Shulin Li

Summary

Affiliation: Louisiana State University
Country: USA

Publications

  1. ncbi request reprint Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA
    Shulin Li
    Department of CBS, SVM, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Mol Ther 11:112-9. 2005
  2. ncbi request reprint Administration route- and immune cell activation-dependent tumor eradication by IL12 electrotransfer
    Shulin Li
    Department of Comparative Biomedical Sciences, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Mol Ther 12:942-9. 2005
  3. pmc Preferential expression of hPGFS in primary SCCHN and tumour cell lines derived from respiratory and digestive organs
    S Li
    Department of Comparative Biomedical Sciences, SVM, Louisiana State University, Skip Bertman Drive, LA 70803, USA
    Br J Cancer 90:1093-9. 2004
  4. ncbi request reprint Candidate genes associated with tumor regression mediated by intratumoral IL-12 electroporation gene therapy
    Shulin Li
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mol Ther 9:347-54. 2004
  5. ncbi request reprint Electroporation gene therapy: new developments in vivo and in vitro
    Shulin Li
    Department of Comparative Biomedical Sciences Louisiana State University Skip Bertman Drive Baton Rouge, LA 70803, USA
    Curr Gene Ther 4:309-16. 2004
  6. doi request reprint Systemic IL-12 gene therapy for treating malignancy via intramuscular electroporation
    Shiguo Zhu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 423:327-37. 2008
  7. doi request reprint Treatment of SCCVII tumors with systemic chemotherapy and Interleukin-12 gene therapy combination
    Marina Torrero
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 423:339-49. 2008
  8. doi request reprint Administering plasmid DNA encoding tumor vessel-anchored IFN-alpha for localizing gene product within or into tumors
    Ryan Craig
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Mol Ther 16:901-6. 2008
  9. ncbi request reprint The mechanism of exogenous B7.1-enhanced IL-12-mediated complete regression of tumors by a single electroporation delivery
    Jianguo Liu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Int J Cancer 119:2113-8. 2006
  10. ncbi request reprint Stat1 deficiency in the host enhances interleukin-12-mediated tumor regression
    Marina N Torrero
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Cancer Res 66:4461-7. 2006

