S M Jazwinski

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Biological aging research today: potential, peeves, and problems
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology and Center for Healthy Aging, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    Exp Gerontol 37:1141-6. 2002
  2. ncbi request reprint New clues to old yeast
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
    Mech Ageing Dev 122:865-82. 2001
  3. ncbi request reprint Profiles of random change during aging contain hidden information about longevity and the aging process
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    J Theor Biol 213:599-608. 2001
  4. ncbi request reprint Rtg2 protein: at the nexus of yeast longevity and aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, P O Box P7 2, New Orleans, LA 70112, USA
    FEMS Yeast Res 5:1253-9. 2005
  5. ncbi request reprint Metabolic mechanisms of yeast ageing
    S M Jazwinski
    Department of Biochemistry and Molecular Biology and Department of Family Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Gerontol 35:671-6. 2000
  6. ncbi request reprint Yeast longevity and aging--the mitochondrial connection
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    Mech Ageing Dev 126:243-8. 2005
  7. ncbi request reprint Growing old: metabolic control and yeast aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Annu Rev Microbiol 56:769-92. 2002
  8. ncbi request reprint The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
    Gene 354:22-7. 2005
  9. ncbi request reprint Heat stress-induced life span extension in yeast
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:379-88. 1998
  10. ncbi request reprint Role of RAS2 in recovery from chronic stress: effect on yeast life span
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:368-78. 1998

Research Grants

  1. Conference on the Biology of Aging
    S Jazwinski; Fiscal Year: 2004
  2. Analysis of Somatic Mutations in Cancer of the Kidney
    WAYNE VEDECKIS; Fiscal Year: 2005
  3. CELLULAR AGING IN A YEAST MODEL SYSTEM
    S Michal Jazwinski; Fiscal Year: 2007
  4. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2004
  5. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2006

Collaborators

  • Michael V Miceli
  • S Kim
  • J Sun
  • Besim Ogretmen
  • Paul A Kirchman
  • J Hunt
  • Eric Ravussin
  • L Li
  • David Welsh
  • Yusuf Awni Hannun
  • WAYNE VEDECKIS
  • James C Jiang
  • J C Jiang
  • Suriyan Ponnusamy
  • Chi Yung Lai
  • Corina Borghouts
  • Lauri O Byerley
  • Jinqing Wang
  • Meghan Allen
  • Can E Senkal
  • Jae Gu Seo
  • S Shama
  • Joseph Su
  • Michael Businelle
  • Donald Scott
  • Jenny Denver
  • Scott W Herke
  • Andrew Pellett
  • Larry Leamy
  • Ryan Russell
  • Sun W Tam
  • Carl Lavie
  • Karri Hawley
  • Henry Rothschild
  • Tiffany Hall
  • Pauline Callinan
  • Pili Zhang
  • Lina E Antikainen
  • Mark Batzer
  • Paula Geiselman
  • Fernanada Holton
  • Kim Landry
  • Jennifer Hayden
  • Chau Wen Chou
  • Jerilyn Walker
  • Beth Kimball
  • Mandy Shipp
  • Evest Broussard
  • Robert Wood
  • Kim Pederson
  • Artie Brown
  • KATIE CHERRY
  • Anita Smith
  • Cruz Velasco-Gonzalez
  • Kay Lopez
  • Lauri Byerley
  • Emily Olinde
  • Hui Chen Hsu
  • Jessi Thompson
  • Arturo Ace
  • Juling Zhou
  • James P Delany
  • Beth Schmidt
  • Yu Wen Chiu
  • Valentina Greco
  • DeQuindra Rouzan
  • Michael Welsch
  • Hui Yi Lin
  • Jennifer Arceneaux
  • Robert Schwartz
  • Darla Kendzor
  • Matthew Leblanc
  • JOHN MOUNTZ
  • Traylor Traylor
  • Devon Dobrosielski
  • Elizabeth Fontham
  • Vijay Hegde
  • Jacek Bielawski
  • Rashna Bhandari
  • Solomon H Snyder
  • Hiroko Hama
  • Nathan L Alderson
  • Jacek Bialewski
  • Debijyati Sinha
  • Michael J Rossi
  • S P Kale
  • Jaroslaw Wawryn
  • Alberto Benguria
  • J Wawryn
  • H M C Shantha Kumara

