James Hill

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia
    Christian Clement
    Department of Ophthalmology, New Orleans, LA 70112, USA
    Mol Vis 14:1209-21. 2008
  2. pmc A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis
    Partha S Bhattacharjee
    Department of Biology, Xavier University of Louisiana, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e15905. 2011
  3. ncbi request reprint The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model
    James M Hill
    Louisiana State University Health Sciences Center LSUHSC, Department of Ophthalmology, 533 Bolivar Street, New Orleans, LA 70112, United States Department of Microbiology, LSUHSC, United States Neuroscience Center, LSUHSC, 2020 Gravier Street, 8th Floor, New Orleans, LA 70112, United States Department of Pharmacology, LSUHSC, 1901 Perdido Street, New Orleans, LA 70112, United States Electronic address
    Antiviral Res 100:14-9. 2013
  4. pmc HSV-1 latent rabbits shed viral DNA into their saliva
    James M Hill
    Department of Ophthalmology LSUHSC School of Medicine, 533 Bolivar Street, Room 3D13, New Orleans, LA 70112, USA
    Virol J 9:221. 2012
  5. pmc Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cells
    Gautam R Bedadala
    Department of Pharmaceutical Sciences, University of Maryland Eastern Shore School of Pharmacy, Princess Anne, MD, USA
    Virol J 8:262. 2011
  6. pmc Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification
    Rajeswara C Pinnoji
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, The University of Louisiana at Monroe, Monroe, LA 71209, USA
    Virol J 4:56. 2007
  7. pmc Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Eye Res 84:801-11. 2007
  8. ncbi request reprint Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease?
    J M Hill
    Departments of Ophthalmology, Neuroscience, Pharmacology, and Microbiology, LSU Health Sciences Center, New Orleans, LA, USA
    Med Hypotheses 64:320-7. 2005
  9. ncbi request reprint Statins lower the risk of developing Alzheimer's disease by limiting lipid raft endocytosis and decreasing the neuronal spread of Herpes simplex virus type 1
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Med Hypotheses 64:53-8. 2005
  10. pmc The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Virol 82:8230-4. 2008

Collaborators

Detail Information

Publications44

  1. pmc Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia
    Christian Clement
    Department of Ophthalmology, New Orleans, LA 70112, USA
    Mol Vis 14:1209-21. 2008
    ....
  2. pmc A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis
    Partha S Bhattacharjee
    Department of Biology, Xavier University of Louisiana, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e15905. 2011
    ..This is the first evidence that a synthetic dimer peptide mimicking human apoE has anti-angiogenesis functions and could be an anti-tumor drug candidate...
  3. ncbi request reprint The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model
    James M Hill
    Louisiana State University Health Sciences Center LSUHSC, Department of Ophthalmology, 533 Bolivar Street, New Orleans, LA 70112, United States Department of Microbiology, LSUHSC, United States Neuroscience Center, LSUHSC, 2020 Gravier Street, 8th Floor, New Orleans, LA 70112, United States Department of Pharmacology, LSUHSC, 1901 Perdido Street, New Orleans, LA 70112, United States Electronic address
    Antiviral Res 100:14-9. 2013
    ..The vehicle control scores were significantly higher and did not effectively treat HSV-1 keratitis. C31G has the potential to be used to treat herpetic keratitis as well as other herpetic topical lesions in humans. ..
  4. pmc HSV-1 latent rabbits shed viral DNA into their saliva
    James M Hill
    Department of Ophthalmology LSUHSC School of Medicine, 533 Bolivar Street, Room 3D13, New Orleans, LA 70112, USA
    Virol J 9:221. 2012
    ..This study used real-time PCR to quantify HSV-1 DNA in the saliva and tears of rabbits latent with HSV-1 McKrae...
