Research Topics
Genomes and GenesSpecies | Walter LukiwSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Publications
Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)Walter J Lukiw
Louisiana State University Health Sciences Center, LSU Neuroscience Center of Excellence, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
Expert Opin Emerg Drugs 13:255-71. 2008....- Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brainWalter J Lukiw
LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 7011 2272, USA
Mol Neurobiol 46:11-9. 2012.... 
Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNAWalter J Lukiw
Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 2272, USA
Neuroreport 23:621-6. 2012..These effects were neutralized using anti-miRNA strategies. Anti-miRNA-based therapeutics may provide a novel and efficacious treatment to stem the miRNA-mediated spreading of inflammatory signaling involved in Alzheimer's disease...
A macroepigenetic approach to identify factors responsible for the autism epidemic in the United StatesRenee Dufault
Food Ingredient and Health Research Institute, Ocean View, HI, USA
Clin Epigenetics 4:6. 2012....- NF-кB-regulated micro RNAs (miRNAs) in primary human brain cellsWalter J Lukiw
LSU Neuroscience Center, New Orleans, LA 70112, USA
Exp Neurol 235:484-90. 2012.... - Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in childrenRenee Dufault
United Tribes Technical College, Bismarck, ND, USA
Behav Brain Funct 5:44. 2009.... - Survival signalling in Alzheimer's diseaseW J Lukiw
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112 2272, USA or
Biochem Soc Trans 34:1277-82. 2006.... - Endogenous signaling complexity in neuropeptides- leucine- and methionine-enkephalinWalter J Lukiw
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans 70112 2272, USA
Cell Mol Neurobiol 26:1003-10. 2006..In this short communication I would like to expand on this observation concerning the "additive effects" contained within the amino acid sequence of the atypical neurotransmitter peptides leucine- and methonine-enkephalin... - Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer's diseaseWalter J Lukiw
Louisiana State University Health Sciences Center, LSU Neuroscience Center and Department of Ophthalmology, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
Expert Rev Neurother 6:683-93. 2006.... - A2E selectively induces cox-2 in ARPE-19 and human neural cellsWalter J Lukiw
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, 70112, USA
Curr Eye Res 31:259-63. 2006.... - A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer diseaseWalter J Lukiw
Louisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
J Clin Invest 115:2774-83. 2005..These results indicate that NPD1 promotes brain cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity... - Alzheimer's disease--a dysfunction in cholesterol and lipid metabolismWalter J Lukiw
LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8D, New Orleans, Louisiana, 70112 2272, USA
Cell Mol Neurobiol 25:475-83. 2005..2. In this short review, recent experimental evidence for these associations is further discussed below... - Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampusWalter J Lukiw
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, LA 70112 2272, USA
Neuroreport 18:297-300. 2007..These data are consistent with the idea that altered micro-RNA-mediated processing of messenger RNA populations may contribute to atypical mRNA abundance and neural dysfunction in Alzheimer's disease brain... - Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM)W J Lukiw
LSU Neuroscience Center of Excellence and LSU Department of Neurosurgery, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8A4, New Orleans, LA, 70112, USA
J Neurooncol 91:27-32. 2009.... - An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cellsWalter J Lukiw
Louisiana State University Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
J Biol Chem 283:31315-22. 2008.... - Docosahexaenoic acid and the aging brainWalter J Lukiw
Department of Ophthalmology, LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Nutr 138:2510-4. 2008.... - Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cellsWalter J Lukiw
LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
Neuroreport 21:922-7. 2010.... - Evidence supporting a biological role for aluminum in chromatin compaction and epigeneticsWalter J Lukiw
Department of Neuroscience, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Inorg Biochem 104:1010-2. 2010..The data further suggests that a specific consequence of 'aluminum biocompaction' may be particularly important in the condensation of A+T-rich chromatin domains, and in silencing the expression of specific kinds of genetic information... - Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndromeW J Lukiw
LSU Neuroscience Center and Departments of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA70112 2272, USA
J Toxicol Environ Health A 74:1460-8. 2011.... - Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary cultureWalter J Lukiw
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
J Inorg Biochem 99:1895-8. 2005..The effect of aluminum on specific stress-related gene expression patterns in human brain cells clearly warrant further investigation... - Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosisWalter J Lukiw
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
Mol Neurobiol 42:10-6. 2010.... - Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxiaWalter J Lukiw
Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 44:4163-70. 2003..Effects of the carboxamide CGP43182 were tested on COX-2 and VEGF activation and prostaglandin (PG)E(2) release... - Gene expression profiling in fetal, aged, and Alzheimer hippocampus: a continuum of stress-related signalingWalter J Lukiw
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
Neurochem Res 29:1287-97. 2004..These findings support the hypothesis that there is a continuum of stress-related gene expression as the brain ages and an advancement of inflammatory, apoptotic, and angiogenic gene signaling that correlates with the transition to AD... - Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cellsAileen I Pogue