Detail Information

Publications40

  1. ncbi request reprint Biological aging research today: potential, peeves, and problems
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology and Center for Healthy Aging, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    Exp Gerontol 37:1141-6. 2002
    ..However, this will require the development of indices of frailty and of healthy aging. In the end, we may be able to 'cure' aging, but only in a statistical sense which is measured at the level of the population...
  2. ncbi request reprint New clues to old yeast
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
    Mech Ageing Dev 122:865-82. 2001
    ..This element of chance provides opportunities for an integrative approach, which is beginning to appear in yeast aging research...
  3. ncbi request reprint Profiles of random change during aging contain hidden information about longevity and the aging process
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
    J Theor Biol 213:599-608. 2001
    ..This expectation was confirmed, providing new avenues for exploring causal factors in yeast aging. The methodology described here can be readily applied to other aspects of aging in yeast and in higher organisms...
  4. ncbi request reprint Rtg2 protein: at the nexus of yeast longevity and aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, P O Box P7 2, New Orleans, LA 70112, USA
    FEMS Yeast Res 5:1253-9. 2005
    ..Phenomena that resemble the retrograde response appear to exist in human cells, with both common and cell type-specific gene expression changes as the output...
  5. ncbi request reprint Metabolic mechanisms of yeast ageing
    S M Jazwinski
    Department of Biochemistry and Molecular Biology and Department of Family Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Gerontol 35:671-6. 2000
    ..Although the retrograde response and caloric restriction are distinct pathways of life span extension, there appears to be some overlap of the longevity effectors under their control...
  6. ncbi request reprint Yeast longevity and aging--the mitochondrial connection
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    Mech Ageing Dev 126:243-8. 2005
    ..Common threads weave their way through the studies of aging in yeast and in other model organisms. This suggests conserved features of aging across phyla...
  7. ncbi request reprint Growing old: metabolic control and yeast aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Annu Rev Microbiol 56:769-92. 2002
    ..Both compensatory and preventive mechanisms determine life span, while epigenetic factors and the element of chance contribute to the role that genes and environment play in aging...
  8. ncbi request reprint The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
    Gene 354:22-7. 2005
    ..Gene regulatory phenomena akin to the retrograde response also operate in human cells, which display both common and cell-type specific changes in gene expression on loss of mitochondrial function...
  9. ncbi request reprint Heat stress-induced life span extension in yeast
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:379-88. 1998
    ..The results raise the possibility that the RAS genes and mitochondria may play a role in the epigenetic inheritance of reduced mortality rate afforded by transient, mild heat stress...
  10. ncbi request reprint Role of RAS2 in recovery from chronic stress: effect on yeast life span
    S Shama
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana, 70112, USA
    Exp Cell Res 245:368-78. 1998
    ..Since RAS2 is known to down-regulate stress responses, this demonstrates that for longevity the ability to recover from stress is at least as important as the ability to mount a stress response...
  11. ncbi request reprint A single gene change can extend yeast life span: the role of Ras in cellular senescence
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    Adv Exp Med Biol 330:45-53. 1993
    ..We liken the senescence factor to the product of an anti-oncogene or tumor suppressor gene that neutralizes Ras...
  12. ncbi request reprint Cloning and characterization of LAG1, a longevity-assurance gene in yeast
    N P D'mello
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    J Biol Chem 269:15451-9. 1994
    ..A gene deletion in haploid cells resulted in a pronounced increase (approximately 50%) in mean and in maximum life span. These results indicate that this gene, which we call LAG1, plays a role in determining yeast longevity...
  13. ncbi request reprint Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast
    J C Jiang
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Box P7 2, 1901 Perdido Street, New Orleans, LA 70112, USA
    Exp Gerontol 37:1023-30. 2002
    ..From the known patterns of gene expression elicited by rpd3delta, hda1delta, and sir2delta, we propose that the major longevity effectors of caloric restriction in yeast involve carbohydrate/energy metabolism and mitochondrial function...
