Walter Lukiw


Affiliation: Louisiana State University Health Sciences Center
Country: USA


  1. McLachlan D, Bergeron C, Alexandrov P, Walsh W, Pogue A, Percy M, et al. Aluminum in Neurological and Neurodegenerative Disease. Mol Neurobiol. 2019;56:1531-1538 pubmed publisher
  2. Cong L, Zhao Y, Pogue A, Lukiw W. Role of microRNA (miRNA) and Viroids in Lethal Diseases of Plants and Animals. Potential Contribution to Human Neurodegenerative Disorders. Biochemistry (Mosc). 2018;83:1018-1029 pubmed publisher
  3. Hill J, Lukiw W. MicroRNA (miRNA)-Mediated Pathogenetic Signaling in Alzheimer's Disease (AD). Neurochem Res. 2016;41:96-100 pubmed publisher
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    Lukiw W. Evidence supporting a biological role for aluminum in chromatin compaction and epigenetics. J Inorg Biochem. 2010;104:1010-2 pubmed
    ..The data further suggests that a specific consequence of 'aluminum biocompaction' may be particularly important in the condensation of A+T-rich chromatin domains, and in silencing the expression of specific kinds of genetic information. ..
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    Lukiw W, Ottlecz A, Lambrou G, Grueninger M, Finley J, Thompson H, et al. Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Invest Ophthalmol Vis Sci. 2003;44:4163-70 pubmed
    ..VEGF expression appears to be regulated through dual interdependent mechanisms involving HIF-1 directly and indirectly through NF-kappaB-mediated COX-2 expression and PGE(2) production. ..
  6. Pogue A, Dua P, Hill J, Lukiw W. Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice. J Inorg Biochem. 2015;152:206-9 pubmed publisher
  7. Zhao Y, Lukiw W. Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration. Mol Neurobiol. 2018;55:9100-9107 pubmed publisher
    ..For the first-time, these results indicate that specific GI tract microbiome-derived neurotoxins have a strong pathogenic role in eliciting alterations in NF-kB-miRNA-directed gene expression that drives the AD process. ..
  8. Alexandrov P, Kruck T, Lukiw W. Nanomolar aluminum induces expression of the inflammatory systemic biomarker C-reactive protein (CRP) in human brain microvessel endothelial cells (hBMECs). J Inorg Biochem. 2015;152:210-3 pubmed publisher
    ..The results suggest that aluminum-induced CRP may in part contribute to a pathophysiological state associated with a chronic systemic inflammation of the human vasculature. ..
  9. Clement C, Hill J, Dua P, Culicchia F, Lukiw W. Analysis of RNA from Alzheimer's Disease Post-mortem Brain Tissues. Mol Neurobiol. 2016;53:1322-8 pubmed publisher

More Information


  1. Lukiw W, Cui J, Marcheselli V, Bodker M, Botkjaer A, Gotlinger K, et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest. 2005;115:2774-83 pubmed
    ..These results indicate that NPD1 promotes brain cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity. ..
  2. Lukiw W, Alexandrov P. Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol Neurobiol. 2012;46:11-9 pubmed
  3. Lukiw W, Alexandrov P, Zhao Y, Hill J, Bhattacharjee S. Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA. Neuroreport. 2012;23:621-6 pubmed publisher
    ..These effects were neutralized using anti-miRNA strategies. Anti-miRNA-based therapeutics may provide a novel and efficacious treatment to stem the miRNA-mediated spreading of inflammatory signaling involved in Alzheimer's disease. ..
  4. Lukiw W, Zhao Y, Cui J. An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem. 2008;283:31315-22 pubmed publisher
  5. Pogue A, Lukiw W. Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer's disease (AD) and Age-Related Macular Degeneration (AMD). Cell Mol Neurobiol. 2018;38:1021-1031 pubmed publisher
    ..5% of the genome) involved in the synchronization of amyloid production and clearance, phagocytosis, innate-immune, pro-inflammatory, and neurotrophic signaling and/or synaptogenesis in diseased tissues. ..
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    Lukiw W, Mukherjee P, Cui J, Bazan N. A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006;31:259-63 pubmed
    ..Stress-induced upregulation of COX-2 gene expression in ARPE-19 and HN cells may play a mechanistic role in promoting proinflammatory and/or pro-oxidative pathology in these tissues. ..
  7. Lukiw W. NF-?B-regulated micro RNAs (miRNAs) in primary human brain cells. Exp Neurol. 2012;235:484-90 pubmed publisher
  8. Lukiw W, Dua P, Pogue A, Eicken C, Hill J. Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome. J Toxicol Environ Health A. 2011;74:1460-8 pubmed publisher
  9. Lukiw W, Cui J, Yuan L, Bhattacharjee P, Corkern M, Clement C, et al. Acyclovir or A?42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Neuroreport. 2010;21:922-7 pubmed publisher
  10. Zhao Y, Pogue A, Lukiw W. MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. Int J Mol Sci. 2015;16:30105-16 pubmed publisher
  11. Pogue A, Lukiw W. Aluminum, the genetic apparatus of the human CNS and Alzheimer's disease (AD). Morphologie. 2016;100:56-64 pubmed publisher
  12. Zhao Y, Alexandrov P, Jaber V, Lukiw W. Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7). Genes (Basel). 2016;7: pubmed
    ..Dysfunction of circRNA-miRNA-mRNA regulatory systems appears to represent another important layer of epigenetic control over pathogenic gene expression programs in the human CNS that are targeted by the sporadic AD process. ..
  13. Alexandrov P, Percy M, Lukiw W. Chromosome 21-Encoded microRNAs (mRNAs): Impact on Down's Syndrome and Trisomy-21 Linked Disease. Cell Mol Neurobiol. 2018;38:769-774 pubmed publisher
    ..1-chr21q21.3 region. ..
  14. Zhao Y, Cong L, Lukiw W. Plant and Animal microRNAs (miRNAs) and Their Potential for Inter-kingdom Communication. Cell Mol Neurobiol. 2018;38:133-140 pubmed publisher
  15. Lukiw W, Cui J, Li Y, Culicchia F. Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol. 2009;91:27-32 pubmed publisher