  5. pmc Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cells
    Gautam R Bedadala
    Department of Pharmaceutical Sciences, University of Maryland Eastern Shore School of Pharmacy, Princess Anne, MD, USA
    Virol J 8:262. 2011
    ..The mechanisms of induction are mediated, at least in part, by signaling pathways such as NFκB and CREB...
  6. pmc Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification
    Rajeswara C Pinnoji
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, The University of Louisiana at Monroe, Monroe, LA 71209, USA
    Virol J 4:56. 2007
    ..We predicted that the Repressor Element Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (REST/NRSF) regulates expression of ICP22 and ICP4...
  7. pmc Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Eye Res 84:801-11. 2007
    ..While many clinical investigations have been reported and, to a lesser extent, transgenic mouse studies have been conducted, no specific mechanisms of how ApoE induces or alters clinical disease are known...
  8. ncbi request reprint Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease?
    J M Hill
    Departments of Ophthalmology, Neuroscience, Pharmacology, and Microbiology, LSU Health Sciences Center, New Orleans, LA, USA
    Med Hypotheses 64:320-7. 2005
    ....
  9. ncbi request reprint Statins lower the risk of developing Alzheimer's disease by limiting lipid raft endocytosis and decreasing the neuronal spread of Herpes simplex virus type 1
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Med Hypotheses 64:53-8. 2005
    ..Although the mechanism by which statins reduce AD risk is unknown, they reduce the amount of cholesterol in the plasma membrane and, thus, may decrease the availability of lipid raft pathways to spread HSV-1 within the brain...
  10. pmc The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender
    James M Hill
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Virol 82:8230-4. 2008
    ..This is the first study that provides statistical analysis that documents that the prevalence of HSV-1 DNA in the human TG is not a function of either gender or age...
  11. ncbi request reprint Gene expression analyzed by microarrays in HSV-1 latent mouse trigeminal ganglion following heat stress
    J M Hill
    Department of Ophthalmology LSU Eye Center, New Orleans, LA 70112, USA
    Virus Genes 23:273-80. 2001
    ..These results suggest that there is a significant difference in the ERG expression profile in latently infected TGs undergoing stress-induced reactivation compared to uninfected TGs...
  12. ncbi request reprint Gene expression profiling in the HSV-1 latently infected mouse trigeminal ganglia following hyperthermic stress
    Shiro Higaki
    Department of Ophthalmology LSU Eye Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, USA
    Curr Eye Res 26:231-8. 2003
    ..To assess gene expression in herpes simplex virus type 1 (HSV-1) latent mouse trigeminal ganglia (TG) at 6 and 24 hours after hyperthermic stress...
  13. ncbi request reprint An HSV-1 chimeric containing HSV-2 latency associated transcript (LAT) sequences has significantly reduced adrenergic reactivation in the rabbit eye model
    James Hill
    LSU Eye Center, New Orleans, LA, USA
    Curr Eye Res 26:219-24. 2003
    ..We sought to determine whether the HSV-2 LAT could function in the context of HSV-1...
  14. pmc A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva
    Manish Kumar
    Department of Ophthalmology, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Invest Ophthalmol Vis Sci 50:5601-8. 2009
    ..Ocular and oral swabs were collected twice daily for 30 days. DNA was extracted from all swabs and HSV-1 DNA copy numbers were determined. Statistical analysis was performed to compare the DNA copy numbers of the three groups...
  15. ncbi request reprint Apolipoprotein E modulates establishment of HSV-1 latency and survival in a mouse ocular model
    Partha S Bhattacharjee
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Curr Eye Res 31:703-8. 2006
    ..To evaluate and compare the neuroinvasiveness and neurovirulence after ocular HSV-1 infection in ApoE knockout (ApoE-/-) and control C57BL/6 (ApoE+/+) mice...
  16. pmc Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1
    Partha S Bhattacharjee
    Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Eye Res 87:122-30. 2008
    ..This is the first report linking a human gene, apoE4, as a risk factor for ocular herpes pathogenesis in a transgenic mouse model...
