S M Jazwinski

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Cloning and characterization of LAG1, a longevity-assurance gene in yeast
    N P D'mello
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    J Biol Chem 269:15451-9. 1994
  2. ncbi request reprint Molecular mechanisms of yeast longevity
    S M Jazwinski
    Dept of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA 70112, USA
    Trends Microbiol 7:247-52. 1999
  3. ncbi request reprint Metabolic control and gene dysregulation in yeast aging
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Ann N Y Acad Sci 908:21-30. 2000
  4. ncbi request reprint Genetics of longevity
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 33:773-83. 1998
  5. ncbi request reprint The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Neurobiol Aging 20:471-8. 1999
  6. ncbi request reprint Epigenetic stratification: the role of individual change in the biological aging process
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 33:571-80. 1998
  7. ncbi request reprint Aging and longevity genes
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Acta Biochim Pol 47:269-79. 2000
  8. ncbi request reprint Heat stress-induced life span extension in yeast
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:379-88. 1998
  9. ncbi request reprint Role of RAS2 in recovery from chronic stress: effect on yeast life span
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:368-78. 1998
  10. pmc Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae
    S Kim
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Mol Biol Cell 10:3125-36. 1999

Collaborators

  • Shubha P Kale
  • S Kim
  • J Sun
  • J Hunt
  • J C Jiang
  • S Shama
  • P A Kirchman
  • I Guillas
  • J Wawryn
  • H M C Shantha Kumara
  • R Chuard
  • A Conzelmann
  • M Pfefferli
  • C Y Lai
  • M Zagulski
  • N P D'mello
  • J M Antoniazzi
  • D S Franklin
  • C Pinswasdi
  • A M Childress

Detail Information

Publications22

  1. ncbi request reprint Cloning and characterization of LAG1, a longevity-assurance gene in yeast
    N P D'mello
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    J Biol Chem 269:15451-9. 1994
    ..A gene deletion in haploid cells resulted in a pronounced increase (approximately 50%) in mean and in maximum life span. These results indicate that this gene, which we call LAG1, plays a role in determining yeast longevity...
  2. ncbi request reprint Molecular mechanisms of yeast longevity
    S M Jazwinski
    Dept of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA 70112, USA
    Trends Microbiol 7:247-52. 1999
    ..The RAS genes have emerged as important modulators of life-maintenance processes and of life span itself...
  3. ncbi request reprint Metabolic control and gene dysregulation in yeast aging
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Ann N Y Acad Sci 908:21-30. 2000
    ..Silencing of ribosomal DNA appears to be of particular importance. Extrachromosomal ribosomal DNA circles are neither sufficient nor necessary for yeast aging...
  4. ncbi request reprint Genetics of longevity
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 33:773-83. 1998
    ..These population genetic studies can be augmented by mechanistic studies in transgenic mice...
  5. ncbi request reprint The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Neurobiol Aging 20:471-8. 1999
    ..As a consequence, the study of yeast aging may be helpful in understanding processes occurring in the aging brain...
  6. ncbi request reprint Epigenetic stratification: the role of individual change in the biological aging process
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 33:571-80. 1998
    ..Experimental evidence in support of this model is presented that spans the levels of population mortality rates, cellular spatial organization, and gene dysregulation...
  7. ncbi request reprint Aging and longevity genes
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Acta Biochim Pol 47:269-79. 2000
    ..The urgency for such studies is great: The population is graying, and this research holds the promise of improvement in the quality of the later years of life...
  8. ncbi request reprint Heat stress-induced life span extension in yeast
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:379-88. 1998
    ..The results raise the possibility that the RAS genes and mitochondria may play a role in the epigenetic inheritance of reduced mortality rate afforded by transient, mild heat stress...
  9. ncbi request reprint Role of RAS2 in recovery from chronic stress: effect on yeast life span
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:368-78. 1998
    ..Since RAS2 is known to down-regulate stress responses, this demonstrates that for longevity the ability to recover from stress is at least as important as the ability to mount a stress response...
  10. pmc Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae
    S Kim
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Mol Biol Cell 10:3125-36. 1999
    ..The functions of RPD3 and HDA1 do not overlap entirely. RPD3 exerts its effect on chromatin at additional sites in the genome, raising the possibility that events at loci other than rDNA play a role in the aging process...
  11. ncbi request reprint A single gene change can extend yeast life span: the role of Ras in cellular senescence
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    Adv Exp Med Biol 330:45-53. 1993
    ..We liken the senescence factor to the product of an anti-oncogene or tumor suppressor gene that neutralizes Ras...
  12. ncbi request reprint Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast
    J C Jiang
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Box P7 2, 1901 Perdido Street, New Orleans, LA 70112, USA
    Exp Gerontol 37:1023-30. 2002
    ..From the known patterns of gene expression elicited by rpd3delta, hda1delta, and sir2delta, we propose that the major longevity effectors of caloric restriction in yeast involve carbohydrate/energy metabolism and mitochondrial function...
  13. ncbi request reprint Longevity, genes, and aging
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Science 273:54-9. 1996
    ..Because of its complexity, the aging process takes us into the realm of integrative biology, and thus, biogerontology should prove instrumental in deciphering the functional and regulatory circuitry of the sequenced genome...
  14. ncbi request reprint Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human
    J C Jiang
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Lousiana 70112, USA
    Genome Res 8:1259-72. 1998
    ..This and its expression profile raise the possibility that it may be involved in neurodegenerative disease. This possibility suggests at least one way in which LAG1Hs might be involved in human aging...
  15. ncbi request reprint Longevity, genes, and aging: a view provided by a genetic model system
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 34:1-6. 1999
    ..There is evidence that this age change plays a causal role. Aging possesses features of a nonlinear process, and it is likely that application of nonlinear system methodology to aging will be productive...
  16. ncbi request reprint Divergent roles of RAS1 and RAS2 in yeast longevity
    J Sun
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    J Biol Chem 269:18638-45. 1994
    ....
  17. ncbi request reprint Differential response to UV stress and DNA damage during the yeast replicative life span
    S P Kale
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Dev Genet 18:154-60. 1996
    ....
  18. ncbi request reprint Profiles of random change during aging contain hidden information about longevity and the aging process
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    J Theor Biol 213:599-608. 2001
    ..This expectation was confirmed, providing new avenues for exploring causal factors in yeast aging. The methodology described here can be readily applied to other aspects of aging in yeast and in higher organisms...
  19. ncbi request reprint Metabolic control and ageing
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Trends Genet 16:506-11. 2000
    ..Finally, protein synthesis is a third aspect, which depends on the transcriptional state of chromatin and the histone deacetylases that modulate it...
  20. ncbi request reprint New clues to old yeast
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
    Mech Ageing Dev 122:865-82. 2001
    ..This element of chance provides opportunities for an integrative approach, which is beginning to appear in yeast aging research...
  21. ncbi request reprint Metabolic mechanisms of yeast ageing
    S M Jazwinski
    Department of Biochemistry and Molecular Biology and Department of Family Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Gerontol 35:671-6. 2000
    ..Although the retrograde response and caloric restriction are distinct pathways of life span extension, there appears to be some overlap of the longevity effectors under their control...
  22. pmc C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p
    I Guillas
    Institute of Biochemistry, University of Fribourg, CH 1700 Fribourg, Switzerland
    EMBO J 20:2655-65. 2001
    ..The participation of Lag1p and Lac1p in ceramide synthesis may explain their role in determining longevity...