Herbert Kaufman

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Can we prevent recurrences of herpes infections without antiviral drugs? The Weisenfeld Lecture
    Herbert E Kaufman
    LSU Eye Center, Health Sciences Center, Louisiana State University School of Medicine, 2020 Gravier Street, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 43:1325-9. 2002
  2. pmc Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center in New Orleans, New Orleans, LA, USA
    J Ocul Pharmacol Ther 24:34-42. 2008
  3. ncbi request reprint Human fibrin tissue adhesive for sutureless lamellar keratoplasty and scleral patch adhesion: a pilot study
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Ophthalmology 110:2168-72. 2003
  4. pmc HSV-1 DNA in tears and saliva of normal adults
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:241-7. 2005
  5. pmc A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva
    Manish Kumar
    Department of Ophthalmology, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Invest Ophthalmol Vis Sci 50:5601-8. 2009
  6. pmc Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits
    Manish Kumar
    Department of Ophthalmology, Neuroscience Center of Excellence, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 51:4703-6. 2010
  7. pmc Heat-induced reactivation of HSV-1 in latent mice: upregulation in the TG of CD83 and other immune response genes and their LAT-ICP0 locus
    Christian Clement
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 50:2855-61. 2009
  8. doi request reprint Ocular HSV-1 latency, reactivation and recurrent disease
    Hassanain S Toma
    Louisiana State University Health Sciences Center, New Orleans, LA 70112 2234, USA
    Semin Ophthalmol 23:249-73. 2008
  9. doi request reprint Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model
    Partha S Bhattacharjee
    Departments of Ophthalmology, School of Public Health, LouisianaState University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 49:4263-8. 2008
  10. pmc The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Virol 82:8230-4. 2008

Research Grants

  1. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2000
  2. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2001
  3. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2002
  4. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2003
  5. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2004
  6. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2004
  7. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2005
  8. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2006
  9. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2007
  10. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 1980