  14. ncbi request reprint Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human
    J C Jiang
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Lousiana 70112, USA
    Genome Res 8:1259-72. 1998
    ..This and its expression profile raise the possibility that it may be involved in neurodegenerative disease. This possibility suggests at least one way in which LAG1Hs might be involved in human aging...
  15. pmc Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae
    S Kim
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Mol Biol Cell 10:3125-36. 1999
    ..The functions of RPD3 and HDA1 do not overlap entirely. RPD3 exerts its effect on chromatin at additional sites in the genome, raising the possibility that events at loci other than rDNA play a role in the aging process...
  16. ncbi request reprint Metabolic control and gene dysregulation in yeast aging
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Ann N Y Acad Sci 908:21-30. 2000
    ..Silencing of ribosomal DNA appears to be of particular importance. Extrachromosomal ribosomal DNA circles are neither sufficient nor necessary for yeast aging...
  17. ncbi request reprint Metabolic control and ageing
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Trends Genet 16:506-11. 2000
    ..Finally, protein synthesis is a third aspect, which depends on the transcriptional state of chromatin and the histone deacetylases that modulate it...
  18. ncbi request reprint Differential response to UV stress and DNA damage during the yeast replicative life span
    S P Kale
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Dev Genet 18:154-60. 1996
    ....
  19. ncbi request reprint Genetics of longevity
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 33:773-83. 1998
    ..These population genetic studies can be augmented by mechanistic studies in transgenic mice...
  20. ncbi request reprint Longevity, genes, and aging: a view provided by a genetic model system
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 34:1-6. 1999
    ..There is evidence that this age change plays a causal role. Aging possesses features of a nonlinear process, and it is likely that application of nonlinear system methodology to aging will be productive...
  21. ncbi request reprint The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Neurobiol Aging 20:471-8. 1999
    ..As a consequence, the study of yeast aging may be helpful in understanding processes occurring in the aging brain...
  22. ncbi request reprint Aging and longevity genes
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Acta Biochim Pol 47:269-79. 2000
    ..The urgency for such studies is great: The population is graying, and this research holds the promise of improvement in the quality of the later years of life...
  23. ncbi request reprint Longevity, genes, and aging
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Science 273:54-9. 1996
    ..Because of its complexity, the aging process takes us into the realm of integrative biology, and thus, biogerontology should prove instrumental in deciphering the functional and regulatory circuitry of the sequenced genome...
  24. pmc Rtg2 protein links metabolism and genome stability in yeast longevity
    Corina Borghouts
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Genetics 166:765-77. 2004
    ..Thus, RTG2 lies at the nexus of cellular metabolism and genome stability, coordinating two pathways that have opposite effects on yeast longevity...
  25. ncbi request reprint Nuclear gene expression changes due to mitochondrial dysfunction in ARPE-19 cells: implications for age-related macular degeneration
    Michael V Miceli
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:1765-73. 2005
    ..To measure changes in nuclear gene expression resulting from mitochondrial dysfunction in retinal pigment epithelial cells...
  26. ncbi request reprint Divergent roles of RAS1 and RAS2 in yeast longevity
    J Sun
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    J Biol Chem 269:18638-45. 1994
    ....
  27. ncbi request reprint Epigenetic stratification: the role of individual change in the biological aging process
    S M Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112, USA
    Exp Gerontol 33:571-80. 1998
    ..Experimental evidence in support of this model is presented that spans the levels of population mortality rates, cellular spatial organization, and gene dysregulation...
  28. ncbi request reprint A novel role of peroxin PEX6: suppression of aging defects in mitochondria
    Jae Gu Seo
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Aging Cell 6:405-13. 2007
    ..The novel function of Pex6p described here may provide insights into peroxisomal and mitochondrial disorders and into metabolic diseases in general...
  29. ncbi request reprint Common and cell type-specific responses of human cells to mitochondrial dysfunction