  17. ncbi request reprint Ocular reactivation phenotype of HSV-1 strain F(MP)E, a corticosteroid-sensitive strain
    Mary Marquart
    Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA, USA
    Curr Eye Res 26:205-9. 2003
    ..Elucidate the ocular reactivation of HSV-1 strain F(MP)E...
  18. pmc Heat-induced reactivation of HSV-1 in latent mice: upregulation in the TG of CD83 and other immune response genes and their LAT-ICP0 locus
    Christian Clement
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 50:2855-61. 2009
    ..To determine changes in host gene expression in HSV-1 latent trigeminal ganglia (TG) after hyperthermic stress...
  19. ncbi request reprint Effect of immunosuppression on gene expression in the HSV-1 latently infected mouse trigeminal ganglion
    Shiro Higaki
    Department of Ophthalmology, LSU Eye Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 43:1862-9. 2002
    ..To determine alterations in expression of genes in herpes simples virus (HSV)-1 latently infected mouse trigeminal ganglia (TGs), after treatment with cyclophosphamide and dexamethasone...
  20. pmc Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits
    Manish Kumar
    Department of Ophthalmology, Neuroscience Center of Excellence, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 51:4703-6. 2010
    ..To assess the effect of high doses of valacyclovir (VCV) on HSV-1 DNA shedding into tears of latently infected rabbits...
  21. pmc A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits
    Partha S Bhattacharjee
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Lousiana, USA
    Curr Eye Res 34:99-102. 2009
    ....
  22. pmc Sodium butyrate: a chemical inducer of in vivo reactivation of herpes simplex virus type 1 in the ocular mouse model
    Donna M Neumann
    Department of Ophthalmology LSU Eye Center of Excellence, Louisiana State University Health Sciences Center at New Orleans, New Orleans, Louisiana 70112, USA
    J Virol 81:6106-10. 2007
    ....
  23. doi request reprint Ocular HSV-1 latency, reactivation and recurrent disease
    Hassanain S Toma
    Louisiana State University Health Sciences Center, New Orleans, LA 70112 2234, USA
    Semin Ophthalmol 23:249-73. 2008
    ..This review will highlight basic HSV-1 virology, and will compare the animal models of latency, reactivation, and recurrent ocular disease to the current clinical data...
  24. doi request reprint Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model
    Partha S Bhattacharjee
    Departments of Ophthalmology, School of Public Health, LouisianaState University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 49:4263-8. 2008
    ....
  25. pmc Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells
    Walter J Lukiw
    LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
    Neuroreport 21:922-7. 2010
    ....
  26. pmc HSV-1 DNA in tears and saliva of normal adults
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:241-7. 2005
    ..To assess the frequency of shedding of herpes simplex virus type 1 (HSV-1) DNA in tears and saliva of asymptomatic individuals...
  27. ncbi request reprint Bupropion (Zyban, Wellbutrin) inhibits nicotine-induced viral reactivation in herpes simplex virus type 1 latent rabbits
    Marvin E Myles
    Louisiana State University Eye Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112 2234, USA
    J Pharmacol Exp Ther 311:640-4. 2004
    ..2%), and nicotine/bupropion-treated rabbits had 47/792 (5.9%) positive/total swabs. Thus, bupropion significantly reduces nicotine-induced HSV reactivation in latent rabbits...
  28. ncbi request reprint Effect of acyclovir on thermal stress-induced herpesvirus reactivation
    Bryan M Gebhardt
    Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112 2234, USA
    Curr Eye Res 29:137-44. 2004
    ..The purpose of the current study was to determine the effect of acyclovir on the appearance of infectious virus in the peripheral nervous system and in an end organ, the eye...
  29. ncbi request reprint Overlapping subdeletions within a 348-bp in the 5' exon of the LAT region that facilitates epinephrine-induced reactivation of HSV-1 in the rabbit ocular model do not further define a functional element
    Partha S Bhattacharjee
    LSU Eye Center, Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Virology 312:151-8. 2003
    ....
