M Elizabeth Hartnett

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Antiphospholipid antibody syndrome in a six-year-old female patient
    M Elizabeth Hartnett
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Ophthalmol 135:542-4. 2003
  2. pmc The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model
    Grace Byfield
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7041, USA
    Invest Ophthalmol Vis Sci 50:3360-5. 2009
  3. pmc Association of retinal vascular endothelial growth factor with avascular retina in a rat model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, University of North Carolina, Chapel Hill, USA
    Arch Ophthalmol 128:1014-21. 2010
  4. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
  5. pmc Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity
    John S Hartmann
    University of North Carolina, Department of Ophthalmology, Chapel Hill, NC, USA
    Mol Vis 17:1577-87. 2011
  6. pmc Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
    Yuta Saito
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 13:840-53. 2007
  7. pmc Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ophthalmol 148:895-901.e1. 2009
  8. pmc Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, School of Medicine, University of North Carolina, 130 Mason Farm Rd, Campus Box 7040, Chapel Hill, NC 27599 7040, USA
    Arch Ophthalmol 128:589-95. 2010
  9. pmc The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599 7040, USA
    Doc Ophthalmol 120:25-39. 2010
  10. pmc Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 49:3107-14. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Antiphospholipid antibody syndrome in a six-year-old female patient
    M Elizabeth Hartnett
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Ophthalmol 135:542-4. 2003
    ..To report the first instance of primary antiphospholipid antibody (APA) syndrome in an otherwise healthy 6-year-old female patient with retinal venous thromboses...
  2. pmc The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model
    Grace Byfield
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7041, USA
    Invest Ophthalmol Vis Sci 50:3360-5. 2009
    ....
  3. pmc Association of retinal vascular endothelial growth factor with avascular retina in a rat model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, University of North Carolina, Chapel Hill, USA
    Arch Ophthalmol 128:1014-21. 2010
    ..To study the effects of oxygen fluctuations on rat vascular endothelial growth factor (VEGF), VEGF receptor 1(VEGFR1), and VEGFR2 in a model of retinopathy of prematurity (ROP)...
  4. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
    ..To study the effects of intravitreous triamcinolone acetonide (TA) on neovascularization (NV), capillary density, and retinal endothelial cell (REC) viability in a model of oxygen-induced retinopathy (OIR)...
  5. pmc Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity
    John S Hartmann
    University of North Carolina, Department of Ophthalmology, Chapel Hill, NC, USA
    Mol Vis 17:1577-87. 2011
    ..To determine the effects of oxygen fluctuations on pigment epithelial-derived factor (PEDF) and vascular endothelial growth factor (VEGF)/PEDF ratios in a relevant rat model of retinopathy of prematurity (ROP)...
  6. pmc Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
    Yuta Saito
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 13:840-53. 2007
    ....
  7. pmc Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ophthalmol 148:895-901.e1. 2009
    ....
  8. pmc Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity
    Steven J Budd
    Department of Ophthalmology, School of Medicine, University of North Carolina, 130 Mason Farm Rd, Campus Box 7040, Chapel Hill, NC 27599 7040, USA
    Arch Ophthalmol 128:589-95. 2010
    ..To determine expression of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor, and their respective receptors in retinas using a model of retinopathy of prematurity...
  9. pmc The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599 7040, USA
    Doc Ophthalmol 120:25-39. 2010
    ..Increased signaling of VEGF appears important to the development of both avascular retina and intravitreous neovascularization...
  10. pmc Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 49:3107-14. 2008
    ..To study the effects of vascular endothelial growth factor (VEGF) on endothelial nitric oxide synthetase (eNOS) and retinal vascular tortuosity and cleavage planes in a rat model of retinopathy of prematurity (ROP)...
  11. pmc Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1
    Lynda J Peterson
    Department of Ophthalmology, 6135 Neuroscience Research Building, University of North Carolina, 103 Mason Farm Road, CB 7041, 6135 NSRB, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 84:737-44. 2007
    ..We hypothesize that contact between CECs and RPE stimulates a signaling pathway involving PI 3-K, Akt1, and Rac1 that facilitates CEC transmigration across the RPE barrier, an important step in the development of neovascular AMD...
  12. ncbi request reprint Comparison of retinal outcomes after scleral buckle or lens-sparing vitrectomy for stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7040, USA
    Retina 24:753-7. 2004
    ..To compare anatomic outcomes after lens-sparing vitrectomy (LSV) or scleral buckle (SB) for stage 4 retinopathy of prematurity (ROP)...