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Inorg Biochem 103:1591-5. 2009.... - Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cellsNicolas G Bazan
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
J Biol Chem 277:30359-67. 2002.... - Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expressionJian Guo Cui
Neuroscience Center and Department of Ophthalmology, Louisiana State University, 2020 Gravier Street, New Orleans, LA 70112, USA
Neuroreport 15:2025-8. 2004..These data suggest potential roles for PS1 in the cellular response to hypoxia and glial-specific gene expression... - Effect of immunosuppression on gene expression in the HSV-1 latently infected mouse trigeminal ganglionShiro Higaki
Department of Ophthalmology, LSU Eye Center, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 43:1862-9. 2002..Changes in expression of genes in the prostaglandin pathway, a transcription factor, and an enzyme in the cell cycle are considered especially important in HSV-1 reactivation by immunosuppression and are reviewed... - Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signalingVittorio Colangelo
Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-2272, USA
J Neurosci Res 70:462-73. 2002.... - Senile plaques in Alzheimer's diseased brains: possible association of beta-amyloid with herpes simplex virus type 1 (HSV-1) L-particlesE M Kammerman
LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112 2234, USA
Med Hypotheses 66:294-9. 2006..These hypotheses are supported by reports of biomolecular changes and pathophysiologies which have been simultaneously observed in both AD- and HSV-infected brains... - Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cellsJian Guo Cui
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Neurochem Res 29:1731-7. 2004.... - The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or genderJames M Hill
Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
J Virol 82:8230-4. 2008..This is the first study that provides statistical analysis that documents that the prevalence of HSV-1 DNA in the human TG is not a function of either gender or age... - Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expressionVictor L Marcheselli
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Biol Chem 278:43807-17. 2003..These results challenge the view that docosahexaenoate only participates in brain damage and demonstrate that this fatty acid is also the endogenous precursor to a neuroprotective signaling response to ischemia-reperfusion... - Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cellsWalter J Lukiw
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Inorg Biochem 101:1265-9. 2007.... - Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cellsYuhai Zhao
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
Neuroreport 18:1187-91. 2007..The results suggest that SORL1 deficits may not only promote the pathogenic processing of betaAPP but may also contribute to Abeta42-mediated inflammatory signaling in stressed human brain cells... - Natural secretory products of human neural and microvessel endothelial cells: Implications in pathogenic "spreading" and Alzheimer's diseaseYuhai Zhao
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Mol Neurobiol 34:181-92. 2006..These data support the hypothesis that paracrine effects of stressed constituent cells of the neurovascular unit may contribute to "spreading effects" characteristic of progressive neurodegenerative disorders... - Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer's diseaseJian Guo Cui
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
Neuroreport 18:115-9. 2007..This upregulation of pathological gene expression could be, in part, responsible for the visual disturbances associated with end-stages of the Alzheimer process... - Prostaglandins and other lipid mediators in Alzheimer's diseaseNicolas G Bazan
Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA
Prostaglandins Other Lipid Mediat 68:197-210. 2002..This review addresses some current ideas concerning how brain PLA2 and brain PGs are early and key players in acute neural trauma and in brain-cell damage associated with chronic neurodegenerative diseases such as AD... - Angiogenic signaling in Alzheimer's diseaseAileen I Pogue
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans LA 70112-2272, USA
Neuroreport 15:1507-10. 2004..Angiogenesis, perhaps as the result of dysfunctional cerebral vasculature, may be both a consequence and a contributory factor to the etiopathology of the Alzheimer's disease process... - HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signalingJames M Hill
LSU Neuroscience Center and Departments of Ophthalmology, Pharmacology, Microbiology, Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Neuroreport 20:1500-5. 2009..These data suggest a role for HSV-1-induced miRNA-146a in the evasion of HSV-1 from the complement system, and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change... - Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondriaM Soledad Cortina
Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Exp Eye Res 81:742-50. 2005..Thus, DNA-repair enzymes such as polymerase gamma and 8-oxoguanine-DNA-glycosylase may provide novel pharmacologic targets to promote DNA repair and rescue photoreceptors in retinal degenerative diseases... - DNA damage and repair in light-induced photoreceptor degenerationWilliam C Gordon
Louisiana State University Health Sciences Center, Department of Ophthalmology and Neuroscience Center, New Orleans 70112, USA
Invest Ophthalmol Vis Sci 43:3511-21. 2002..These events may provide useful drug targets to promote photoreceptor survival in various forms of retinal degeneration... - Isolation of high spectral quality RNA using run-on gene transcription; application to gene expression profiling of human brainJian-Guo Cui
LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-2272, USA
