DSS colitis was also associated with an increased expression of PSGL-1 in the colonic vasculature. These findings indicate that the recruitment of leukocytes and platelets in inflamed colonic venules are co-dependent processes...
  68. ncbi request reprint Sickle cell disease: role of reactive oxygen and nitrogen metabolites
    Katherine C Wood
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Clin Exp Pharmacol Physiol 34:926-32. 2007
    ..4. The emerging role of reactive oxygen and nitrogen species in the pathogenesis of SCD provides a platform for the development of novel agents to treat this painful and lethal disease...
  69. pmc The microcirculation: a motor for the systemic inflammatory response and large vessel disease induced by hypercholesterolaemia?
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    J Physiol 562:647-53. 2005
    ....
  70. pmc Selectin-mediated recruitment of bone marrow stromal cells in the postischemic cerebral microvasculature
    Gokhan Yilmaz
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Stroke 42:806-11. 2011
    ..This study addresses the hypothesis that selectins mediate the recruitment of BMSCs into the postischemic cerebral microvasculature...
  71. pmc Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis
    Hideo Yoshida
    Eiju General Hospital, Tokyo, Japan
    Am J Pathol 177:2774-81. 2010
    ..These findings implicate IL-1β as a mediator of enhanced microvascular thromboses that occur in extra-intestinal tissues during colonic inflammation...
  72. pmc Role of T lymphocytes in angiotensin II-mediated microvascular thrombosis
    Elena Y Senchenkova
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
    Hypertension 58:959-65. 2011
    ..NADPH oxidase-derived reactive oxygen species, produced by cells other than T lymphocytes, also appear critical for the Ang II-enhanced, T cell-dependent thrombosis response...
  73. pmc Roles of inflammation and the activated protein C pathway in the brain edema associated with cerebral venous sinus thrombosis
    Mutsumi Nagai
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Stroke 41:147-52. 2010
    ..The objective of this study was to define the role of the protein C pathway in the BBB permeability and edema elicited by experimental CVST. The role of neutrophil recruitment was also evaluated...
  74. pmc Triggering CD40 on endothelial cells contributes to tumor growth
    Claudia Chiodoni
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    J Exp Med 203:2441-50. 2006
    ..Collectively, these data point to a participation of CD40/CD40L in the angiogenic processes associated with mammary carcinogenesis of BALB/NeuT mice...
  75. ncbi request reprint Spatial heterogeneity of TNF-alpha-induced T cell migration to colonic mucosa is mediated by MAdCAM-1 and VCAM-1
    Chikako Watanabe
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 283:G1379-87. 2002
    ..Spatial heterogeneity of MAdCAM-1 and VCAM-1 activation following TNF-alpha challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa...
  76. ncbi request reprint T-cell derived interferon-gamma contributes to arteriolar dysfunction during acute hypercholesterolemia
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 E Kings Highway, Shreveport, LA 71130 3932, USA
    Arterioscler Thromb Vasc Biol 27:1998-2004. 2007
    ..Our objectives were to determine whether: (1) T-lymphocytes are the source of this IFN-gamma, and (2) whether T-cell-derived IFN-gamma also mediates the accompanying arteriolar dysfunction and platelet adhesion...
  77. ncbi request reprint Role of T lymphocytes and interferon-gamma in ischemic stroke
    Gokhan Yilmaz
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Circulation 113:2105-12. 2006
    ....
  78. ncbi request reprint Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Med 12:621-3. 2006
    ..These findings suggest that Notch signaling may be a therapeutic target for treatment of stroke and related neurodegenerative conditions...
  79. ncbi request reprint Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction
    Katherine C Wood
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    Free Radic Biol Med 40:1443-53. 2006
    ....
  80. ncbi request reprint Inflammatory responses underlying the microvascular dysfunction associated with obesity and insulin resistance
    Georg Singer
    Department of Pediatric Surgery, Medical University of Graz, Graz, Austria
    Microcirculation 14:375-87. 2007
    ....
