Patricia Molina

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Opioids and opiates: analgesia with cardiovascular, haemodynamic and immune implications in critical illness
    P E Molina
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Intern Med 259:138-54. 2006
  2. doi request reprint Alcohol does not modulate the augmented acetylcholine-induced vasodilatory response in hemorrhaged rodents
    Miguel F Molina
    Department of Physiology and Alcohol and Drug Abuse Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA
    Shock 32:601-7. 2009
  3. doi request reprint Alcohol abuse and the injured host: dysregulation of counterregulatory mechanisms review
    Patricia E Molina
    Department of Physiology and Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, USA
    Shock 39:240-9. 2013
  4. pmc Augmented central nitric oxide production inhibits vasopressin release during hemorrhage in acute alcohol-intoxicated rodents
    Annie M Whitaker
    Louisiana State University Health Science Center, Department of Physiology and Alcohol and Drug Abuse, Center of Excellence, New Orleans, Louisiana 70112 1393, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1529-39. 2011
  5. pmc Cannabinoid neuroimmune modulation of SIV disease
    Patricia E Molina
    Department of Physiology, LSUHSC at New Orleans, 1901 Perdido Street, Medical Education Building, New Orleans, LA 70112, USA
    J Neuroimmune Pharmacol 6:516-27. 2011
  6. pmc Cannabinoid administration attenuates the progression of simian immunodeficiency virus
    Patricia E Molina
    Department of Physiology, Alcohol Research Center, LSUHSC, New Orleans, Louisiana, USA
    AIDS Res Hum Retroviruses 27:585-92. 2011
  7. pmc Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting
    Patricia E Molina
    LSUHSC Department of Physiology and Alcohol Research Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 32:138-47. 2008
  8. ncbi request reprint Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infection
    Patricia E Molina
    Department of Physiology, LSUHSC, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 30:2065-78. 2006
  9. ncbi request reprint Consequences of alcohol-induced early dysregulation of responses to trauma/hemorrhage
    Patricia E Molina
    Department of Physiology and Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Alcohol 33:217-27. 2004
  10. ncbi request reprint Hemodynamic and immune consequences of opiate analgesia after trauma/hemorrhage
    Patricia E Molina
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Shock 21:526-34. 2004

