Walter Lukiw

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)
    Walter J Lukiw
    Louisiana State University Health Sciences Center, LSU Neuroscience Center of Excellence, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
    Expert Opin Emerg Drugs 13:255-71. 2008
  2. pmc Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease
    Peter N Alexandrov
    Russian Academy of Medical Sciences, Moscow, Russia
    Neuroreport 22:623-7. 2011
  3. pmc microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)
    Peter N Alexandrov
    Russian Academy of Medical Sciences Moscow 113152, Russia
    Int J Biochem Mol Biol 3:365-73. 2012
  4. ncbi request reprint Regulatory region variability in the human presenilin-2 (PSEN2) gene: potential contribution to the gene activity and risk for AD
    N Riazanskaia
    Laboratory of Molecular Brain Genetics, Research Center of Mental Health, Russian Academy of Medical Sciences of Russia, Moscow 113152, Russia
    Mol Psychiatry 7:891-8. 2002
  5. pmc Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line
    Peter N Alexandrov
    Russian Academy of Medical Sciences, Moscow 113152, Russia
    J Inorg Biochem 128:267-9. 2013
  6. pmc HSV-1 latent rabbits shed viral DNA into their saliva
    James M Hill
    Department of Ophthalmology LSUHSC School of Medicine, 533 Bolivar Street, Room 3D13, New Orleans, LA 70112, USA
    Virol J 9:221. 2012
  7. pmc Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain
    Walter J Lukiw
    LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 7011 2272, USA
    Mol Neurobiol 46:11-9. 2012
  8. doi request reprint Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA
    Walter J Lukiw
    Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 2272, USA
    Neuroreport 23:621-6. 2012
  9. pmc A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States
    Renee Dufault
    Food Ingredient and Health Research Institute, Ocean View, HI, USA
    Clin Epigenetics 4:6. 2012
  10. pmc NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells
    Walter J Lukiw
    LSU Neuroscience Center, New Orleans, LA 70112, USA
    Exp Neurol 235:484-90. 2012

Research Grants

  1. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)
    Walter J Lukiw
    Louisiana State University Health Sciences Center, LSU Neuroscience Center of Excellence, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
    Expert Opin Emerg Drugs 13:255-71. 2008
    ....
  2. pmc Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease
    Peter N Alexandrov
    Russian Academy of Medical Sciences, Moscow, Russia
    Neuroreport 22:623-7. 2011
    ..The superior colliculus and retina obtained from late-stage Alzheimer's disease revealed upregulated amyloidogenic and inflammatory signaling along the anteroposterior axis of the retinal-primary visual cortex pathway...
  3. pmc microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)
    Peter N Alexandrov
    Russian Academy of Medical Sciences Moscow 113152, Russia
    Int J Biochem Mol Biol 3:365-73. 2012
    ....
  4. ncbi request reprint Regulatory region variability in the human presenilin-2 (PSEN2) gene: potential contribution to the gene activity and risk for AD
    N Riazanskaia
    Laboratory of Molecular Brain Genetics, Research Center of Mental Health, Russian Academy of Medical Sciences of Russia, Moscow 113152, Russia
    Mol Psychiatry 7:891-8. 2002
    ....
  5. pmc Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line
    Peter N Alexandrov
    Russian Academy of Medical Sciences, Moscow 113152, Russia
    J Inorg Biochem 128:267-9. 2013
    ....
  6. pmc HSV-1 latent rabbits shed viral DNA into their saliva
    James M Hill
    Department of Ophthalmology LSUHSC School of Medicine, 533 Bolivar Street, Room 3D13, New Orleans, LA 70112, USA
    Virol J 9:221. 2012
    ..This study used real-time PCR to quantify HSV-1 DNA in the saliva and tears of rabbits latent with HSV-1 McKrae...
  7. pmc Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain
    Walter J Lukiw
    LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 7011 2272, USA
    Mol Neurobiol 46:11-9. 2012
    ....
