Research Topics
| James HillSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
HSV-1 latent rabbits shed viral DNA into their salivaJames M Hill
Department of Ophthalmology LSUHSC School of Medicine, 533 Bolivar Street, Room 3D13, New Orleans, LA, 70112, USA
Virol J 9:221. 2012..abstract:..- Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cellsGautam R Bedadala
Department of Pharmaceutical Sciences, University of Maryland Eastern Shore School of Pharmacy, Princess Anne, MD, USA
Virol J 8:262. 2011..The mechanisms of induction are mediated, at least in part, by signaling pathways such as NFκB and CREB... 
Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modificationRajeswara C Pinnoji
Department of Basic Pharmaceutical Sciences, College of Pharmacy, The University of Louisiana at Monroe, Monroe, LA 71209, USA
Virol J 4:56. 2007..We predicted that the Repressor Element Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (REST/NRSF) regulates expression of ICP22 and ICP4...
Gene expression analyzed by microarrays in HSV-1 latent mouse trigeminal ganglion following heat stressJ M Hill
Department of Ophthalmology LSU Eye Center, New Orleans, LA 70112, USA
Virus Genes 23:273-80. 2001..These results suggest that there is a significant difference in the ERG expression profile in latently infected TGs undergoing stress-induced reactivation compared to uninfected TGs...- Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease?J M Hill
Departments of Ophthalmology, Neuroscience, Pharmacology, and Microbiology, LSU Health Sciences Center, New Orleans, LA, USA
Med Hypotheses 64:320-7. 2005.... - The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or genderJames M Hill
Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
J Virol 82:8230-4. 2008..This is the first study that provides statistical analysis that documents that the prevalence of HSV-1 DNA in the human TG is not a function of either gender or age... - Statins lower the risk of developing Alzheimer's disease by limiting lipid raft endocytosis and decreasing the neuronal spread of Herpes simplex virus type 1James M Hill
Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Med Hypotheses 64:53-8. 2005..Although the mechanism by which statins reduce AD risk is unknown, they reduce the amount of cholesterol in the plasma membrane and, thus, may decrease the availability of lipid raft pathways to spread HSV-1 within the brain... - Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal diseaseJames M Hill
Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Exp Eye Res 84:801-11. 2007..While many clinical investigations have been reported and, to a lesser extent, transgenic mouse studies have been conducted, no specific mechanisms of how ApoE induces or alters clinical disease are known... - An HSV-1 chimeric containing HSV-2 latency associated transcript (LAT) sequences has significantly reduced adrenergic reactivation in the rabbit eye modelJames Hill
LSU Eye Center, New Orleans, LA, USA
Curr Eye Res 26:219-24. 2003..CONCLUSIONS: The HSV-2 LAT cannot substitute for the HSV-1 LAT in promoting reactivation from HSV-1 latency from rabbit trigeminal ganglia. This is consistent with the LAT being the major determinant of site-specific HSV reactivation... - A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and salivaManish Kumar
Department of Ophthalmology, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Invest Ophthalmol Vis Sci 50:5601-8. 2009..Ocular and oral swabs were collected twice daily for 30 days. DNA was extracted from all swabs and HSV-1 DNA copy numbers were determined. Statistical analysis was performed to compare the DNA copy numbers of the three groups... - Apolipoprotein E modulates establishment of HSV-1 latency and survival in a mouse ocular modelPartha S Bhattacharjee
Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Curr Eye Res 31:703-8. 2006..To evaluate and compare the neuroinvasiveness and neurovirulence after ocular HSV-1 infection in ApoE knockout (ApoE-/-) and control C57BL/6 (ApoE+/+) mice... - Gene expression profiling in the HSV-1 latently infected mouse trigeminal ganglia following hyperthermic stressShiro Higaki
Department of Ophthalmology (LSU Eye Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, USA
