Guohong Li

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
    Guohong Li
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, United States
    Atherosclerosis 208:358-65. 2010
  2. ncbi request reprint CD147: a novel modulator of inflammatory and immune disorders
    X Zhu
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Curr Med Chem 21:2138-45. 2014
  3. pmc CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury
    Zifang Song
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, LSU Health Science Center in Shreveport, Shreveport, Louisiana, United States of America
    PLoS ONE 6:e23239. 2011
  4. pmc Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst
    Rong Jin
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Science Center in Shreveport, Shreveport, Louisiana, United States of America
    PLoS ONE 8:e64631. 2013
  5. pmc Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Stroke 42:2033-44. 2011
  6. pmc Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions
    Zifang Song
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Arterioscler Thromb Vasc Biol 32:50-64. 2012
  7. pmc Role of inflammation and its mediators in acute ischemic stroke
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Science Center, Shreveport, LA, USA
    J Cardiovasc Transl Res 6:834-51. 2013
  8. pmc Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke
    Rong Jin
    Department of Neurosurgery, Vascular Biology and Stroke Research Laboratory, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Biochem Biophys Res Commun 399:458-64. 2010
  9. pmc MicroRNA expression and function in cardiac ischemic injury
    Shiyong Yu
    Department of Neurosurgery, LSU Health Science Center, Shreveport, LA 71130, USA
    J Cardiovasc Transl Res 3:241-5. 2010
  10. pmc Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice
    Rong Jin
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Stroke 44:1135-43. 2013

Research Grants

Collaborators

Detail Information

Publications14

  1. pmc Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
    Guohong Li
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, United States
    Atherosclerosis 208:358-65. 2010
    ..These results reveal a mechanism whereby PN mediates vascular SMC migration through an interaction with alphaV-integrins (mainly alphanubeta3) and subsequent activation of FAK pathway...
  2. ncbi request reprint CD147: a novel modulator of inflammatory and immune disorders
    X Zhu
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Curr Med Chem 21:2138-45. 2014
    ..Here we review the current understanding of CD147 expression and functions in inflammatory and immune responses and potential implications for treatment of inflammatory disorders. ..
  3. pmc CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury
    Zifang Song
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, LSU Health Science Center in Shreveport, Shreveport, Louisiana, United States of America
    PLoS ONE 6:e23239. 2011
    ..Our findings firmly established the role for CD40 in neointima formation in 2 distinct injury models...
  4. pmc Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst
    Rong Jin
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Science Center in Shreveport, Shreveport, Louisiana, United States of America
    PLoS ONE 8:e64631. 2013
    ..These findings may contribute to a better understanding of the underlying mechanisms by which sCD40L/CD40 pathway contributes to inflammation and vascular diseases...
  5. pmc Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Stroke 42:2033-44. 2011
    ..This study was conducted to investigate the role of the PI3Kγ in the blood-brain barrier dysfunction and brain damage induced by focal cerebral ischemia/reperfusion...
  6. pmc Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions
    Zifang Song
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Arterioscler Thromb Vasc Biol 32:50-64. 2012
    ..Because CD40 and TRAF6 are expressed not only in leukocytes but also in vascular cells, we examined the role of CD40 contributed by vascular wall cells in neointimal formation after carotid ligation in an atherogenic environment...
  7. pmc Role of inflammation and its mediators in acute ischemic stroke
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Science Center, Shreveport, LA, USA
    J Cardiovasc Transl Res 6:834-51. 2013
    ..A better understanding of the dynamic balance between pro- and anti-inflammatory responses and identifying the discrepancies between pre-clinical studies and clinical trials may serve as a basis for designing effective therapies. ..
  8. pmc Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke
    Rong Jin
    Department of Neurosurgery, Vascular Biology and Stroke Research Laboratory, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Biochem Biophys Res Commun 399:458-64. 2010
    ..The results suggest that PI3Kgamma is an ischemia-responsive gene in brain microglia and contributes to ischemia-induced microglial activation and expansion...
  9. pmc MicroRNA expression and function in cardiac ischemic injury
    Shiyong Yu
    Department of Neurosurgery, LSU Health Science Center, Shreveport, LA 71130, USA
    J Cardiovasc Transl Res 3:241-5. 2010
    ....
  10. pmc Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice
    Rong Jin
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Stroke 44:1135-43. 2013
    ..We investigated the effects of simvastatin treatment on stroke-induced splenic atrophy and lung susceptibility to bacterial infection in acute experimental stroke in mice...
  11. pmc Role of specific microRNAs in regulation of vascular smooth muscle cell differentiation and the response to injury
    Zifang Song
    Department of Neurosurgery, LSU Health Science Center, Shreveport, LA, USA
    J Cardiovasc Transl Res 3:246-50. 2010
    ..Here, we review recent advance regarding functions of specific miRNAs in vasculature and discuss possible mechanisms by which miRNAs modulate proliferation and differentiation of VSMCs...
  12. pmc Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator
    Rong Jin
    Department of Neurosurgery, LSU Health Science Center, Shreveport, LA 71130, USA
    Neurobiol Dis 38:376-85. 2010
    ..We discuss how MMPs and tPA contribute to BBB disruption during ischemic stroke and highlight recent findings of molecular signaling pathways involved in neurotoxicity of tPA therapy...
  13. pmc Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
    Rong Jin
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    J Leukoc Biol 87:779-89. 2010
    ..We discuss how these cells contribute to ischemic brain injury and highlight certain recent findings and currently unanswered questions about inflammatory cells in the pathophysiology of ischemic stroke...
  14. pmc Role of specific microRNAs for endothelial function and angiogenesis
    Fusheng Wu
    Department of Neurosurgery and Physiology, LSU Health Science Center, Shreveport, LA 71130, USA
    Biochem Biophys Res Commun 386:549-53. 2009
    ..In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis...

Research Grants3

  1. Mechanisms of CD40/CD40L in vascular injury and repair
    Guohong Li; Fiscal Year: 2009
    ..The results obtained will provide novel insights into the mechanisms of restenosis and promise to provide valuable information for the development of novel therapeutic strategies to prevent and treat vascular disease in humans. ..
  2. Mechanisms of CD40/CD40L in vascular injury and repair
    Guohong Li; Fiscal Year: 2010
    ..The results obtained will provide novel insights into the mechanisms of restenosis and promise to provide valuable information for the development of novel therapeutic strategies to prevent and treat vascular disease in humans. ..