    Michael V Miceli
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Cell Res 302:270-80. 2005
    ..These expression changes may help explain the response of different tissues to the loss of mitochondrial function due to aging or disease...
  30. pmc Development of a serum profile for healthy aging
    Lauri O Byerley
    Physiology Department, Louisiana State University Health Science Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Age (Dordr) 32:497-507. 2010
    ..These preliminary results show that the proteomics approach can be used to identify potential proteins or markers that may be involved in the aging process and/or be important determinants of longevity...
  31. ncbi request reprint Prohibitins and Ras2 protein cooperate in the maintenance of mitochondrial function during yeast aging
    Paul A Kirchman
    Department of Biochemistry and Molecular Biology and Center on Aging, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 U S A
    Acta Biochim Pol 50:1039-56. 2003
    ..This aggravation of the initial damage is ameliorated by the suppression of the production of mitochondrial proteins in the absence of Ras2p signaling of mitochondrial biogenesis...
  32. ncbi request reprint Molecular mechanisms of yeast longevity
    S M Jazwinski
    Dept of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA 70112, USA
    Trends Microbiol 7:247-52. 1999
    ..The RAS genes have emerged as important modulators of life-maintenance processes and of life span itself...
  33. pmc Gene regulatory changes in yeast during life extension by nutrient limitation
    Jinqing Wang
    Department of Medicine and the Tulane Center for Aging, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Exp Gerontol 45:621-31. 2010
    ..These gene regulatory events portend an increase in the generation of biosynthetic intermediates necessary for the production of daughter cells, which is the measure of yeast replicative life span...
  34. ncbi request reprint The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity
    Sangkyu Kim
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biogerontology 5:305-16. 2004
    ..Rtg2p and Gcn5p in the SLIK complex link metabolism to stress responses, chromatin-dependent gene regulation, and genome stability in yeast aging...
  35. ncbi request reprint Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity
    James C Jiang
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans 70112, USA
    Exp Gerontol 39:999-1009. 2004
    ..Homologues of Lag1p have been identified in higher eukaryotes, including human, raising the possibility that ceramide and other sphingolipid metabolites play a wider role in biological aging...
  36. ncbi request reprint Yeast replicative life span--the mitochondrial connection
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    FEMS Yeast Res 5:119-25. 2004
    ..In sum, it is clear that mitochondria lie at the nexus of yeast longevity and aging...
  37. pmc A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae
    Chi Yung Lai
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genetics 162:73-87. 2002
    ..We propose, more generally, that age asymmetry depends on partition of active and undamaged cellular components to the progeny and that this "filter" breaks down with age...
  38. ncbi request reprint Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas
    Can E Senkal
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Mol Cancer Ther 6:712-22. 2007
    ..In conclusion, these data suggest an important role for LASS1/C(18)-ceramide in gemcitabine/doxorubicin-induced cell death via the activation of caspase-9/3 in HNSCC...
  39. pmc Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function
    Suriyan Ponnusamy
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 283:27514-24. 2008
    ....
  40. ncbi request reprint LAG1 puts the focus on ceramide signaling
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, PO Box P7 2, New Orleans, LA 70112, USA
    Int J Biochem Cell Biol 34:1491-5. 2002
    ..This provides a wide range of physiologic processes through which Lag 1 p may impinge upon life span...

Research Grants5

  1. Conference on the Biology of Aging
    S Jazwinski; Fiscal Year: 2004
    ..abstract_text> ..
  2. Analysis of Somatic Mutations in Cancer of the Kidney
    WAYNE VEDECKIS; Fiscal Year: 2005
    ..B) Is there a correlation between other suspected risk factors, hypertension and obesity, and p53 gene mutation prevalence and spectrum? (C) Is there a correlation between survival and p53 gene mutation prevalence and spectrum? ..
  3. CELLULAR AGING IN A YEAST MODEL SYSTEM
    S Michal Jazwinski; Fiscal Year: 2007
    ..abstract_text> ..
  4. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2004
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..
  5. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2006
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..