Curr Eye Res 26:231-8. 2003..CONCLUSION: Altered gene expression at 6 and 24 hours after heat stress was different from previously reported changes in gene expression 1 hour after hyperthermia in HSV-1 latently infected mice... - Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1Partha S Bhattacharjee
Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Exp Eye Res 87:122-30. 2008..This is the first report linking a human gene, apoE4, as a risk factor for ocular herpes pathogenesis in a transgenic mouse model... - Heat-induced reactivation of HSV-1 in latent mice: upregulation in the TG of CD83 and other immune response genes and their LAT-ICP0 locusChristian Clement
Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 50:2855-61. 2009..To determine changes in host gene expression in HSV-1 latent trigeminal ganglia (TG) after hyperthermic stress... - Effect of immunosuppression on gene expression in the HSV-1 latently infected mouse trigeminal ganglionShiro Higaki
Department of Ophthalmology, LSU Eye Center, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 43:1862-9. 2002..Changes in expression of genes in the prostaglandin pathway, a transcription factor, and an enzyme in the cell cycle are considered especially important in HSV-1 reactivation by immunosuppression and are reviewed... - Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbitsManish Kumar
Department of Ophthalmology, Neuroscience Center of Excellence, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Invest Ophthalmol Vis Sci 51:4703-6. 2010..To assess the effect of high doses of valacyclovir (VCV) on HSV-1 DNA shedding into tears of latently infected rabbits... - Sodium butyrate: a chemical inducer of in vivo reactivation of herpes simplex virus type 1 in the ocular mouse modelDonna M Neumann
Department of Ophthalmology LSU Eye Center of Excellence, Louisiana State University Health Sciences Center at New Orleans, New Orleans, Louisiana 70112, USA
J Virol 81:6106-10. 2007.... - A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbitsPartha S Bhattacharjee
Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Lousiana, USA
Curr Eye Res 34:99-102. 2009.... - Ocular reactivation phenotype of HSV-1 strain F(MP)E, a corticosteroid-sensitive strainMary Marquart
Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA, USA
Curr Eye Res 26:205-9. 2003..Elucidate the ocular reactivation of HSV-1 strain F(MP)E... - Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cellsWalter J Lukiw
LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
Neuroreport 21:922-7. 2010.... 
Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye modelPartha S Bhattacharjee
Departments of Ophthalmology, School of Public Health, LouisianaState University Health Sciences Center, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 49:4263-8. 2008....- Ocular HSV-1 latency, reactivation and recurrent diseaseHassanain S Toma
Louisiana State University Health Sciences Center, New Orleans, LA 70112 2234, USA
Semin Ophthalmol 23:249-73. 2008..This review will highlight basic HSV-1 virology, and will compare the animal models of latency, reactivation, and recurrent ocular disease to the current clinical data... - Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal gangliaChristian Clement
Department of Ophthalmology, New Orleans, LA 70112, USA
Mol Vis 14:1209-21. 2008.... - HSV-1 DNA in tears and saliva of normal adultsHerbert E Kaufman
Department of Ophthalmology, LSU Eye Center, New Orleans, LA 70112, USA
Invest Ophthalmol Vis Sci 46:241-7. 2005..To assess the frequency of shedding of herpes simplex virus type 1 (HSV-1) DNA in tears and saliva of asymptomatic individuals... - Bupropion (Zyban, Wellbutrin) inhibits nicotine-induced viral reactivation in herpes simplex virus type 1 latent rabbitsMarvin E Myles
Louisiana State University Eye Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112-2234, USA
J Pharmacol Exp Ther 311:640-4. 2004..2%), and nicotine/bupropion-treated rabbits had 47/792 (5.9%) positive/total swabs. Thus, bupropion significantly reduces nicotine-induced HSV reactivation in latent rabbits... - Effect of acyclovir on thermal stress-induced herpesvirus reactivationBryan M Gebhardt
Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112 2234, USA