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA
    Shulin Li
    Department of CBS, SVM, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Mol Ther 11:112-9. 2005
    ..Our finding indicates that the 4T1 tumor cell line, which is resistant to the DNA transfection-mediated induction of IFN-regulated genes, can be used to determine the real therapeutic gene function...
  2. ncbi request reprint Administration route- and immune cell activation-dependent tumor eradication by IL12 electrotransfer
    Shulin Li
    Department of Comparative Biomedical Sciences, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Mol Ther 12:942-9. 2005
    ....
  3. pmc Preferential expression of hPGFS in primary SCCHN and tumour cell lines derived from respiratory and digestive organs
    S Li
    Department of Comparative Biomedical Sciences, SVM, Louisiana State University, Skip Bertman Drive, LA 70803, USA
    Br J Cancer 90:1093-9. 2004
    ..These data link hPGFS expression to tumours located in the respiratory and digestive organs...
  4. ncbi request reprint Candidate genes associated with tumor regression mediated by intratumoral IL-12 electroporation gene therapy
    Shulin Li
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mol Ther 9:347-54. 2004
    ..These data suggest that these three genes may positively correlate with the antitumor efficacy of intratumoral Il-12 electroporation gene therapy...
  5. ncbi request reprint Electroporation gene therapy: new developments in vivo and in vitro
    Shulin Li
    Department of Comparative Biomedical Sciences Louisiana State University Skip Bertman Drive Baton Rouge, LA 70803, USA
    Curr Gene Ther 4:309-16. 2004
    ..Resolving these issues will shed new light on this field...
  6. doi request reprint Systemic IL-12 gene therapy for treating malignancy via intramuscular electroporation
    Shiguo Zhu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 423:327-37. 2008
    ..This approach is not effective in treating tumors larger than 3-5 mm in diameter...
  7. doi request reprint Treatment of SCCVII tumors with systemic chemotherapy and Interleukin-12 gene therapy combination
    Marina Torrero
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 423:339-49. 2008
    ..This combination therapy has great potential to be translated to a clinical setting for treating malignancies...
  8. doi request reprint Administering plasmid DNA encoding tumor vessel-anchored IFN-alpha for localizing gene product within or into tumors
    Ryan Craig
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Mol Ther 16:901-6. 2008
    ..This gene product-based tumor-targeted gene therapy approach could complement any other tumor-targeted gene delivery method for improving tumor-targeting efficiency...
  9. ncbi request reprint The mechanism of exogenous B7.1-enhanced IL-12-mediated complete regression of tumors by a single electroporation delivery
    Jianguo Liu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Int J Cancer 119:2113-8. 2006
    ..1 expression. We therefore propose a 2-signal stimulation model to explain the synergistic effect of the coadministration of IL-12 and B7.1 on the regression of the tumors...
  10. ncbi request reprint Stat1 deficiency in the host enhances interleukin-12-mediated tumor regression
    Marina N Torrero
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Cancer Res 66:4461-7. 2006
    ..Together, the data show that inhibition of Stat1 expression in the host enhances tumor-local IL-12 gene therapy for regressing tumors. This conclusion provides a new concept for designing an effective treatment strategy...
  11. ncbi request reprint Doxorubicin directs the accumulation of interleukin-12 induced IFN gamma into tumors for enhancing STAT1 dependent antitumor effect
    Shiguo Zhu
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Clin Cancer Res 13:4252-60. 2007
    ..To examine the mechanism by which doxorubicin plus interleukin-12 (IL-12) gene transfer induces enhanced therapeutic efficacy against tumors...
  12. doi request reprint Intratumoral bleomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs
    Jeffry Cutrera
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 423:319-25. 2008
    ..The papillary tumor was completely eradicated in less than 2 weeks, and the bone tumor was not visible 23 weeks after the administration...
  13. pmc Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance
    Denada Dibra
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Cancer Res 69:5505-13. 2009
    ..Our results reveal an IL-27-independent function of WSX1: sensitizing NK cell-mediated antitumor surveillance via a NKG2D-dependent mechanism...
  14. doi request reprint Delivery of DNA into tumors
    Shulin Li
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 423:311-8. 2008
    ..More efforts in defining the optimal injection volume should be made to further advance intratumoral electroporation gene therapy for treating tumors...
  15. pmc Electroporation advances in large animals
    Scott D Reed
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Curr Gene Ther 9:316-26. 2009
    ....
  16. ncbi request reprint Regression of high-grade malignancy in mice by bleomycin and interleukin-12 electrochemogenetherapy
    Marina N Torrero
    Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Clin Cancer Res 12:257-63. 2006
    ..In this study, we explore the coadministration of bleomycin and interleukin-12 (IL-12) followed by electroporation for treating primary and metastatic tumors...
  17. ncbi request reprint Function and molecular mechanism of tumor-targeted peptides for delivering therapeutic genes and chemical drugs
    Ryan Craig
    Department of Comparative Biomedical Sciences, Louisiana State University, Skip Bertman Drive, Baton Rouge, 70803, USA
    Mini Rev Med Chem 6:757-64. 2006
    ..This review will discuss the discovery, function, application, and mechanism by which the short peptides (5-9) work for tumor-targeted gene or drug delivery...
  18. doi request reprint Bleomycin/interleukin-12 electrochemogenetherapy for treating naturally occurring spontaneous neoplasms in dogs
    S D Reed
    Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA
    Cancer Gene Ther 17:571-8. 2010
    ..ECGT seems to be a safe and resulted in complete responses in SCC and acanthomatous ameloblastoma...
  19. ncbi request reprint Applications of muscle electroporation gene therapy
    Shulin Li
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Curr Gene Ther 2:101-5. 2002
    ..In this review, I discuss the applications of intramuscular electroporation gene therapy to treat malignancies, renal disease, and anemia, and to prevent drug toxicity to sensory nerves...
  20. ncbi request reprint Regression of tumor growth and induction of long-term antitumor memory by interleukin 12 electro-gene therapy
    Shulin Li
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    J Natl Cancer Inst 94:762-8. 2002
    ..To overcome this obstacle, we used electroporation to deliver the IL-12 gene intratumorally in a murine squamous cell carcinoma (SCC) model, SCCVII...
  21. ncbi request reprint Atrial natriuretic peptide receptor upregulation in the rat inner ear
    John L Dornhoffer
    Department of Otolaryngology Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Ann Otol Rhinol Laryngol 111:1040-4. 2002
    ..Gene expression was significantly higher 24 hours after injection. These findings demonstrate that ANP receptors in the inner ear can be upregulated after injection of ANPs...
  22. ncbi request reprint Electroporation gene therapy. Preface
    Shulin Li
    Methods Mol Biol 423:v-vii. 2008
  23. ncbi request reprint Alternatively spliced TCR mRNA induced by disruption of reading frame
    Jun Wang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Box 180, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Science 297:108-10. 2002
    ..The finding that translation signals regulate the levels of alternatively spliced mRNAs generated in the nucleus may alter the current view of how gene expression is controlled in eukaryotic cells...
  24. ncbi request reprint A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation
    Jun Wang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 277:18489-93. 2002
    ....