  8. doi request reprint Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA
    Walter J Lukiw
    Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 2272, USA
    Neuroreport 23:621-6. 2012
    ..These effects were neutralized using anti-miRNA strategies. Anti-miRNA-based therapeutics may provide a novel and efficacious treatment to stem the miRNA-mediated spreading of inflammatory signaling involved in Alzheimer's disease...
  9. pmc A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States
    Renee Dufault
    Food Ingredient and Health Research Institute, Ocean View, HI, USA
    Clin Epigenetics 4:6. 2012
    ....
  10. pmc NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells
    Walter J Lukiw
    LSU Neuroscience Center, New Orleans, LA 70112, USA
    Exp Neurol 235:484-90. 2012
    ....
  11. pmc Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children
    Renee Dufault
    United Tribes Technical College, Bismarck, ND, USA
    Behav Brain Funct 5:44. 2009
    ....
  12. ncbi request reprint Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    Walter J Lukiw
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, LA 70112 2272, USA
    Neuroreport 18:297-300. 2007
    ..These data are consistent with the idea that altered micro-RNA-mediated processing of messenger RNA populations may contribute to atypical mRNA abundance and neural dysfunction in Alzheimer's disease brain...
  13. ncbi request reprint Survival signalling in Alzheimer's disease
    W J Lukiw
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112 2272, USA or
    Biochem Soc Trans 34:1277-82. 2006
    ....
  14. ncbi request reprint Endogenous signaling complexity in neuropeptides- leucine- and methionine-enkephalin
    Walter J Lukiw
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans 70112 2272, USA
    Cell Mol Neurobiol 26:1003-10. 2006
    ..3. In this short communication I would like to expand on this observation concerning the "additive effects" contained within the amino acid sequence of the atypical neurotransmitter peptides leucine- and methonine-enkephalin...
  15. ncbi request reprint Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer's disease
    Walter J Lukiw
    Louisiana State University Health Sciences Center, LSU Neuroscience Center and Department of Ophthalmology, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
    Expert Rev Neurother 6:683-93. 2006
    ....
  16. ncbi request reprint A2E selectively induces cox-2 in ARPE-19 and human neural cells
    Walter J Lukiw
    LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, 70112, USA
    Curr Eye Res 31:259-63. 2006
    ....
  17. pmc Docosahexaenoic acid and the aging brain
    Walter J Lukiw
    Department of Ophthalmology, LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Nutr 138:2510-4. 2008
    ....
  18. doi request reprint Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM)
    W J Lukiw
    LSU Neuroscience Center of Excellence and LSU Department of Neurosurgery, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8A4, New Orleans, LA, 70112, USA
    J Neurooncol 91:27-32. 2009
    ....
  19. pmc An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
    Walter J Lukiw
    Louisiana State University Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
    J Biol Chem 283:31315-22. 2008
    ....
  20. doi request reprint Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosis
    Walter J Lukiw
    LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
    Mol Neurobiol 42:10-6. 2010
    ....
  21. pmc Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells
    Walter J Lukiw
    LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
    Neuroreport 21:922-7. 2010
    ....
  22. ncbi request reprint Evidence supporting a biological role for aluminum in chromatin compaction and epigenetics
    Walter J Lukiw
    Department of Neuroscience, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Inorg Biochem 104:1010-2. 2010
    ..The data further suggests that a specific consequence of 'aluminum biocompaction' may be particularly important in the condensation of A+T-rich chromatin domains, and in silencing the expression of specific kinds of genetic information...
  23. pmc Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome
    W J Lukiw
    LSU Neuroscience Center and Departments of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA70112 2272, USA
    J Toxicol Environ Health A 74:1460-8. 2011
    ....
  24. pmc A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
    Walter J Lukiw
    Louisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Clin Invest 115:2774-83. 2005
    ..These results indicate that NPD1 promotes brain cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity...
  25. ncbi request reprint Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism
    Walter J Lukiw
    LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8D, New Orleans, Louisiana, 70112 2272, USA
    Cell Mol Neurobiol 25:475-83. 2005
    ..2. In this short review, recent experimental evidence for these associations is further discussed below...