  30. ncbi request reprint Nicotine applied by transdermal patch induced HSV-1 reactivation and ocular shedding in latently infected rabbits
    M E Myles
    Department of Ophthalmology, LSU Eye Center, Baton Rouge, LA, USA
    J Ocul Pharmacol Ther 19:121-33. 2003
    ..These results suggest that an initial systemic exposure to nicotine significantly increases HSV-1 reactivation. Further studies are needed to reveal any effects of nicotine dependency and nicotine withdrawal on herpesvirus reactivation...
  31. pmc In vivo changes in the patterns of chromatin structure associated with the latent herpes simplex virus type 1 genome in mouse trigeminal ganglia can be detected at early times after butyrate treatment
    Donna M Neumann
    Department of Ophthalmology LSU Eye Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Virol 81:13248-53. 2007
    ..5 h and 1 h post-butyrate treatment, respectively. This is the first study to combine in vivo reactivation with the examination of the HSV-1 genome through ChIP assays at early times after the introduction of in vivo reactivation stimuli...
  32. ncbi request reprint Sustained-release ophthalmic drug delivery systems for treatment of macular disorders: present and future applications
    Blake A Booth
    Department of Ophthalmology, LSU Health Sciences Center, New Orleans, Louisiana, USA
    Drugs Aging 24:581-602. 2007
    ..If successful, therapeutic modalities will significantly delay loss of vision and improve the quality of life for patients with chronic macular disorders...
  33. pmc HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling
    James M Hill
    LSU Neuroscience Center and Departments of Ophthalmology, Pharmacology, Microbiology, Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Neuroreport 20:1500-5. 2009
    ..These data suggest a role for HSV-1-induced miRNA-146a in the evasion of HSV-1 from the complement system, and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change...
  34. ncbi request reprint Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis
    Marvin E Myles
    Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA, USA
    Adv Drug Deliv Rev 57:2063-79. 2005
    ..This review will summarize recent literature concerning ocular drug delivery of bioactive compounds to the posterior segment of the eye with emphasis on transscleral iontophoresis...
  35. ncbi request reprint Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer's disease
    Jian Guo Cui
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
    Neuroreport 18:115-9. 2007
    ..This upregulation of pathological gene expression could be, in part, responsible for the visual disturbances associated with end-stages of the Alzheimer process...
  36. pmc Apolipoprotein E epsilon4 offers protection against age-related macular degeneration
    Duncan A Friedman
    Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA 70112 2234, United States
    Med Hypotheses 68:1047-55. 2007
    ..The general behavior of the epsilon4 isoform of ApoE is different than the predominant epsilon3 isoform...
  37. ncbi request reprint Herpesvirus infection of ICAM-1-deficient mice
    Hyo W Jung
    Immunomodulation Research Center, University of Ulsan, 29 Mukeo dong, Nam Ku, Ulsan, Korea 680 749
    Curr Eye Res 29:201-8. 2004
    ..To determine the effect of ICAM-1 deficiency on viral infection of the cornea...
  38. pmc Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells
    Robert J Danaher
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Dentistry and College of Medicine, Lexington, KY 40536 0297, USA
    J Neurovirol 11:306-17. 2005
    ..e., recrudescence)...
  39. ncbi request reprint Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations
    Soumyajit Majumdar
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, 64110 2499, USA
    J Ocul Pharmacol Ther 21:463-74. 2005
    ..The aim of this study was to evaluate a series of dipeptide monoester ganciclovir (GCV) prodrugs with the goal of improving ocular bioavailability of GCV from topical ophthalmic solutions...
  40. pmc During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genes
    Nicole V Giordani
    Department of Molecular Genetics and Microbiology, Box 100266, University of Florida College of Medicine, Gainesville, FL 32610 0266, USA
    J Virol 82:6056-60. 2008
    ..These results suggest that, for efficient reactivation from latency in rabbits, the LAT is important for increased transcription of lytic genes during latency...