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Can we prevent recurrences of herpes infections without antiviral drugs? The Weisenfeld Lecture
    Herbert E Kaufman
    LSU Eye Center, Health Sciences Center, Louisiana State University School of Medicine, 2020 Gravier Street, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 43:1325-9. 2002
  2. pmc Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center in New Orleans, New Orleans, LA, USA
    J Ocul Pharmacol Ther 24:34-42. 2008
    ..The aim of this study was to evaluate the effect of BAY 57-1293, a helicase-primase inhibitor, on herpes simplex virus type 1 (HSV-1) reactivation in mice and its efficacy on established disease in rabbits...
  3. ncbi request reprint Human fibrin tissue adhesive for sutureless lamellar keratoplasty and scleral patch adhesion: a pilot study
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Ophthalmology 110:2168-72. 2003
    ..To determine whether a fibrin adhesive can facilitate the performance of sutureless lamellar keratoplasty and attachment of amnion to bare sclera...
  4. pmc HSV-1 DNA in tears and saliva of normal adults
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:241-7. 2005
    ..To assess the frequency of shedding of herpes simplex virus type 1 (HSV-1) DNA in tears and saliva of asymptomatic individuals...
  5. pmc A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva
    Manish Kumar
    Department of Ophthalmology, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Invest Ophthalmol Vis Sci 50:5601-8. 2009
    ..Ocular and oral swabs were collected twice daily for 30 days. DNA was extracted from all swabs and HSV-1 DNA copy numbers were determined. Statistical analysis was performed to compare the DNA copy numbers of the three groups...
  6. pmc Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits
    Manish Kumar
    Department of Ophthalmology, Neuroscience Center of Excellence, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 51:4703-6. 2010
    ..To assess the effect of high doses of valacyclovir (VCV) on HSV-1 DNA shedding into tears of latently infected rabbits...
  7. pmc Heat-induced reactivation of HSV-1 in latent mice: upregulation in the TG of CD83 and other immune response genes and their LAT-ICP0 locus
    Christian Clement
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 50:2855-61. 2009
    ..To determine changes in host gene expression in HSV-1 latent trigeminal ganglia (TG) after hyperthermic stress...
  8. doi request reprint Ocular HSV-1 latency, reactivation and recurrent disease
    Hassanain S Toma
    Louisiana State University Health Sciences Center, New Orleans, LA 70112 2234, USA
    Semin Ophthalmol 23:249-73. 2008
    ..This review will highlight basic HSV-1 virology, and will compare the animal models of latency, reactivation, and recurrent ocular disease to the current clinical data...
  9. doi request reprint Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model
    Partha S Bhattacharjee
    Departments of Ophthalmology, School of Public Health, LouisianaState University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 49:4263-8. 2008
    ....
  10. pmc The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Virol 82:8230-4. 2008
    ..This is the first study that provides statistical analysis that documents that the prevalence of HSV-1 DNA in the human TG is not a function of either gender or age...
  11. doi request reprint Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis
    Kirk R Wilhelmus
    Sid W Richardson Ocular Microbiology Laboratory, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin St, Houston, TX 77030, USA
    Arch Ophthalmol 127:161-6. 2009
    ..To validate photographic bioimaging for evaluating the severity of herpes simplex virus keratitis...
  12. ncbi request reprint Inhibition of cyclooxygenase 2 synthesis suppresses Herpes simplex virus type 1 reactivation
    Bryan M Gebhardt
    Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 2234, USA
    J Ocul Pharmacol Ther 21:114-20. 2005
    ..It may be possible to use COX-2 inhibitors to prevent viral reactivation in high-risk patients by drug prophylaxis...
  13. doi request reprint Confocal microscopy of corneal wound healing after deep lamellar keratoplasty in rabbits
    Almamoun Abdelkader
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, USA
    Arch Ophthalmol 128:75-80. 2010
    ..To compare wound healing and morphologic characteristics of the host-donor interface in rabbit corneas after maximum-depth and near-Descemet membrane anterior lamellar keratoplasty...
  14. ncbi request reprint Effect of acyclovir on thermal stress-induced herpesvirus reactivation
    Bryan M Gebhardt
    Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112 2234, USA
    Curr Eye Res 29:137-44. 2004
    ..The purpose of the current study was to determine the effect of acyclovir on the appearance of infectious virus in the peripheral nervous system and in an end organ, the eye...
  15. ncbi request reprint Acetylsalicylic acid reduces viral shedding induced by thermal stress
    Bryan M Gebhardt
    Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112 2234, USA
    Curr Eye Res 29:119-25. 2004
    ..To investigate the effect of acetylsalicylic acid on ocular shedding of herpes simplex virus type 1 (HSV-1)...
  16. ncbi request reprint Ocular reactivation phenotype of HSV-1 strain F(MP)E, a corticosteroid-sensitive strain
    Mary Marquart
    Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA, USA
    Curr Eye Res 26:205-9. 2003
    ..Elucidate the ocular reactivation of HSV-1 strain F(MP)E...
  17. ncbi request reprint A new surgical technique for anterior segment ectasia: tectonic lamellar sclerokeratoplasty
    Salomon Esquenazi
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Ophthalmic Surg Lasers Imaging 37:434-6. 2006
    ..The suturing of a corneoscleral graft over a severely ectatic cornea may be an acceptable technique for providing tectonic tissue support and stabilizing eyes with severe anterior segment ectasia...
  18. ncbi request reprint Human fibrin tissue glue for corneal lamellar adhesion in rabbits: a preliminary study
    Hosam A Ibrahim-Elzembely
    LSU Eye Center, Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Cornea 22:735-9. 2003
    ..To evaluate the use of a human fibrin tissue adhesive in the adherence of corneal lamellar flaps in rabbit eyes...
  19. ncbi request reprint Healing process at the flap edge in its influence in the development of corneal ectasia after LASIK
    Almamoun Abdelkader
    Department of Ophthalmology, LSU Eye and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Curr Eye Res 31:903-8. 2006
    ..This study compares, in a rabbit model, the stability of previously sutured and unsutured microkeratome flaps...
  20. ncbi request reprint The effect of roscovitine on herpetic keratitis
    Avni Murat Avunduk
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Exp Eye Res 76:679-83. 2003
    ..Considering high cost of roscovitine and the poor efficacy in these experiments, we feel that roscovitine is not feasible antiviral agent for today...
  21. ncbi request reprint Comparison of efficacy of topical and oral fluconazole treatment in experimental Aspergillus keratitis
    Avni Murat Avunduk
    Department of Ophthalmology, LSU Medical School, New Orleans, LA, USA
    Curr Eye Res 26:113-7. 2003
    ..To investigate the therapeutic role of topical and oral fluconazole treatment using a rabbit model of Aspergillus fumigatus keratitis...
  22. ncbi request reprint The use of the Fugo Blade in corneal surgery: a preliminary animal study
    Vasileios Peponis
    Eye Center, Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Cornea 25:206-8. 2006
    ..To evaluate the performance of the Fugo Blade in cutting corneal tissue in animals, both in vitro and in vivo...
  23. ncbi request reprint Clinical corneal confocal microscopy
    Auguste G Y Chiou
    Louisiana State University Eye Center, New Orleans, Louisiana, USA
    Surv Ophthalmol 51:482-500. 2006
    ..Confocal microscopy proves to be a powerful diagnostic tool and is especially of value in certain corneal diseases by allowing straightforward and non-invasive recognition of the pathologic conditions...
  24. ncbi request reprint Corneal healing after uncomplicated LASIK and its relationship to refractive changes: a six-month prospective confocal study
    Avni Murat Avunduk
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Invest Ophthalmol Vis Sci 45:1334-9. 2004
    ..To investigate corneal healing and the factor(s) possibly responsible for refractive changes after laser in situ keratomileusis (LASIK)...
  25. ncbi request reprint Does everyone have herpes?
    Herbert E Kaufman
    Cornea 23:111-2. 2004
  26. ncbi request reprint Preliminary in vitro evaluation of 2-octyl cyanoacrylate (Dermabond) to seal corneal incisions
    Gloria Y S Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, People s Republic of China
    Cornea 24:998-9. 2005
    ..To compare the efficacy of Dermabond with conventional nylon sutures for sealing linear corneal incisions...
  27. ncbi request reprint How has confocal microscopy helped us in refractive surgery?
    Stephen C Kaufman
    Henry Ford Health System Ophthalmology, Troy, Michigan 48083, USA
    Curr Opin Ophthalmol 17:380-8. 2006
    ..To summarize the known uses of in-vivo confocal microscopy in refractive surgery, highlighting the current developments in the field...
  28. ncbi request reprint Strengthening the cornea
    Herbert E Kaufman
    Cornea 23:432. 2004