  26. ncbi request reprint Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia
    Walter J Lukiw
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 44:4163-70. 2003
    ..Effects of the carboxamide CGP43182 were tested on COX-2 and VEGF activation and prostaglandin (PG)E(2) release...
  27. ncbi request reprint Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture
    Walter J Lukiw
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112 2272, USA
    J Inorg Biochem 99:1895-8. 2005
    ..The effect of aluminum on specific stress-related gene expression patterns in human brain cells clearly warrant further investigation...
  28. ncbi request reprint Gene expression profiling in fetal, aged, and Alzheimer hippocampus: a continuum of stress-related signaling
    Walter J Lukiw
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
    Neurochem Res 29:1287-97. 2004
    ..These findings support the hypothesis that there is a continuum of stress-related gene expression as the brain ages and an advancement of inflammatory, apoptotic, and angiogenic gene signaling that correlates with the transition to AD...
  29. doi request reprint Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells
    Aileen I Pogue
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Inorg Biochem 103:1591-5. 2009
    ....
  30. ncbi request reprint Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells
    Nicolas G Bazan
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
    J Biol Chem 277:30359-67. 2002
    ....
  31. ncbi request reprint Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression
    Jian Guo Cui
    Neuroscience Center and Department of Ophthalmology, Louisiana State University, 2020 Gravier Street, New Orleans, LA 70112, USA
    Neuroreport 15:2025-8. 2004
    ..These data suggest potential roles for PS1 in the cellular response to hypoxia and glial-specific gene expression...
  32. ncbi request reprint Effect of immunosuppression on gene expression in the HSV-1 latently infected mouse trigeminal ganglion
    Shiro Higaki
    Department of Ophthalmology, LSU Eye Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 43:1862-9. 2002
    ..To determine alterations in expression of genes in herpes simples virus (HSV)-1 latently infected mouse trigeminal ganglia (TGs), after treatment with cyclophosphamide and dexamethasone...
  33. ncbi request reprint Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling
    Vittorio Colangelo
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
    J Neurosci Res 70:462-73. 2002
    ....
  34. ncbi request reprint Senile plaques in Alzheimer's diseased brains: possible association of beta-amyloid with herpes simplex virus type 1 (HSV-1) L-particles
    E M Kammerman
    LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112 2234, USA
    Med Hypotheses 66:294-9. 2006
    ..These hypotheses are supported by reports of biomolecular changes and pathophysiologies which have been simultaneously observed in both AD- and HSV-infected brains...
  35. ncbi request reprint Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells
    Jian Guo Cui
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Neurochem Res 29:1731-7. 2004
    ....
  36. ncbi request reprint Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression
    Victor L Marcheselli
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 278:43807-17. 2003
    ..These results challenge the view that docosahexaenoate only participates in brain damage and demonstrate that this fatty acid is also the endogenous precursor to a neuroprotective signaling response to ischemia-reperfusion...
  37. pmc The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Virol 82:8230-4. 2008
    ..This is the first study that provides statistical analysis that documents that the prevalence of HSV-1 DNA in the human TG is not a function of either gender or age...
  38. ncbi request reprint Prostaglandins and other lipid mediators in Alzheimer's disease
    Nicolas G Bazan
    Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Prostaglandins Other Lipid Mediat 68:197-210. 2002
    ..This review addresses some current ideas concerning how brain PLA2 and brain PGs are early and key players in acute neural trauma and in brain-cell damage associated with chronic neurodegenerative diseases such as AD...
  39. pmc Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells
    Walter J Lukiw
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Inorg Biochem 101:1265-9. 2007
    ....
  40. ncbi request reprint Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells
    Yuhai Zhao
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    Neuroreport 18:1187-91. 2007
    ..The results suggest that SORL1 deficits may not only promote the pathogenic processing of betaAPP but may also contribute to Abeta42-mediated inflammatory signaling in stressed human brain cells...
  41. ncbi request reprint Natural secretory products of human neural and microvessel endothelial cells: Implications in pathogenic "spreading" and Alzheimer's disease
    Yuhai Zhao
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Mol Neurobiol 34:181-92. 2006
    ..These data support the hypothesis that paracrine effects of stressed constituent cells of the neurovascular unit may contribute to "spreading effects" characteristic of progressive neurodegenerative disorders...
