Affiliation: Louisiana State University Health Sciences Center
Liang D, Zeng Q, Xu Z, Zhang H, Gui L, Xu C, et al
. BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells. Biochem Pharmacol. 2014;87:332-43 pubmed publisher
..Our data suggest that inhibitors of CaMKII and Erk1/2, activator of PP2A or manipulation of intracellular Ca(2+) may be exploited for prevention of excessive BAFF-induced aggressive B-cell malignancies and autoimmune diseases. ..
Zhang H, Dong X, Zhao R, Zhang R, Xu C, Wang X, et al
. Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells. Cell Signal. 2019;55:26-39 pubmed publisher
..Our findings underscore that inhibition of Akt to improve autophagic flux is a promising strategy against Cd-induced neurotoxicity and neurodegeneration. ..
Dong X, Qin J, Ma J, Zeng Q, Zhang H, Zhang R, et al
. BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells. Cell Signal. 2019;53:68-79 pubmed publisher
Xu C, Liu C, Liu L, Zhang R, Zhang H, Chen S, et al
. Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways. Neuropharmacology. 2015;97:35-45 pubmed publisher
..Our results highlight that rapamycin may be exploited for the prevention of Cd-induced neurodegenerative disorders. ..
Zeng Q, Zhang H, Qin J, Xu Z, Gui L, Liu B, et al
. Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells. Cell Mol Life Sci. 2015;72:4867-84 pubmed publisher
..Our data highlight that rapamycin may be exploited for preventing excessive BAFF-induced aggressive B-cell malignancies and autoimmune diseases. ..
Zhou H, Shang C, Wang M, Shen T, Kong L, Yu C, et al
. Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK. Biochem Pharmacol. 2016;116:39-50 pubmed publisher
..Therefore, the results indicate that CPX exerts the anticancer effect by activating AMPK, resulting in inhibition of mTORC1 signaling. ..
Xu C, Wang X, Zhu Y, Dong X, Liu C, Zhang H, et al
. Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A. Neuropharmacology. 2016;105:270-284 pubmed publisher
..Our results underline that rapamycin may have a potential in preventing Cd-induced oxidative stress and neurodegenerative diseases. ..