Cherie Ann Nathan

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway
    Cherie Ann O Nathan
    Louisiana State University Health Sciences Center, Feist Weiller Cancer Center, Veterans Administration, Shreveport, Louisiana, USA
    Clin Cancer Res 10:5820-7. 2004
  2. pmc Topical curcumin-based cream is equivalent to dietary curcumin in a skin cancer model
    Kunal Sonavane
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    J Skin Cancer 2012:147863. 2012
  3. pmc Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models
    Oleksandr Ekshyyan
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    BMC Cancer 13:320. 2013
  4. doi Curcumin inhibits carcinogen and nicotine-induced Mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma
    Cheryl A Clark
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, Director of Head and Neck Surgical Oncology, Feist Weiller Cancer Center, Shreveport, LA 71130 3932, USA
    Cancer Prev Res (Phila) 3:1586-95. 2010
  5. ncbi Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
    Cherie Ann O Nathan
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Cancer Res 67:2160-8. 2007
  6. ncbi COX-2 expression in dysplasia of the head and neck: correlation with elF4E
    C A Nathan
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center and Veterans Administration Medical Center, 1501 Kings Highway, PO Box 33932, Shreveport, LA 71130, USA
    Cancer 92:1888-95. 2001
  7. ncbi Botulinum toxin: helpful adjunct to early resolution of laryngeal granulomas
    Joanne Pham
    Department of Otolaryngology, Head and Neck Surgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130, USA
    J Laryngol Otol 118:781-5. 2004
  8. pmc Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A
    Cary A Moody
    Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Virol 79:5499-506. 2005
  9. ncbi Expression of the proto-oncogene eIF4E in inflammation of the oral cavity
    Binoy Chandy
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Science Center and Veterans Administration Shreveport, 71130, USA
    Otolaryngol Head Neck Surg 126:290-5. 2002
  10. doi Skull base osteomyelitis and bisphosphonate use in multiple myeloma: report of two cases and literature review
    Jeffrey M Phillips
    Louisiana State University Health Sciences, Center Shreveport, LA, USA
    Laryngoscope 120:S175. 2010