  42. ncbi request reprint Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer's disease
    Jian Guo Cui
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
    Neuroreport 18:115-9. 2007
    ..This upregulation of pathological gene expression could be, in part, responsible for the visual disturbances associated with end-stages of the Alzheimer process...
  43. ncbi request reprint Angiogenic signaling in Alzheimer's disease
    Aileen I Pogue
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans LA 70112 2272, USA
    Neuroreport 15:1507-10. 2004
    ..Angiogenesis, perhaps as the result of dysfunctional cerebral vasculature, may be both a consequence and a contributory factor to the etiopathology of the Alzheimer's disease process...
  44. ncbi request reprint Isolation of high spectral quality RNA using run-on gene transcription; application to gene expression profiling of human brain
    Jian Guo Cui
    LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
    Cell Mol Neurobiol 25:789-94. 2005
    ....
  45. ncbi request reprint Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus
    Walter J Lukiw
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 338:77-81. 2005
    ....
  46. ncbi request reprint Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria
    M Soledad Cortina
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Exp Eye Res 81:742-50. 2005
    ..Thus, DNA-repair enzymes such as polymerase gamma and 8-oxoguanine-DNA-glycosylase may provide novel pharmacologic targets to promote DNA repair and rescue photoreceptors in retinal degenerative diseases...
  47. ncbi request reprint DNA damage and repair in light-induced photoreceptor degeneration
    William C Gordon
    Louisiana State University Health Sciences Center, Department of Ophthalmology and Neuroscience Center, New Orleans 70112, USA
    Invest Ophthalmol Vis Sci 43:3511-21. 2002
    ..However, cells lost 10 days after light treatment are fewer than the TUNEL-labeled cells observed earlier. Therefore, this study was undertaken to monitor DNA fragmentation and cell death to explain the discrepancy...
  48. pmc Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival
    Rajee Antony
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 285:18301-8. 2010
    ..Thus, NPD1 modulates the activation of this Bcl-2 family protein by dephosphorylating in a PP2A-dependent manner, suggesting a coordinated, NPD1-mediated regulation of cell survival in response to oxidative stress...
  49. pmc HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling
    James M Hill
    LSU Neuroscience Center and Departments of Ophthalmology, Pharmacology, Microbiology, Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Neuroreport 20:1500-5. 2009
    ..These data suggest a role for HSV-1-induced miRNA-146a in the evasion of HSV-1 from the complement system, and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change...
  50. ncbi request reprint Gene expression profiling in the HSV-1 latently infected mouse trigeminal ganglia following hyperthermic stress
    Shiro Higaki
    Department of Ophthalmology LSU Eye Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, USA
    Curr Eye Res 26:231-8. 2003
    ..To assess gene expression in herpes simplex virus type 1 (HSV-1) latent mouse trigeminal ganglia (TG) at 6 and 24 hours after hyperthermic stress...
  51. doi request reprint Upregulation of beta-amyloid precursor protein expression in glioblastoma multiforme
    Frank Culicchia
    LSU Neuroscience Center and Department of Neurosurgery, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
    Neuroreport 19:981-5. 2008
    ..These studies suggest that glioma and glioblastoma exhibit robust upregulation of proinflammatory and neurodegenerative genetic markers that may contribute to the pathobiology, phenotype, and proliferation of glial cell growth...
  52. ncbi request reprint Light-induced photoreceptor damage triggers DNA repair: differential fate of rods and cones
    M Soledad Cortina
    Neuroscience Center of Excellence, Department of Ophthalmology, Louisiana State University Health Sci Center, New Orleans, LA 70112, USA
    Adv Exp Med Biol 533:229-40. 2003
    ..In addition, maintenance or enhancement of existing in-house repair mechanisms could provide additional approaches for the rescue of neurons with stress-induced nuclear damage...
  53. ncbi request reprint Characterization of a cyclooxygenase-2-765G-->C promoter polymorphism in human neural cells
    Jian Guo Cui
    Neuroscience Center, Louisiana State University School of Medicine, New Orleans, Louisiana, USA
    Neuroreport 16:575-9. 2005
    ....