Research Grants32

  1. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2000
    ..An effective drug that would reduce ocular herpetic recurrences could prevent the severe corneal damage and morbidity caused by repeated episodes of disease. ..
  2. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2001
    ..abstract_text> ..
  3. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2002
    ..abstract_text> ..
  4. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2003
    ..abstract_text> ..
  5. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2004
    ..abstract_text> ..
  6. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2004
    ..abstract_text> ..
  7. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2005
    ..If they are additive to or synergistic with acyclovir in suppressing viral DNA production, tests on human infection could almost certainly follow. ..
  8. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2006
    ..If they are additive to or synergistic with acyclovir in suppressing viral DNA production, tests on human infection could almost certainly follow. ..
  9. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2007
    ..If they are additive to or synergistic with acyclovir in suppressing viral DNA production, tests on human infection could almost certainly follow. ..
  10. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 1980
    ..A new model for varicella-zoster in the Patas monkey will be explored. If it is truly a model for the human zoster iritis, studies will be done on the treatment of the iritis, as well as on the mechanisms of the infection. ..
  11. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 1999
    ..An effective drug that would reduce ocular herpetic recurrences could prevent the severe corneal damage and morbidity caused by repeated episodes of disease. ..
  12. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 1990
    ..The ultimate goal of these studies is to improve our understanding of ocular herpevirus infection and thereby develop and test more specific treatments to cure this devastating and blinding eye disease...
  13. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 1991
    ..The ultimate goal of these studies is to improve our understanding of ocular herpevirus infection and thereby develop and test more specific treatments to cure this devastating and blinding eye disease...
  14. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 1992
    ..The ultimate goal of these studies is to improve our understanding of ocular herpevirus infection and thereby develop and test more specific treatments to cure this devastating and blinding eye disease...
  15. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 1993
    ..The ultimate goal of these studies is to improve our understanding of ocular herpevirus infection and thereby develop and test more specific treatments to cure this devastating and blinding eye disease...