Cell Mol Neurobiol 25:789-94. 2005.... - Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampusWalter J Lukiw
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, LA 70112, USA
Biochem Biophys Res Commun 338:77-81. 2005.... - Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survivalRajee Antony
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Biol Chem 285:18301-8. 2010..Thus, NPD1 modulates the activation of this Bcl-2 family protein by dephosphorylating in a PP2A-dependent manner, suggesting a coordinated, NPD1-mediated regulation of cell survival in response to oxidative stress... - Gene expression profiling in the HSV-1 latently infected mouse trigeminal ganglia following hyperthermic stressShiro Higaki
Department of Ophthalmology (LSU Eye Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, USA
Curr Eye Res 26:231-8. 2003..CONCLUSION: Altered gene expression at 6 and 24 hours after heat stress was different from previously reported changes in gene expression 1 hour after hyperthermia in HSV-1 latently infected mice... - Upregulation of beta-amyloid precursor protein expression in glioblastoma multiformeFrank Culicchia
LSU Neuroscience Center and Department of Neurosurgery, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
Neuroreport 19:981-5. 2008..These studies suggest that glioma and glioblastoma exhibit robust upregulation of proinflammatory and neurodegenerative genetic markers that may contribute to the pathobiology, phenotype, and proliferation of glial cell growth... - Characterization of a cyclooxygenase-2-765G-->C promoter polymorphism in human neural cellsJian Guo Cui
Neuroscience Center, Louisiana State University School of Medicine, New Orleans, Louisiana, USA
Neuroreport 16:575-9. 2005.... - Light-induced photoreceptor damage triggers DNA repair: differential fate of rods and conesM Soledad Cortina
Neuroscience Center of Excellence, Department of Ophthalmology, Louisiana State University Health Sci. Center, New Orleans, LA 70112, USA
Adv Exp Med Biol 533:229-40. 2003..In addition, maintenance or enhancement of existing in-house repair mechanisms could provide additional approaches for the rescue of neurons with stress-induced nuclear damage... - Hypoxia signaling to genes: significance in Alzheimer's diseaseNicolas G Bazan
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans 70112-2272, USA
Mol Neurobiol 26:283-98. 2002.... - DNA repair in photoreceptor survivalM Soledad Cortina
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Mol Neurobiol 28:111-22. 2003.... - Apolipoprotein E epsilon4 offers protection against age-related macular degenerationDuncan A Friedman
Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA 70112 2234, United States
Med Hypotheses 68:1047-55. 2007..The general behavior of the epsilon4 isoform of ApoE is different than the predominant epsilon3 isoform... - Metal sulfate-mediated induction of pathogenic genes and repression by phenyl butyl nitrone and Feralex-GTheodore P A Kruck
Neurogenetics Laboratory, Surrey Place Centre and Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Neuroreport 19:245-9. 2008..These findings support the idea that specific antioxidants and metal ion chelators when used together can effectively and synergistically quench ROS-mediated induction of pathogenic gene expression... - Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cellsAnja Boetkjaer
The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Neurosci Lett 426:59-63. 2007..These, or analogous classes of compounds, may be useful in the design of more effective combinatorial pharmacotherapeutic strategies in the treatment of complex neuro-inflammatory disorders... - High-field 19.6T 27Al solid-state MAS NMR of in vitro aluminated brain tissuePamela L Bryant
Department of Physical Sciences, Howard Payne University, Brownwood, TX 76801 2794, USA
J Magn Reson 170:257-62. 2004..Thus, brain tissue is susceptible to a broad range of coordination by aluminum. Furthermore, the moderate (27)Al C(Q) values (all less than 10 MHz) suggest future NMR studies may be performed at 9.4T and a spin rate of 20 kHz... - Hypoxia-sensitive domain in the human cytosolic phospholipase A2 promoterPiotr N Alexandrov
Russian Academy of Medical Sciences, Moscow, Russia
Neuroreport 17:303-7. 2006.... - Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cellsPeter N Alexandrov
Russian Academy of Medical Sciences, Moscow 113152, Russia
J Alzheimers Dis 8:117-27; discussion 209-15. 2005..These data indicate that physiologically relevant amounts of iron and aluminum are capable of inducing Fenton chemistry-triggered gene expression programs that may support downstream pathogenic responses and brain cell dysfunction... - Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cellsMerete Boedker
Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Neurosci Lett 380:176-80. 2005.... - Expression of AgRP, NPY, POMC and CART in human fetal and adult hippocampusFulu Bai
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Neuropeptides 39:439-43. 2005..CART, POMC and NPY are, therefore, differentially expressed in the human fetal and adult hippocampus and could play a role in its development or could be regulated by various stimuli involved in the development of this brain structure... - 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cellsPiotr Alexandrov
Russian Academy of Medical Sciences, Moscow 113152, Russia
Neuroreport 16:909-13. 2005..These data indicate that cholesterol oxides induce atypical gene expression in neural cells that may contribute to the etiology or pathogenesis of inflammatory brain disease... - Molecular shuttle chelation: the use of ascorbate, desferrioxamine and Feralex-G in combination to remove nuclear bound aluminumTheo P Kruck
Surrey Place Centre and Department of Physiology, University of Toronto, Ontario, Canada
Cell Mol Neurobiol 24:443-59. 2004..8. The proposed mechanism, called molecular shuttle chelation may provide a useful pharmacotherapy in the potential treatment of Al(III) overload disease...
Research Grants
- Gene Expression in Alzheimer's DiseaseWalter Lukiw; Fiscal Year: 2006..abstract_text> ..