  41. ncbi request reprint In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model
    Banmeet S Anand
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri 64110 2499, USA
    Invest Ophthalmol Vis Sci 44:2529-34. 2003
    ..A dipeptide prodrug of the antiviral nucleoside acyclovir (ACV), val-val-ACV (VVACV), was evaluated in vivo as a potential drug candidate for improving antiviral efficacy against herpetic epithelial and stromal keratitis...
  42. ncbi request reprint The region of the HSV-1 latency-associated transcript required for epinephrine-induced reactivation in the rabbit does not include the 2.0-kb intron
    Richard G Jarman
    Department of Microbiology, Arizona State University, Tempe, Arizona 85287 2701, USA
    Virology 292:59-69. 2002
    ..These results indicate that the elements governing induced reactivation reside within the first 699 bp of the primary LAT transcript encoding the 5prime prime or minute LAT exon...
  43. ncbi request reprint Brief report: the impact of subcortical band heterotopia and associated complications on the neuropsychological functioning of a 13-year-old child
    Beata S Beaudoin
    Department of Psychiatry, University of Medicine and Dentistry of New Jersey at Newark, New Jersey Medical School, Newark, NJ, USA
    J Autism Dev Disord 37:983-92. 2007
    ..Similar motor patterns as in younger children were found in the older adolescents. The association of autistic symptoms with motor performance points towards an essential role of motor impairment in autism spectrum disorders...
  44. ncbi request reprint 4-1BB-like molecule is expressed in islet-infiltrating mononuclear cells and in the gray matter of the brain
    Ho Y Lim
    The Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan, 680 749, Korea
    Cell Biol Int 26:271-8. 2002
    ..The staining pattern strongly resembled the receptor/nerve terminals in the brain and in the peripheral nervous system. Taken together, BBLP may be associated with the early phase of inflammation and with brain function...

Research Grants40

  1. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1993
    ..Patients with bacterial keratitis would reap significant benefits from the development of a specific therapeutic regimen that minimizes corneal scarring...
  2. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1992
    ..Patients with bacterial keratitis would reap significant benefits from the development of a specific therapeutic regimen that minimizes corneal scarring...
  3. Aging, Herpesviruses, and Alzheimer's Disease
    James Hill; Fiscal Year: 2007
    ..B) Detect and quantitate HSV-1 mRNAs in tissues positive for HSV-1. This project could lead to strategies to identify high-risk individuals who would be treated with antivirals, thus reducing their risk of developing AD. ..
  4. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 2002
    ..The development of new therapies that prevent the corneal scarring caused by repeated episodes of herpetic disease would represent an important advance protecting vision and decreasing the need for corneal transplantation. ..
  5. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 2004
    ..The development of new therapies that prevent the corneal scarring caused by repeated episodes of herpetic disease would represent an important advance protecting vision and decreasing the need for corneal transplantation. ..
  6. Aging, Herpesviruses, and Alzheimer's Disease
    James Hill; Fiscal Year: 2006
    ..B) Detect and quantitate HSV-1 mRNAs in tissues positive for HSV-1. This project could lead to strategies to identify high-risk individuals who would be treated with antivirals, thus reducing their risk of developing AD. ..
  7. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 2001
    ..The development of new therapies that prevent the corneal scarring caused by repeated episodes of herpetic disease would represent an important advance protecting vision and decreasing the need for corneal transplantation. ..
  8. Aging, Herpesviruses, and Alzheimer's Disease
    James Hill; Fiscal Year: 2004
    ..B) Detect and quantitate HSV-1 mRNAs in tissues positive for HSV-1. This project could lead to strategies to identify high-risk individuals who would be treated with antivirals, thus reducing their risk of developing AD. ..