Curr Eye Res 29:137-44. 2004..The purpose of the current study was to determine the effect of acyclovir on the appearance of infectious virus in the peripheral nervous system and in an end organ, the eye... - Overlapping subdeletions within a 348-bp in the 5' exon of the LAT region that facilitates epinephrine-induced reactivation of HSV-1 in the rabbit ocular model do not further define a functional elementPartha S Bhattacharjee
LSU Eye Center, Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Virology 312:151-8. 2003.... - In vivo changes in the patterns of chromatin structure associated with the latent herpes simplex virus type 1 genome in mouse trigeminal ganglia can be detected at early times after butyrate treatmentDonna M Neumann
Department of Ophthalmology LSU Eye Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Virol 81:13248-53. 2007..5 h and 1 h post-butyrate treatment, respectively. This is the first study to combine in vivo reactivation with the examination of the HSV-1 genome through ChIP assays at early times after the introduction of in vivo reactivation stimuli... - Nicotine applied by transdermal patch induced HSV-1 reactivation and ocular shedding in latently infected rabbitsM E Myles
Department of Ophthalmology, LSU Eye Center, Baton Rouge, LA, USA
J Ocul Pharmacol Ther 19:121-33. 2003..These results suggest that an initial systemic exposure to nicotine significantly increases HSV-1 reactivation. Further studies are needed to reveal any effects of nicotine dependency and nicotine withdrawal on herpesvirus reactivation... - HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signalingJames M Hill
LSU Neuroscience Center and Departments of Ophthalmology, Pharmacology, Microbiology, Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Neuroreport 20:1500-5. 2009..These data suggest a role for HSV-1-induced miRNA-146a in the evasion of HSV-1 from the complement system, and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change... - Sustained-release ophthalmic drug delivery systems for treatment of macular disorders: present and future applicationsBlake A Booth
Department of Ophthalmology, LSU Health Sciences Center, New Orleans, Louisiana, USA
Drugs Aging 24:581-602. 2007..If successful, therapeutic modalities will significantly delay loss of vision and improve the quality of life for patients with chronic macular disorders... - Apolipoprotein E epsilon4 offers protection against age-related macular degenerationDuncan A Friedman
Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA 70112 2234, United States
Med Hypotheses 68:1047-55. 2007..The general behavior of the epsilon4 isoform of ApoE is different than the predominant epsilon3 isoform... - Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer's diseaseJian Guo Cui
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
Neuroreport 18:115-9. 2007..This upregulation of pathological gene expression could be, in part, responsible for the visual disturbances associated with end-stages of the Alzheimer process... - Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresisMarvin E Myles
Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA, USA
Adv Drug Deliv Rev 57:2063-79. 2005..This review will summarize recent literature concerning ocular drug delivery of bioactive compounds to the posterior segment of the eye with emphasis on transscleral iontophoresis... - Herpesvirus infection of ICAM-1-deficient miceHyo W Jung
Immunomodulation Research Center, University of Ulsan, 29 Mukeo dong, Nam Ku, Ulsan, Korea 680 749
Curr Eye Res 29:201-8. 2004..To determine the effect of ICAM-1 deficiency on viral infection of the cornea... - Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluationsSoumyajit Majumdar
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, 64110-2499, USA
J Ocul Pharmacol Ther 21:463-74. 2005..CONCLUSIONS: Val-Val-GCV demonstrates excellent corneal permeability and chemical stability, high aqueous solubility, and substantial in vivo antiviral activity against the HSV-1... - During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genesNicole V Giordani
Department of Molecular Genetics and Microbiology, Box 100266, University of Florida College of Medicine, Gainesville, FL 32610 0266, USA
J Virol 82:6056-60. 2008..These results suggest that, for efficient reactivation from latency in rabbits, the LAT is important for increased transcription of lytic genes during latency... - Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cellsRobert J Danaher
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Dentistry and College of Medicine, Lexington, KY 40536-0297, USA