Research Grants

  1. Cannabinoid effects on HIV/AIDS
    Patricia Molina; Fiscal Year: 2009
  2. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
  3. Cannabinoid effects on HIV/AIDS
    Patricia Molina; Fiscal Year: 2009
  4. Cannabinoid effects on HIV/AIDS
    Patricia Molina; Fiscal Year: 2007
  5. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
  6. Alcoholism and Disease: Immune /Pathological Mechanisms
    Patricia Molina; Fiscal Year: 2002
  7. Cannabinoid Epigenomic and miRNA mechanisms impact HIV/SIV disease progression
    Patricia E Molina; Fiscal Year: 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Opioids and opiates: analgesia with cardiovascular, haemodynamic and immune implications in critical illness
    P E Molina
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Intern Med 259:138-54. 2006
    ..Overall, the scientific basis to enhance clinical judgment and expectations when using opioid sedation and analgesia in the management of the injured, septic or postsurgical patient will be discussed...
  2. doi request reprint Alcohol does not modulate the augmented acetylcholine-induced vasodilatory response in hemorrhaged rodents
    Miguel F Molina
    Department of Physiology and Alcohol and Drug Abuse Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA
    Shock 32:601-7. 2009
    ..However, our results suggest a role for accentuated vasodilatory responses that may be central in progression to decompensatory shock...
  3. doi request reprint Alcohol abuse and the injured host: dysregulation of counterregulatory mechanisms review
    Patricia E Molina
    Department of Physiology and Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, USA
    Shock 39:240-9. 2013
    ..Moreover, it discusses the neuroendocrine mechanisms underlying alcohol-induced hemodynamic dysregulation and its relevance to host defense restoration of homeostasis after injury...
  4. pmc Augmented central nitric oxide production inhibits vasopressin release during hemorrhage in acute alcohol-intoxicated rodents
    Annie M Whitaker
    Louisiana State University Health Science Center, Department of Physiology and Alcohol and Drug Abuse, Center of Excellence, New Orleans, Louisiana 70112 1393, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1529-39. 2011
    ..Furthermore, these data demonstrate that the attenuated AVP response to hemorrhage is the result of augmented central NO inhibition...
  5. pmc Cannabinoid neuroimmune modulation of SIV disease
    Patricia E Molina
    Department of Physiology, LSUHSC at New Orleans, 1901 Perdido Street, Medical Education Building, New Orleans, LA 70112, USA
    J Neuroimmune Pharmacol 6:516-27. 2011
    ..Here, we review the evidence supporting an immunomodulatory role for cannabinoids and its impact on disease progression with focus on HIV/SIV infection...
  6. pmc Cannabinoid administration attenuates the progression of simian immunodeficiency virus
    Patricia E Molina
    Department of Physiology, Alcohol Research Center, LSUHSC, New Orleans, Louisiana, USA
    AIDS Res Hum Retroviruses 27:585-92. 2011
    ..We speculate that reduced levels of SIV, retention of body mass, and attenuation of inflammation are likely mechanisms for Δ(9)-THC-mediated modulation of disease progression that warrant further study...
  7. pmc Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting
    Patricia E Molina
    LSUHSC Department of Physiology and Alcohol Research Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 32:138-47. 2008
    ..We hypothesized that alcohol-induced loss in lean body mass is likely to exacerbate the AIDS wasting syndrome, particularly at the terminal stage of AIDS (SAIDS)...
  8. ncbi request reprint Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infection
    Patricia E Molina
    Department of Physiology, LSUHSC, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 30:2065-78. 2006
    ..HIV infection has become a more chronic disease during which alcohol-induced metabolic alterations may become more prevalent and pronounced...
  9. ncbi request reprint Consequences of alcohol-induced early dysregulation of responses to trauma/hemorrhage
    Patricia E Molina
    Department of Physiology and Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Alcohol 33:217-27. 2004
    ..Our results indicate that alcohol-induced alterations in early hemodynamic and neuroimmune responses to shock have an impact on susceptibility to an infectious challenge during the early recovery period...
  10. ncbi request reprint Hemodynamic and immune consequences of opiate analgesia after trauma/hemorrhage
    Patricia E Molina
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Shock 21:526-34. 2004
    ..These results indicate that morphine and ketamine analgesia compromise the hemodynamic and host defense responses after tx/hem, directly affecting mortality and morbidity during the recovery period...
  11. ncbi request reprint Endogenous opioid analgesia in hemorrhagic shock
    Patricia E Molina
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    J Trauma 54:S126-32. 2003
    ..However, it is unclear whether endogenous opioid activation is triggered by noxious stimuli and furthermore whether it produces analgesia...
  12. ncbi request reprint Mechanisms of alcohol-induced tissue injury
    Patricia E Molina
    Department of Physiology LSUHSC, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 27:563-75. 2003
  13. ncbi request reprint L-tryptophan attenuation of the dopaminergic and behavioral responses to cocaine
    P E Molina
    Department of Physiology, LSUMC, New Orleans, LA 70112, USA
    Life Sci 69:1897-906. 2001
    ..The results of these studies demonstrate the feasibility of acute dietary manipulation of neurochemical and behavioral responses to cocaine. The duration, adaptation and tolerance to these effects remain to be elucidated...
  14. ncbi request reprint Noradrenergic inhibition of TNF upregulation in hemorrhagic shock
    P E Molina
    Department of Physiology, LSUHSC, New Orleans, LA 70112 1393, USA
    Neuroimmunomodulation 9:125-33. 2001
    ..The central role of the neuroendocrine system in modulating these proinflammatory responses has been strongly suggested by recent studies...
  15. ncbi request reprint Molecular pathology and clinical aspects of alcohol-induced tissue injury
    Patricia E Molina
    Alcohol Research Center and Department of Physiology at Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 26:120-8. 2002
    ..Guidot; (6) Metabolic and inflammatory contribution of alcohol to trauma-induced tissue injury by Patricia E. Molina; (7) Growth factor and protein synthesis dysregulation: Role in alcoholic myopathy by Charles H. Lang...