  54. pmc Apolipoprotein E epsilon4 offers protection against age-related macular degeneration
    Duncan A Friedman
    Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA 70112 2234, United States
    Med Hypotheses 68:1047-55. 2007
    ..The general behavior of the epsilon4 isoform of ApoE is different than the predominant epsilon3 isoform...
  55. ncbi request reprint DNA repair in photoreceptor survival
    M Soledad Cortina
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Mol Neurobiol 28:111-22. 2003
    ....
  56. ncbi request reprint Hypoxia signaling to genes: significance in Alzheimer's disease
    Nicolas G Bazan
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans 70112 2272, USA
    Mol Neurobiol 26:283-98. 2002
    ....
  57. doi request reprint Metal sulfate-mediated induction of pathogenic genes and repression by phenyl butyl nitrone and Feralex-G
    Theodore P A Kruck
    Neurogenetics Laboratory, Surrey Place Centre and Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 19:245-9. 2008
    ..These findings support the idea that specific antioxidants and metal ion chelators when used together can effectively and synergistically quench ROS-mediated induction of pathogenic gene expression...
  58. pmc Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells
    Anja Boetkjaer
    The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Neurosci Lett 426:59-63. 2007
    ..These, or analogous classes of compounds, may be useful in the design of more effective combinatorial pharmacotherapeutic strategies in the treatment of complex neuro-inflammatory disorders...
  59. ncbi request reprint Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells
    Peter N Alexandrov
    Russian Academy of Medical Sciences, Moscow 113152, Russia
    J Alzheimers Dis 8:117-27; discussion 209-15. 2005
    ..These data indicate that physiologically relevant amounts of iron and aluminum are capable of inducing Fenton chemistry-triggered gene expression programs that may support downstream pathogenic responses and brain cell dysfunction...
  60. ncbi request reprint Hypoxia-sensitive domain in the human cytosolic phospholipase A2 promoter
    Piotr N Alexandrov
    Russian Academy of Medical Sciences, Moscow, Russia
    Neuroreport 17:303-7. 2006
    ....
  61. ncbi request reprint 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells
    Piotr Alexandrov
    Russian Academy of Medical Sciences, Moscow 113152, Russia
    Neuroreport 16:909-13. 2005
    ..These data indicate that cholesterol oxides induce atypical gene expression in neural cells that may contribute to the etiology or pathogenesis of inflammatory brain disease...
  62. ncbi request reprint Expression of AgRP, NPY, POMC and CART in human fetal and adult hippocampus
    Fulu Bai
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Neuropeptides 39:439-43. 2005
    ..CART, POMC and NPY are, therefore, differentially expressed in the human fetal and adult hippocampus and could play a role in its development or could be regulated by various stimuli involved in the development of this brain structure...
  63. ncbi request reprint High-field 19.6T 27Al solid-state MAS NMR of in vitro aluminated brain tissue
    Pamela L Bryant
    Department of Physical Sciences, Howard Payne University, Brownwood, TX 76801 2794, USA
    J Magn Reson 170:257-62. 2004
    ..Thus, brain tissue is susceptible to a broad range of coordination by aluminum. Furthermore, the moderate (27)Al C(Q) values (all less than 10 MHz) suggest future NMR studies may be performed at 9.4T and a spin rate of 20 kHz...
  64. ncbi request reprint Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells
    Merete Boedker
    Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Neurosci Lett 380:176-80. 2005
    ....
  65. ncbi request reprint Molecular shuttle chelation: the use of ascorbate, desferrioxamine and Feralex-G in combination to remove nuclear bound aluminum
    Theo P Kruck
    Surrey Place Centre and Department of Physiology, University of Toronto, Ontario, Canada
    Cell Mol Neurobiol 24:443-59. 2004
    ..8. The proposed mechanism, called molecular shuttle chelation may provide a useful pharmacotherapy in the potential treatment of Al(III) overload disease...

Research Grants6

  1. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..