J Neurovirol 11:306-17. 2005..e., recrudescence)... - In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye modelBanmeet S Anand
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri 64110-2499, USA
Invest Ophthalmol Vis Sci 44:2529-34. 2003.... - The region of the HSV-1 latency-associated transcript required for epinephrine-induced reactivation in the rabbit does not include the 2.0-kb intronRichard G Jarman
Department of Microbiology, Arizona State University, Tempe, Arizona 85287-2701, USA
Virology 292:59-69. 2002..These results indicate that the elements governing induced reactivation reside within the first 699 bp of the primary LAT transcript encoding the 5prime prime or minute LAT exon... - Brief report: the impact of subcortical band heterotopia and associated complications on the neuropsychological functioning of a 13-year-old childBeata S Beaudoin
Department of Psychiatry, University of Medicine and Dentistry of New Jersey at Newark, New Jersey Medical School, Newark, NJ, USA
J Autism Dev Disord 37:983-92. 2007..Similar motor patterns as in younger children were found in the older adolescents. The association of autistic symptoms with motor performance points towards an essential role of motor impairment in autism spectrum disorders... - 4-1BB-like molecule is expressed in islet-infiltrating mononuclear cells and in the gray matter of the brainHo Y Lim
The Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan, 680 749, Korea
Cell Biol Int 26:271-8. 2002..The staining pattern strongly resembled the receptor/nerve terminals in the brain and in the peripheral nervous system. Taken together, BBLP may be associated with the early phase of inflammation and with brain function...
Research Grants
- OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCEJames Hill; Fiscal Year: 2001..The long-term goal is to provide insights into HSV pathogenesis that could result in the development of therapeutic strategies to block neuronal HSV reactivation and the morbidity caused by repeated episodes of herpetic disease. ..
- OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITISJames Hill; Fiscal Year: 2001....
- Ocular HSV-Latency, Reactivation, and RecurrenceJames Hill; Fiscal Year: 2009..The use of two receptor-based ApoE mimetic peptides that exhibit potent anti-viral and anti-inflammatory activity, and which act to suppress this gene, holds great promise as a new therapy for ocular and other HSV-related diseases. ..
- Aging, Herpesviruses, and Alzheimer's DiseaseJames Hill; Fiscal Year: 2007..B) Detect and quantitate HSV-1 mRNAs in tissues positive for HSV-1. This project could lead to strategies to identify high-risk individuals who would be treated with antivirals, thus reducing their risk of developing AD. ..
- Ocular HSV-Latency, Reactivation, and RecurrenceJames Hill; Fiscal Year: 2007..The availability of sensitive and comprehensive host gene expression analysis methods, especially the new rabbit gene array already integrated into our ongoing studies, will aid us in achieving these aims. ..
- OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCEJames Hill; Fiscal Year: 2004..The development of new therapies that prevent the corneal scarring caused by repeated episodes of herpetic disease would represent an important advance protecting vision and decreasing the need for corneal transplantation. ..
- OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITISJames Hill; Fiscal Year: 1993..Patients with bacterial keratitis would reap significant benefits from the development of a specific therapeutic regimen that minimizes corneal scarring...
- OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCEJames Hill; Fiscal Year: 1993....
- OCULAR HSV: LATENCY, REACTIVATION, & RECURRENCEJames Hill; Fiscal Year: 1991..If the trigger that causes the reactivation of latent herpes virus can be identified, a therapeutic strategy, perhaps a specific blocker, can be formulated to inhibit the reactivation of HSV-1 and block recurrent herpetic ocular disease...
- Ocular HSV-Latency, Reactivation, and RecurrenceJames M Hill; Fiscal Year: 2010..The use of two receptor-based ApoE mimetic peptides that exhibit potent anti-viral and anti-inflammatory activity, and which act to suppress this gene, holds great promise as a new therapy for ocular and other HSV-related diseases. ..