  9. Aging, Herpesviruses, and Alzheimer's Disease
    James Hill; Fiscal Year: 2005
    ..B) Detect and quantitate HSV-1 mRNAs in tissues positive for HSV-1. This project could lead to strategies to identify high-risk individuals who would be treated with antivirals, thus reducing their risk of developing AD. ..
  10. Ocular HSV-Latency, Reactivation, and Recurrence
    James Hill; Fiscal Year: 2005
    ..The availability of sensitive and comprehensive host gene expression analysis methods, especially the new rabbit gene array already integrated into our ongoing studies, will aid us in achieving these aims. ..
  11. Ocular HSV-Latency, Reactivation, and Recurrence
    James Hill; Fiscal Year: 2006
    ..The availability of sensitive and comprehensive host gene expression analysis methods, especially the new rabbit gene array already integrated into our ongoing studies, will aid us in achieving these aims. ..
  12. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 2004
    ..The development of new therapies that prevent the corneal scarring caused by repeated episodes of herpetic disease would represent an important advance protecting vision and decreasing the need for corneal transplantation. ..
  13. Ocular HSV-Latency, Reactivation, and Recurrence
    James Hill; Fiscal Year: 2007
    ..The availability of sensitive and comprehensive host gene expression analysis methods, especially the new rabbit gene array already integrated into our ongoing studies, will aid us in achieving these aims. ..
  14. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 2001
    ..The long-term goal is to provide insights into HSV pathogenesis that could result in the development of therapeutic strategies to block neuronal HSV reactivation and the morbidity caused by repeated episodes of herpetic disease. ..
  15. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 2000
    ....
  16. Ocular HSV-Latency, Reactivation, and Recurrence
    James M Hill; Fiscal Year: 2010
    ..The use of two receptor-based ApoE mimetic peptides that exhibit potent anti-viral and anti-inflammatory activity, and which act to suppress this gene, holds great promise as a new therapy for ocular and other HSV-related diseases. ..
  17. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 1992
    ....
  18. OCULAR HSV: LATENCY, REACTIVATION, & RECURRENCE
    James Hill; Fiscal Year: 1990
    ..If the trigger that causes the reactivation of latent herpes virus can be identified, a therapeutic strategy, perhaps a specific blocker, can be formulated to inhibit the reactivation of HSV-1 and block recurrent herpetic ocular disease...
  19. OCULAR HSV: LATENCY, REACTIVATION, & RECURRENCE
    James Hill; Fiscal Year: 1991
    ..If the trigger that causes the reactivation of latent herpes virus can be identified, a therapeutic strategy, perhaps a specific blocker, can be formulated to inhibit the reactivation of HSV-1 and block recurrent herpetic ocular disease...
  20. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 1993
    ....
  21. Ocular HSV-Latency, Reactivation, and Recurrence
    James Hill; Fiscal Year: 2009
    ..The use of two receptor-based ApoE mimetic peptides that exhibit potent anti-viral and anti-inflammatory activity, and which act to suppress this gene, holds great promise as a new therapy for ocular and other HSV-related diseases. ..
  22. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 2000
    ..The long-term goal is to provide insights into HSV pathogenesis that could result in the development of therapeutic strategies to block neuronal HSV reactivation and the morbidity caused by repeated episodes of herpetic disease. ..
  23. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 2001
    ....
  24. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1999
    ....
  25. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 1999
    ..The long-term goal is to provide insights into HSV pathogenesis that could result in the development of therapeutic strategies to block neuronal HSV reactivation and the morbidity caused by repeated episodes of herpetic disease. ..
  26. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 2003
    ..The development of new therapies that prevent the corneal scarring caused by repeated episodes of herpetic disease would represent an important advance protecting vision and decreasing the need for corneal transplantation. ..
  27. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1991
    ..Patients with bacterial keratitis would reap significant benefits from the development of a specific therapeutic regimen that minimizes corneal scarring...