Walter Lukiw

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. request reprint
    Lukiw W, Mukherjee P, Cui J, Bazan N. A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006;31:259-63 pubmed
    ..Stress-induced upregulation of COX-2 gene expression in ARPE-19 and HN cells may play a mechanistic role in promoting proinflammatory and/or pro-oxidative pathology in these tissues. ..
  2. Lukiw W, Zhao Y, Cui J. An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem. 2008;283:31315-22 pubmed publisher
    ....
  3. Lukiw W, Alexandrov P. Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol Neurobiol. 2012;46:11-9 pubmed
    ....
  4. Lukiw W, Alexandrov P, Zhao Y, Hill J, Bhattacharjee S. Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA. Neuroreport. 2012;23:621-6 pubmed publisher
    ..These effects were neutralized using anti-miRNA strategies. Anti-miRNA-based therapeutics may provide a novel and efficacious treatment to stem the miRNA-mediated spreading of inflammatory signaling involved in Alzheimer's disease. ..
  5. Pogue A, Lukiw W. Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer's disease (AD) and Age-Related Macular Degeneration (AMD). Cell Mol Neurobiol. 2018;: pubmed publisher
    ..5% of the genome) involved in the synchronization of amyloid production and clearance, phagocytosis, innate-immune, pro-inflammatory, and neurotrophic signaling and/or synaptogenesis in diseased tissues. ..
  6. Lukiw W, Cui J, Li Y, Culicchia F. Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol. 2009;91:27-32 pubmed publisher
    ....
  7. Lukiw W, Cui J, Yuan L, Bhattacharjee P, Corkern M, Clement C, et al. Acyclovir or A?42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Neuroreport. 2010;21:922-7 pubmed publisher
    ....
  8. Lukiw W, Dua P, Pogue A, Eicken C, Hill J. Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome. J Toxicol Environ Health A. 2011;74:1460-8 pubmed publisher
    ....
  9. Lukiw W. NF-?B-regulated micro RNAs (miRNAs) in primary human brain cells. Exp Neurol. 2012;235:484-90 pubmed publisher
    ....
  10. Zhao Y, Pogue A, Lukiw W. MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. Int J Mol Sci. 2015;16:30105-16 pubmed publisher
    ....

Locale

Detail Information

Publications14

  1. request reprint
    Lukiw W, Mukherjee P, Cui J, Bazan N. A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006;31:259-63 pubmed
    ..Stress-induced upregulation of COX-2 gene expression in ARPE-19 and HN cells may play a mechanistic role in promoting proinflammatory and/or pro-oxidative pathology in these tissues. ..
  2. Lukiw W, Zhao Y, Cui J. An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem. 2008;283:31315-22 pubmed publisher
    ....
  3. Lukiw W, Alexandrov P. Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol Neurobiol. 2012;46:11-9 pubmed
    ....
  4. Lukiw W, Alexandrov P, Zhao Y, Hill J, Bhattacharjee S. Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA. Neuroreport. 2012;23:621-6 pubmed publisher
    ..These effects were neutralized using anti-miRNA strategies. Anti-miRNA-based therapeutics may provide a novel and efficacious treatment to stem the miRNA-mediated spreading of inflammatory signaling involved in Alzheimer's disease. ..
  5. Pogue A, Lukiw W. Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer's disease (AD) and Age-Related Macular Degeneration (AMD). Cell Mol Neurobiol. 2018;: pubmed publisher
    ..5% of the genome) involved in the synchronization of amyloid production and clearance, phagocytosis, innate-immune, pro-inflammatory, and neurotrophic signaling and/or synaptogenesis in diseased tissues. ..
  6. Lukiw W, Cui J, Li Y, Culicchia F. Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol. 2009;91:27-32 pubmed publisher
    ....
  7. Lukiw W, Cui J, Yuan L, Bhattacharjee P, Corkern M, Clement C, et al. Acyclovir or A?42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Neuroreport. 2010;21:922-7 pubmed publisher
    ....
  8. Lukiw W, Dua P, Pogue A, Eicken C, Hill J. Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome. J Toxicol Environ Health A. 2011;74:1460-8 pubmed publisher
    ....
  9. Lukiw W. NF-?B-regulated micro RNAs (miRNAs) in primary human brain cells. Exp Neurol. 2012;235:484-90 pubmed publisher
    ....
  10. Zhao Y, Pogue A, Lukiw W. MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. Int J Mol Sci. 2015;16:30105-16 pubmed publisher
    ....
  11. Pogue A, Lukiw W. Aluminum, the genetic apparatus of the human CNS and Alzheimer's disease (AD). Morphologie. 2016;100:56-64 pubmed publisher
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  12. Zhao Y, Alexandrov P, Jaber V, Lukiw W. Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7). Genes (Basel). 2016;7: pubmed
    ..Dysfunction of circRNA-miRNA-mRNA regulatory systems appears to represent another important layer of epigenetic control over pathogenic gene expression programs in the human CNS that are targeted by the sporadic AD process. ..
  13. Alexandrov P, Percy M, Lukiw W. Chromosome 21-Encoded microRNAs (mRNAs): Impact on Down's Syndrome and Trisomy-21 Linked Disease. Cell Mol Neurobiol. 2018;38:769-774 pubmed publisher
    ..1-chr21q21.3 region. ..
  14. Zhao Y, Cong L, Lukiw W. Plant and Animal microRNAs (miRNAs) and Their Potential for Inter-kingdom Communication. Cell Mol Neurobiol. 2018;38:133-140 pubmed publisher
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