  16. ncbi request reprint Contribution of excitatory amino acids to hypoglycemic counter-regulation
    P E Molina
    Department of Physiology, Louisana State University Health and Science Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Brain Res 899:201-8. 2001
    ..This mechanism appears to play an important role in the sustained elevation in hepatic glucose production during hypoglycemia...
  17. ncbi request reprint Stress-specific opioid modulation of haemodynamic counter-regulation
    Patricia E Molina
    Department of Physiology Louisiana State Univesity Health Sciences Center, New Orleans, Louisiana 70112, USA
    Clin Exp Pharmacol Physiol 29:248-53. 2002
    ..Our findings suggest stress-specific roles for opiate-sensitive haemodynamic counter-regulatory responses...
  18. ncbi request reprint Alcohol binge before trauma/hemorrhage impairs integrity of host defense mechanisms during recovery
    Patrick Greiffenstein
    Department of Physiology and Alcohol Research Center, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 31:704-15. 2007
    ..In the present study, we examined the impact of a 3-day alcohol binge on host responses during trauma/hemorrhage (T x Hem) and following overnight recovery...
  19. ncbi request reprint Altered hemodynamic counter-regulation to hemorrhage by acute moderate alcohol intoxication
    Keisa W Mathis
    Department of Physiology, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Shock 26:55-61. 2006
    ..These results indicate that moderate acute alcohol intoxication results in significant modulation of hemodynamic and neuroendocrine responses to hemorrhagic shock...
  20. pmc Central acetylcholinesterase inhibition improves hemodynamic counterregulation to severe blood loss in alcohol-intoxicated rats
    Keisa W Mathis
    Department of Physiology and Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Am J Physiol Regul Integr Comp Physiol 297:R437-45. 2009
    ..This study provides evidence for a central (and not peripheral) role of alcohol in impairing hemodynamic stability during hemorrhagic shock...
  21. pmc Alcohol exposure impairs myeloid dendritic cell function in rhesus macaques
    Robert W Siggins
    Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
    Alcohol Clin Exp Res 33:1524-31. 2009
    ..This study investigated the impact of chronic alcohol exposure on the alteration of hematopoietic precursor cell and DC populations in the bone marrow and peripheral blood of rhesus macaques...
  22. pmc Comparison of selamectin and imidacloprid plus permethrin in eliminating Leporacarus gibbus infestation in laboratory rabbits (Oryctolagus cuniculus)
    Leslie L Birke
    Department of Animal Care, LSU Health Sciences Center, New Orleans, Louisiana, USA
    J Am Assoc Lab Anim Sci 48:757-62. 2009
    ..We conclude that although both imidocloprid plus permethrin and selamectin were effective against L. gibbus, treatment with selamectin more rapidly eliminated the infestation...
  23. doi request reprint Alcohol-induced alterations on host defense after traumatic injury
    Patrick Greiffenstein
    Department of Physiology, and National Institute on Alcohol Abuse and Alcoholism, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Trauma 64:230-40. 2008
  24. doi request reprint Transient central cholinergic activation enhances sympathetic nervous system activity but does not improve hemorrhage-induced hypotension in alcohol-intoxicated rodents
    Keisa W Mathis
    LSUHSC Department of Physiology and Alcohol and Drug Abuse Center of Excellence, New Orleans, Louisiana 70112 1393, USA
    Shock 32:410-5. 2009
    ..These results indicate that ICV choline produced immediate neuroendocrine activation and elevation in MABP that was not sustained sufficiently to improve hemodynamic counter-regulation in alcohol-treated animals...
  25. ncbi request reprint Impact of alcohol intoxication on hemodynamic, metabolic, and cytokine responses to hemorrhagic shock
    Herbert Phelan
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    J Trauma 52:675-82. 2002
    ..We hypothesized that acute alcohol intoxication would aggravate the immediate outcome from hemorrhagic shock by impairing homeostatic counterregulation to blood loss...
  26. ncbi request reprint Neurobiology of the stress response: contribution of the sympathetic nervous system to the neuroimmune axis in traumatic injury
    Patricia E Molina
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Shock 24:3-10. 2005
    ....
  27. doi request reprint Systemic administration of a centrally acting acetylcholinesterase inhibitor improves outcome from hemorrhagic shock during acute alcohol intoxication
    Keisa W Mathis
    Louisiana State University Health Sciences Center, Department of Physiology and Alcohol and Drug Abuse Center of Excellence, New Orleans, LA 70112 1393, USA
    Shock 34:162-8. 2010
    ..Additional studies are warranted to determine the effect of central acetylcholinesterase inhibition on tissue injury and survival after severe blood loss, as well as its effects on long-term metabolic and inflammatory responses...
  28. ncbi request reprint Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 166:264-70. 2003
    ..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans...
  29. doi request reprint Alcohol--intoxicating roadblocks and bottlenecks in hepatic protein and lipid metabolism
    Patricia E Molina
    Am J Physiol Endocrinol Metab 295:E1-2. 2008
  30. ncbi request reprint Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex
    Douglas A Marsteller
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropsychopharmacology 27:163-70. 2002
    ..These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge...

Research Grants19

  1. Cannabinoid effects on HIV/AIDS
    Patricia Molina; Fiscal Year: 2009
    ....
  2. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ....
  3. Cannabinoid effects on HIV/AIDS
    Patricia Molina; Fiscal Year: 2009
    ....
  4. Cannabinoid effects on HIV/AIDS
    Patricia Molina; Fiscal Year: 2007
    ..abstract_text> ..
  5. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
    ..abstract_text> ..
  6. Alcoholism and Disease: Immune /Pathological Mechanisms
    Patricia Molina; Fiscal Year: 2002
    ..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
  7. Cannabinoid Epigenomic and miRNA mechanisms impact HIV/SIV disease progression
    Patricia E Molina; Fiscal Year: 2010
    ..The expected results will have a profound impact on the potential development of targeted therapeutic interventions to ameliorate HIV disease progression. ..