  13. pmc Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity
    Manabu McCloskey
    Department of Ophthalmology, The John Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 54:2020-6. 2013
    ..We sought to understand causes of late-onset IVNV and AVA following anti-VEGF using an ROP model...
  14. ncbi request reprint Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Eye Res 31:739-48. 2006
    ..To investigate and compare the characteristics of four different types of retinal pigment epithelium (RPE) cells cultured for 2 to 5 weeks to provide guidance when choosing RPE cells for experimentation...
  15. pmc Upregulation of CCR3 by age-related stresses promotes choroidal endothelial cell migration via VEGF-dependent and -independent signaling
    Haibo Wang
    Department of Ophthalmology, The John Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
    Invest Ophthalmol Vis Sci 52:8271-7. 2011
    ....
  16. pmc The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE
    Haibo Wang
    Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:570-8. 2011
    ..To determine the role of vascular endothelial growth factor 189 (VEGF₁₈₉) in choroidal endothelial cell (CEC) migration across the retinal pigment epithelium (RPE) and to explore the molecular mechanisms involved...
  17. pmc Fibrovascular organization in the vitreous following laser for ROP: implications for prognosis
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7040, USA
    Retina 26:S24-31. 2006
    ..To study associations between surgical outcome and mean postmenstrual age (PMA) when fibrovascular organization is detected between vascular and avascular retina following laser for acute retinopathy of prematurity (ROP)...
  18. pmc Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, 6135 Neuroscience Research Building, 103 Mason Farm Road, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 83:438-46. 2006
    ..Antibody to LIF restored the cell counts to untreated levels. LIF reduced the number of cells in S phase. LIF attenuates retinal vascular development in vivo through growth arrest, and not apoptosis, of endothelial cells...
  19. ncbi request reprint Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB No 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 82:608-19. 2006
    ..These findings may have relevance to the transformation of occult CNV into CNV within the neurosensory retina in AMD...
  20. ncbi request reprint Long-term vision results measured with Teller Acuity Cards and a new Light Perception/Projection Scale after management of late stages of retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill 27599 7040, USA
    Arch Ophthalmol 121:991-6. 2003
    ....
  21. pmc Soluble mediators of diabetic macular edema: the diagnostic role of aqueous VEGF and cytokine levels in diabetic macular edema
    Leah A Owen
    Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Curr Diab Rep 13:476-80. 2013
    ..Further studies targeting individual cytokine activity will be important to our understanding of the pathogenesis and treatment. ..
  22. pmc New-onset maternal gestational hypertension and risk of retinopathy of prematurity
    Mohamed A Zayed
    Department of Ophthalmology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 51:4983-8. 2010
    ..To evaluate associations between conditions of maternal new-onset gestational hypertension (mHTN) and the features imparting risk of severe retinopathy of prematurity (ROP) in preterm infants...
  23. pmc Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes
    Robyn Reynolds
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:5818-27. 2009
    ..This study was conducted to determine whether alterations in circulating levels of these markers of complement activation and regulation are also independently associated with advanced AMD and whether they are related to AMD genotypes...
  24. pmc VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 10:512-20. 2004
    ..We also determined whether pigment epithelium-derived factor (PEDF) was dysregulated by oxygen fluctuations perhaps contributing to a delay in normal retinal vascular development...
  25. ncbi request reprint Quantification of macular and optic disc hyperfluorescence after phacoemulsification in diabetes mellitus
    George K Escaravage
    Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Cataract Refract Surg 32:803-11. 2006
    ....
  26. pmc Retinal features predictive of progressive stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Retina 24:237-41. 2004
    ..To determine the retinal features predictive of progressive stage 4 retinopathy of prematurity (ROP) after laser treatment for threshold ROP...
  27. ncbi request reprint Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 5109D Bioinformatics Building, 130 Mason Farm Road, CB 7040, Chapel Hill, NC 27599 7040, USA
    Exp Eye Res 77:593-9. 2003
    ..To investigate the effect of endothelial cells (EC) on the barrier function of the retinal pigment epithelium (RPE)...
  28. ncbi request reprint Features associated with surgical outcome in patients with stages 4 and 5 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, 27599, USA
    Retina 23:322-9. 2003
    ..To present ocular features associated with surgical outcomes in infants with stages 4 and 5 retinopathy of prematurity (ROP)...
  29. ncbi request reprint Prothrombin gene mutation G20210A, homocysteine, antiphospholipid antibodies and other hypercoagulable states in ocular thrombosis
    Elizabeth M Van Cott
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Blood Coagul Fibrinolysis 15:393-7. 2004
    ..Testing for homocysteine, antiphospholipid antibodies, and the prothrombin G20210A mutation should be considered in patients with ocular thromboses...