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway
    Cherie Ann O Nathan
    Louisiana State University Health Sciences Center, Feist Weiller Cancer Center, Veterans Administration, Shreveport, Louisiana, USA
    Clin Cancer Res 10:5820-7. 2004
    ..We hypothesize that overexpressed eIF4E is functionally active in tumor margins through activation of the Akt/mammalian target of rapamycin (mTOR) pathway..
  2. pmc Topical curcumin-based cream is equivalent to dietary curcumin in a skin cancer model
    Kunal Sonavane
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    J Skin Cancer 2012:147863. 2012
    ..Prevention strategies offer the best hope of future health care costs in a disease that is increasing in incidence due to increased sun exposure...
  3. pmc Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models
    Oleksandr Ekshyyan
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    BMC Cancer 13:320. 2013
    ..The lymphatic suppressing properties of mTOR inhibitors are not yet well understood...
  4. doi Curcumin inhibits carcinogen and nicotine-induced Mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma
    Cheryl A Clark
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, Director of Head and Neck Surgical Oncology, Feist Weiller Cancer Center, Shreveport, LA 71130 3932, USA
    Cancer Prev Res (Phila) 3:1586-95. 2010
    ..These studies indicate that inhibiting the AKT/MTOR pathway with curcumin may be useful as an oral chemopreventive agent...
  5. ncbi Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
    Cherie Ann O Nathan
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Cancer Res 67:2160-8. 2007
    ..These results pave the way for a clinical trial using targeted molecular therapy with CCI-779 as a single agent for mTOR-activated residual cells...
  6. ncbi COX-2 expression in dysplasia of the head and neck: correlation with elF4E
    C A Nathan
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center and Veterans Administration Medical Center, 1501 Kings Highway, PO Box 33932, Shreveport, LA 71130, USA
    Cancer 92:1888-95. 2001
    ..Hence, the authors wanted to determine if COX-2 is expressed in dysplasia of the head and neck and to study the correlation of expression of COX-2 with eIF4E as a potential surrogate endpoint for determining response to COX-2 inhibitors...
  7. ncbi Botulinum toxin: helpful adjunct to early resolution of laryngeal granulomas
    Joanne Pham
    Department of Otolaryngology, Head and Neck Surgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130, USA
    J Laryngol Otol 118:781-5. 2004
    ..The addition of a single injection of botulinum toxin A to the standard treatment expeditiously eliminated persistent and recurrent laryngeal granulomas...
  8. pmc Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A
    Cary A Moody
    Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Virol 79:5499-506. 2005
    ..Intervention by this DNA tumor virus in cellular translational controls is likely to be an integral component of EBV tumorigenesis...
  9. ncbi Expression of the proto-oncogene eIF4E in inflammation of the oral cavity
    Binoy Chandy
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Science Center and Veterans Administration Shreveport, 71130, USA
    Otolaryngol Head Neck Surg 126:290-5. 2002
    ..However, it is not elevated in normal mucosa. In this study, we hypothesize that 4E is not significantly elevated in inflammation unlike its expression in premalignant lesions of the oral cavity...
  10. doi Skull base osteomyelitis and bisphosphonate use in multiple myeloma: report of two cases and literature review
    Jeffrey M Phillips
    Louisiana State University Health Sciences, Center Shreveport, LA, USA
    Laryngoscope 120:S175. 2010
    ..We described a new entity of skull base erosion resulting from osteonecrosis, presenting with malignant features in patients using bisphosphonates for multiple myeloma...
  11. ncbi Radiologic findings after successful chemoradiation for nasopharyngeal cancer with skull base erosion
    Federico Ampil
    Division of Therapeutic Radiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Ear Nose Throat J 89:38-41. 2010
    ..We report a case in which imaging studies documented the successful treatment of the patient's locally extensive nasopharyngeal carcinoma with this nonsurgical approach...
  12. doi All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis
    Zanobia Syed
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center and The Feist Weiller Cancer Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Cancer Prev Res (Phila) 2:903-11. 2009
    ..Stat3C mice, in which Stat3 activity is constitutive, it cannot suppress tumor formation...
  13. pmc Oral dysplasia and squamous cell carcinoma: correlation between increased expression of CD21, Epstein-Barr virus and CK19
    Ru Jiang
    Center for Molecular and Tumor Virology and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Oral Oncol 48:836-41. 2012
    ..As cells become dysplastic they are reported to express higher levels of CK19. We sought to evaluate whether CD21 and CK19 expression change as oral epithelial cells outside Waldeyer's ring become dysplastic...
  14. pmc Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer
    Vyomesh Patel
    Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 71:7103-12. 2011
    ..These findings may provide a rationale for the future clinical evaluation of mTOR inhibitors, including rapamycin and its analogues, as part of a molecular-targeted metastasis preventive strategy for the treatment of patients with HNSCC...
  15. ncbi A pilot study of quantitative aspiration in patients with symptoms of obstructive sleep apnea: comparison to a historic control group
    Michael Beal
    Department of Otolaryngology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Laryngoscope 114:965-8. 2004
    ..The purpose of this study was to determine whether patients with symptoms of OSA are predisposed to pharyngeal aspiration...
  16. ncbi Synovial metaplasia, a specialized form of repair
    Marjorie R Fowler
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Arch Pathol Lab Med 126:727-30. 2002
    ..Thus, synovial metaplasia might represent a specialized form of healing in cases that have this combination of physical features...
  17. ncbi Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients
    Cherie Ann O Nathan
    Department of Otolaryngology Head and Neck Surgery, The Feist Weiller Cancer Center, Louisiana State University Health Science Center and Veterans Administration Shreveport, 71130
    Laryngoscope 112:2129-40. 2002
    ....
  18. ncbi Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control
    J Michael Mathis
    Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Gene Med 8:1105-20. 2006
    ..These results indicate that translational targeting of suicide gene expression in tumor cells in vitro and in vivo is effective and may provide a platform for enhanced cancer gene therapy specificity...
  19. ncbi Squamous cell carcinoma of the oral cavity following breast cancer treatment
    Gang Ye
    South Med J 99:1150-1. 2006
  20. ncbi Return of vocal cord movement: an independent predictor of response to nonsurgical management of laryngeal cancers
    Kenny Iloabachie
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Science Center Shreveport, Shreveport, LA, USA
    Laryngoscope 117:1925-9. 2007
    ..To determine whether return of vocal cord function after treatment of T2b/T3 laryngeal carcinoma is an independent prognostic factor for locoregional recurrence...
  21. ncbi Aggressive fibromatosis of the parapharyngeal space: two cases and treatment recommendations
    Kenneth W Sanders
    Department of Otolaryngology Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Ear Nose Throat J 83:262, 264, 266 passim. 2004
    ..Nonsurgical treatment includes radiation and chemotherapy, both of which are usually reserved for recurrences. We describe two cases of aggressive fibromatosis of the parapharyngeal space, and we review the available treatment options...
  22. ncbi Predictive factors for posterior triangle metastasis in HNSCC
    Chad M McDuffie
    Department of Otolaryngology Head and Neck Surgery, Department of Biometry, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA
    Laryngoscope 115:2114-7. 2005
    ..In this study, we examine the incidence of nodal metastasis to all nodal levels involved with upper aerodigestive squamous cell carcinoma and attempt to determine when level V dissection is indicated...

Research Grants5

  1. Multi-institutional trial: molecular analysis of margins
    Cherie Ann Nathan; Fiscal Year: 2006
    ..If our hypotheses were proven, our long-term goal would be to conduct a clinical trial with CCI-779 as adjuvant therapy, for eIF4E-positive margin patients to possibly decrease recurrence rates. ..
  2. Multi-institutional trial: molecular analysis of margins
    Cherie Ann Nathan; Fiscal Year: 2007
    ..If our hypotheses were proven, our long-term goal would be to conduct a clinical trial with CCI-779 as adjuvant therapy, for eIF4E-positive margin patients to possibly decrease recurrence rates. ..
  3. Multi-institutional trial: molecular analysis of margins
    Cherie Ann Nathan; Fiscal Year: 2009
    ..If our hypotheses were proven, our long-term goal would be to conduct a clinical trial with CCI-779 as adjuvant therapy, for eIF4E-positive margin patients to possibly decrease recurrence rates. ..
  4. Multi-institutional trial: molecular analysis of margins
    Cherie Ann Nathan; Fiscal Year: 2009
    ..If our hypotheses were proven, our long-term goal would be to conduct a clinical trial with CCI-779 as adjuvant therapy, for eIF4E-positive margin patients to possibly decrease recurrence rates. ..