  81. ncbi request reprint Hepatic microcirculation in murine sepsis: role of lymphocytes
    Georg Singer
    Department of Pediatric Surgery, Medical University of Graz, Graz, Austria
    Pediatr Surg Int 24:13-20. 2008
    ..These findings indicate that lymphocytes mediate the microvascular dysfunction, but protect against the hepatocellular injury associated with murine sepsis...
  82. ncbi request reprint Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature
    Mami Ishikawa
    Department of Neurosurgery, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke City, Tochigi, 329 0498 Japan
    Am J Physiol Heart Circ Physiol 292:H2306-15. 2007
    ....
  83. ncbi request reprint Gaining more from gamma globulins
    Karen Y Stokes
    Circulation 112:1918-20. 2005
  84. ncbi request reprint Platelet recruitment in the murine hepatic microvasculature during experimental sepsis: role of neutrophils
    Georg Singer
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Microcirculation 13:89-97. 2006
    ..While inflammatory cell activation has been implicated as an early critical event in sepsis-induced liver dysfunction, there is growing evidence for the involvement of activated platelets in this pathologic process...

Research Grants27

  1. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 2003
    ..The results obtained from the proposed studies should lead to an improved understanding of the mechanisms by which hypercholesterolemia exacerbates ischemic tissue injury. ..
  2. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2004
    ..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. ..
  3. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2005
    ..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. ..
  4. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2005
    ..The proposed work should lead to an improved understanding of the microvascular alterations that precede the appearance of overt large artery pathology during hypercholesterolemia. ..
  5. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2006
    ..The proposed work should lead to an improved understanding of the microvascular alterations that precede the appearance of overt large artery pathology during hypercholesterolemia. ..
  6. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2006
    ..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. ..
  7. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2007
    ..The proposed work should lead to an improved understanding of the microvascular alterations that precede the appearance of overt large artery pathology during hypercholesterolemia. ..
  8. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2007
    ..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. ..
  9. Microvascular responses to hypercholesterolemia
    D Granger; Fiscal Year: 2009
    ..The proposed work should lead to an improved understanding of the microvascular alterations that precede the appearance of overt large artery pathology during hypercholesterolemia. ..
  10. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 2002
    ..The results obtained from the proposed studies should lead to an improved understanding of the mechanisms by which hypercholesterolemia exacerbates ischemic tissue injury. ..
  11. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 2001
    ..The results obtained from the proposed studies should lead to an improved understanding of the mechanisms by which hypercholesterolemia exacerbates ischemic tissue injury. ..
  12. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 2000
    ..The results obtained from the proposed studies should lead to an improved understanding of the mechanisms by which hypercholesterolemia exacerbates ischemic tissue injury. ..
  13. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 1999
    ..The results obtained from the proposed studies should lead to an improved understanding of the mechanisms by which hypercholesterolemia exacerbates ischemic tissue injury. ..
  14. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 1991
    ..The results obtained should extend our understanding of the mechanisms underlying the enhanced vascular fluid and protein leakage and interstitial edema that accompanies an acute inflammatory response...
  15. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 1990
    ..Furthermore, the proposed studies should improve our understanding of the factors responsible for the interstitial edema associated with various intestinal disorders...
  16. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 1992
    ..The results obtained should extend our understanding of the mechanisms underlying the enhanced vascular fluid and protein leakage and interstitial edema that accompanies an acute inflammatory response...
  17. TRANSCAPILLARY FLUID EXCHANGE
    D Granger; Fiscal Year: 1993
    ..The results obtained should extend our understanding of the mechanisms underlying the enhanced vascular fluid and protein leakage and interstitial edema that accompanies an acute inflammatory response...
  18. Risk factor-enhanced microvascular responses to ischemia-reperfusion.
    D Neil Granger; Fiscal Year: 2010
    ....